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    OCULAR SURFACE INTERFEROMETRY (OSI) FOR IMAGING, PROCESSING, AND/OR DISPLAYING AN OCULAR TEAR FILM
    1.
    发明申请
    OCULAR SURFACE INTERFEROMETRY (OSI) FOR IMAGING, PROCESSING, AND/OR DISPLAYING AN OCULAR TEAR FILM 有权

    公开(公告)号：US20220133143A1

    公开(公告)日：2022-05-05

    申请号：US17573899

    申请日：2022-01-12

    Applicant: TearScience, Inc.

    Inventor： Donald R. Korb ,  William L. Weber ,  Randal B. Chinnock ,  Benjamin T. Gravely ,  Stephen M. Grenon

    IPC: A61B3/10 ,  A61B3/00 ,  G06T7/00 ,  A61B3/14

    Abstract: Ocular surface interferometry devices, systems, and methods are disclosed for imaging an ocular tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in a first image, wherein the specularly reflected light may be produced from various portions of the ocular tear film by obliquely illuminating various portions of the ocular tear film with a multi-wavelength light source, such as in a tiling pattern(s). The imaging device can also be focused on the lipid layer to capture a second image containing the background signal(s) present in the first image. The second image can be subtracted from the first image to reduce and/or eliminate the background signal(s) in the first image to produce a resulting image, which can used to measure a tear film layer thickness.

    OCULAR SURFACE INTERFEROMETRY (OSI) DEVICES AND SYSTEMS FOR IMAGING, PROCESSING, AND/OR DISPLAYING AN OCULAR TEAR FILM
    3.
    发明申请
    OCULAR SURFACE INTERFEROMETRY (OSI) DEVICES AND SYSTEMS FOR IMAGING, PROCESSING, AND/OR DISPLAYING AN OCULAR TEAR FILM 有权
    用于成像，处理和/或显示眼镜片的OCULAR SURFACE INTERFEROMETRY（OSI）设备和系统

    公开(公告)号：US20160242640A1

    公开(公告)日：2016-08-25

    申请号：US15143834

    申请日：2016-05-02

    Applicant: TearScience Inc.

    Inventor： Donald R. Korb ,  William L. Weber ,  Randal B. Chinnock ,  Benjamin T. Gravely ,  Stephen M. Grenon

    IPC: A61B3/10 ,  A61B3/00 ,  A61B3/14

    CPC classification number: A61B3/101 ,  A61B3/0025 ,  A61B3/0041 ,  A61B3/1005 ,  A61B3/14 ,  G06T7/0012 ,  G06T2207/30041

    Abstract: Ocular surface interferometry (OSI) devices, systems, and methods are disclosed for measuring a tear film layer thickness (TFLT) of the ocular tear film, including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT). The measured TFLT can be used to diagnosis dry eye syndrome (DES). In certain disclosed embodiments, a multi-wavelength light source can be controlled to illuminate the ocular tear film. Light emitted from the multi-wavelength light source undergoes optical wave interference interactions in the tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in a first image. The imaging device can also be focused on the lipid layer of the tear film to capture a second image containing the background signal(s) present in the first image. The second image can be subtracted from the first image to reduce and/or eliminate the background signal(s) in the first image to produce a resulting image. The resulting image can be processed and analyzed to measure a tear film layer thickness (TFLT), including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT).

    Abstract translation: 公开了用于测量眼泪膜的泪膜层厚度（TFLT），包括脂质层厚度（LLT）和/或水层厚度（ALT）的眼表干涉测量（OSI）装置，系统和方法。 测量的TFLT可用于诊断干眼综合征（DES）。 在某些公开的实施例中，可以控制多波长光源以照射眼泪膜。 从多波长光源发射的光在泪膜中经历光波干涉相互作用。 成像装置可以集中在泪膜的脂质层上，以捕获与第一图像中的背景信号结合的来自泪膜的镜面反射光的光波干涉相互作用。 成像装置还可以聚焦在泪膜的脂质层上，以捕获包含存在于第一图像中的背景信号的第二图像。 可以从第一图像中减去第二图像以减少和/或消除第一图像中的背景信号以产生所得图像。 可以对所得图像进行处理和分析，以测量泪膜层厚度（TFLT），包括脂质层厚度（LLT）和/或水层厚度（ALT）。

    Ocular surface interferometry (OSI) for imaging, processing, and/or displaying an ocular tear film
    4.
    发明授权
    Ocular surface interferometry (OSI) for imaging, processing, and/or displaying an ocular tear film 有权

    公开(公告)号：US11259700B2

    公开(公告)日：2022-03-01

    申请号：US16782384

    申请日：2020-02-05

    Applicant: TearScience, Inc.

