公开(公告)号：US20210324139A1

公开(公告)日：2021-10-21

申请号：US17273386

申请日：2019-09-04

Applicant: Lonza Guangzhou Nansha Ltd. ,  Lonza Ltd

Inventor： Dieter Scherer ,  Benjamin Wyler ,  Jieping Wei ,  Yanling Yang ,  Daniel Shan ,  Reta Zhu ,  Paul Hanselmann ,  Tania Kjellerup Lind ,  Emelie Josefina Nilsson ,  Vitaly Kocherbitov ,  Johan Engblom

IPC: C08G65/332

Abstract: The invention discloses a method for preparation of polyoxyethylene 1,4-sorbitan fatty acid ester, such as Polysorbate 80, by a reaction of polyoxyethylene 1,4-sorbitan with a fatty acid chloride, and polyoxyethylene 1,4-sorbitan fatty acid esters obtainable by this method.

公开(公告)号：US20160220466A1

公开(公告)日：2016-08-04

申请号：US15010180

申请日：2016-01-29

Applicant: Lonza Ltd.

Inventor： Paul Hanselmann ,  Florencio Zaragoza Doerwald

IPC: A61K8/49 ,  A61K8/37 ,  A45D7/06 ,  A61Q5/06

CPC classification number: A61K8/4973 ,  A45D7/06 ,  A61K8/37 ,  A61K8/375 ,  A61K8/42 ,  A61K8/46 ,  A61K2800/40 ,  A61Q5/04 ,  A61Q5/06

Abstract: A hair treatment composition is described that contains an acetoacetylated compound. The acetoacetylated compound, for instance, can be a bis acetoacetylated compound. In one embodiment, for instance, the acetoacetylated compound comprises a bis acetoacetate or a bis acetoacetamide. In one embodiment, the hair treatment composition can be used to straighten hair. The composition is also well suited for decreasing hair frizz. The acetoacetylated compound is capable of crosslinking hair fibers upon the application of heat.

Abstract translation: 描述了含有乙酰乙酰化化合物的头发处理组合物。 乙酰乙酰化的化合物例如可以是二乙酰乙酰化的化合物。 在一个实施方案中，例如，乙酰乙酰化的化合物包含双乙酰乙酸酯或双乙酰乙酰胺。 在一个实施方案中，头发处理组合物可用于矫正头发。 该组合物也适用于减少头发卷曲。 乙酰乙酰化化合物能够在施加热量时交联毛发纤维。

公开(公告)号：US11174236B2

公开(公告)日：2021-11-16

申请号：US17265939

申请日：2019-08-26

Applicant: Lonza Guangzhou Pharmaceutical Ltd. ,  Lonza Ltd

Inventor： Jieping Wei ,  Yanling Yang ,  Daniel Shan ,  Reta Zhu ,  Paul Hanselmann ,  Dieter Scherer

IPC: C07D307/20

Abstract: The invention discloses a method for preparation of 1,4-sorbitan by dehydration of D-sorbitol, wherein one equivalent of water is removed and a cyclization occurs, followed by a treatment with ethanol and isopropanol.

公开(公告)号：US09394238B2

公开(公告)日：2016-07-19

申请号：US14521700

申请日：2014-10-23

Applicant: Lonza Ltd.

Inventor： Paul Hanselmann ,  Ellen Klegraf

IPC: C07C229/12 ,  C07C229/22 ,  C07C227/08 ,  C07C227/40 ,  C07C227/42 ,  C07D305/12

CPC classification number: C07C229/22 ,  C07C227/08 ,  C07C227/40 ,  C07C227/42 ,  C07D305/12

Abstract: The invention relates to a method for the production of L-carnitine, wherein a β-lactone, which is a 4-(halomethyl)oxetane-2-one, is converted into carnitine with trimethylamine (TMA), wherein the β-lactone is not subjected to a basic hydrolysis step before being contacted with the trimethylamine. The invention also relates to a carnitine having a unique impurity profile.

Abstract translation: 本发明涉及生产L-肉毒碱的方法，其中将4-（卤代甲基）氧杂环丁烷-2-酮的一种内酯与三甲胺（TMA）一起转化为肉碱，其中， 内酯在与三甲胺接触之前不经历碱性水解步骤。 本发明还涉及具有独特杂质分布的肉碱。

公开(公告)号：US11001552B2

公开(公告)日：2021-05-11

申请号：US16620001

申请日：2018-07-16

Applicant: LONZA LTD

Inventor： Michael Bersier ,  Anna Kulesza ,  Paul Hanselmann ,  Christof Aellig ,  Sarah Filliger

IPC: C07C201/08 ,  C07C205/58

Abstract: The invention discloses a method for preparation of 5-fluoro-2-methyl-3-nitrobenzoic acid and its methyl ester by conversion of 5-fluoro-2-methylbenzoic acid with fuming nitric acid and oleum and subsequent conversion with methanol.

公开(公告)号：US10689350B1

公开(公告)日：2020-06-23

申请号：US16621222

申请日：2018-07-16

Applicant: LONZA LTD

Inventor： Michael Bersier ,  Paul Hanselmann ,  Candid Stoffel

IPC: C07D239/47 ,  C07D239/30

Abstract: The invention discloses a method for preparation of 4,6-dichloro-5-nitro-2-(propylthio)pyrimidine by conversion of 5-nitro-2-propylthiopyrimidine-4,6-diol with phosgene in the presence of DMF.