公开(公告)号：US20080147164A1

公开(公告)日：2008-06-19

申请号：US11639079

申请日：2006-12-13

Applicant: David C. Gale ,  Bin Huang ,  Vincent J. Guertguian ,  Syed F.A. Hossainy

Inventor： David C. Gale ,  Bin Huang ,  Vincent J. Guertguian ,  Syed F.A. Hossainy

IPC: A61F2/06

CPC classification number: A61F2/95 ,  A61F2/91 ,  A61F2002/9522 ,  A61L31/06 ,  Y10T29/49771 ,  Y10T29/49908 ,  Y10T29/49913 ,  Y10T29/49938 ,  C08L67/04

Abstract: Disclosed herein is a method of fabricating a stent assembly comprising radially expanding a polymeric tube to an optimal degree of radial expansion; fabricating a stent from the expanded polymeric tube; and crimping the stent onto a catheter assembly, wherein the temperature of the stent during crimping is an optimal crimping temperature, wherein the optimal degree of radial expansion and the optimal crimping temperature correspond to an optimal fracture toughness exhibited by the crimped stent upon its deployment as a function of degree of radial expansion and crimping temperature.

Abstract translation: 本文公开了一种制造支架组件的方法，包括将聚合物管径向膨胀至最佳径向膨胀程度; 从扩张的聚合物管制造支架; 并将支架卷曲到导管组件上，其中在卷曲期间支架的温度是最佳卷曲温度，其中最佳径向膨胀程度和最佳卷曲温度对应于卷曲支架在展开时表现出的最佳断裂韧性 径向膨胀度和卷曲温度的函数。

公开(公告)号：US20070286941A1

公开(公告)日：2007-12-13

申请号：US11453175

申请日：2006-06-13

Applicant: Bin Huang ,  David C. Gale ,  Daniel Castro ,  Timothy A. Limon

Inventor： Bin Huang ,  David C. Gale ,  Daniel Castro ,  Timothy A. Limon

IPC: A61L33/00

CPC classification number: A61F2/82 ,  A61F2/91 ,  A61L2400/18 ,  C08J7/02

Abstract: Methods of treating the polymeric surfaces of a stent with a fluid including a solvent for the surface polymer are disclosed.

Abstract translation: 公开了一种用包括用于表面聚合物的溶剂的流体处理支架的聚合物表面的方法。

公开(公告)号：US20070282431A1

公开(公告)日：2007-12-06

申请号：US11443870

申请日：2006-05-30

Applicant: David C. Gale ,  Yunbing Wang ,  Syed Faiyaz Ahmed Hossainy ,  Bin Huang ,  Garth L. Wilkes ,  Vincent J. Gueriguian

Inventor： David C. Gale ,  Yunbing Wang ,  Syed Faiyaz Ahmed Hossainy ,  Bin Huang ,  Garth L. Wilkes ,  Vincent J. Gueriguian

IPC: A61F2/06

CPC classification number: A61F2/82 ,  A61L31/127 ,  A61L31/128 ,  A61L31/148 ,  B29C47/0007 ,  B29C47/0014 ,  B29C47/0021 ,  B29C47/0023 ,  Y10S977/753 ,  Y10S977/776 ,  Y10S977/831 ,  Y10S977/931

Abstract: Methods and devices relating to polymer-bioceramic composite implantable medical devices are disclosed.

Abstract translation: 公开了与聚合物 - 生物陶瓷复合植入式医疗装置有关的方法和装置。

公开(公告)号：US09188558B2

公开(公告)日：2015-11-17

申请号：US12796546

申请日：2010-06-08

Applicant: Abigail Freeman ,  David C. Gale ,  Bin Huang ,  Daniel Castro

Inventor： Abigail Freeman ,  David C. Gale ,  Bin Huang ,  Daniel Castro

IPC: H04Q5/22 ,  G01N25/72 ,  A61B19/00 ,  A61L2/08 ,  A61L2/10 ,  A61F2/82 ,  A61F2/06

CPC classification number: G01N25/72 ,  A61B90/90 ,  A61B90/98 ,  A61F2/06 ,  A61F2/82 ,  A61F2250/0085 ,  A61L2/081 ,  A61L2/082 ,  A61L2/085 ,  A61L2/087 ,  A61L2/10 ,  A61L2202/14

Abstract: A method and system of monitoring environmental exposure of stents using radiofrequency identification is disclosed.