    Inventor： Donald R. Korb ,  William L. Weber ,  Randal B. Chinnock ,  Benjamin T. Gravely ,  Stephen M. Grenon

    IPC: A61B3/14 ,  A61B3/10 ,  A61B3/02 ,  A61B5/05 ,  A61B3/00 ,  G06T7/00

    Abstract: Ocular surface interferometry devices, systems, and methods are disclosed for imaging an ocular tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in a first image, wherein the specularly reflected light may be produced from various portions of the ocular tear film by obliquely illuminating various portions of the ocular tear film with a multi-wavelength light source, such as in a tiling pattern(s). The imaging device can also be focused on the lipid layer to capture a second image containing the background signal(s) present in the first image. The second image can be subtracted from the first image to reduce and/or eliminate the background signal(s) in the first image to produce a resulting image, which can used to measure a tear film layer thickness.

    Ocular surface interferometry (OSI) devices and systems for imaging, processing, and/or displaying an ocular tear film
    7.
    发明授权
    Ocular surface interferometry (OSI) devices and systems for imaging, processing, and/or displaying an ocular tear film 有权

    公开(公告)号：US09408534B2

    公开(公告)日：2016-08-09

    申请号：US14299504

    申请日：2014-06-09

    Applicant: TearScience Inc.

    Inventor： Donald R. Korb ,  William L. Weber ,  Randal B. Chinnock ,  Benjamin T. Gravely ,  Stephen M. Grenon

    IPC: A61B3/14 ,  A61B3/10 ,  A61B3/02 ,  A61B5/05 ,  A61B3/00 ,  G06T7/00

    Abstract: Ocular surface interferometry (OSI) devices, systems, and methods are disclosed for measuring a tear film layer thickness (TFLT) of the ocular tear film, including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT). The measured TFLT can be used to diagnosis dry eye syndrome (DES). In certain disclosed embodiments, a multi-wavelength light source can be controlled to illuminate the ocular tear film. Light emitted from the multi-wavelength light source undergoes optical wave interference interactions in the tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in a first image. The imaging device can also be focused on the lipid layer of the tear film to capture a second image containing the background signal(s) present in the first image. The second image can be subtracted from the first image to reduce and/or eliminate the background signal(s) in the first image to produce a resulting image. The resulting image can be processed and analyzed to measure a tear film layer thickness (TFLT), including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT).

    OPTICAL PHANTOMS FOR USE WITH OCULAR SURFACE INTERFEROMETRY (OSI) DEVICES AND SYSTEMS CONFIGURED TO MEASURE TEAR FILM LAYER THICKNESS(ES), AND RELATED USE FOR CALIBRATION
    8.
    发明申请
    OPTICAL PHANTOMS FOR USE WITH OCULAR SURFACE INTERFEROMETRY (OSI) DEVICES AND SYSTEMS CONFIGURED TO MEASURE TEAR FILM LAYER THICKNESS(ES), AND RELATED USE FOR CALIBRATION 审中-公开
    用于表面干涉测量（OSI）的光学仪器配置用于测量薄膜厚度（ES）的仪器和系统，以及用于校准的相关用途

    公开(公告)号：US20130293842A1

    公开(公告)日：2013-11-07

    申请号：US13886383

    申请日：2013-05-03

    Applicant: TEARSCIENCE, INC.

    Inventor： Stephen M. Grenon ,  Donald R. Korb ,  William L. Weber ,  Scott Liddle

    IPC: A61B3/10 ,  G02B5/28

    CPC classification number: A61B3/101 ,  B82Y15/00 ,  G01B11/0625 ,  G01N21/293 ,  G01N21/41 ,  G02B5/286 ,  G02B27/0018 ,  G09B23/30 ,  Y10S977/954

    Abstract: Embodiments of the detailed description include optical phantoms for use with ocular surface interferometery (OSI) devices and systems configured to measure tear film layer thickness(es), and related use for calibration. The ocular surface interferometry (OSI) devices, systems, and methods can be used for imaging an ocular tear film and/or measuring a tear film layer thickness (TFLT) in a patient's ocular tear film. The OSI devices, systems, and methods can be used to measure the thickness of the lipid layer component (LLT) and/or the aqueous layer component (ALT) of the ocular tear film. “TFLT” as used herein includes LLT, ALT, or both LLT and ALT. “Measuring TFLT” as used herein includes measuring LLT, ALT, or both LLT and ALT. Imaging the ocular tear film and measuring TFLT can be used in the diagnosis of a patient's tear film, including but not limited to lipid layer and aqueous layer deficiencies.

    Abstract translation: 详细描述的实施例包括用于眼表面干涉仪（OSI）装置的光学幻影和被配置为测量泪膜层厚度的系统以及用于校准的相关用途。 可以使用眼表干涉测量（OSI）装置，系统和方法来成像眼泪膜和/或测量患者眼泪膜中的泪膜层厚度（TFLT）。 OSI装置，系统和方法可用于测量眼泪膜的脂质层组分（LLT）和/或水层组分（ALT）的厚度。 本文所用的“TFLT”包括LLT，ALT或LLT和ALT两者。 本文所用的“测量TFLT”包括测量LLT，ALT或LLT和ALT两者。 成像眼泪膜并测量TFLT可用于诊断患者的泪膜，包括但不限于脂质层和水层缺陷。

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