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    Synthetic apelin mimetics for the treatment of heart failure
    62.
    发明授权
    Synthetic apelin mimetics for the treatment of heart failure 有权
    用于治疗心力衰竭的合成apelin模拟物

    公开(公告)号：US09067971B2

    公开(公告)日：2015-06-30

    申请号：US14165680

    申请日：2014-01-28

    Applicant: Frederic Zecri ,  Andrei Golosov ,  Philippr Grosche ,  Hongjuan Zhao ,  Qi-Ying Hu ,  Hidetomo Imase

    Inventor： Frederic Zecri ,  Andrei Golosov ,  Philippr Grosche ,  Hongjuan Zhao ,  Qi-Ying Hu ,  Hidetomo Imase

    IPC: C07K7/08 ,  C07K7/56 ,  C07K7/60 ,  A61K38/00

    CPC classification number: A61M16/0816 ,  A61K38/00 ,  A61K38/10 ,  A61M16/0066 ,  A61M16/201 ,  A61M2016/0027 ,  A61M2016/003 ,  A61M2205/35 ,  A61M2205/502 ,  C07K7/08 ,  C07K7/56 ,  C07K7/60

    Abstract: The invention provides a synthetic polypeptide of Formula I′: or an amide, an ester or a salt thereof, wherein X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, X11, X12 and X13 are defined herein. The polypeptides are agonist of the APJ receptor. The invention also relates to a method for manufacturing the polypeptides of the invention, and its therapeutic uses such as treatment or prevention of acute decompensated heart failure (ADHF), chronic heart failure, pulmonary hypertension, atrial fibrillation, Brugada syndrome, ventricular tachycardia, atherosclerosis, hypertension, restenosis, ischemic cardiovascular diseases, cardiomyopathy, cardiac fibrosis, arrhythmia, water retention, diabetes (including gestational diabetes), obesity, peripheral arterial disease, cerebrovascular accidents, transient ischemic attacks, traumatic brain injuries, amyotrophic lateral sclerosis, burn injuries (including sunburn) and preeclampsia. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

    Abstract translation: 本发明提供式I'的合成多肽：或其酰胺，酯或其盐，其中X1，X2，X3，X4，X5，X6，X7，X8，X9，X10，X11，X12和X13被定义 这里。 多肽是APJ受体的激动剂。 本发明还涉及制备本发明多肽的方法及其治疗用途，例如治疗或预防急性失代偿性心力衰竭（ADHF），慢性心力衰竭，肺动脉高压，心房颤动，Brugada综合征，室性心动过速，动脉粥样硬化 ，高血压，再狭窄，缺血性心血管疾病，心肌病，心脏纤维化，心律失常，保水，糖尿病（包括妊娠糖尿病），肥胖，外周动脉疾病，脑血管意外，短暂性脑缺血发作，创伤性脑损伤，肌萎缩性侧索硬化，烧伤（ 包括晒伤）和先兆子痫。 本发明还提供药理活性剂和药物组合物的组合。

    Valve system for use with a flexible gas supply tube extending to a patient
    63.
    发明授权
    Valve system for use with a flexible gas supply tube extending to a patient 有权
    用于延伸到患者的柔性气体供应管的阀系统

    公开(公告)号：US09067038B2

    公开(公告)日：2015-06-30

    申请号：US12584080

    申请日：2009-08-31

    Applicant: William A. Leffel

    Inventor： William A. Leffel

    IPC: A62B9/02 ,  E21B33/06 ,  A61M16/20 ,  F16K1/30 ,  F16K3/26

    CPC classification number: A61M16/20 ,  A61M16/201 ,  A61M2202/0208 ,  A61M2205/3334 ,  A62B9/02 ,  F16K1/307 ,  F16K3/26 ,  F16K3/265

    Abstract: Low pressure oxygen or other breathable gas is supplied from a tank or other source to a patient or other person through a flexible plastic tube, and a safety valve system is connected between the source and the tube. The valve system includes a valve member having a tubular outlet portion and supported for axial movement within a valve body having an inlet connected to the gas source. Fluid passages are formed within the valve member and valve body, and the valve member shifts axially to an open position in response to connecting the flexible tube to the tubular outlet portion of the valve member. The valve member shifts to a closed position in response to removing the tube from the tubular outlet portion, and the supply gas holds the valve member in the closed position.

