公开(公告)号：US20210198171A1

公开(公告)日：2021-07-01

申请号：US17060455

申请日：2020-10-01

Applicant: The Board of Trustees of The University of Alabama ,  University of South Carolina

Inventor： Elizabeth Papish ,  Aaron Vannucci

IPC: C07C41/18 ,  B01J31/22

Abstract: Disclosed are methods of selective hydrodeoxygenation of aromatic compounds by using catalyst systems comprising N-heterocyclic carbene (NHC) and 4-pyridinol-derived pincer ligands and metal complexes containing these ligands.

公开(公告)号：US20210183268A1

公开(公告)日：2021-06-17

申请号：US17184939

申请日：2021-02-25

Applicant: UNIVERSITY OF SOUTH CAROLINA ,  PRISMA HEALTH - UPSTATE

Inventor： DAVID L. CULL ,  THOMAS B. O'HANLAN

IPC: G09B23/28 ,  G09B23/34

Abstract: A cannulation simulation device and methods for using the device are described. The device is designed to teach dialysis technicians/nurses or patients to cannulate arteriovenous (AV) fistulas for hemodialysis. The simulator includes one or more artificial fistulas. The simulator includes a pad of simulated flesh that can cover the artificial fistula(s). The pad can be reversed, rotated, and replaced with thicker or thinner pads. A personal simulation device for teaching self-cannulation can include a sleeve for a limb that can carry an artificial fistula. A clinical simulation device can include a plurality of artificial fistulas held in a support. Optionally, the artificial fistulas can vibrate to simulate an actual fistula.

公开(公告)号：US20210176959A1

公开(公告)日：2021-06-17

申请号：US17124620

申请日：2020-12-17

Applicant: University of South Carolina

Inventor： Hossein Haj-Hariri ,  Gavin Thomas Garner ,  Mitra Minter Haj-Hariri ,  Dara Davisson Haj-Hariri

IPC: A01K11/00 ,  G08B29/18 ,  G08B21/18 ,  A01K29/00

Abstract: A system for maintaining inter-object separation between different objects such as animals, machinery, or people, that uses distance signaling to provide and maintain separation via correction activities that may also be used to keep the first two objects at a prescribed distance from a third object.

公开(公告)号：US11007207B2

公开(公告)日：2021-05-18

申请号：US14833711

申请日：2015-08-24

Applicant: University of South Carolina

Inventor： Peisheng Xu ,  Bei Cheng ,  Huacheng He

IPC: A61K31/704 ,  A61K41/00 ,  A61K51/04 ,  B82B1/00 ,  A61K51/12 ,  G01N1/00 ,  A61K9/51

Abstract: Described is a method to fabricate a gold/mesoporous silica hybrid nanoparticle. According to the process, a gold nanoparticle can be conjugated onto the surface of a mesoporous silica nanoparticle to yield a photothermal stable theranostic platform, gold/mesoporous silica hybrid nanoparticle. The nanoparticles can be useful for disease detection, treatment, and monitoring.

公开(公告)号：US11000482B2

公开(公告)日：2021-05-11

申请号：US16568865

申请日：2019-09-12

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： Peisheng Xu

IPC: A61K9/51 ,  A61K31/17 ,  A61P35/00 ,  A61K31/704

Abstract: A nanoparticle system for the treatment of metastatic cancer is provided. The nanoparticle system includes a plurality of nanoparticles. Each of the nanoparticles includes a biodegradable matrix, a polysulphonated naphthylurea, and a chemotherapeutic agent. The biodegradable matrix can be a natural polysaccharide, a protein, a peptide, or a derivative thereof. Further, the polysulphonated naphthylurea can include suramin or a pharmaceutically acceptable salt thereof, and the chemotherapeutic agent can include an anthracycline. In addition, each of the nanoparticles has a diameter ranging from about 20 nanometers to about 400 nanometers. A method of forming the nanoparticle system and a method of treating cancer in a mammal with the nanoparticle system are also provided.

