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    Ocular surface interferometry (OSI) devices and systems for imaging, processing, and/or displaying an ocular tear film
    64.
    发明授权
    Ocular surface interferometry (OSI) devices and systems for imaging, processing, and/or displaying an ocular tear film 有权

    公开(公告)号：US09554698B2

    公开(公告)日：2017-01-31

    申请号：US14299504

    申请日：2014-06-09

    Applicant: TearScience Inc.

    Inventor： Donald R. Korb ,  William L. Weber ,  Randal B. Chinnock ,  Benjamin T. Gravely ,  Stephen M. Grenon

    IPC: A61B3/14 ,  A61B3/10 ,  A61B3/02 ,  A61B5/05 ,  A61B3/00 ,  G06T7/00

    Abstract: Ocular surface interferometry (OSI) devices, systems, and methods are disclosed for measuring a tear film layer thickness (TFLT) of the ocular tear film, including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT). The measured TFLT can be used to diagnosis dry eye syndrome (DES). In certain disclosed embodiments, a multi-wavelength light source can be controlled to illuminate the ocular tear film. Light emitted from the multi-wavelength light source undergoes optical wave interference interactions in the tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in a first image. The imaging device can also be focused on the lipid layer of the tear film to capture a second image containing the background signal(s) present in the first image. The second image can be subtracted from the first image to reduce and/or eliminate the background signal(s) in the first image to produce a resulting image. The resulting image can be processed and analyzed to measure a tear film layer thickness (TFLT), including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT).

    FULL-EYE ILLUMINATION OCULAR SURFACE IMAGING OF AN OCULAR TEAR FILM FOR DETERMINING TEAR FILM THICKNESS AND/OR PROVIDING OCULAR TOPOGRAPHY
    66.
    发明申请
    FULL-EYE ILLUMINATION OCULAR SURFACE IMAGING OF AN OCULAR TEAR FILM FOR DETERMINING TEAR FILM THICKNESS AND/OR PROVIDING OCULAR TOPOGRAPHY 有权
    全眼照射用于确定眼膜厚度和/或提供OCULAR TOPOGRAPHY的眼部眼膜的OCALAR表面成像

    公开(公告)号：US20150138505A1

    公开(公告)日：2015-05-21

    申请号：US14543931

    申请日：2014-11-18

    Applicant: TearScience, Inc.

    Inventor： Stephen M. Grenon ,  Donald R. Korb

    IPC: A61B3/10 ,  A61B3/14 ,  A61B3/00

    CPC classification number: A61B3/101 ,  A61B3/0008 ,  A61B3/0025 ,  A61B3/0058 ,  A61B3/1005 ,  A61B3/107 ,  A61B3/14 ,  G02B26/023

    Abstract: Ocular surface interferometry (OSI) devices, systems, and methods are disclosed for measuring a tear film layer thickness (TFLT) of the ocular tear film, including the lipid layer thickness (LLT) and/or the aqueous layer thickness (ALT). The TFLT can be used to diagnose dry eye syndrome (DES). Certain embodiments also include ocular topography devices, systems and methods for deducing corneal shape by capturing an image of a target reflecting from the surface of the cornea. The image of the target contains topography information that is reviewable by a clinician to diagnose the health of the patient's eye by detecting corneal aberrations and/or abnormalities in corneal shape. Certain embodiments also include a combination of the OSI and ocular topography devices, systems and methods to provide imaging that can be used to yield a combined diagnosis of the patient's tear film and corneal shape.

    Abstract translation: 公开了用于测量眼泪膜的泪膜层厚度（TFLT），包括脂质层厚度（LLT）和/或水层厚度（ALT）的眼表干涉测量（OSI）装置，系统和方法。 TFLT可用于诊断干眼综合征（DES）。 某些实施例还包括眼部地形设备，用于通过捕获从角膜表面反射的目标的图像来推导角膜形状的系统和方法。 目标的图像包含地形信息，临床医生可以通过检测角膜畸形和/或角膜形状的异常来诊断患者眼睛的健康状况。 某些实施方案还包括OSI和眼部形貌设备的组合，用于提供可用于产生患者的泪膜和角膜形状的组合诊断的成像的系统和方法。

