公开(公告)号：US11559538B2

公开(公告)日：2023-01-24

申请号：US17082102

申请日：2020-10-28

Applicant: Pfizer Inc.

Inventor： Joseph Walter Strohbach ,  Tsutomu Akama ,  David Clive Blakemore ,  Robert Toms Jacobs ,  Peter Jones ,  David Christopher Limburg ,  Martins Sunday Oderinde ,  Matthew Alexander Perry ,  Jacob John Plattner ,  Rubben Federico Torella ,  Yasheen Zhou ,  Thean Yeow Yeoh

IPC: C07F5/02 ,  A61K31/69 ,  A61K31/519

Abstract: The present invention relates to boron containing compounds of Formula (IA): that inhibit phosphodiesterase 4 (PDE4). The invention also encompasses pharmaceutical compositions containing these compounds and methods for treating diseases, conditions, or disorders ameliorated by inhibition of PDE4.

公开(公告)号：US20230019853A1

公开(公告)日：2023-01-19

申请号：US17341877

申请日：2021-06-08

Applicant: Pfizer Inc.

Inventor： Christopher Ryan Butler ,  Michelle Renee Garnsey ,  Kevin Alexander Ogilvie ,  Jana Polivkova ,  Matthew Forrest Sammons ,  Aaron Christopher Smith ,  Qingyi Yang

IPC: C07D471/20 ,  C07D519/00

Abstract: Described herein are compounds of Formula I: and their pharmaceutically acceptable salts, wherein R1, R2, R3, X1, Y1, Y2, Y3, Y4 and Y5 are defined herein; their use as MC4R antagonists; pharmaceutical compositions containing such compounds and salts; the use of such compounds and salts to treat, for example, cachexia, anorexia, or anorexia nervosa; and intermediates and processes for preparing such compounds and salts.

公开(公告)号：US20230013253A1

公开(公告)日：2023-01-19

申请号：US17756951

申请日：2020-12-16

Applicant: Pfizer Inc.

Inventor： Saurabh Kant Bhardwaj ,  Chia Hung Chu

IPC: C12N15/86

Abstract: Provided are compositions and methods for stabilizing a transfection cocktail containing DNA-cationic polymer complexes for an extended time, while maintaining high transfection efficiency. Such stabilized transfection cocktail can be used to generate transfected cells that can produce, for example, rAAV vectors on a large scale without impacting the key attributes of the virus production, such as, titer, DNA packaged rAAV particle fraction, and rAAV vector purification profile.

公开(公告)号：US20230002386A1

公开(公告)日：2023-01-05

申请号：US17886807

申请日：2022-08-12

Applicant: PFIZER INC.

Inventor： Thomas Allen Chappie ,  Nandini Chaturbhai Patel ,  Patrick Robert Verhoest ,  Christopher John Helal ,  Simone Sciabola ,  Erik Alphie LaChapelle ,  Travis T. Wager ,  Ramalakshmi Yegna Chandrasekaran

IPC: C07D471/14 ,  C07D491/147 ,  C07D491/22 ,  C07D513/14 ,  C07D519/00 ,  C07D487/04 ,  C07D487/14 ,  C07D498/22 ,  C07D471/22

Abstract: The present invention is directed to compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein the substituents A, R1, R2, R3a, R3b, R4a, R4b and n are as defined herein. The inventions also directed to pharmaceutical compositions comprising the compounds, methods of treatment using the compounds and methods of preparing the compounds.

公开(公告)号：US20220401544A1

公开(公告)日：2022-12-22

申请号：US17764153

申请日：2020-09-24

Applicant: Pfizer Inc.