公开(公告)号：US20210130621A1

公开(公告)日：2021-05-06

申请号：US17145612

申请日：2021-01-11

Applicant: University of South Carolina

Inventor： Morgan Stefik ,  Hasala N. Lokupitiya

IPC: C09D1/00 ,  C01B33/12 ,  C01G33/00 ,  C01G41/02 ,  C08L71/02 ,  C08F293/00

Abstract: Products derived from and methods of micelle templating that allow for orthogonal control over structural features.

公开(公告)号：US20210111938A1

公开(公告)日：2021-04-15

申请号：US17064899

申请日：2020-10-07

Applicant: University of South Carolina

Inventor： Alphan Sahin ,  David Matolak ,  Nozhan Hosseini

IPC: H04L27/26 ,  H04B1/707

Abstract: Apparatuses, systems, and methods for transmitting and multiplexing chirp signals for communications are provided. An example apparatus includes an antenna, a radio, and processing circuitry. The radio may be configured to transmit and receive wireless communications via the antenna, and the processing circuitry configured to establish a wireless communications link with a receiving communications device. The signaling transmitted by the antenna via the radio as controlled by the processing circuitry may include a plurality of sequenced chirp signals within an orthogonal frequency division multiplexing (OFDM) framework.

公开(公告)号：US20210111936A1

公开(公告)日：2021-04-15

申请号：US17065949

申请日：2020-10-08

Applicant: University of South Carolina

Inventor： Alphan Sahin ,  David Matolak

IPC: H04L27/26 ,  G06N3/04

Abstract: A new layer tailored for Artificial Intelligence-based communication systems to limit the instantaneous peak power for the signals that relies on manipulation of complementary sequences through neural networks. Disclosed is a method for providing non-linear distortion in end-to-end learning communication systems, the communication system comprising a transmitter and a receiver. The method includes mapping transmitted information bits to an input of a first neural network; controlling, by an output of the neural network, parameters of a complementary sequence (CS) encoder, producing an encoded CS; transmitting the encoded CS through an orthogonal frequency division multiplexing (OFDM) signal; processing, by Discrete Fourier Transform (DFT), the encoded CS, to produce a received information signal in a frequency domain; and processing, by a second neural network, the received information signal.

公开(公告)号：US20210095238A1

公开(公告)日：2021-04-01

申请号：US16939685

申请日：2020-07-27

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： Ehsan JABBARZADEH ,  Christopher WU

IPC: C12M1/34 ,  C12M1/12 ,  C12M1/42 ,  C12M1/00

Abstract: Biocompatible, mechanically-dynamic thermoresponsive devices, methods for forming the devices, and exemplary applications for the devices are described. The devices include a series of wells therein and provide for temperature-controlled mechanostimulation of single cells or groups of cells that can be retained in the wells of a device. Mechanostimulation can be single instance of any duration, continuous, or regular or irregular cyclic mechanostimulation of single cells, cell clusters, cell spheroids, or organoids and may be utilized in any of a variety of biomedical applications including, without limitation, cellular engineering, cellular phenotyping, and drug discovery/screening.

公开(公告)号：US10940441B2

公开(公告)日：2021-03-09

申请号：US16151408

申请日：2018-10-04

Applicant: University of South Carolina

Inventor： Chuanbing Tang ,  Tianyu Zhu

IPC: C07F17/02 ,  C08F30/04 ,  B01J45/00 ,  H01M8/1072 ,  B01D67/00 ,  B01D71/82 ,  H01M8/1048 ,  H01M8/1023 ,  H01M8/1067 ,  B01J47/12 ,  C08J5/22 ,  B01D69/02 ,  B01D69/14 ,  C08G61/08

Abstract: Chemically inert, mechanically tough, cationic metallo-polyelectrolytes designed as durable anion-exchange membranes (AEMs) via ring-opening metathesis polymerization (ROMP) of cobaltocenium-containing cyclooctene with triazole as the only linker group, followed by backbone hydrogenation to provide a new class of AEMs with a polyethylene-like framework and alkaline-stable cobaltocenium cation for ion transport, which exhibit excellent thermal, chemical and mechanical stability, as well as high ion conductivity.