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公开(公告)号：US10967138B2
公开(公告)日：2021-04-06
申请号：US15762387
申请日：2016-09-22
Applicant: Stamford Devices Limited
Inventor： Joseph Grehan , Michael Casey , Shaun Porter , Niall Smith
Abstract: A digital processor of a nebulizer controller controls and monitors drive current (I) applied to an aperture plate. The drive current is detected as a series of discrete values at each of multiple measuring points, each having a particular drive frequency The processor in real time calculates a slope or rate of change of drive current with frequency and additionally determines a minimum value for drive current leading up to the peak value. The processor uses both the value of the minimum drive current during the scan and also the maximum slope value to achieve reliable prediction of end of dose, when the aperture plate becomes dry.
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公开(公告)号：US20200347507A1
公开(公告)日：2020-11-05
申请号：US16852692
申请日：2020-04-20
Applicant: Stamford Devices Limited
Inventor： Hong XU
IPC: C25D7/00 , B41J2/16 , C25D5/02 , C25D5/10 , C25D1/00 , B05B17/00 , C25D3/38 , C25D3/46 , C25D3/48 , C25D3/54 , C25D5/34 , C25D5/48 , C25D5/54
Abstract: In one embodiment, a method for manufacturing an aperture plate includes depositing a releasable seed layer above a substrate, applying a first patterned photolithography mask above the releasable seed layer, the first patterned photolithography mask having a negative pattern to a desired aperture pattern, electroplating a first material above the exposed portions of the releasable seed layer and defined by the first mask, applying a second photolithography mask above the first material, the second photolithography mask having a negative pattern to a first cavity, electroplating a second material above the exposed portions of the first material and defined by the second mask, removing both masks, and etching the releasable seed layer to release the first material and the second material. The first and second material form an aperture plate for use in aerosolizing a liquid. Other aperture plates and methods of producing aperture plates are described according to other embodiments.
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公开(公告)号：US10662543B2
公开(公告)日：2020-05-26
申请号：US15001551
申请日：2016-01-20
Applicant: Stamford Devices Limited
Inventor： Hong Xu
IPC: C25D7/00 , B41J2/16 , C25D5/02 , C25D5/10 , C25D1/00 , B05B17/00 , C25D3/38 , C25D3/46 , C25D3/48 , C25D3/54 , C25D5/34 , C25D5/48 , C25D5/54
Abstract: A method for manufacturing an aperture plate includes depositing a releasable seed layer above a substrate, applying a first patterned photolithography mask above the releasable seed layer, the first patterned photolithography mask having a negative pattern to a desired aperture pattern, electroplating a first material above the exposed portions of the releasable seed layer and defined by the first mask, applying a second photolithography mask above the first material, the second photolithography mask having a negative pattern to a first cavity, electroplating a second material above the exposed portions of the first material and defined by the second mask, removing both masks, and etching the releasable seed layer to release the first material and the second material. The first and second material form an aperture plate for use in aerosolizing a liquid. Other aperture plates and methods of producing aperture plates are described.
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公开(公告)号：US20200155788A1
公开(公告)日：2020-05-21
申请号：US16750507
申请日：2020-01-23
Applicant: Stamford Devices Limited
Inventor： Ronan MACLOUGHLIN , Niall Smith
Abstract: A high flow nasal therapy system (1) has a gas supply (2), a nebulizer (12), and a nasal interface (7). There are two branches (11, 10) and a valve (6) linked with the controller, the branches including a first branch (11) for delivery of aerosol and a second branch (10) for delivery of non-aerosolized gas. The controller controls delivery into the branches (11, 10), in which flow is unidirectional in the first and second branches, from the gas supply towards the nasal interface. The first branch (11) includes the nebulizer (12) and a line configured to store a bolus of aerosol during flow through the second branch (10). The valve (6) comprises a Y-junction between the gas inlet on one side and the branches on the other side.