Inventor： Annaliesa Sybil Anderson ,  John Lance Perez ,  Kathrin Ute Jansen ,  Paul Liberator ,  Cuiwen Tan ,  Thomas Richard Jones ,  Johannes Frederik Beeslaar ,  Judith Absalon ,  Jason Douglas Maguire ,  Shannon Lea Harris

IPC: A61K39/095 ,  A61P31/04 ,  A61K47/02

Abstract: NEW MATERIAL: Recombinant plasmid pTPGIF2 having a size of 4,660 base pairs and a structure obtained by inserting a DNA having a size of 52 base pairs and containing a sequence coding somatostatin into a BamHI incision site of a plasmid vector pTP70-1 capable or fusing a heteropeptide to a carboxy-terminal of a dihydrofolic acid reductase gene of E. coli. USE: Producton of fused protein containing somatostatin.
PREPARATION: A somatostatin gene is integrated into a plasmid vector pTP70-1. pTPGIF2 is kept in stable state when introduced into E. coli. C600 strain. The E. coli. C600 train containing pTPGIF2 is deposited in Fermentation Research institute as FERM BP-1577.

公开(公告)号：US11529344B2

公开(公告)日：2022-12-20

申请号：US16762388

申请日：2018-11-09

Applicant: Pfizer Inc.

Inventor： Manfred Kraus ,  Pei-Pei Kung ,  Thomas Andrew Paul ,  Shikhar Sharma ,  Dominique Verhelle

IPC: A61K31/4725 ,  A61P35/00 ,  A61K33/243 ,  A61K31/357 ,  A61K31/4412 ,  A61K31/4433 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/501 ,  A61K31/5355 ,  A61K39/395 ,  A61K45/06

Abstract: This invention relates to combination therapies comprising an EZH2 inhibitor and a chemotherapeutic agent, and associated pharmaceutical compositions, methods of treatment, and pharmaceutical uses.

公开(公告)号：US20220387576A1

公开(公告)日：2022-12-08

申请号：US17824295

申请日：2022-05-25

Applicant: Pfizer Inc.

Inventor： Annaliesa Sybil Anderson ,  Caitlyn Gallagher ,  Jianxin Gu ,  Isis Kanevsky ,  Jin-Hwan Kim ,  Justin Keith Moran ,  Suddham Singh ,  Naveen Surendran

IPC: A61K39/09 ,  A61P31/04

Abstract: The present invention relates to new conjugated capsular saccharide antigens (glycoconjugates), immunogenic compositions comprising said glycoconjugates and uses thereof.

公开(公告)号：US20220370606A1

公开(公告)日：2022-11-24

申请号：US17415348

申请日：2019-12-18

Applicant: Pfizer Inc.

Inventor： Shih-Hsun CHEN ,  Luca MICCI ,  Cecilia Marianne ODERUP ,  Shahram SALEK-ARDAKANI ,  Jie WEI

IPC: A61K39/395 ,  C07K16/28 ,  A61P35/00 ,  A61K31/713 ,  A61K31/7125

Abstract: The present disclosure describes combination therapies and uses thereof for the treatment of cancer. The combinations therapies include at least a first therapeutic agent and a second therapeutic agent.

公开(公告)号：US20220362372A1

公开(公告)日：2022-11-17

申请号：US17733566

申请日：2022-04-29

Applicant: PFIZER INC.

Inventor： Philip Ralph Dormitzer ,  Advait Vijay Badkar ,  Christina Van Geen Hoven ,  Kathrin Ute Jansen ,  Pirada Suphaphiphat Allen ,  Ramin Darvari ,  Mark Duda

IPC: A61K39/145 ,  A61P31/16

Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use ribonucleic acid vaccines comprising polynucleotide molecules encoding one or more influenza antigens, such as hemagglutinin antigens.

公开(公告)号：US11472850B2

公开(公告)日：2022-10-18

申请号：US17060067

申请日：2020-09-30

Applicant: PFIZER INC.

Inventor： Annaliesa Sybil Anderson ,  Susan Kay Hoiseth ,  Kathrin Ute Jansen ,  Justin Keith Moran ,  Mark Edward Ruppen

IPC: C07K14/22 ,  A61K39/095 ,  A61K39/00

Abstract: In one aspect, the invention relates to a non-lipidated and non-pyruvylated Neisseria meningitidis serogroup B polypeptide and methods of use thereof. In another aspect, the invention relates to an immunogenic composition including an isolated non-lipidated, non-pyruvylated ORF2086 polypeptide from Neisseria meningitidis serogroup B, and at least one conjugated capsular saccharide from a meningococcal serogroup, and methods of use thereof.