公开(公告)号：US09410892B2

公开(公告)日：2016-08-09

申请号：US12675370

申请日：2008-09-02

Applicant: David Erickson ,  Sudeep Mandal

Inventor： David Erickson ,  Sudeep Mandal

IPC: G02B6/12 ,  G01N21/77 ,  B82Y20/00 ,  G02B6/122 ,  B01L3/00 ,  G01N21/78

CPC classification number: G01N21/7746 ,  B01L3/5027 ,  B82Y20/00 ,  G01N21/774 ,  G01N21/78 ,  G01N2021/7776 ,  G01N2021/7789 ,  G02B6/12007 ,  G02B6/1225 ,  G02B2006/12061 ,  G02B2006/1213 ,  G02B2006/12138

Abstract: An optofluidic architecture for label free, highly parallel, detection of molecular interactions is based on the use of optically resonant devices whose resonant wavelength is shifted due to a local change in refractive index caused by a positive binding event between a surface bound molecule and its solution phase target. These devices have an extremely low limit of detection and are compatible with aqueous environments. The device combines the sensitivity (limit of detection) of nanosensor technology with the parallelity of the microarray type format.

Abstract translation: 用于无标记，高度平行，分子相互作用检测的光流体结构基于使用光学谐振装置，其谐振波长由于表面结合分子与其溶液之间的正结合事件引起的折射率的局部变化而偏移 阶段目标。 这些装置具有极低的检测限，并且与水性环境兼容。 该器件将纳米传感器技术的灵敏度（检测限）与微阵列型格式的并行性相结合。

公开(公告)号：US09357269B2

公开(公告)日：2016-05-31

申请号：US12650020

申请日：2009-12-30

Applicant: Xuemin Chen ,  Marcus Kellerman ,  Vladimir Silyaev ,  David Erickson

Inventor： Xuemin Chen ,  Marcus Kellerman ,  Vladimir Silyaev ,  David Erickson

IPC: G06F15/167 ,  H04N21/4782 ,  H04L29/06 ,  H04N21/475 ,  H04L9/08 ,  H04L12/28

CPC classification number: H04N21/4782 ,  G06F17/30893 ,  H04L9/0838 ,  H04L12/2834 ,  H04L63/0209 ,  H04L63/0272 ,  H04L67/02 ,  H04N21/2355 ,  H04N21/4622 ,  H04N21/4753 ,  H04N21/63775 ,  H04N21/6581

Abstract: An Internet capable set-top-box (STB) may be operable to extend a security boundary from the Internet capable STB to an application server to allow support of web browsing operations from the application server. A secure link between the Internet capable STB and the application server may be established. The Internet capable STB may communicate a request for web page information from a secure web server along with cryptographic credentials to the application server, via the secure link. The application server may be allowed to receive the web page information directly from the secure web server and process at least the unsupported portion of the received web page information. The Internet capable STB may then receive the web page information with at least the unsupported portion processed from the application server, via the secure link, for further processing and rendering.

Abstract translation: 具有因特网功能的机顶盒（STB）可以可操作以将安全边界从可从Internet的STB扩展到应用服务器，以允许从应用服务器支持web浏览操作。 可以建立具有因特网功能的STB与应用服务器之间的安全链路。 具有因特网功能的STB可以经由安全链路将来自安全web服务器的网页信息的请求以及密码凭证传送到应用服务器。 可以允许应用服务器直接从安全web服务器接收网页信息，并处理所接收到的网页信息的至少不受支持的部分。 因此，具有因特网功能的STB可以经由安全链路至少从应用服务器处理的不受支持的部分接收网页信息，以进一步处理和呈现。

公开(公告)号：US09106437B2

公开(公告)日：2015-08-11

申请号：US12650141

申请日：2009-12-30

Applicant: Vladimir Silyaev ,  Marcus Kellerman ,  Xuemin Chen ,  David Erickson

Inventor： Vladimir Silyaev ,  Marcus Kellerman ,  Xuemin Chen ,  David Erickson

IPC: G06F15/16 ,  H04L12/28 ,  H04L29/08 ,  H04N21/222 ,  H04N21/20 ,  H04N21/462

CPC classification number: H04N21/4782 ,  H04L12/2836 ,  H04L67/02 ,  H04N21/20 ,  H04N21/222 ,  H04N21/2221 ,  H04N21/2393 ,  H04N21/437 ,  H04N21/4622 ,  H04N21/64322

Abstract: A STB, communicatively coupled to a server, receives a web page request when, for example, a URI, is entered into a web browser running in the STB. In response, the STB sends a processing assistance request to the server for processing the entire web page regardless of processing capability of the STB. The STB receives processed information resources or contents associated with the entire web page from the server. The server retrieves information resources or contents associated with the entire web page from a web server based on the received processing assistance request. The server determines content type such as video and/or graphics of the retrieved information resources or contents for corresponding content processing. The server determines content formats supported by the STB for content encoding. The STB decodes the resulting encoded information resources or contents from the server to render the entire web page in the STB.