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公开(公告)号：US20180256829A1
公开(公告)日：2018-09-13
申请号：US15762387
申请日：2016-09-22
Applicant: Stamford Devices Limited
Inventor： Joseph GREHAN , Michael CASEY , Shaun PORTER , Niall SMITH
IPC: A61M11/00
Abstract: A digital processor of a nebulizer controller controls and monitors drive current (I) applied to an aperture plate. The drive current is detected as a series of discrete values at each of multiple measuring points, each having a particular drive frequency The processor in real time calculates a slope or rate of change of drive current with frequency and additionally determines a minimum value for drive current leading up to the peak value. The processor uses both the value of the minimum drive current during the scan and also the maximum slope value to achieve reliable prediction of end of dose, when the aperture plate becomes dry.
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Patent Agency Ranking
公开(公告)号：US09572950B2
公开(公告)日：2017-02-21
申请号：US13829044
申请日：2013-03-14
Applicant: STAMFORD DEVICES LIMITED
Inventor： John Sylvester Power , James B. Fink , Conor Paul Duffy , Trevor Stephen Fahy
IPC: A61M11/00 , A61M16/16 , A61M15/00 , A61M16/14 , A61M16/00 , A61M16/06 , A61M16/08 , B05B12/08 , B05B17/00 , B05B17/06
CPC classification number: A61M16/14 , A61M11/002 , A61M11/003 , A61M11/005 , A61M15/0085 , A61M16/0057 , A61M16/0666 , A61M16/0672 , A61M16/0833 , A61M16/0875 , A61M16/147 , A61M16/16 , A61M2202/0208 , A61M2206/14 , B05B12/081 , B05B17/0646 , B05B17/0669
Abstract: A supplemental oxygen delivery system is described in which Aerosol is delivered into a housing which sits in the circuit from the supplemental oxygen supply and optional humidifier. The supplemental oxygen passes through this chamber in which the aerosol is located, and collects the aerosol transporting it to a patient via a nasal cannula or a face mask. An aerosol generator is mounted to the housing and delivers aerosol into an oxygen stream flowing between an inlet and an outlet of the housing. The housing also has a removable plug in the base thereof for draining any liquid that accumulates in the housing. There is no disruption of oxygen delivery to patients using nasal cannulas who currently have to use a separate face-mask when receiving nebulized medication.
Abstract translation: 描述了补充氧气输送系统，其中气溶胶被输送到从辅助氧气供应和可选的加湿器位于电路中的壳体中。 补充的氧气通过气溶胶所在的腔室，并将通过鼻插管或面罩将其运送到患者的气溶胶收集。 将气溶胶发生器安装到壳体并将气溶胶输送到在壳体的入口和出口之间流动的氧气流中。 壳体还在其底部具有可移除的塞子，用于排出积聚在壳体中的任何液体。 使用鼻腔插管的患者不会中断输氧，目前在接受雾化药物时必须使用单独的面罩。
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公开(公告)号：US20150336115A1
公开(公告)日：2015-11-26
申请号：US14719036
申请日：2015-05-21
Applicant: Stamford Devices Limited
Inventor： Brendan HOGAN , Hong XU
CPC classification number: B05B1/02 , A61M11/005 , A61M15/0085 , A61M2207/00 , B05B17/0638 , B05B17/0653 , C25D1/08 , C25D7/04
Abstract: An aperture plate is manufactured by plating metal around a mask of resist columns having a desired size, pitch, and profile, which yields a wafer about 60 μm thickness. This is approximately the full desired target aperture plate thickness. The plating is continued so that the metal overlies the top surfaces of the columns until the desired apertures are achieved. This needs only one masking/plating cycle to achieve the desired plate thickness. Also, the plate has passageways formed beneath the apertures, formed as an integral part of the method, by mask material removal. These are suitable for entrainment of aerosolized droplets exiting the apertures.
