MULTI-SPECTRAL SCATTERING-MATRIX TOMOGRAPHY

    公开(公告)号:US20230128254A1

    公开(公告)日:2023-04-27

    申请号:US17972073

    申请日:2022-10-24

    Abstract: A method for multi-spectral scattering-matrix tomography includes a step of splitting an input light signal into an incident light signal and a reference light signal. The sample light signal is directed to a sample in either a reflection configuration or a transmission configuration such that an output light signal includes light scattered from or transmitted through the sample. The incident signal and the reference light signal are directed to a camera angled to allow for amplitude and phase to be calculated by off-axis holography. A total light signal is measured with a camera that is a coherent sum of the reference light signal and the output signal. The total light signal for each light frequency and each incident angle are collected as collected total light signal data. A computing device derives an image of the sample from a calculated reflection matrix or transmission matrix or both of them.

    OPIOID RECEPTOR ANTAGONISTS
    69.
    发明申请

    公开(公告)号:US20230111856A1

    公开(公告)日:2023-04-13

    申请号:US17908203

    申请日:2021-03-02

    Abstract: The first selective SuFEx antagonists to μ-opioid receptors (MOR) were developed by functionalizing an opioid scaffold with an SO2—F warhead. Our model, based on a MOR structure with antagonist β-FNA, indicates the naloxone carbonyl as an advantageous point for derivatization as it is chemically accessible and is not involved in interaction with receptors. Of the three accessible Tyr residues in MOR pocket, Tyr77, Tyr130 and Tyr150, Tyr150 in proximity to the carbonyl of the docked naloxone was selected as a target, which resulted in the development of highly potent antagonists.

    Optical phased array receiver architectures

    公开(公告)号:US11626929B2

    公开(公告)日:2023-04-11

    申请号:US17571391

    申请日:2022-01-07

    Inventor: Hossein Hashemi

    Abstract: Described herein are optical phased array receivers. In various embodiments, an optical phased array receiver includes a set of antennas, each antenna configured to receive an optical signal; a local oscillator configured to generate one or more optical carrier signals; one or more optical signal combiners coupled to the set of antennas and the local oscillator, the one or more optical signal combiners configured to combine (i) the optical signals received by the antennas and (ii) the optical carrier signal; and one or more photodetectors configured to extract information carried by one or more of the received optical signals into an electrical signal, wherein the extracted information is indicative of a phase and an amplitude of the one or more of the received optical signals.

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