公开(公告)号：US20220273779A1

公开(公告)日：2022-09-01

申请号：US17295152

申请日：2019-11-18

Applicant: The Board of Regents of the University of Texas System

Inventor： Marc I. DIAMOND ,  Kenneth DROMBOSKY ,  Dailu CHEN ,  Victor MANON ,  Xiaohua LIU ,  Hamid MIRZAEI ,  Jaime VAQUER-ALICEA ,  Hilda MIRBAHA ,  Lukasz A. JOACHIMIAK

IPC: A61K39/00 ,  A61P25/28 ,  A61K38/16 ,  A61K38/03 ,  A61K9/00

Abstract: The disclosure provides methods and compositions for treating and diagnosing tauopathies. More specifically, the disclosure relates to the identification of epitopes on tau and their use as vaccines or as reagents to generate monoclonal antibodies that can be used for both diagnosis and treatment of tau-related diseases.

公开(公告)号：US20230288432A1

公开(公告)日：2023-09-14

申请号：US18014850

申请日：2021-07-02

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Marc I. DIAMOND ,  Jaime VAQUER-ALICEA ,  Gianna C. MAGGIORE

IPC: G01N33/68 ,  C12N5/071 ,  C12N15/86 ,  G01N33/542

CPC classification number: G01N33/6896 ,  C12N5/0686 ,  C12N15/86 ,  G01N33/542 ,  G01N2800/2814 ,  C12N2503/00 ,  C12N2740/15043 ,  G01N2333/4709 ,  G01N2333/4704

Abstract: The present disclosure provides methods for the identification, characterization and ranking of putative tau monomer stabilizing agents. Specifically, the disclosure provides methods for assessing the capability of a test compound to stabilize a tau monomer, methods of prioritizing a plurality of test compounds from a library identified as tau monomer stabilizing agents, methods of screening a test compound library to identify tau monomer stabilizing agents, and a kit providing the reagents to perform the described methods.