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公开(公告)号：US20210403644A1
公开(公告)日：2021-12-30
申请号：US17242647
申请日：2021-04-28
Applicant: University of South Carolina
Inventor： Peisheng Xu
Abstract: Described herein are systems and methods for the degradation of endogenous protein with the help of a nanocarrier, which has the advantage of easy scale-up and feasibility for in vivo application.
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公开(公告)号：US20210369861A1
公开(公告)日：2021-12-02
申请号：US17213750
申请日：2021-03-26
Applicant: University of South Carolina
Inventor： Peisheng Xu
Abstract: A carrier-free nanoparticle based on the self-assembly of curcumin-erlotinib conjugate (EPC) that exhibits stronger cell killing, better anti-migration effects, and anti-invasion effects for pancreatic cancer cells than the combination of free curcumin and erlotinib.
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公开(公告)号：US11007207B2
公开(公告)日：2021-05-18
申请号：US14833711
申请日：2015-08-24
Applicant: University of South Carolina
Inventor： Peisheng Xu , Bei Cheng , Huacheng He
Abstract: Described is a method to fabricate a gold/mesoporous silica hybrid nanoparticle. According to the process, a gold nanoparticle can be conjugated onto the surface of a mesoporous silica nanoparticle to yield a photothermal stable theranostic platform, gold/mesoporous silica hybrid nanoparticle. The nanoparticles can be useful for disease detection, treatment, and monitoring.
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公开(公告)号：US11000482B2
公开(公告)日：2021-05-11
申请号：US16568865
申请日：2019-09-12
Applicant: UNIVERSITY OF SOUTH CAROLINA
Inventor： Peisheng Xu
IPC: A61K9/51 , A61K31/17 , A61P35/00 , A61K31/704
Abstract: A nanoparticle system for the treatment of metastatic cancer is provided. The nanoparticle system includes a plurality of nanoparticles. Each of the nanoparticles includes a biodegradable matrix, a polysulphonated naphthylurea, and a chemotherapeutic agent. The biodegradable matrix can be a natural polysaccharide, a protein, a peptide, or a derivative thereof. Further, the polysulphonated naphthylurea can include suramin or a pharmaceutically acceptable salt thereof, and the chemotherapeutic agent can include an anthracycline. In addition, each of the nanoparticles has a diameter ranging from about 20 nanometers to about 400 nanometers. A method of forming the nanoparticle system and a method of treating cancer in a mammal with the nanoparticle system are also provided.
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公开(公告)号：US10221271B2
公开(公告)日：2019-03-05
申请号：US15783282
申请日：2017-10-13
Applicant: University of South Carolina
Inventor： Peisheng Xu , Huacheng He
IPC: C08F220/28 , A61K31/00 , A61K31/795 , A61K33/34
Abstract: Polymer/copper combinations that can selectively target and kill cancer cells are described. Materials can include the reaction product of a biocompatible hydrophilic polymer and pyridine-2-thiol containing monomer. The copolymer reaction product can include pyridine-2-thiol side groups pendant to the backbone via a disulfide linkage. The hydrophilic component can form the polymer backbone and/or can form hydrophilic pendant groups off of the backbone. Copper ions can be associated with the copolymer.
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Patent Agency Ranking
6.发明申请公开(公告)号：US20170095558A1
公开(公告)日：2017-04-06
申请号：US15269058
申请日：2016-09-19
Applicant: UNIVERSITY OF SOUTH CAROLINA
Inventor： Peisheng Xu , Huacheng He
IPC: A61K41/00 , A61K31/704 , A61N5/06 , A61K9/16
CPC classification number: A61K41/0057 , A61K9/0009 , A61K9/513 , A61K31/704 , A61K41/0028 , A61K41/0052 , A61K47/6849 , A61K47/6935 , A61K47/6937 , A61N5/062 , A61N5/0625 , A61N2005/0659
Abstract: Described is a biodegradable and biocompatible hybrid nanoparticle for use in photothermal applications. The hybrid nanoparticle includes a poly(lactide-co-glycolic acid) core and a polydopamine shell. Optionally, the hybrid nanoparticle can be loaded with an active agent such as an anti-cancer agent. The hybrid nanoparticles can include detection agents, targeting agents, etc. The nanoparticles can be useful for disease detection, treatment, and monitoring.
