Screening system for zinc finger polypeptides for a desired binding ability
    74.
    发明授权
    Screening system for zinc finger polypeptides for a desired binding ability 有权
    锌指多肽的筛选系统具有所需的结合能力

    公开(公告)号:US06733970B2

    公开(公告)日:2004-05-11

    申请号:US09851271

    申请日:2001-05-08

    CPC classification number: C07K14/4702 C12N15/1041

    Abstract: This invention relates to a method for producing a zinc finger nucleic acid binding protein comprising preparing a zinc finger protein according design rules, varying the protein at one or more positions, and selecting variants which bind to a target nucleic acid sequence by polysome display.

    Abstract translation: 本发明涉及一种锌指核酸结合蛋白的制备方法,包括根据设计规则制备锌指蛋白,改变一个或多个位置的蛋白质,并通过多核苷酸显示选择与靶核酸序列结合的变体。

    Cytokine production and tyrosine kinase inhibitors
    75.
    发明授权
    Cytokine production and tyrosine kinase inhibitors 失效
    细胞因子生成和酪氨酸激酶抑制剂

    公开(公告)号:US06518316B1

    公开(公告)日:2003-02-11

    申请号:US09743284

    申请日:2001-03-27

    Abstract: A compound of formula (I), wherein &agr;X is ═O, ═N—OR6, &bgr;NHR or &bgr;OH wherein R6 is H or C1-C6 alkyl, bond a is oriented &ggr; or &dgr; and R is H, C1-C6 alkyl which is unsubstituted or substituted by C6-C10 aryl, or C3-C6 cycloalkyl; &egr; is a bond when &zgr; and &eegr; are not bonds or, when X is ═O, &zgr; and &eegr; are both bonds and &egr; is not a bond; R1 and R2, which are the same or different, are H or a halogen; R3 and R4, which are the same or different, are H, C1-C6 alkyl, C3-C6 cycloalkyl, a heterocyclic group or an aromatic group; bond e is oriented &ggr; or &dgr;; and R5 is C1-C6 alkyl; or formula (Ib), or formula (II), or formula (III), has activity as a cytokine production inhibitor and an inhibitor and an inhibitor of tyrosine kinase. A process for producing some of the compounds from a fungal strain, processes for producing synthetic analogues from these compounds and the use of the compounds in treating immunoinflammatory and cancerous conditions are also described.

    Abstract translation: 式(I)化合物,其中αX为= O,= N-OR6,βNHR或βOH,其中R6为H或C1-C6烷基,键a为取向的γ或δ,R为H,C 1 -C 6烷基为 未取代或被C 6 -C 10芳基或C 3 -C 6环烷基取代; 当zeta和eta不是键时,epsi是一个键,或当X = O时,zeta和eta都是键,而epsi不是键; R 1和R 2相同或不同,为H或卤素; R 3和R 4相同或不同,为H,C 1 -C 6烷基,C 3 -C 6环烷基,杂环基或芳基; 键e是取向的γ或δ; R5是C1-C6烷基; 或式(Ib)或式(II)或式(III))具有作为细胞因子产生抑制剂和抑制剂和酪氨酸激酶抑制剂的活性。 还描述了从真菌菌株产生一些化合物的方法,从这些化合物制备合成类似物的方法以及该化合物在治疗免疫炎症和癌症病症中的用途。

    Ice cube guide for ice apparatus
    76.
    发明授权
    Ice cube guide for ice apparatus 失效
    制冰机冰块导轨

    公开(公告)号:US06122927A

    公开(公告)日:2000-09-26

    申请号:US313976

    申请日:1999-05-19

    Applicant: Michael Moore

    Inventor: Michael Moore

    CPC classification number: F25C1/12 F25C5/16 F25C2400/04

    Abstract: An ice guide plate with a trapezoidal main body joined to a right triangular side plate by a joining plate. The joining plate has only two lateral water recovery slots in a lower section thereof. A pair of drip ridges are provided on the back of the joining plate as continuations of two reinforcing ribs of the main body and the side plate. A valley gutter slot is provided along the lower edge of the joining plates and extends up into the main body and the adjacent side plate as well.

    Abstract translation: 具有梯形主体的导冰板,通过接合板连接到右三角形侧板。 接合板在其下部仅具有两个侧向水回收槽。 在连接板的背面设有一对滴水脊,作为主体和侧板的两个加强肋的延伸。 沿着连接板的下边缘设置谷沟槽,并且向上延伸到主体和相邻的侧板中。

    Compressible stuff sack
    77.
    发明授权
    Compressible stuff sack 失效
    可压缩的东西袋

    公开(公告)号:US06089752A

    公开(公告)日:2000-07-18

    申请号:US111582

    申请日:1998-07-08

    Applicant: Michael Moore

    Inventor: Michael Moore

    CPC classification number: A45C7/0063

    Abstract: A compressible stuff sack is disclosed, designed to be relatively easy to use and inexpensive to manufacture. The stuff sack includes a body made of flexible material with a main opening. A hands-free, one-way valve is provided on the sack which enables excess air to automatically escape from the sack when the sack is compressed. In one embodiment, the body is cylindrically-shaped and made of waterproof material. Attached to one end of the body is a bottom cap including an end plate with surrounding compression rings which are simultaneously welded over an opened end of the body. The opposite end of the body is opened and covered with a removable top cap. Four, spaced-apart compression straps are aligned longitudinally over the outside surface of the body and attached to the bottom and top caps. When the compression straps are shortened, the bottom and top caps are squeezed together to reduce the overall length of the sack and to compress the cargo.

