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公开(公告)号：US10053392B2
公开(公告)日：2018-08-21
申请号：US15870421
申请日：2018-01-12
Inventor： Matthew D. Wallenstein , Colin W. Bell
IPC: C05F11/08
Abstract: The present disclosure relates to consortia of bacteria strains and composition comprising one or more bacterial strains disclosed herein. These consortia of isolated bacteria cultures and compositions comprising said cultures, having greater activity than would be observed for the individual bacteria cultures and compositions. A composition of the disclosure may advantageously be used for enhancing the availability of soil phosphorus and other macronutrients and/or micronutrients to plants, and thereby enhancing their growth and yield.
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公开(公告)号：US20180224459A1
公开(公告)日：2018-08-09
申请号：US15891981
申请日：2018-02-08
Inventor： Brian R. McNaughton , Virginia J. Bruce
Abstract: Systems and methods for detecting a target protein using a nanobody-peptide receptor pair are described.
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公开(公告)号：US20180174432A1
公开(公告)日：2018-06-21
申请号：US15887296
申请日：2018-02-02
Inventor： Aaron R. Pettigrew , Brian T. Sedlak , Scott A. Seeley
Abstract: A method may include gathering data from a first set of sensors disposed throughout a first facility at a first fire alarm control panel. The method may also include exchanging one or more messages between the first fire alarm control panel and a control center computer. The method may also include translating the one or more messages between a first communication protocol according to which the first fire alarm control panel communicates and a second communication protocol according to which the control center computer communicates. The second communication protocol is distinct from the first communication protocol.
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公开(公告)号：US20180172668A1
公开(公告)日：2018-06-21
申请号：US15738878
申请日：2016-06-23
Inventor： Salman R. Khetani , Matthew D. Davidson
Abstract: The present disclosure provides co-cultures of a population of hepatocytes, at least one non-parenchymal cell population, and a population of hepatic stellate cells in vitro, methods of preparing the co-cultures, and methods of using the co-cultures for high throughput screening and evaluation of drug candidates. The hepatocytes co-culture system provides an in vitro model in which both cell viability and phenotype are maintained for extended periods relative to conventional monoculture.
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公开(公告)号：US20180113072A1
公开(公告)日：2018-04-26
申请号：US15847758
申请日：2017-12-19
Inventor： Kevin Lear , Timothy Erickson
CPC classification number: G01N21/4133 , G01M11/33 , G01N33/1833 , G01N2021/4166 , G01N2201/0873 , G02B6/028 , G02B6/12004 , G02B6/1221 , G02B6/4291 , G02B27/56 , G02B2006/12123 , G02B2006/12138 , Y02A20/206
Abstract: A chip-scale, reusable sensor can detect aromatic hydrocarbons, such as benzene, toluene, ethylbenzene, and xylenes (BTEX), rapidly in water without sample preparation. The device is capable of real-time, continuous monitoring for BTEX solutes, which diffuse into a film, such as a polymer, on the sensors surface. In operation BTEX analytes concentrate in the film, causing an increase in refractive index, which modulates evanescent coupling into the chips integrated photodetector array. Integration of the photodetector array simplifies system instrumentation and permits incorporation of an on-chip photocurrent reference region in the immediate vicinity of the sensing region, reducing drift due to temperature fluctuations. In some examples, the chip responds linearly for BTEX concentrations between 1 ppm and 30 ppm, with a limit of detection of 359 ppb, 249 ppb, and 103 ppb for benzene, toluene, and xylene in water, respectively.
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Patent Agency Ranking
公开(公告)号：US20180105825A1
公开(公告)日：2018-04-19
申请号：US15787562
申请日：2017-10-18
Inventor： June I. Medford , Mauricio S. Antunes , Tessema K. Kassaw
IPC: C12N15/82
Abstract: The present disclosure provides synthetic repressor constructs and the proteins encoded therein, as well as synthetic repressible promoter constructs for use in combination with the synthetic repressor constructs/synthetic repressors disclosed herein. Various combinations of synthetic repressor constructs and synthetic repressible promoter constructs are also provided in synthetic genetic circuits for modifying expression of a protein of interest in a plant cell.
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公开(公告)号：US20180087085A9
公开(公告)日：2018-03-29
申请号：US15124651
申请日：2015-03-11
Inventor： Susan E. KNUDSON , Richard A. SLAYDEN
IPC: C12Q1/18
CPC classification number: C12Q1/18
Abstract: The invention provides methods for determining and evaluating the in vitro-in vivo activity relationship of the efficacy of families of compounds for infectious diseases such as tuberculosis. The validity of the methods can be confirmed by evaluation of the compounds in animal models, for example, in murine models of tuberculosis. Examples of families of antibacterial compounds that can be evaluated for in vivo efficacy using the in vitro methods described herein include benzimidazoles, pyridopyrazines, pteridines, diphenyl ethers, beta-lactams, PBP inhibitors, and compounds that are non-ribonucleic acid and protein synthesis inhibitors. The methods can be used to evaluate classes of small molecule compounds and inhibitors that may be effective against any bacterial pathogen. The methods aid the identification of compounds, such as various benzimidazoles, with modes of action having activity against clinical isolates, as well as non-replicating persistent bacilli, which can therefore enhance current clinical therapeutic regimens.
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公开(公告)号：US20180057510A1
公开(公告)日：2018-03-01
申请号：US15555792
申请日：2016-03-04
Applicant: Colorado State University Research Foundation , Dana-Farber Cancer Institute, Inc. , University of Notre Dame du Lac
Inventor： Robert M. Williams , James E. Bradner , Dane Clausen , Olaf G. Wiest , Le Zhao , Christine Elizabeth Dunne
IPC: C07D513/18 , A61K31/429 , A61K45/06
Abstract: Analogs of largazole are described herein. Methods of treating cancer, blood disorders, autoimmune disease, and Alzheimer's Disease using largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.
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公开(公告)号：US09896712B2
公开(公告)日：2018-02-20
申请号：US14876671
申请日：2015-10-06
Inventor： Kenneth F. Reardon
IPC: C12N9/02 , C12N11/00 , C12Q1/26 , C12Q1/34 , G01N21/77 , C12Q1/32 , G01N21/64 , C12M1/34 , C12M1/40
CPC classification number: C12Q1/26 , C12M1/34 , C12M1/40 , C12N9/0004 , C12N9/0069 , C12N9/0071 , C12Q1/32 , C12Y102/01002 , C12Y113/00 , C12Y114/00 , C12Y114/13 , G01N21/6408 , G01N21/6486 , G01N2021/6432 , G01N2333/90241 , G01N2333/90245
Abstract: The present disclosure relates to biosensing systems and biosensing elements having increased storage capability and increased functional lifetimes through using compositions and methods for recycling cofactors.
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80.发明申请公开(公告)号：US20180000901A1
公开(公告)日：2018-01-04
申请号：US15541871
申请日：2016-01-07
Applicant: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVIC , COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
Inventor： Nadya I. Tarasova , Mercedes Gonzalez-Juarrero
Abstract: The invention provides a method of treating pathogenic bacterial infection (e.g., tuberculosis infection) in an animal comprising administering a peptide-based inhibitor of the STAT3-IL10 pathway or a nucleic acid encoding the peptide-based inhibitor to the animal. The invention also provides methods of treating chronic granulomatous disease and Wegener's granulomatosis in an animal comprising administering a peptide-based inhibitor of the STAT3-IL10 pathway or a nucleic acid encoding the peptide-based inhibitor to the animal.
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