-
公开(公告)号：US20220313962A1
公开(公告)日：2022-10-06
申请号：US17709155
申请日：2022-03-30
Inventor： Daniel H. KIM , Dong Suk SHIN
IPC: A61M25/09
Abstract: Provided herein as a guidewire controller cassette for positioning a guidewire within a patient body, including a housing having an interior space; a translational module received within the interior space and having an entry side, an opposed exit side and a lateral wall being disposed therebetween, the translational module comprising a first guidewire path extending between the entry side and the exit side and configured to move the guidewire translationally along the first guidewire path; and a rotational module received within the interior space and mounted at the lateral wall, the rotational module comprising an opening for receiving the proximal end of the guidewire, a rotating axis allowing the proximal end of the guidewire being rotated thereabout, and a second guidewire path which is a loop path extending out from the opening to the entry side.
-
公开(公告)号：US20220306584A1
公开(公告)日：2022-09-29
申请号：US17596816
申请日：2020-06-20
Inventor： Jer-Tsong HSIEH , Jung-Mo AHN , Zhi-Ping LIU
IPC: C07D215/26 , C07D401/12 , C07D401/14 , C07D405/14 , A61P35/00
Abstract: The present disclosure provides a new series of 8-hydroxyquinoline derivatives/analogs that are potent KDM4 inhibitors with high activity and selectivity against KDM4 enzymes. Also disclosed are the pharmaceutical compositions comprising such 8-hydroxyquinoline-based potent KDM4 inhibitors, or a pharmaceutically acceptable salt thereof, and method of use thereof, for treating cancer and neoplastic diseases and the like.
-
公开(公告)号：US11450087B2
公开(公告)日：2022-09-20
申请号：US17048817
申请日：2019-04-18
Inventor： Karen Panetta , Shreyas Kamath Kalasa Mohandas , Sos Agaian
Abstract: The present disclosure includes systems and methods for multimedia image analytic including automated binarization, segmentation, and enhancement using bio-inspired based visual morphology schemes. The present disclosure further includes systems and methods for biometric multimedia content authentication using extracted geometric features and one or more of the binarization, segmentation, and enhancement methods.
-
公开(公告)号：US20220277427A1
公开(公告)日：2022-09-01
申请号：US17633133
申请日：2020-08-10
Inventor： Raquel Bromberg , Zbyszek Otwinowski , Dominika Borek
Abstract: Methods for correcting one or more image aberrations in an electron microscopy image, including cryo-EM images, are provided. The method includes obtaining a plurality of electron microscope (EM) images of an internal reference grid sample having one or more known properties, the plurality of electron microscope images obtained for a plurality of optical conditions and for a plurality of coordinated beam-image shifts. The method may also include, among other features, determining an aberration correction function that predicts aberrations for every point in the imaged area using kernel canonical correlation analysis (KCCA).
-
公开(公告)号：US20220275035A1
公开(公告)日：2022-09-01
申请号：US17672346
申请日：2022-02-15
Inventor： Peter Ulrichts , Christophe Blanchetot , Torsten Dreier , Johannes de Haard , E. Sally Ward Ober , Nicolas G. H. Ongenae
Abstract: Provided are novel FcRn antagonist compositions comprising a variant Fc region that binds specifically to FcRn with increased affinity and reduced pH dependence relative to the native Fc region. Also provided are FcRn antagonists with enhanced CD16 binding affinity. Also provided are methods of treating antibody-mediated disorders (e.g. autoimmune diseases) using the these FcRn antagonist compositions, nucleic acids encoding the FcRn antagonist compositions, recombinant expression vectors and host cells for making the FcRn antagonist compositions, and pharmaceutical compositions comprising the FcRn antagonist compositions.
-
Patent Agency Ranking
公开(公告)号：US20220273779A1
公开(公告)日：2022-09-01
申请号：US17295152
申请日：2019-11-18
Inventor： Marc I. DIAMOND , Kenneth DROMBOSKY , Dailu CHEN , Victor MANON , Xiaohua LIU , Hamid MIRZAEI , Jaime VAQUER-ALICEA , Hilda MIRBAHA , Lukasz A. JOACHIMIAK
Abstract: The disclosure provides methods and compositions for treating and diagnosing tauopathies. More specifically, the disclosure relates to the identification of epitopes on tau and their use as vaccines or as reagents to generate monoclonal antibodies that can be used for both diagnosis and treatment of tau-related diseases.
-
公开(公告)号：US11431470B2
公开(公告)日：2022-08-30
申请号：US16996061
申请日：2020-08-18
Applicant: The Board of Regents of The University of Texas System , The Regents of the University of California , Microsoft Technology Licensing, LLC
Inventor： Xiaoqian Jiang , Miran Kim , Yongsoo Song , Kristin Lauter
Abstract: A method, system and computer program product for performing computations on sensitive data while guaranteeing privacy. A service provider receives a first and a second ciphertext from a medical provider that homomorphically encrypts matrices A and B, respectively, using an encryption key, where the matrices A and B include medical data encoded as vectors. The service provider performs a homomorphic matrix multiplication on the first and second ciphertexts without decrypting the first and second ciphertexts. An encrypted result from the performed homomorphic matrix multiplication on the first and second ciphertexts is generated and transmitted to the medical provider to decrypt which matches a result of performing a matrix multiplication on unencrypted matrices A and B thereby enabling computations to be performed on the medical data in a secure manner.
-
公开(公告)号：US11426448B2
公开(公告)日：2022-08-30
申请号：US16410789
申请日：2019-05-13
Applicant: NORTHWESTERN UNIVERSITY , THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIVERSITY , THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
Inventor： Carol Podlasek , Samuel I. Stupp , Kevin McVary , Dan Harrington
IPC: A61K38/18 , A61P15/10 , C07K14/47 , A61K38/00 , C07K14/475
Abstract: Provided herein is technology relating to compositions comprising sonic hedgehog protein and therapeutic uses thereof. In particular, the technology relates to compositions comprising a hedgehog protein and one or more peptide amphiphiles for use in methods of treating or preventing stress urinary incontinence and/or erectile dysfunction in a subject.
-
公开(公告)号：US11419691B2
公开(公告)日：2022-08-23
申请号：US16495028
申请日：2018-06-28
Inventor： Daniel H. Kim , Dong Suk Shin , Taeho Jang , Yongman Park , Jeihan Lee , Hongmin Kim , Kihoon Nam , Seokyung Han
Abstract: The disclosure provides a surgical apparatus comprising: a steerable member that is bendable and comprises a plurality of bending segments with channels therein; and a plurality of bending actuation wires that are arranged to pass through the steerable member and cause the steerable member to bend, the steerable member comprising at least one outwardly opening lumen through which the bending actuation wires pass.
-
80.发明申请公开(公告)号：US20220249874A1
公开(公告)日：2022-08-11
申请号：US17597508
申请日：2020-07-13
Inventor： Xuejun GU , David PARSONS
IPC: A61N5/10
Abstract: The present disclosures describes a remotely controlled stereotactic radiotherapy system. The system may include a gamma-ray irradiation system for radioablation of a target region of human tissue, the system having an irradiating unit configured to produce a radiation field, and a processor remote from the gamma-ray irradiation system configured to control the dosage and position of the radiation field applied to the target region.
-
-
-
-
-
-
-
-
-
Search Results
1244
records
(took 0.043 seconds)
