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1.发明申请PREPARATION AND CHARACTERIZATION OF BONE-TARGETED VANCOMYCIN-LOADED LIPOSOMES FOR OSTEOMYELITIS TREATMENT 审中-公开用于骨质疏松症治疗的骨靶向血管收缩脂质体的制备和表征公开(公告)号：US20160030343A1
公开(公告)日：2016-02-04
申请号：US14815360
申请日：2015-07-31
Applicant: Texas Tech University System
Inventor： Amr Abdelgawad , Eman Atef , Basel Karzoun
CPC classification number: A61K38/14 , A61K47/548 , A61K47/6911
Abstract: A treatment method, system, and compound comprise directly targets osteomyelitis-infected bone tissue with one or more surface-modified liposomes. The surface-modified liposome(s) includes an alendronate targeting moiety utilized to modify the surface of the liposome. Alendronate targets hydroxyapatite in bone tissue, wherein the surface-modified liposome further comprises encapsulated vancomycin that directly targets the hydroxyapatite in the infected bone tissue and prevents bone implant related infection.
Abstract translation: 治疗方法，系统和化合物包括用一种或多种表面改性的脂质体直接靶向骨髓炎感染的骨组织。 表面改性的脂质体包括用于改变脂质体表面的阿仑膦酸盐靶向部分。 阿仑膦酸盐靶向骨组织中的羟基磷灰石，其中表面改性的脂质体还包括直接靶向感染的骨组织中的羟基磷灰石的包封的万古霉素并防止骨植入相关感染。
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Patent Agency Ranking
公开(公告)号：US20180085151A1
公开(公告)日：2018-03-29
申请号：US15566280
申请日：2016-04-14
Applicant: Texas Tech University System
Inventor： Amr Abdelgawad
CPC classification number: A61B17/7291 , A61B17/72 , A61B17/7241 , A61B17/846 , A61F2/4202
Abstract: The present invention includes a tibio-talar device and a method for providing stabilizing support between a tibia and a talus comprising: a bone nail adapted to traverse the talus and the tibia, wherein the bone nail is curved such that it traverses the talus and enters the tibia at an angle, wherein the nail is angled from side to side, wherein the bone nail is configured to provide for intra medullary fusion of the ankle without obstructing the subtalar joint. The nail is introduced from talus and curves to pass to the tibia fusing the ankle joint.
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公开(公告)号：US20170100173A1
公开(公告)日：2017-04-13
申请号：US15315248
申请日：2015-05-29
Inventor： Amr Abdelgawad , Noe Vargas-Hernandez , Khaled Emara , Mario E. Rodriguez
IPC: A61B17/80
CPC classification number: A61B17/8004 , A61B17/8057 , A61B2017/00075 , A61B2017/00199 , A61B2017/00212 , A61B2017/00398 , A61B2017/00734 , A61B2017/00991
Abstract: An extramedullary bone lengthener and use thereof that is an internal device that does not require nailing. The invention includes a telescoping plate that attaches to the upper and lower portions of the bone via screws; a small motor affixed on or within the plate. This motor, controlled remotely, will controllably lengthen the plate, thus lengthening the bone. The bone will be cut (osteotomy) then the plate will be applied to both ends and fixed to each end with screws. The motor will be controlled from outside by a remote control which will allow the plate to expand causing lengthening of the attached bone.
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公开(公告)号：US20220151664A1
公开(公告)日：2022-05-19
申请号：US17590286
申请日：2022-02-01
Applicant: Texas Tech University System
Inventor： Amr Abdelgawad
IPC: A61B17/72
Abstract: The present invention includes a tibio-talar device for providing stabilizing support between a tibia and a talus including: a bone nail adapted to traverse the tibia and the talus, wherein the bone nail is curved such that it traverses the tibia and enters the talus at an angle, wherein the bone nail is angled from lateral to medial, wherein the bone nail is configured to provide for intra medullary fusion of the ankle without obstructing the subtalar joint, wherein the bone nail has openings are positioned along the length of the bone nail, and wherein the screw engages the bone nail to lock its rotation in relation to the tibia and talus and optionally for compression of two or more bones selected from tibia to talus, fibula to tibia, or fibula to talus,
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公开(公告)号：US20210038270A1
公开(公告)日：2021-02-11
申请号：US16978836
申请日：2019-03-08
Applicant: Texas Tech University System
Inventor： Amr Abdelgawad
IPC: A61B17/72
Abstract: The present invention includes a tibio-talar device for providing stabilizing support between a tibia and a talus including: a bone nail adapted to traverse the tibia and the talus, wherein the bone nail is curved such that it traverses the tibia and enters the talus at an angle, wherein the bone nail is angled from lateral to medial, wherein the bone nail is configured to provide for intra medullary fusion of the ankle without obstructing the subtalar joint, wherein the bone nail has openings are positioned along the length of the bone nail, and wherein the screw engages the bone nail to lock its rotation in relation to the tibia and talus and optionally for compression of two or more bones selected from tibia to talus, fibula to tibia, or fibula to talus,
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公开(公告)号：US09949772B2
公开(公告)日：2018-04-24
申请号：US15315248
申请日：2015-05-29
Inventor： Amr Abdelgawad , Noe Vargas-Hernandez , Khaled Emara , Mario E. Rodriguez
CPC classification number: A61B17/8004 , A61B17/8057 , A61B2017/00075 , A61B2017/00199 , A61B2017/00212 , A61B2017/00398 , A61B2017/00734 , A61B2017/00991
Abstract: An extramedullary bone lengthener and use thereof that is an internal device that does not require nailing. The invention includes a telescoping plate that attaches to the upper and lower portions of the bone via screws; a small motor affixed on or within the plate. This motor, controlled remotely, will controllably lengthen the plate, thus lengthening the bone. The bone will be cut (osteotomy) then the plate will be applied to both ends and fixed to each end with screws. The motor will be controlled from outside by a remote control which will allow the plate to expand causing lengthening of the attached bone.
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