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    CANCER TESTIS ANTIGEN SPERM PROTEIN 17 AS A TARGET FOR BREAST CANCER IMMUNOTHERAPY AND DIAGNOSIS
    73.
    发明申请
    CANCER TESTIS ANTIGEN SPERM PROTEIN 17 AS A TARGET FOR BREAST CANCER IMMUNOTHERAPY AND DIAGNOSIS 审中-公开
    癌症TESTIS抗原蛋白17作为乳腺癌的手段免疫和诊断

    公开(公告)号：US20160030539A1

    公开(公告)日：2016-02-04

    申请号：US14815330

    申请日：2015-07-31

    Applicant: Texas Tech University System

    Inventor： Maurizio Chiriva-Internati

    IPC: A61K39/00 ,  A61K9/127 ,  G01N33/574 ,  A61K45/06

    CPC classification number: A61K39/0011 ,  A61K31/138 ,  A61K31/555 ,  A61K45/06 ,  A61K2039/5154 ,  A61K2039/5158 ,  G01N33/57415 ,  G01N2333/705 ,  G01N2800/52 ,  A61K2300/00

    Abstract: The present invention includes compositions and methods for treating a breast cancer cell, a metastatic breast cancer cell, or a triple negative breast cancer cell comprising: identifying a subject in need for treatment for a breast cancer cell, a metastatic breast cancer cell, or a triple negative breast cancer cell; and administering a therapeutically effective amount of a formulation that leads to the presentation of an immunogenic SP17 protein or peptide antigen on an antigen presenting cell to activate T cells that are SP17-specific T cells, wherein the SP17-specific T cells impair the growth of the breast cancer cell, the metastatic breast cancer cell, or the triple negative breast cancer cell growth.

    Abstract translation: 本发明包括用于治疗乳腺癌细胞，转移性乳腺癌细胞或三阴性乳腺癌细胞的组合物和方法，包括：鉴定需要治疗乳腺癌细胞，转移性乳腺癌细胞或 三阴性乳腺癌细胞; 以及施用治疗有效量的制剂，其导致在抗原呈递细胞上呈递免疫原性SP17蛋白或肽抗原以活化作为SP17特异性T细胞的T细胞，其中所述SP17特异性T细胞损害 乳腺癌细胞，转移性乳腺癌细胞或三阴性乳腺癌细胞生长。

    PREPARATION AND CHARACTERIZATION OF BONE-TARGETED VANCOMYCIN-LOADED LIPOSOMES FOR OSTEOMYELITIS TREATMENT
    74.
    发明申请
    PREPARATION AND CHARACTERIZATION OF BONE-TARGETED VANCOMYCIN-LOADED LIPOSOMES FOR OSTEOMYELITIS TREATMENT 审中-公开
    用于骨质疏松症治疗的骨靶向血管收缩脂质体的制备和表征

    公开(公告)号：US20160030343A1

    公开(公告)日：2016-02-04

    申请号：US14815360

    申请日：2015-07-31

    Applicant: Texas Tech University System

    Inventor： Amr Abdelgawad ,  Eman Atef ,  Basel Karzoun

    IPC: A61K9/127 ,  A61K38/14

    CPC classification number: A61K38/14 ,  A61K47/548 ,  A61K47/6911

    Abstract: A treatment method, system, and compound comprise directly targets osteomyelitis-infected bone tissue with one or more surface-modified liposomes. The surface-modified liposome(s) includes an alendronate targeting moiety utilized to modify the surface of the liposome. Alendronate targets hydroxyapatite in bone tissue, wherein the surface-modified liposome further comprises encapsulated vancomycin that directly targets the hydroxyapatite in the infected bone tissue and prevents bone implant related infection.