    Abstract translation: 低压氧气或其他透气气体通过柔性塑料管从罐或其他源供应给患者或其他人，并且安全阀系统连接在源管与管之间。 阀系统包括具有管状出口部分并被支撑用于在具有连接到气体源的入口的阀体内的轴向运动的阀构件。 流体通道形成在阀构件和阀体内，并且阀构件响应于将柔性管连接到阀构件的管状出口部分而轴向移动到打开位置。 响应于从管状出口部分移除管，阀构件移动到关闭位置，并且供应气体将阀构件保持在关闭位置。

    Supply valve for air respirator
    64.
    发明授权
    Supply valve for air respirator 有权
    空气呼吸器供气阀

    公开(公告)号：US09050478B2

    公开(公告)日：2015-06-09

    申请号：US13643733

    申请日：2011-04-26

    Applicant: Hironobu Takeuchi

    Inventor： Hironobu Takeuchi

    IPC: A61M11/00 ,  A62B18/10 ,  A61M16/20 ,  A62B9/02 ,  F16K1/30 ,  F16K31/143 ,  F16K31/163 ,  A61M16/00

    CPC classification number: A62B18/10 ,  A61M16/20 ,  A61M16/201 ,  A61M16/207 ,  A61M2016/0015 ,  A62B9/02 ,  F16K1/307 ,  F16K31/143 ,  F16K31/163

    Abstract: A supply valve for supplying air to a wearer of an air respirator is attached to a facepiece and includes an inflow port for medium-pressure air (S1), a supply port for the medium-pressure air (S1) with respect to the facepiece, and a diaphragm. The supply valve includes a cylindrical housing and a slider that is reciprocally slidable on the inner peripheral surface of the housing in an axial direction thereof. The housing includes a pilot valve seat urged toward a pilot valve on an outer side of the one end portion in the axial direction and a main valve seat on an inner side of an opposite end portion in the axial direction. The inflow port is formed between the one end portion and the opposite end portion. The slider includes the pilot valve contactable with the pilot valve seat and a main valve urged toward the main valve seat.

    Abstract translation: 用于向空气呼吸器的使用者供给空气的供给阀附接到面罩，并且包括用于中压空气的流入口（S1），相对于面罩的中压空气供给口（S1） 和隔膜。 供给阀包括圆柱形壳体和滑动件，其在壳体的内周面上沿其轴向往复滑动。 壳体包括沿轴向在一端部的外侧朝向先导阀推压的先导阀座和在轴向上的相对端部的内侧的主阀座。 流入口形成在一端部和相对端部之间。 滑块包括可与先导阀座接触的先导阀和朝主阀座推动的主阀。

    EXHALATION VALVE AND RESPIRATORY ASSISTANCE DEVICE
    65.
    发明申请
    EXHALATION VALVE AND RESPIRATORY ASSISTANCE DEVICE 有权
    排气阀和呼吸辅助装置

    公开(公告)号：US20150040904A1

    公开(公告)日：2015-02-12

    申请号：US14344189

    申请日：2012-09-12

    Applicant: Metran Co., Ltd.

    Inventor： Kazufuku Nitta

    IPC: A61M16/20 ,  A61M16/00

    CPC classification number: A61M16/205 ,  A61M16/0003 ,  A61M16/0066 ,  A61M16/0069 ,  A61M16/024 ,  A61M16/20 ,  A61M16/201 ,  A61M16/202 ,  A61M16/203 ,  A61M16/206 ,  A61M2016/0027 ,  A61M2016/0039 ,  A61M2205/0244 ,  A61M2205/3337 ,  A61M2205/50

    Abstract: Exhalation valve including a diaphragm for opening and closing an outlet of an exhalation flow path for guiding exhaled air to the outside air, a back chamber provided opposite the exhalation flow path in the diaphragm and forming a space together with the diaphragm, and a pump unit fixed to the circumference of the back chamber for adjusting the air pressure inside the back chamber by feeding and discharging of air to and from the back chamber. The diaphragm closes the outlet of the exhalation flow path when the air pressure inside the exhalation flow path is lower than the air pressure inside the back chamber, and opens the outlet of the exhalation flow path when the air pressure inside the exhalation flow path is higher than the air pressure inside the back chamber.