    OCULAR SURFACE INTERFEROMETRY (OSI) DEVICES AND SYSTEMS FOR IMAGING, PROCESSING, AND/OR DISPLAYING AN OCULAR TEAR FILM
    67.
    发明申请
    OCULAR SURFACE INTERFEROMETRY (OSI) DEVICES AND SYSTEMS FOR IMAGING, PROCESSING, AND/OR DISPLAYING AN OCULAR TEAR FILM 有权
    用于成像，处理和/或显示眼镜片的OCULAR SURFACE INTERFEROMETRY（OSI）设备和系统

    公开(公告)号：US20140285767A1

    公开(公告)日：2014-09-25

    申请号：US14299504

    申请日：2014-06-09

    Applicant: TearScience Inc.

    Inventor： Donald R. Korb ,  William L. Weber ,  Randal B. Chinnock ,  Benjamin T. Gravely ,  Stephen M. Grenon

    IPC: A61B3/10 ,  A61B3/00

    CPC classification number: A61B3/101 ,  A61B3/0025 ,  A61B3/0041 ,  A61B3/1005 ,  A61B3/14 ,  G06T7/0012 ,  G06T2207/30041

    Abstract: Ocular surface interferometry (OSI) devices, systems, and methods are disclosed for measuring a tear film layer thickness (TFLT) of the ocular tear film, including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT). The measured TFLT can be used to diagnosis dry eye syndrome (DES). In certain disclosed embodiments, a multi-wavelength light source can be controlled to illuminate the ocular tear film. Light emitted from the multi-wavelength light source undergoes optical wave interference interactions in the tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in a first image. The imaging device can also be focused on the lipid layer of the tear film to capture a second image containing the background signal(s) present in the first image. The second image can be subtracted from the first image to reduce and/or eliminate the background signal(s) in the first image to produce a resulting image. The resulting image can be processed and analyzed to measure a tear film layer thickness (TFLT), including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT).

    Abstract translation: 公开了用于测量眼泪膜的泪膜层厚度（TFLT），包括脂质层厚度（LLT）和/或水层厚度（ALT）的眼表干涉测量（OSI）装置，系统和方法。 测量的TFLT可用于诊断干眼综合征（DES）。 在某些公开的实施例中，可以控制多波长光源以照射眼泪膜。 从多波长光源发射的光在泪膜中经历光波干涉相互作用。 成像装置可以集中在泪膜的脂质层上，以捕获与第一图像中的背景信号结合的来自泪膜的镜面反射光的光波干涉相互作用。 成像装置还可以聚焦在泪膜的脂质层上，以捕获包含存在于第一图像中的背景信号的第二图像。 可以从第一图像中减去第二图像以减少和/或消除第一图像中的背景信号以产生所得图像。 可以对所得图像进行处理和分析，以测量泪膜层厚度（TFLT），包括脂质层厚度（LLT）和/或水层厚度（ALT）。

    METHODS AND APPARATUSES FOR DETERMINING CONTACT LENS INTOLERANCE IN CONTACT LENS WEARER PATIENTS BASED ON DRY EYE TEAR FILM CHARACTERISTIC ANALYSIS AND DRY EYE SYMPTOMS
    68.
    发明申请
    METHODS AND APPARATUSES FOR DETERMINING CONTACT LENS INTOLERANCE IN CONTACT LENS WEARER PATIENTS BASED ON DRY EYE TEAR FILM CHARACTERISTIC ANALYSIS AND DRY EYE SYMPTOMS 有权
    用于确定接触镜片的联系人眼镜不透明度的方法和装置基于干眼眼膜的特征分析和干眼症状

    公开(公告)号：US20140240671A1

    公开(公告)日：2014-08-28

    申请号：US14268647

    申请日：2014-05-02

    Applicant: TEARSCIENCE, Inc.