    Abstract translation: 治疗方法，系统和化合物包括用一种或多种表面改性的脂质体直接靶向骨髓炎感染的骨组织。 表面改性的脂质体包括用于改变脂质体表面的阿仑膦酸盐靶向部分。 阿仑膦酸盐靶向骨组织中的羟基磷灰石，其中表面改性的脂质体还包括直接靶向感染的骨组织中的羟基磷灰石的包封的万古霉素并防止骨植入相关感染。

    Method and Apparatus for Gender Selection Based on PH
    75.
    发明申请
    Method and Apparatus for Gender Selection Based on PH 审中-公开
    基于PH的性别选择方法与装置

    公开(公告)号：US20160024456A1

    公开(公告)日：2016-01-28

    申请号：US14857981

    申请日：2015-09-18

    Applicant: Texas Tech University System

    Inventor： Samuel D. Prien ,  Lindsay L. Penrose

    IPC: C12M1/00

    CPC classification number: C12M47/04 ,  C12N5/0612

    Abstract: The present invention includes methods and apparatus to separate X or Y-chromosome bearing sperm cells in a population by first placing the population of sperm cells at physiological pH environment, and simultaneously contacting the population of sperm cells with one or more additional sub-environments with different pH values. The exposure allows mobile sperm cells bearing X or Y-chromosome to migrate to the different pH sub-environments, wherein each cell only exposed or come in contact with one pH sub-environment. Finally, the collecting X or Y-chromosome enriched population of sperm cells is performed.

    Abstract translation: 本发明包括通过首先将精子细胞群体置于生理pH环境中来分离群体中携带X或Y染色体的精子细胞的方法和装置，同时使精子细胞群与一个或多个其它亚环境接触， 不同的pH值。 暴露允许携带X或Y染色体的移动精子细胞迁移到不同的pH亚环境，其中每个细胞仅暴露或与一个pH亚环境接触。 最后，进行收集X或Y染色体富集的精子细胞群体。

    FIBRILLAR STRUCTURES TO REDUCE VISCOUS DRAG ON AERODYNAMIC AND HYDRODYNAMIC WALL SURFACES
    76.
    发明申请
    FIBRILLAR STRUCTURES TO REDUCE VISCOUS DRAG ON AERODYNAMIC AND HYDRODYNAMIC WALL SURFACES 审中-公开
    减少航空动力和水动力墙面上的粘弹带的结构

    公开(公告)号：US20160017902A1

    公开(公告)日：2016-01-21

    申请号：US14774767

    申请日：2014-03-12

    Applicant: TEXAS TECH UNIVERSITY SYSTEM ,  NANOGRIPTECH, INC.

    Inventor： Luciano Castillo ,  Burak Aksak ,  Metin Sitti

    IPC: F15D1/00 ,  B63B1/36 ,  B64C21/10

    CPC classification number: F15D1/003 ,  B63B1/36 ,  B64C21/10 ,  B64C2230/26 ,  F15D1/0035 ,  Y02T50/166 ,  Y02T70/121

    Abstract: An aerodynamic or hydrodynamic wall surface has an array of fibrillar structures disposed on and extending from the wall surface, wherein each fibrillar structure comprises a stalk and a tip. The stalk has a first end and a second end, wherein the first end is attached to the wall surface, and the stalk is oriented with respect to the wall surface at a stalk angle between approximately 1 degrees and 179 degrees. The tip has a first side and a second side, wherein the first side is attached proximate to the second end of the stalk, the tip has a larger cross-sectional area than the stalk, and the second side comprises a substantially planar surface that is oriented with respect to the stalk at a tip angle between approximately 0 degrees and 90 degrees.

    Abstract translation: 空气动力学或流体动力学壁表面具有布置在壁表面上并从壁表面延伸的纤维结构阵列，其中每个纤维结构包括茎和尖端。 茎具有第一端和第二端，其中第一端附接到壁表面，并且茎以约1度至179度之间的柄角度相对于壁表面定向。 尖端具有第一侧和第二侧，其中第一侧靠近杆的第二端附接，尖端具有比杆更大的横截面面积，第二侧包括基本平坦的表面， 在约0度和90度之间的尖端角度相对于杆定向。

    TARGET INHIBITION MAP SYSTEM FOR COMBINATION THERAPY DESIGN AND METHODS OF USING SAME
    77.
    发明申请
    TARGET INHIBITION MAP SYSTEM FOR COMBINATION THERAPY DESIGN AND METHODS OF USING SAME 审中-公开
    用于组合治疗设计的目标抑制地图系统及其使用方法

