公开(公告)号：US20160187273A1

公开(公告)日：2016-06-30

申请号：US14583239

申请日：2014-12-26

Applicant: Palo Alto Research Center Incorporated

Inventor： Michael I. Recht ,  Joerg Martini ,  Gregory L. Whiting ,  Francisco E. Torres

IPC: G01N25/48

CPC classification number: G01N25/482 ,  G01N21/00 ,  G01N25/20

Abstract: A method for detecting an enthalpy change includes providing a first mixture and a second mixture to a drop generator. The first mixture includes a ligand. The second mixture contains a target molecule. The method further includes generating a drop in the drop generator. The drop includes the target molecule, a temperature-sensitive reporter compound, and the ligand. The method also includes measuring a property of the temperature-sensitive reporter compound in the drop to determine an amount of enthalpy change that has occurred.

Abstract translation: 用于检测焓变的方法包括向液滴发生器提供第一混合物和第二混合物。 第一混合物包括配体。 第二混合物含有靶分子。 该方法还包括在液滴发生器中产生液滴。 该滴包括靶分子，温度敏感的报导物化合物和配体。 该方法还包括测量滴液中温度敏感性报告化合物的性质，以确定发生的焓变量。

公开(公告)号：US09261452B2

公开(公告)日：2016-02-16

申请号：US14139246

申请日：2013-12-23

Applicant: Palo Alto Research Center Incorporated

Inventor： Joerg Martini ,  Noble M. Johnson ,  Michael I. Recht ,  David M. Johnson ,  Tim Curley ,  Peter Kiesel ,  Martin Sheridan

IPC: G01N21/00 ,  G01N15/14

CPC classification number: G01N15/1459 ,  G01N15/1436 ,  G01N2015/1447

Abstract: Embodiments are directed to a host structure that includes a waveguide configured to deliver measurement light to a compartment at least partially within the host structure. The compartment is configured to reversibly engage a fluidic optical cartridge. The host structure also includes a detector configured to receive and process output light emanating from the fluidic optical cartridge as well as electronics to process signals from the detector.

Abstract translation: 实施例涉及一种主机结构，其包括被配置为将测量光至少部分地在主机结构内传送到隔间的波导。 隔室被配置成可逆地接合流体光学盒。 主机结构还包括检测器，其被配置为接收和处理从流体光学存储器发出的输出光以及处理来自检测器的信号的电子装置。

公开(公告)号：US09207066B2

公开(公告)日：2015-12-08

申请号：US14181524

申请日：2014-02-14

Applicant: Palo Alto Research Center Incorporated

Inventor： Joerg Martini ,  Marshall W. Bern ,  Noble M. Johnson ,  Peter Kiesel ,  Doron Kletter ,  Bowen Cheng ,  Michael I. Recht

IPC: G01B11/04 ,  G01B11/06

CPC classification number: G01B11/046 ,  G01B11/0691

Abstract: A device includes a spatial filter arranged in a Cartesian coordinate system having orthogonal x, y, and z axes. The spatial filter has mask features that are more light transmissive and mask features that are less light transmissive. The mask features are arranged along the x-axis in the flow direction of a flow path. A detector is positioned to detect light emanating from at least one object in the flow path, the object having a width along the y-axis, a thickness along the z-axis, and a length along the x-axis. Light emanating from the object is time modulated according to the mask features as the object moves along the flow path. The detector is configured to generate a time-varying electrical signal in response to the detected light that includes information about the width or thickness of the object.

Abstract translation: 装置包括布置在具有正交x，y和z轴的笛卡尔坐标系中的空间滤波器。 空间滤波器具有更透光的掩模特征和较少透光的掩模特征。 掩模特征沿着流动路径的流动方向沿x轴布置。 定位检测器以检测从流动路径中的至少一个物体发出的光，该物体具有沿着y轴的宽度，沿z轴的厚度和沿着x轴的长度。 当物体沿着流动路径移动时，根据掩模特征对从物体发出的光进行时间调制。 检测器被配置为响应于检测到的光产生包括关于物体的宽度或厚度的信息的时变电信号。