Abstract translation: 当通信地耦合到服务器的STB在例如URI输入到在STB中运行的web浏览器时接收网页请求。 作为响应，STB无论STB的处理能力如何，都向服务器发送处理辅助请求以处理整个网页。 STB从服务器接收处理的信息资源或与整个网页相关联的内容。 服务器根据接收到的处理协助请求从Web服务器检索与整个网页相关联的信息资源或内容。 服务器确定所检索的信息资源或内容的内容类型，例如视频和/或图形，用于相应的内容处理。 服务器确定STB支持的内容格式进行内容编码。 STB从服务器解码所得到的编码信息资源或内容，以呈现STB中的整个网页。

公开(公告)号：US09015230B2

公开(公告)日：2015-04-21

申请号：US13114314

申请日：2011-05-24

Applicant: Sherman (Xuemin) Chen ,  David Erickson ,  Vladimir Silyaev ,  Alan Trerise ,  Marcus C. Kellerman ,  Jeyhan Karaoguz

Inventor： Sherman (Xuemin) Chen ,  David Erickson ,  Vladimir Silyaev ,  Alan Trerise ,  Marcus C. Kellerman ,  Jeyhan Karaoguz

IPC: G06F15/16 ,  H04L29/06

CPC classification number: H04L65/4084 ,  H04L65/605 ,  H04N21/4622

Abstract: A gateway includes at least one communications interface and processing circuitry and establishes communications with at least one service provider device and with a serviced client device. The gateway receives serviced client device display structure instructions, first streamed content from a service provider device, and second streamed content from a cloud server, the second streamed content based upon an Internet session hosted by the cloud server. Based upon the serviced client device display structure instructions, the gateway combines the first streamed content with the second streamed content to form merged streamed content and transmits the merged streamed content to the serviced client device. In another operation the gateway forwards the first streamed content to a first client device and the second streamed content to a second client device based upon the serviced client device display structure instructions.

Abstract translation: 网关包括至少一个通信接口和处理电路，并建立与至少一个服务提供商设备和服务的客户端设备的通信。 网关从云服务器接收服务的客户端设备显示结构指令，来自服务提供商设备的第一流式内容和来自云服务器的第二流内容，基于由云服务器托管的因特网会话的第二流内容。 基于服务的客户端设备显示结构指令，网关将第一流传输的内容与第二流内容相结合，以形成合并的流内容，并将合并的流式内容传输到服务客户端设备。 在另一操作中，网关基于服务的客户端设备显示结构指令将第一流传输的内容转发到第一客户端设备，并将第二流传输的内容转发到第二客户端设备。

公开(公告)号：US09009218B2

公开(公告)日：2015-04-14

申请号：US13114967

申请日：2011-05-24

Applicant: Sherman (Xuemin) Chen ,  David Erickson ,  Vladimir Silyaev ,  Alan Trerise ,  Marcus C. Kellerman

Inventor： Sherman (Xuemin) Chen ,  David Erickson ,  Vladimir Silyaev ,  Alan Trerise ,  Marcus C. Kellerman

IPC: G06F15/16 ,  G06F17/30 ,  H04L29/08 ,  H04L29/06

CPC classification number: H04L67/42 ,  G06F17/30905 ,  H04L29/08846 ,  H04L63/0281 ,  H04L67/02 ,  H04L67/04 ,  H04L67/141 ,  H04L67/22

Abstract: A gateway having at least one communications interface and processing circuitry establishes communications with at least one service provider device and at least one serviced client device. The gateway then determines that a serviced client device is to establish an Internet browsing session. Based upon characteristics of the serviced client device, the gateway determines where to instantiate a web browser to service the Internet browsing session. Based upon the determination, in a first operation, instantiates the web browser to service the Internet browsing session at the gateway or client device. In a second operation, the gateway instantiates the web browser to service the Internet browsing session at a service provider server. In other operations, the gateway may determine to instantiate a browser for a first client device at a cloud server and to instantiate a browser for a second client device either locally or at the second client device.