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7.发明申请公开(公告)号：US20160008289A1
公开(公告)日：2016-01-14
申请号：US14859661
申请日：2015-09-21
Applicant: UNIVERSITY OF SOUTH CAROLINA
Inventor： Peisheng Xu , Remant Bahadur KC
IPC: A61K9/50 , A61K47/34 , C12N15/113 , A61K31/713
CPC classification number: A61K9/5036 , A61K9/51 , A61K9/5161 , A61K9/5184 , A61K31/713 , A61K47/34 , A61K48/00 , C12N15/113 , C12N15/87 , C12N2310/14
Abstract: Delivery systems and their methods of formation are generally provided. The delivery system can protect a delivery molecule (e.g., DNA/RNA) and deliver it into a cell via serum. In one embodiment, the method can include binding a delivery molecule with polyethylenimine such that an end of the delivery molecule is exposed; capping the end of the delivery molecule with a first biocompatible polymer to form a core; and encapsulating the core with a second biocompatible polymer. The resulting delivery system can include a delivery molecule bonded with polyethylenimine such that an end of the delivery molecule is exposed; a first biocompatible polymer electrostatically bonded to the end of the delivery molecule to form a core; and a second biocompatible polymer encapsulating the core.
Abstract translation: 一般提供输送系统及其形成方法。 递送系统可以保护递送分子（例如DNA / RNA）并通过血清将其递送到细胞中。 在一个实施方案中，该方法可以包括将递送分子与聚乙烯亚胺结合，使得递送分子的末端被暴露; 用第一生物相容性聚合物覆盖递送分子的末端以形成核心; 并用第二生物相容性聚合物包封核心。 所得到的递送系统可以包括与聚乙烯亚胺结合的递送分子，使得分泌分子的末端被暴露; 第一生物相容性聚合物静电结合到输送分子的末端以形成核心; 和封装芯的第二生物相容性聚合物。
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公开(公告)号：US20250025560A1
公开(公告)日：2025-01-23
申请号：US18648946
申请日：2024-04-29
Applicant: UNIVERSITY OF SOUTH CAROLINA
Inventor： Peisheng Xu , Mingming Wang
Abstract: Methods are described for treatment of Alzheimer's Disease as well as other neurodegenerative disorders in which microglia and/or astrocyte abilities have been altered and impaired. Methods include brain-targeting of PD-L1 using a brain targeted nanogel loaded with PDL1 antibody and functionalized with two particular targeting ligands. The nanogels can successfully cross the blood brain barrier to release the antibody and reduce PD-L1 expression in the brain while preserving the integrity of the BBB.
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9.发明公开公开(公告)号：US20240033240A1
公开(公告)日：2024-02-01
申请号：US18479393
申请日：2023-10-02
Applicant: UNIVERSITY OF SOUTH CAROLINA
Inventor： Peisheng Xu , Eleni Markoutsa
IPC: A61K31/198 , A61K47/69 , A61K47/54 , A61K47/55
CPC classification number: A61K31/198 , A61K47/6933 , A61K47/6935 , A61K47/54 , A61K47/55
Abstract: The preparation of dual functionalized nanoparticles is generally provided along with their application. The dual functionalized nanoparticles provide dual targeting and can effectively pass the blood brain barrier and target brain tissue. The dual targeted and dual responsive nanoparticles are functionalized to include at least two different ligands that are capable of transport across the blood brain barrier. The nanoparticles can be prepared from polymeric materials that can be biocompatible, provide long circulation life in a body, and be successfully ligated to both functionalities by use of acid-sensitive and/or redox potential-sensitive bonds for delivery across the blood brain barrier and delivery of a payload to brain tissue.
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公开(公告)号：US20230310331A1
公开(公告)日：2023-10-05
申请号：US17965880
申请日：2022-10-14
Applicant: University of South Carolina
Inventor： Peisheng Xu
IPC: A61K9/50 , C12N9/08 , A61K9/51 , A61K33/244 , A61K31/704 , A61P35/00
CPC classification number: A61K9/5068 , C12N9/0065 , C12Y111/01006 , A61K9/5123 , A61K33/244 , A61K31/704 , A61P35/00 , B82Y5/00
Abstract: Described herein are systems and methods for employing a tumor targeted cerium oxide nanoparticle system, T-CeNP, for cancer therapy to hinder cancer associated fibroblast (CAF) transdifferentiation and reprogram CAFs back to normal fibroblasts to reduce tumor size and prevent metastasis.
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