Abstract translation: 公开了使用射频识别来监测支架的环境暴露的方法和系统。

公开(公告)号：US08940037B2

公开(公告)日：2015-01-27

申请号：US13281286

申请日：2011-10-25

Applicant: Bin Huang ,  David C. Gale

Inventor： Bin Huang ,  David C. Gale

IPC: A61F2/06 ,  A61F2/91 ,  A61F2/915 ,  A61L31/06 ,  A61L31/14

CPC classification number: A61F2/89 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/9155 ,  A61F2210/0057 ,  A61F2250/001 ,  A61F2250/0029 ,  A61F2250/0036 ,  A61F2250/0071 ,  A61L31/06 ,  A61L31/14 ,  C08L67/04

Abstract: Disclosed is a method of treating a bodily lumen with a stent, the method comprising: disposing a stent within a bodily lumen, the stent comprising a plurality of deformable struts that are substantially circumferentially aligned and are configured to selectively deform in a circumferential direction in localized regions in the struts upon application of an outward radial force; and expanding the stent by applying the outward radial force, wherein the outward radial force causes selective deformation of the deformable struts in a localized region in the struts.

公开(公告)号：US08925177B2

公开(公告)日：2015-01-06

申请号：US13551538

申请日：2012-07-17

Applicant: Bin Huang ,  David C. Gale ,  Daniel Castro

Inventor： Bin Huang ,  David C. Gale ,  Daniel Castro

IPC: B21D39/04 ,  A61F2/84 ,  A61F2/958 ,  A61F2/95

CPC classification number: A61F2/958 ,  A61F2002/9505 ,  A61F2002/9522 ,  A61F2002/9583 ,  A61F2002/9586 ,  B23P11/005 ,  Y10T29/49863 ,  Y10T29/49913 ,  Y10T29/49925 ,  Y10T29/49927 ,  Y10T29/53065 ,  Y10T29/53987

Abstract: A method of crimping a stent on a balloon of a catheter assembly is provided. A polymeric stent is disposed over a balloon in an inflated configuration. The stent is crimped over the inflated balloon to a reduced crimped configuration so that the stent is secured onto the balloon. The balloon wall membrane is wedged or pinched between the strut elements of the stent for increasing the retention of the stent on the balloon.

Abstract translation: 提供了一种将支架卷曲在导管组件的球囊上的方法。 将聚合物支架设置在膨胀构型的气球上。 将支架卷曲在膨胀的气囊上以减小卷曲构造，使得支架固定在气球上。 球囊壁膜被楔入或夹在支架的支柱元件之间，以增加支架在气囊上的保留。

公开(公告)号：US08747879B2

公开(公告)日：2014-06-10

申请号：US11444596

申请日：2006-05-31

Applicant: Bin Huang ,  David C. Gale

Inventor： Bin Huang ,  David C. Gale

IPC: A61F2/82 ,  A61F2/06

CPC classification number: A61L31/06 ,  A61F2/915 ,  A61L31/148 ,  B23K26/402 ,  B23K2103/42 ,  B23K2103/50 ,  B29B13/02 ,  B29C71/0063 ,  B29L2031/7532 ,  C08L67/04

Abstract: The invention provides a method for fabricating an implantable medical device to increase biocompatibility of the device, the method comprising: heat setting a polymer construct, wherein the polymer construct is at a temperature range of from about Tg to about 0.6(Tm−Tg)+Tg such that the set polymer construct comprises a crystalline structure having crystals at a size less than about 2 microns; and fabricating an implantable medical device from the heat set polymer construct.

Abstract translation: 本发明提供一种用于制造可植入医疗装置以提高装置的生物相容性的方法，所述方法包括：热定形聚合物构造物，其中所述聚合物构造物的温度范围为约Tg至约0.6（Tm-Tg）+ Tg使得所述聚合物构件包含具有小于约2微米尺寸的晶体的晶体结构; 以及从所述热固性聚合物构造物制造可植入医疗装置。