Abstract translation: 具有至少一个通信接口和处理电路的网关建立与至少一个服务提供商设备和至少一个服务的客户端设备的通信。 网关然后确定服务的客户端设备将建立因特网浏览会话。 基于服务的客户端设备的特征，网关确定在哪里实例化web浏览器来服务于互联网浏览会话。 基于该确定，在第一操作中，实例化网络浏览器以在网关或客户端设备处为因特网浏览会话服务。 在第二操作中，网关实例化Web浏览器以在服务提供商服务器处为因特网浏览会话服务。 在其他操作中，网关可以确定在云服务器处实例化用于第一客户端设备的浏览器，并在本地或在第二客户端设备实例化用于第二客户端设备的浏览器。

公开(公告)号：US09001322B2

公开(公告)日：2015-04-07

申请号：US13597688

申请日：2012-08-29

Applicant: David Erickson ,  Aram J. Chung ,  Yun Suk Huh

Inventor： David Erickson ,  Aram J. Chung ,  Yun Suk Huh

IPC: G01J3/44 ,  B82Y30/00 ,  B82Y40/00 ,  G01N21/65

CPC classification number: B82Y30/00 ,  B82Y40/00 ,  G01N21/658

Abstract: Surface enhanced Raman scattering (SERS) substrates may be fabricated using a shadow mask assisted evaporation (SMAE) method to provide for enhanced detection sensitivity with respect to target molecules that are located upon, and sensitized by, the SERS enhanced substrates. Such SERS substrates provide a two dimensional array of repeating nanostructures that may include, but are not limited to nano-pillar, nano-nib, nano-elliptical cylinder and nano-triangular tip nanostructures, any of which may be augmented with gold nanospheres. The particular SERS enhanced substrates in accordance with the embodiments, in particular when augmented with gold nanospheres, provide desirably enhanced sensitivity.

Abstract translation: 可以使用荫罩辅助蒸发（SMAE）方法制造表面增强拉曼散射（SERS）衬底，以提供相对于位于SERS增强衬底上并由其敏化的靶分子的增强的检测灵敏度。 这样的SERS衬底提供重复纳米结构的二维阵列，其可以包括但不限于纳米柱，纳米笔尖，纳米椭圆形圆柱体和纳米三角形尖端纳米结构，其中任何一种可以用金纳米球增强。 特别是根据实施例的特殊的SERS增强基板，特别是当用金纳米球增强时，提供期望的增强的灵敏度。

公开(公告)号：US08987307B2

公开(公告)日：2015-03-24

申请号：US13406572

申请日：2012-02-28

Applicant: Caterina Bissantz ,  Henrietta Dehmlow ,  Shawn David Erickson ,  Prabha Saba Karnachi ,  Kyungjin Kim ,  Rainer E. Martin ,  Patrizio Mattei ,  Ulrike Obst Sander ,  Sherrie Lynn Pietranico-Cole ,  Hans Richter ,  Christoph Ullmer

Inventor： Caterina Bissantz ,  Henrietta Dehmlow ,  Shawn David Erickson ,  Prabha Saba Karnachi ,  Kyungjin Kim ,  Rainer E. Martin ,  Patrizio Mattei ,  Ulrike Obst Sander ,  Sherrie Lynn Pietranico-Cole ,  Hans Richter ,  Christoph Ullmer

IPC: A61K31/44 ,  C07D213/72 ,  C07D213/75 ,  C07D213/81 ,  C07D213/82 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D405/12 ,  C07D413/04 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D491/107

CPC classification number: C07D213/75 ,  C07D213/81 ,  C07D213/82 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D405/12 ,  C07D413/04 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D491/107

Abstract: This invention relates to novel 3-aminopyridines of the formula wherein B1, B2 and R1 to R6 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and can be used as medicaments for the treatment of diseases such as type II diabetes.

Abstract translation: 本发明涉及下式的新的3-氨基吡啶类，其中B1，B2和R1至R6如说明书和权利要求书中所定义，以及其药学上可接受的盐。 这些化合物是GPBAR1激动剂，可用作治疗II型糖尿病等疾病的药物。

公开(公告)号：US08656443B2

公开(公告)日：2014-02-18

申请号：US12649971

申请日：2009-12-30

Applicant: Marcus Kellerman ,  Xuemin Chen ,  Vladimir Silyaev ,  David Erickson

Inventor： Marcus Kellerman ,  Xuemin Chen ,  Vladimir Silyaev ,  David Erickson

IPC: H04N7/173

CPC classification number: H04N21/4782 ,  G06F17/3089 ,  H04N21/26208 ,  H04N21/4786 ,  H04N21/6125

Abstract: A server may be used to handle at least some of processing of content retrieved via and/or derived from Internet access operations of a plurality of set-top boxes (STBs). Resource allocation and/or utilization, and/or tasks or applications performed in the server during the processing may be configured based on control data, which may be determined by the server and which may comprise capabilities of links between the server and each of the plurality of STBs, requirements of the tasks, characteristics of the content and/or the Internet access operations, user preferences and/or interactions, and/or content provider preferences. The server may dynamically reconfigure the tasks and/or resources based on monitoring of its operations and/or changes of the control data. Configuring tasks and/or resources may comprise time slicing access to resources that are commonly used during concurrent servicing of at least some of the plurality of STBs by the support server.