    Abstract translation: 呼出阀，包括用于打开和关闭用于将呼出的空气引导到外部空气的呼出流路的出口的隔膜;与隔膜中的呼出流路相对设置的后室，以及与隔膜一起形成的空间;以及泵单元 固定到后室的圆周上，用于通过向后室供给和排出空气来调节后室中的空气压力。 当呼气流路内的空气压力低于后室内的空气压力时，隔膜关闭呼气流路的出口，当呼气流路内的空气压力较高时打开呼气流路的出口 比后室内的气压高。

    System and Method for Circuits to Allow CPAP to Provide Zero Pressure
    66.
    发明申请
    System and Method for Circuits to Allow CPAP to Provide Zero Pressure 有权
    电路允许CPAP提供零压力的系统和方法

    公开(公告)号：US20150000666A1

    公开(公告)日：2015-01-01

    申请号：US14486460

    申请日：2014-09-15

    Applicant: New York University

    Inventor： David M. Rapoport

    IPC: A61M16/20 ,  A61M16/00

    CPC classification number: A61M16/0069 ,  A61M1/00 ,  A61M16/0003 ,  A61M16/0066 ,  A61M16/06 ,  A61M16/0875 ,  A61M16/10 ,  A61M16/20 ,  A61M16/201 ,  A61M16/202 ,  A61M2016/0027 ,  A61M2016/003 ,  A61M2202/0225 ,  A61M2205/3334 ,  A61M2202/0085

    Abstract: A system comprises a respiratory delivery arrangement adapted to cover at least one respiratory orifice of a patient. The system also comprises a first conduit having a first end and a second end, the second end connected to the respiratory delivery arrangement. A positive pressure is provided to the respiratory orifice via the first conduit and a second conduit having a third end and a fourth end, the fourth end connected to the respiratory delivery arrangement. An exhaled gas is extracted from the respiratory orifice by one or both of a valve configured to redirect flow through the respiratory delivery arrangement and a venturi opening.

    Abstract translation: 一种系统包括适于覆盖患者的至少一个呼吸孔的呼吸递送装置。 该系统还包括具有第一端和第二端的第一导管，第二端连接到呼吸输送装置。 经由第一导管向呼吸孔提供正压力，第二导管具有第三端和第四端，第四端连接到呼吸输送装置。 通过被配置成重定向流过呼吸输送装置的流量的阀门和文氏管开口中的一个或两个，从呼吸孔抽出呼出气体。

    Ventilation mask with integrated piloted exhalation valve
    68.
    发明授权
    Ventilation mask with integrated piloted exhalation valve 有权
    具有集成导向呼气阀的通风面罩

    公开(公告)号：US08839791B2

    公开(公告)日：2014-09-23

    申请号：US13411407

    申请日：2012-03-02

    Applicant: Todd Allum ,  Enrico Brambilla ,  Joseph Cipollone

    Inventor： Todd Allum ,  Enrico Brambilla ,  Joseph Cipollone

    IPC: A61M11/00 ,  A61M16/06 ,  A61M16/20 ,  A61M16/08 ,  A61M16/10

    CPC classification number: A61M16/208 ,  A61M16/0003 ,  A61M16/0605 ,  A61M16/0622 ,  A61M16/0666 ,  A61M16/0833 ,  A61M16/0858 ,  A61M16/0875 ,  A61M16/1045 ,  A61M16/201 ,  A61M16/207 ,  A61M2016/0027 ,  A61M2205/3334

    Abstract: In accordance with the present disclosure, there is provided a mask for achieving positive pressure mechanical ventilation (inclusive of CPAP, ventilator support, critical care ventilation, emergency applications), and a method for a operating a ventilation system including such mask. The mask of the present disclosure includes a piloted exhalation valve that is used to achieve the target pressures/flows to the patient. The pilot for the valve may be pneumatic and driven from the gas supply tubing from the ventilator. The pilot may also be a preset pressure derived in the mask, a separate pneumatic line from the ventilator, or an electro-mechanical control. The mask of the present disclosure may further include a heat and moisture exchanger (HME) which is integrated therein.

    Abstract translation: 根据本公开，提供了一种用于实现正压机械通气（包括CPAP，呼吸机支架，重要护理通气，紧急应用）的面罩以及用于操作包括这种面罩的通风系统的方法。 本公开的掩模包括用于实现目标压力/流向患者的先导呼气阀。 阀门的先导阀可以是气动的，并且来自呼吸机的气体供应管道驱动。 驾驶员也可以是在面罩中产生的预设压力，来自呼吸机的独立气动管路或机电控制。 本公开的掩模还可以包括集成在其中的热和湿气交换器（HME）。

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