    Inventor： Donald R. Korb ,  Stephen M. Grenon ,  Steve Bacich

    IPC: A61B3/00 ,  A61B3/10

    CPC classification number: A61B3/0025 ,  A61B3/101 ,  G06T7/0012 ,  G06T2207/30041

    Abstract: Methods and apparatuses for determining contact lens intolerance in contact lens wearer patients based on tear film characteristics analysis and dry eye symptoms are disclosed. In embodiments herein, imaging of the ocular tear film is performed during contact lens wear. An analysis of the image of the ocular tear film is performed to determine one or more tear film characteristics of the ocular tear film. The tear film characteristics can be used to determine the effect or possible effect of contact lens wear on the ocular tear film, and thus be used to determine contact lens intolerance of the patient. The tear film characteristics used to analyze contact lens intolerance based on images of the ocular tear film involving contact lens wear may include dry eye symptoms, including but not limited to tear film (e.g., lipid and/or aqueous) thickness, tear film viscosity, and tear film movement rate in the eye.

    Abstract translation: 公开了基于泪膜特性分析和干眼症状来确定隐形眼镜佩戴者患者中隐形眼镜不耐受性的方法和装置。 在本文的实施例中，在隐形眼镜佩戴期间进行眼泪膜的成像。 执行眼泪膜的图像分析，以确定眼泪膜的一个或多个泪膜特性。 可以使用泪膜特性来确定隐形眼镜磨损对眼泪膜的影响或可能的影响，因此用于确定患者的隐形眼镜不耐受性。 基于涉及隐形眼镜磨损的眼泪膜的图像，用于分析隐形眼镜不耐受的泪膜特征可包括干眼症状，包括但不限于泪膜（例如，脂质和/或水性）厚度，泪膜粘度， 和眼膜中的泪膜移动速率。

    FULL-EYE ILLUMINATION OCULAR SURFACE IMAGING OF AN OCULAR TEAR FILM FOR DETERMINING TEAR FILM THICKNESS AND/OR PROVIDING OCULAR TOPOGRAPHY
    69.
    发明申请
    FULL-EYE ILLUMINATION OCULAR SURFACE IMAGING OF AN OCULAR TEAR FILM FOR DETERMINING TEAR FILM THICKNESS AND/OR PROVIDING OCULAR TOPOGRAPHY 有权
    全眼照射用于确定眼膜厚度和/或提供OCULAR TOPOGRAPHY的眼部眼膜的OCALAR表面成像

    公开(公告)号：US20140104574A1

    公开(公告)日：2014-04-17

    申请号：US14137105

    申请日：2013-12-20

    Applicant: TearScience, Inc.

    Inventor： Stephen M. Grenon ,  Donald R. Korb

    IPC: A61B3/00 ,  A61B3/10 ,  A61B3/107 ,  A61B3/14

    CPC classification number: A61B3/0025 ,  A61B3/0058 ,  A61B3/1005 ,  A61B3/101 ,  A61B3/107 ,  A61B3/14 ,  G06T7/0012 ,  G06T2207/10016 ,  G06T2207/10144 ,  G06T2207/20224 ,  G06T2207/30041

    Abstract: Ocular surface interferometry (OSI) devices, systems, and methods are disclosed for measuring a tear film layer thickness (TFLT) of the ocular tear film, including the lipid layer thickness (LLT) and/or the aqueous layer thickness (ALT). The TFLT can be used to diagnose dry eye syndrome (DES). Certain embodiments also include ocular topography devices, systems and methods for deducing corneal shape by capturing an image of a target reflecting from the surface of the cornea. The image of the target contains topography information that is reviewable by a clinician to diagnose the health of the patient's eye by detecting corneal aberrations and/or abnormalities in corneal shape. Certain embodiments also include a combination of the OSI and ocular topography devices, systems and methods to provide imaging that can be used to yield a combined diagnosis of the patient's tear film and corneal shape.

    Abstract translation: 公开了用于测量眼泪膜的泪膜层厚度（TFLT），包括脂质层厚度（LLT）和/或水层厚度（ALT）的眼表干涉测量（OSI）装置，系统和方法。 TFLT可用于诊断干眼综合征（DES）。 某些实施例还包括眼部地形设备，用于通过捕获从角膜表面反射的目标的图像来推导角膜形状的系统和方法。 目标的图像包含地形信息，临床医生可以通过检测角膜畸形和/或角膜形状的异常来诊断患者眼睛的健康状况。 某些实施方案还包括OSI和眼部形貌设备的组合，用于提供可用于产生患者的泪膜和角膜形状的组合诊断的成像的系统和方法。

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