公开(公告)号：US08741201B2

公开(公告)日：2014-06-03

申请号：US12878937

申请日：2010-09-09

Applicant: Bin Huang ,  David C. Gale

Inventor： Bin Huang ,  David C. Gale

IPC: B29C57/00 ,  B29C71/00 ,  B29C59/02 ,  A61F2/06

CPC classification number: A61F2/915 ,  A61F2/04 ,  A61F2/06 ,  A61F2/90 ,  A61F2/91 ,  A61F2002/072 ,  A61F2002/91508 ,  A61F2002/91575 ,  A61F2210/0004 ,  A61F2210/0009 ,  A61F2210/0076 ,  A61F2220/005 ,  A61F2230/0013 ,  A61F2250/0098 ,  A61L31/129 ,  B23K26/402 ,  B23K26/50 ,  B23K2103/42 ,  B23K2103/50 ,  B29C43/02 ,  B29C45/0001 ,  B29C45/0005 ,  B29C45/0055 ,  B29C47/0004 ,  B29C47/0023 ,  B29C47/0026 ,  B29C47/0066 ,  B29C47/06 ,  B29C47/1045 ,  B29C53/566 ,  B29C53/583 ,  B29C59/02 ,  B29C59/021 ,  B29C2043/028 ,  B29K2101/00 ,  B29K2105/12 ,  B29K2267/043 ,  B29K2995/0056 ,  B29K2995/006 ,  B29L2023/003 ,  B29L2031/7546 ,  D03D3/02

Abstract: Polymeric composite stents reinforced with fibers for implantation into a bodily lumen are disclosed.

Abstract translation: 公开了用纤维增强的用于植入体腔的聚合复合支架。

公开(公告)号：US08709071B1

公开(公告)日：2014-04-29

申请号：US11864472

申请日：2007-09-28

Applicant: Bin Huang ,  David C. Gale ,  Daniel A. Castro ,  Vincent J. Gueriguian

Inventor： Bin Huang ,  David C. Gale ,  Daniel A. Castro ,  Vincent J. Gueriguian

IPC: A61F2/06

CPC classification number: A61L31/10 ,  A61F2/86 ,  A61F2240/001 ,  A61F2250/0051 ,  A61F2250/0067 ,  A61K31/436 ,  A61L31/022 ,  A61L31/06 ,  A61L31/08 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/416 ,  A61L2420/02 ,  A61L2420/08 ,  B05D1/02 ,  B05D1/18 ,  B05D1/32

Abstract: This invention relates to stents, a type of implantable medical device, with an antiproliferative coating and a prohealing luminal coating and methods of fabricating stents with an antiproliferative coating and a prohealing luminal coating.

Abstract translation: 本发明涉及支架，一种可植入医疗装置，其具有抗增殖性涂层和预呼流道腔涂层，以及制造具有抗增殖性涂层和预呼流道涂层的支架的方法。

公开(公告)号：US08663192B2

公开(公告)日：2014-03-04

申请号：US12768628

申请日：2010-04-27

Applicant: Jerome E. Hester ,  Anthony J. Abbate ,  Richard E. Kaufman ,  David C. Gale ,  Gail M. Zaler ,  Bin Huang ,  Lisa Earnhardt ,  Vijaykumar Rajasekhar

Inventor： Jerome E. Hester ,  Anthony J. Abbate ,  Richard E. Kaufman ,  David C. Gale ,  Gail M. Zaler ,  Bin Huang ,  Lisa Earnhardt ,  Vijaykumar Rajasekhar

IPC: A61M31/00

CPC classification number: A61L31/16 ,  A61B17/04 ,  A61B17/06166 ,  A61B17/064 ,  A61B17/0644 ,  A61B17/068 ,  A61B17/08 ,  A61B17/083 ,  A61B17/26 ,  A61B17/3468 ,  A61B2017/0073 ,  A61B2017/00893 ,  A61B2017/06176 ,  A61B2017/0641 ,  A61B2017/0647 ,  A61B2017/0649 ,  A61B2090/3987 ,  A61B2090/3991 ,  A61L17/10 ,  A61M31/00 ,  A61M31/002 ,  A61M37/0069

Abstract: Described here are devices and methods for treating one or more conditions or symptoms associated with a tonsil procedure. In some variations, a drug-releasing device may be at least partially delivered to one or more tonsillar tissues before, during, or after a tonsil procedure. In some variations, the drug-releasing device may be configured to be biodegradable. In other variations, the drug-releasing device may comprise one or more hemostatic materials or one or more adhesives. The drug-releasing device may be configured to release one or more drugs or agents, such as, for example, one or more analgesics, local anesthetics, vasoconstrictors, antibiotics, combinations thereof and the like.

Abstract translation: 这里描述了用于治疗与扁桃体过程相关的一种或多种病症或症状的装置和方法。 在一些变型中，药物释放装置可以在扁桃体手术之前，期间或之后至少部分递送至一个或多个扁桃体组织。 在一些变型中，药物释放装置可以被配置为可生物降解的。 在其它变型中，药物释放装置可以包括一种或多种止血材料或一种或多种粘合剂。 药物释放装置可以被配置为释放一种或多种药物或药剂，例如一种或多种止痛剂，局部麻醉剂，血管收缩剂，抗生素及其组合等。