公开(公告)号：US20150233703A1

公开(公告)日：2015-08-20

申请号：US14181530

申请日：2014-02-14

Applicant: Palo Alto Research Center Incorporated

Inventor： Joerg Martini ,  Marshall W. Bern ,  Noble M. Johnson ,  Peter Kiesel ,  Doron Kletter ,  Bowen Cheng ,  Michael I. Recht

IPC: G01B11/04 ,  G01P3/36 ,  G01P15/00

CPC classification number: G01B11/043 ,  G01N15/1459 ,  G01N2015/1447 ,  G01N2015/1493 ,  G01P3/36 ,  G01P15/00

Abstract: Spatially modulated light emanating from an object moving along a flow path is used to determine various object characteristics including object length along the flow direction. Light emanating from at least one object moving along in a flow path along a flow direction of a spatial filter is sensed. The intensity of the sensed light is time modulated according to features of the spatial filter. A time varying electrical signal is generated which includes a plurality of pulses in response to the sensed light. Pulse widths of at least some of the pulses are measured at a fraction of a local extremum of the pulses. The length of the object along the flow direction is determined based on the measured pulse widths.

Abstract translation: 使用从沿着流路移动的物体发出的空间调制光来确定包括沿着流动方向的物体长度的各种物体特性。 感测从沿着空间滤波器的流动方向在流动路径中移动的至少一个物体发出的光。 感测光的强度根据空间滤波器的特征进行时间调制。 产生包括响应于所感测的光的多个脉冲的时变电信号。 至少部分脉冲的脉冲宽度在脉冲的局部极值的一部分被测量。 沿着流动方向的物体的长度是基于所测量的脉冲宽度确定的。

公开(公告)号：US20140192359A1

公开(公告)日：2014-07-10

申请号：US14155094

申请日：2014-01-14

Applicant: Palo Alto Research Center Incorporated

Inventor： Joerg Martini ,  Peter Kiesel ,  Malte Huck ,  Marshall W. Bern ,  Noble M. Johnson ,  Michael Bassler ,  Markus Beck

IPC: G01N21/25

CPC classification number: G01N21/25 ,  G01J3/26 ,  G01J3/28 ,  G01J3/2803 ,  G01J2003/1213 ,  G01N21/05 ,  G01N21/255 ,  G01N21/645 ,  G01N2021/0346 ,  G02B21/16 ,  G02B27/46

Abstract: A filter arrangement can transmit and/or reflect light emanating from a moving object so that the emanating light has time variation, and the time variation can include information about the object, such as its type. For example, emanating light from segments of a path can be transmitted/reflected through positions of a filter assembly, and the transmission functions of the positions can be sufficiently different that time variation occurs in the emanating light between segments. Or emanating light from a segment can be transmitted/reflected through a filter component in which simpler transmission functions are superimposed, so that time variation occurs in the emanating light in accordance with superposition of two simpler non-uniform transmission functions. Many filter arrangements could be used, e.g. the filter component could include the filter assembly, which can have one of the simpler non-uniform transmission functions. Time-varying waveforms from sensing results can be compared to obtain spectral differences. The filter arrangement, in a practical commercial embodiment, can be manufactured to be disposable, and used in a point-of-care device for use practically anywhere, at low cost, and can also be implemented in an in-line monitoring system.

Abstract translation: 滤波器装置可以发射和/或反射从移动物体发出的光，使得发射光具有时间变化，并且时间变化可以包括关于物体的信息，例如其类型。 例如，可以通过路径的区段发出光，并通过过滤器组件的位置进行透射/反射，并且位置的透射函数可以充分地不同，从而在区间之间的发光中发生时间变化。 或者发射来自光束的光可以通过其中叠加更简单的透射函数的滤光器部件被透射/反射，使得根据两个更简单的不均匀透射函数的叠加在发射光中发生时间变化。 可以使用许多过滤装置，例如 过滤器组件可以包括过滤器组件，其可以具有更简单的不均匀传输功能之一。 可以比较感测结果中的时变波形，以获得光谱差异。 在实用的商业实施例中，过滤器装置可以制造为一次性的，并且用于实际上在任何地方，以低成本使用的点护理装置，并且也可以在在线监测系统中实现。