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    NITRATION REACTOR AND METHOD
    63.
    发明申请
    NITRATION REACTOR AND METHOD 有权

    公开(公告)号：US20210260560A1

    公开(公告)日：2021-08-26

    申请号：US17260414

    申请日：2018-11-15

    Applicant: NORAM INTERNATIONAL LIMITED

    Inventor： Stefan F. Meili

    IPC: B01J19/24 ,  B01J19/00 ,  B01J10/00 ,  C07C201/08

    Abstract: A nitration reactor (10) incorporating sections of downward flow for use in preparing nitrated organic compounds. It comprises a first vertically-oriented reactor section (12), a second vertically-oriented reactor section (14), a connecting section (16) between the two reactor sections, one or more inlets (20, 22) for introducing nitration reactants into the reactor, an outlet (24) for the removal of nitration reaction products, a vertically-downward flowpath (26) for the nitration reactants in one of the reactor sections or the connecting section, and operating conditions that produce a flow regime in the vertically-downward flowpath that is a dispersed flow regime or a bubbly flow regime. The invention overcomes the limitations of prior art nitration reactors of the type in which fluids flow largely in a vertically upward direction, with respect to hydrostatic demands and plant layout considerations.

    Method of synthesizing diclofenac sodium
    65.
    发明授权
    Method of synthesizing diclofenac sodium 有权

    公开(公告)号：US10662145B2

    公开(公告)日：2020-05-26

    申请号：US16288031

    申请日：2019-02-27

    Applicant: FUDAN UNIVERSITY

    Inventor： Fener Chen ,  Lingdong Wang ,  Ge Meng ,  Zedu Huang ,  Dang Cheng ,  Haihui Peng ,  Guanfeng Liang

    IPC: C07C227/18 ,  C07C201/08 ,  C07C227/16 ,  C07C227/06

    Abstract: The invention relates to the chemical synthesis of pharmaceutical API, and specifically to a method of synthesizing diclofenac sodium, which is a kind of nonsteroidal anti-inflammatory drug for relieving pain. The method includes: nitrating phenylacetate to prepare o-nitrophenylacetate (2); hydrogenating o-nitrophenylacetate (2) to prepare o-aminophenylacetate (3); amidating an amino group of o-aminophenylacetate (3) to obtain 2-(2-benzoylaminophenyl) acetate (4); 2-(2-benzoylaminophenyl) acetate (4) reacting with thionyl chloride to prepare a chloroimine intermediate, and then condensing the intermediate of chloroimine with 2,6-dichlorophenol using an inorganic base to prepare (E)-methyl-2-(2-((2,6-dichlorophenoxy)(phenyl)methyleneamino) phenyl ester (5); subjecting (E)-methyl-2-(2-((2,6-dichlorophenoxy)(phenyl)methyleneamino) phenyl ester (5) to Chapman rearrangement to afford methyl 2-(2-(N-(2,6-dichlorophenyl)benzoylamino)phenyl) ester (6); and hydrolyzing methyl 2-(2-(N-(2,6-dichlorophenyl)benzoylamino)phenyl) ester (6) to provide the target compound as of diclofenac sodium API. The overall yield is up to 67% based on methyl phenylacetate.

    Methods for producing chemical products with operation interruptions
    66.
    发明授权
    Methods for producing chemical products with operation interruptions 有权

    公开(公告)号：US10513487B2

    公开(公告)日：2019-12-24

    申请号：US15320807

    申请日：2015-06-22

    Applicant: Covestro Deutschland AG

    Inventor： Thomas Knauf ,  Peter Drinda ,  Stefan Wershofen ,  Klaus-Gerd Gruner ,  Volker Hartjes

    IPC: C07C201/08 ,  C07C205/06 ,  B01J19/24 ,  C07C201/16

    Abstract: This invention relates to methods for producing chemical products, wherein the one or more feed materials are reacted to form a chemical product or a chemical composition. The invention further relates to plants for performing such methods, said plants being designed in such a way that, during an interruption of the methods, no input of at least one feed material into the reaction occurs and the plant parts not affected by a revision measure, maintenance measure, repair measure, or cleaning measure are operated in so-called re-circulation mode. It is thereby achieved, among other things, that only the affected plant part needs to be shut down for the time of the measure, which can be advantageous with regard to the productivity and economy of the method and the quality of the produced products. Finally, the invention relates to methods for operating plants in the event that individual plant parts are taken out of service.

    Process for producing nitrobenzene
    68.
    发明授权
    Process for producing nitrobenzene 有权

    公开(公告)号：US10023524B2

    公开(公告)日：2018-07-17

    申请号：US15320804

    申请日：2015-06-22

    Applicant: Covestro Deutschland AG

    Inventor： Thomas Knauf ,  Peter Drinda

    IPC: C07C201/08 ,  C07C201/16 ,  B01J19/24

    Abstract: The present invention relates to a process for the continuous production of nitrobenzene by the nitration of benzene with nitric acid and sulphuric acid under adiabatic conditions, not the entire production plant being shut down during a production stop, but the production plant being entirely or at least partly operated in recirculation mode. The invention further relates to a plant for producing nitrobenzene and to a method for operating a plant for producing nitrobenzene.

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