Abstract translation: 可以使用服务器来处理通过多个机顶盒（STB）的因特网接入操作经由和/或导出的内容的至少一些处理。 在处理期间在服务器中执行的资源分配和/或利用和/或任务或应用可以基于控制数据来配置，所述控制数据可以由服务器确定，并且哪些可以包括服务器与多个 的STB，任务的要求，内容的特征和/或因特网访问操作，用户偏好和/或交互，和/或内容提供商偏好。 服务器可以基于对其操作的监视和/或控制数据的改变来动态地重新配置任务和/或资源。 配置任务和/或资源可以包括对由支持服务器对多个STB中的至少一些的并发服务期间通常使用的资源的时间分片访问。

公开(公告)号：US08552363B2

公开(公告)日：2013-10-08

申请号：US12143952

申请日：2008-06-23

Applicant: David Erickson ,  Sudeep Mandal

Inventor： David Erickson ,  Sudeep Mandal

IPC: H01S3/00

CPC classification number: G01N30/58 ,  B01L3/50273 ,  B01L3/502761 ,  B01L2300/0838 ,  B01L2400/0454 ,  G01N2030/285 ,  G01N2030/582 ,  G02B6/02328 ,  G02B6/02347 ,  G02B6/02385

Abstract: An optical chromatography system employs fluid filled hollow core fibers, such as photonic crystal fibers (PCFs), which confine an incident optical beam from a laser, for example, in the core and cause separation of particles in the fluid along the length of the PCF. The incident optical beam is confined in the fluid filled core of the PCF by a periodic lattice of air capillaries surrounding the core. The lattice either creates a lower refractive index in the cladding than in the fluid filled core or creates a 1D photonic bandgap structure where the guiding is accomplished by surrounding the fluid filled core with a periodically changing array of dielectric constant which prohibits radial dilution of the optical energy over a range of wavelengths through photonic bandgap effects.

Abstract translation: 光学色谱系统采用流体填充的中空芯纤维，例如光子晶体纤维（PCF），其将来自激光器的入射光束例如限制在芯中，并且沿着PCF的长度导致流体中的颗粒分离 。 入射光束通过围绕芯的空气毛细管的周期性晶格限制在PCF的流体填充芯中。 晶格在包层中产生比在流体填充芯中低的折射率，或者产生一个1D光子带隙结构，其中引导通过周期性地改变的介电常数阵列来围绕流体填充芯来实现，该阵列禁止光学 通过光子带隙效应在一定范围的波长上的能量。

公开(公告)号：US20120269481A1

公开(公告)日：2012-10-25

申请号：US13504297

申请日：2010-10-27

Applicant: David Erickson ,  Aram J. Chung ,  Erica E. Jung

Inventor： David Erickson ,  Aram J. Chung ,  Erica E. Jung

IPC: G02B6/26

CPC classification number: G01N21/7746 ,  G02B6/354 ,  G02B2006/0325

Abstract: A reconfigurable optofluidic apparatus includes a microfluidic chip including a microfluidic channel further including an inlet for a liquid core waveguide fluid; a channel pathway for the liquid core waveguide fluid; a plurality of non-core waveguide fluid inlets; a switching chamber having a larger cross sectional area than the channel pathway; and an outlet for the liquid core waveguide fluid and non-core waveguide fluid, further including a plurality of non-liquid core waveguides disposed in the switching chamber. Light input to the apparatus propagates in the liquid core/liquid cladding (liquid) waveguide. The path of the liquid waveguide can be steered in a region of the apparatus over one of the non-liquid core waveguides such that the light is end-fire- or evanescently-coupled into the non-liquid core waveguide and output therefrom or between two of the non-liquid core waveguides and not coupled or output. Associated optofluidic switching methods are disclosed.

Abstract translation: 可重构光流体装置包括微流体芯片，其包括微流体通道，其还包括用于液芯波导流体的入口; 用于液芯波导流体的通道路径; 多个非芯波导流体入口; 开关室具有比通道路径更大的横截面面积; 以及用于液芯波导流体和非芯波导流体的出口，还包括设置在开关室中的多个非液体芯波导。 输入到设备的光在液芯/液体包层（液体）波导中传播。 液体波导的路径可以在非液体核心波导之一上的设备的区域中被引导，使得光被端火或ev逝耦合到非液体芯波导中并从其输出或两者之间输出 的非液体芯波导，并且不耦合或输出。 公开了相关的光流控开关方法。