    公开(公告)号：US20150269307A1

    公开(公告)日：2015-09-24

    申请号：US14661918

    申请日：2015-03-18

    Applicant: Texas Tech University System

    Inventor： Ranadip Pal ,  Charles Keller, III ,  Noah E. Berlow ,  Bernard Seguin

    IPC: G06F19/12 ,  G06F19/24 ,  C12Q1/68 ,  G01N33/574 ,  G01N33/50

    CPC classification number: G16B5/00 ,  G01N33/5014 ,  G01N33/574 ,  G01N2500/10 ,  G01N2570/00 ,  G16B40/00

    Abstract: Disclosed is a system and method for targeted therapy designs which model a cancer pathway for predicting the effectiveness of targeted anti-cancer drugs. The disclosed system and method includes utilization of a computer processor allowing for the selection of a set of drugs from available drugs using approximation algorithms utilizing cell viability data associated with a testable culture of a patient's tumor for generating a probabilistic target inhibition map (PTIM) from viability data for considering the selection of a set of drugs from available drugs, and further supports a wide variety of scenarios for personalized cancer therapy, related products and services.

    Abstract translation: 公开了用于靶向治疗设计的系统和方法，该系统和方法模拟用于预测靶向抗癌药物的有效性的癌症途径。 所公开的系统和方法包括使用计算机处理器，其允许使用利用与患者肿瘤的可测试培养物相关联的细胞存活力数据的近似算法从可用药物中选择一组药物，以生成概率性靶标抑制图（PTIM） 考虑从现有药物中选择一组药物的可行性数据，并进一步支持个性化癌症治疗，相关产品和服务的各种场景。

    LACTIC ACID AND OTHER PROBIOTIC BACTERIA TO REDUCE PATHOGENS IN LYMPH NODES AND OTHER LYMPHATIC TISSUES OF LIVESTOCK ANIMALS
    78.
    发明申请
    LACTIC ACID AND OTHER PROBIOTIC BACTERIA TO REDUCE PATHOGENS IN LYMPH NODES AND OTHER LYMPHATIC TISSUES OF LIVESTOCK ANIMALS 有权
    柠檬酸和其他生物细菌减少LYMPH NODES中的病原体和其他LIVESTOCK动物的淋巴组织

    公开(公告)号：US20150182565A1

    公开(公告)日：2015-07-02

    申请号：US14585850

    申请日：2014-12-30

    Applicant: Texas Tech University System

    Inventor： Mindy M. Brashears ,  Guy H. Loneragan ,  Kendra Nightingale ,  J. Chance Brooks

    IPC: A61K35/747 ,  C12Q1/18 ,  A61K35/741

    Abstract: The present invention includes compositions and methods for eliminating or reducing microbial contamination in lymph nodes that enter the food supply from livestock comprising: identifying an animal in need of eliminating or reducing microbial contamination in non-gut associated lymph nodes that enter the food supply, and providing the animal with an effective amount of a lactic acid bacteria or probiotic bacterial sufficient to reduce or eliminate the microbial contamination in non-gut associated lymph nodes.

    Abstract translation: 本发明包括用于消除或减少从家畜进入食物供应的淋巴结中的微生物污染的组合物和方法，包括：鉴定需要消除或减少进入食物供应的非肠道相关淋巴结中的微生物污染的动物，以及 为动物提供足够的有效量的乳酸菌或益生菌以减少或消除非肠道相关淋巴结中的微生物污染。

    Method, apparatus and computer program product for automatically generating a computer program using consume, simplify and produce semantics with normalize, transpose and distribute operations
    79.
    发明授权
    Method, apparatus and computer program product for automatically generating a computer program using consume, simplify and produce semantics with normalize, transpose and distribute operations 有权
    用于使用消费自动生成计算机程序的方法，装置和计算机程序产品，简化并产生具有归一化，转置和分配操作的语义