Abstract translation: 通过在具有期望的尺寸，间距和轮廓的抗蚀剂柱的掩模上镀覆金属来制造孔板，其产生约60μm厚度的晶片。 这大约是完全期望的目标孔板厚度。 继续进行电镀，使得金属覆盖在柱的顶表面上，直到达到所需的孔。 这只需要一个掩模/电镀周期来实现所需的板厚度。 此外，板具有形成在孔下方的通道，其形成为该方法的整体部分，通过掩模材料去除。 这些适合于夹带离开孔的雾化液滴。
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公开(公告)号：US20150122248A1
公开(公告)日：2015-05-07
申请号：US14530173
申请日：2014-10-31
Applicant: Stamford Devices Limited
Inventor： Patrick Joseph POWER , Jimmy EATON-EVANS
CPC classification number: A61M11/02 , A61M11/003 , A61M15/0021 , A61M15/0085 , A61M16/06 , A61M16/208 , A61M2202/0208 , A61M2202/04
Abstract: A system for delivery of aerosol therapy to spontaneously breathing patients comprises a housing which defines a chamber. The housing has a base, a top and a main body extending between the base and the top. An ambient air inlet is located adjacent to the base and is normally closed by an inlet valve. The housing also has a patient port for receiving a mouthpiece or a face mask. The mouthpiece has an exhaust outlet closed by an exhaust valve. Similarly, the face mask has an exhaust outlet closed by an exhaust valve. Exhaled air is exhausted through the valves and to prevent recirculation through the chamber which would adversely affect dose efficiencies. The housing also has an aerosol port for receiving a vibrating mesh aerosol generating device. The aerosol port is located in a side of the main body of the housing for delivery of aerosol into the chamber between the inlet valve and the patient port. A boss extends upwardly from the base and is spaced-apart inwardly of the main body of the housing to define a reception space or well.
Abstract translation: 用于将气溶胶疗法递送到自发呼吸患者的系统包括限定腔室的壳体。 壳体具有在基部和顶部之间延伸的基部，顶部和主体。 环境空气入口位于基座附近，并且通常由入口阀封闭。 外壳还具有用于接收口器或面罩的患者口。 接口具有由排气阀关闭的排气口。 类似地，面罩具有由排气阀封闭的排气口。 呼出的空气通过阀排出，并防止通过室的再循环，这将不利地影响剂量效率。 壳体还具有用于接收振动网孔气溶胶发生装置的气溶胶口。 气溶胶口位于壳体的主体的一侧，用于将气溶胶输送到入口阀和患者端口之间的腔室中。 凸台从基座向上延伸并且与壳体的主体向内间隔开以限定接收空间或井。
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公开(公告)号：US20150101596A1
公开(公告)日：2015-04-16
申请号：US14401480
申请日：2013-05-24
Applicant: Stamford Devices Limited
Inventor： Brendan Hogan
Abstract: A photo-resist (21) is applied in a pattern of vertical columns having the dimensions of holes or pores of the aperture plate to be produced. This mask pattern provides the apertures which define the aerosol particle size, having up to 2500 holes per square mm. There is electro-deposition of metal (22) into the spaces around the columns (21). There is further application of a second photo-resist mask (25) of much larger (wider and taller) columns, encompassing the area of a number of first columns (21). The hole diameter in the second plating layer is chosen according to a desired flow rate.
Abstract translation: 光刻胶（21）以要制造的孔板的孔或孔的尺寸的垂直列的图案施加。 该掩模图形提供限定气溶胶颗粒尺寸的孔，每平方毫米具有多达2500个孔。 将金属（22）电沉积到柱（21）周围的空间中。 进一步应用包括多个第一列（21）的区域的更大（更宽和更高）的列的第二光刻胶掩模（25）。 根据期望的流速选择第二镀层中的孔直径。
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公开(公告)号：US20250082869A1
公开(公告)日：2025-03-13
申请号：US18726062
申请日：2022-11-07
Applicant: CANSINO BIOLOGICS INC. , STAMFORD DEVICES LIMITED
Inventor： Weixue SI , Xiaolong ZHAO , Yueran WANG , Yueying JIANG , Liping WANG , Xuefeng YU , Shoubai CHAO , Tao ZHU
IPC: A61M11/00
Abstract: Disclosed are a nebulization cup and application in nebulized inhalation administration thereof, and especially application in nebulized inhalation administration of a preventive and/or therapeutic drug for a respiratory disease (such as SARS-CoV-2 vaccine). After adding an antistatic agent, the nebulization cup can effectively maintain the stability of drug mist within a certain period of time, with stable particle size, less drug residue in the cup, thus ensuring effective inhalable amount, and the administration operation is simple and convenient, thus the nebulization cup can significantly improve the inoculation efficiency and can be used for large-scale inoculation.
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