    Abstract translation: 公开了可压缩的袋子,设计成相对容易使用并且制造成本低廉。 袋子包括由主开口的柔性材料制成的主体。 袋上提供免提单向阀,当袋被压缩时,能使多余的空气自动从袋中逸出。 在一个实施例中,本体为圆柱形并由防水材料制成。 附着在本体的一端的是底盖,其包括具有围绕压缩环的端板,其同时焊接在主体的开口端上。 身体的另一端被打开并覆盖有可移除的顶盖。 四个间隔开的压紧带在主体的外表面上纵向排列并且附接到底盖和顶盖。 当压缩带缩短时,底部和顶部帽被挤压在一起以减小袋的总长度并压缩货物。

    Water supply apparatus for ice making machine
    78.
    发明授权
    Water supply apparatus for ice making machine 失效
    制冰机供水装置

    公开(公告)号:US6076749A

    公开(公告)日:2000-06-20

    申请号:US264868

    申请日:1999-03-09

    CPC classification number: F25C1/12 F25C2400/14

    Abstract: A water spraying apparatus for an ice making machine including an icing water sprayer having three spray tubes, a lateral header portion joining one end of each of the spray tubes together, and a pair of spray tube inlets connected to the lateral header portion. The spray tubes are spaced apart from and extend in parallel to each other. The bottom wall of each of the tubes has a plurality of water spray holes formed therein. The icing water sprayer is an integral one-piece structure. The spray tube inlets are symmetrically provided with respect to the longitudinal axis of the sprayer and have water supply connection openings with central axes in parallel with the lateral axis and facing each other. The spray tube inlets are preferably formed as a tee joint having a stem joined to the first wall of the lateral header portion and two arms with one arm having the water supply connection opening and the other arm being closed.

    Abstract translation: 一种用于制冰机的喷水装置,包括具有三个喷射管的结冰水喷雾器,将每个喷射管的一端连接在一起的横向集管部分和连接到横向集管部分的一对喷射管入口。 喷射管彼此间隔开并平行延伸。 每个管的底壁上形成有多个喷水孔。 结冰水喷雾器是一体的单件式结构。 喷射管入口相对于喷雾器的纵向轴线对称地设置,并且具有供水连接开口,其中心轴线与横向轴线平行并且彼此面对。 喷射管入口优选地形成为具有连接到横向集管部分的第一壁的杆的T形接头,并且具有一个臂的两个臂具有供水连接开口,另一个臂关闭。

    Method and apparatus for tracking of organized storms
    79.
    发明授权
    Method and apparatus for tracking of organized storms 失效
    跟踪有组织风暴的方法和装置

    公开(公告)号:US5959567A

    公开(公告)日:1999-09-28

    申请号:US986738

    申请日:1997-12-08

    CPC classification number: G01S13/723 G01S13/95 G06T7/20

    Abstract: A method and apparatus for tracking of organized storms using weather radar images. An image filter approximating the envelope of the organized storm radar image is used to improve tracking of the large scale storm features. The image filter is repeatedly rotated to different orientations at each point in the weather radar images to produce filtered images. The filtered images are provided to an image tracker to generate an array of track vectors. Application of the array of track vectors to the unfiltered image generates a predicted weather radar image.

    Abstract translation: 使用气象雷达图像跟踪有组织风暴的方法和装置。 逼近有组织的风暴雷达图像包络的图像滤波器用于改进大规模风暴特征的跟踪。 图像滤波器在天气雷达图像的每个点处重复地旋转到不同的取向以产生滤波图像。 经滤波的图像被提供给图像跟踪器以产生轨迹矢量的阵列。 将轨道矢量阵列应用于未经滤波的图像产生预测的气象雷达图像。

    Multi-function machine with interleaved job execution
    80.
    发明授权
    Multi-function machine with interleaved job execution 失效
    具有交错作业执行功能的多功能机

    公开(公告)号:US5299296A

    公开(公告)日:1994-03-29

    申请号:US71929

    申请日:1993-06-04

    Abstract: A multi-function machine with interleaved job execution is disclosed. The multi-function machine performs multiple functions such as printing and digital copying. Multiple users of the machine are intermittently serviced as the machine switches from printing to copying jobs and vice versa. The manner of switching is partially determined by whether the requisite set-up time for a particular job is complete. The manner of switching may also be determined by user-set priorities. In either embodiment, jobs are interleaved so as to eliminate unused time associated with the period required to set-up a job. As a result, the machine operates optimally while intermittently making progress on multiple jobs.

    Abstract translation: 公开了具有交错作业执行的多功能机器。 多功能机执行打印和数字复印等多种功能。 当机器从打印切换到复印作业时,机器的多个用户被间歇地服务,反之亦然。 切换的方式部分取决于特定作业的必要设置时间是否完成。 切换的方式也可以由用户设置的优先级来确定。 在任一实施例中,作业被交织以消除与设置作业所需的周期相关联的未使用时间。 因此,机器在多个作业中间歇性地取得进展的同时运行最佳。

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