    公开(公告)号：US08839212B2

    公开(公告)日：2014-09-16

    申请号：US14042699

    申请日：2013-09-30

    Applicant: Texas Tech University System

    Inventor： Daniel E. Cooke ,  J. Nelson Rushton ,  Brad Nemanich

    IPC: G06F9/45 ,  G06F9/44

    CPC classification number: G06F8/443 ,  G06F8/30 ,  G06F8/456

    Abstract: A code generator and multi-core framework are executable in a computer system to implement methods as disclosed herein, including a method for the code generator to automatically generate multi-threaded source code from functional specifications, and for the multi-core framework, which is a run time component, to generate multi-threaded task object code from the multi-threaded source code and to execute the multi-threaded task object code on respective processor cores. The methods provide transparency to the programmer, and during execution, provide automatic identification of processing parallelisms. The methods implement Consume-Simplify-Produce and Normalize-Transpose-Distribute operations to reduce complex expression sets in a functional specification to simplified expression sets operable in parallel processing environments through the generated multi-threaded task object code. The result is a code generator which compiles transparent declarative code into multi-threaded code and that in the process identifies and assigns parallel processing paths to improve overall processing performance.

    Abstract translation: 代码生成器和多核框架可在计算机系统中执行以实现本文所公开的方法，包括用于代码生成器从功能规范自动生成多线程源代码的方法，以及用于多核框架 运行时组件，用于从多线程源代码生成多线程任务对象代码，并在相应的处理器内核上执行多线程任务对象代码。 这些方法为程序员提供了透明度，并且在执行期间提供了处理并行性的自动识别。 该方法实现消费简化生产和规范化 - 转置 - 分发操作，以减少功能规范中的复杂表达式集，以通过生成的多线程任务对象代码在并行处理环境中可操作的简化表达式集。 结果是代码生成器，它将透明的声明性代码编译成多线程代码，并且在该过程中识别并分配并行处理路径以提高整体处理性能。

    Method, Apparatus and Computer Program Product for Automatically Generating a Computer Program Using Consume, Simplify and Produce Semantics with Normalize, Transpose and Distribute Operations
    80.
    发明申请
    Method, Apparatus and Computer Program Product for Automatically Generating a Computer Program Using Consume, Simplify and Produce Semantics with Normalize, Transpose and Distribute Operations 有权
    自动生成计算机程序的方法，设备和计算机程序产品，通过消耗，简化和生成符合规范化，转置和分配操作的语义

    公开(公告)号：US20140109039A1

    公开(公告)日：2014-04-17

    申请号：US14042699

    申请日：2013-09-30

    Applicant: Texas Tech University System

    Inventor： Daniel E. Cooke ,  J. Nelson Rushton ,  Brad Nemanich

    IPC: G06F9/45 ,  G06F9/44

    CPC classification number: G06F8/443 ,  G06F8/30 ,  G06F8/456

    Abstract: A code generator and multi-core framework are executable in a computer system to implement methods as disclosed herein, including a method for the code generator to automatically generate multi-threaded source code from functional specifications, and for the multi-core framework, which is a run time component, to generate multi-threaded task object code from the multi-threaded source code and to execute the multi-threaded task object code on respective processor cores. The methods provide transparency to the programmer, and during execution, provide automatic identification of processing parallelisms. The methods implement Consume-Simplify-Produce and Normalize-Transpose-Distribute operations to reduce complex expression sets in a functional specification to simplified expression sets operable in parallel processing environments through the generated multi-threaded task object code. The result is a code generator which compiles transparent declarative code into multi-threaded code and that in the process identifies and assigns parallel processing paths to improve overall processing performance.

    Abstract translation: 代码生成器和多核框架可在计算机系统中执行以实现本文所公开的方法，包括用于代码生成器从功能规范自动生成多线程源代码的方法，以及用于多核框架 运行时组件，用于从多线程源代码生成多线程任务对象代码，并在相应的处理器内核上执行多线程任务对象代码。 这些方法为程序员提供了透明度，并且在执行期间提供了处理并行性的自动识别。 该方法实现消费简化生产和规范化 - 转置 - 分发操作，以减少功能规范中的复杂表达式集，以通过生成的多线程任务对象代码在并行处理环境中可操作的简化表达式集。 结果是代码生成器，它将透明的声明性代码编译成多线程代码，并且在该过程中识别并分配并行处理路径以提高整体处理性能。

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