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    AMINO ACID MIMETIC COPOLYMERS AND MEDICAL DEVICES COATED WITH THE COPOLYMERS
    71.
    发明申请
    AMINO ACID MIMETIC COPOLYMERS AND MEDICAL DEVICES COATED WITH THE COPOLYMERS 有权

    公开(公告)号：US20110160391A1

    公开(公告)日：2011-06-30

    申请号：US13045465

    申请日：2011-03-10

    Applicant: Stephen Pacetti

    Inventor： Stephen Pacetti

    IPC: C09D177/00

    CPC classification number: A61L27/54 ,  A61L27/34 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/00 ,  C08L27/18

    Abstract: Biocompatible polymers are manufactured to include an amino acid mimetic monomer and one or more hydrophobic acrylate monomers. The amino acid mimetic monomers are selected to mimic the side chain of the amino acids asparagine or glutamine. The amino acid mimetic monomer can be a methacryloyl or acryloyl derivative of 2-hydroxyacetamide, 3-hydroxypropionamide, alaninamide, lactamide, or glycinamide. These amide functional groups offer the advantage of moderate hydrophilicity with little chemical reactivity. The amino acid mimetic monomer can be copolymerized with one or more hydrophobic acrylate monomers to obtain desired coating properties.

    HYDROPHOBIC THERAPUEUTIC AGENT AND SOLID EMULSIFIER COATING FOR DRUG COATED BALLOON
    72.
    发明申请
    HYDROPHOBIC THERAPUEUTIC AGENT AND SOLID EMULSIFIER COATING FOR DRUG COATED BALLOON 审中-公开
    用于药物包衣气球的疏水治疗剂和固体乳化剂涂层

    公开(公告)号：US20110144578A1

    公开(公告)日：2011-06-16

    申请号：US12636246

    申请日：2009-12-11

    Applicant: Stephen Pacetti ,  John Stankus

    Inventor： Stephen Pacetti ,  John Stankus

    IPC: A61M29/02 ,  B05D3/02

    CPC classification number: A61L29/16 ,  A61L29/085 ,  A61L29/143 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2300/802

    Abstract: The disclosed subject matter is directed to a coated medical device such as a balloon or stent and methods of manufacturing the device, where the device has a working length disposed between a distal end and a proximal end thereof; and a coating applied to at least a length of the body. The coating includes a hydrophobic therapeutic agent having a water solubility less than about 15.0 μg/ml and an emulsifier that is a solid at ambient temperature.

    Abstract translation: 所公开的主题涉及涂覆的医疗装置，例如球囊或支架，以及制造该装置的方法，其中装置具有设置在其远端和近端之间的工作长度; 以及施加到身体的至少一段长度上的涂层。 该涂层包括水溶解度小于约15.0μg/ ml的疏水治疗剂和在环境温度下为固体的乳化剂。

    Zwitterionic copolymers, method of making and use on medical devices
    74.
    发明授权
    Zwitterionic copolymers, method of making and use on medical devices 有权
    两性离子共聚物，制造和使用在医疗器械上的方法

    公开(公告)号：US07781551B2

    公开(公告)日：2010-08-24

    申请号：US11942693

    申请日：2007-11-19

    Applicant: Stephen Pacetti ,  Wouter Roorda

    Inventor： Stephen Pacetti ,  Wouter Roorda

    IPC: C08F12/30 ,  C08F12/26 ,  C08F20/26

    CPC classification number: A61L27/54 ,  A61L27/34 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/00 ,  C08L27/18

    Abstract: Biocompatible copolymers are manufactured to include a zwitterionic monomer and an alkoxy acrylate monomer. The alkoxy acrylate monomer can be a 2-methoxyethyl methacrylate (MOEMA) or 2-ethoxyethyl methacrylate (EOEMA). Alternatively, the alkoxy acrylate can be 2-methoxyethyl acrylate (MOEA) or 2-ethoxyethyl acrylate (EOEA). The alkoxy acrylate monomers advantageously give the zwitterionic copolymers greater ductility, strength, and toughness while maintaining a desired amount of hydrophilicity. The improved toughness allows the zwitterionic copolymers to be processed without cross-linking, which improves the elongation properties of the zwitterionic copolymer, and reduces the risk of cracking during use.

    Abstract translation: 制造生物相容性共聚物以包括两性离子单体和烷氧基丙烯酸酯单体。 烷氧基丙烯酸酯单体可以是甲基丙烯酸2-甲氧基乙酯（MOEMA）或甲基丙烯酸2-乙氧基乙酯（EOEMA）。 或者，烷氧基丙烯酸酯可以是丙烯酸2-甲氧基乙酯（MOEA）或丙烯酸2-乙氧基乙酯（EOEA）。 烷氧基丙烯酸酯单体有利地使两性离子共聚物具有更高的延展性，强度和韧性，同时保持所需量的亲水性。 改进的韧性使得两性离子共聚物在不交联的情况下进行加工，这提高了两性离子共聚物的伸长性能，并降低了使用过程中的开裂风险。

    Methods and compositions for treatment of lesioned sites of body vessels
    75.
    发明授权
    Methods and compositions for treatment of lesioned sites of body vessels 有权
    用于治疗体内损伤部位的方法和组合物

    公开(公告)号：US07744928B2

    公开(公告)日：2010-06-29

    申请号：US11404233

    申请日：2006-04-14

    Applicant: Florian Niklas Ludwig ,  Stephen Pacetti ,  Paul Consigny

    Inventor： Florian Niklas Ludwig ,  Stephen Pacetti ,  Paul Consigny

    IPC: A61K33/00

    CPC classification number: A61K33/00 ,  A61K9/00 ,  A61K31/198 ,  A61K38/005 ,  A61K38/44 ,  A61L27/38 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/40

    Abstract: Methods and compositions for inducing apoptosis of cells, such as macrophages, at a lesioned site of a body vessel are disclosed herein. Nitric oxide can be directly or indirectly delivered to a treatment site to increase macrophage apoptosis. Delivery can include site specific delivery of nitric oxide gas, nitric oxide in aqueous solution or a substance(s) which releases nitric oxide or causes nitric oxide to be generated from an endogenous source. Delivery can be achieved by a delivery system such as a catheter assembly, stent or other suitable device.

    Abstract translation: 本文公开了在身体损伤部位诱导细胞例如巨噬细胞凋亡的方法和组合物。 一氧化氮可以直接或间接地递送到治疗部位以增加巨噬细胞凋亡。 交付可以包括一氧化氮气体，一氧化氮在水溶液中的位置特异性递送或释放一氧化氮或从内源产生一氧化氮的物质。 可以通过诸如导管组件，支架或其他合适的装置之类的递送系统实现递送。

    Method for coating implantable medical devices
    77.
    发明申请
    Method for coating implantable medical devices 有权
    可植入医疗器械的涂敷方法

    公开(公告)号：US20070269584A1

    公开(公告)日：2007-11-22

    申请号：US11825443

    申请日：2007-07-05

    Applicant: Stephen Pacetti

    Inventor： Stephen Pacetti

    IPC: A61L33/00

    CPC classification number: B05D3/0486 ,  A61L31/10

    Abstract: A method of coating an implantable medical device is disclosed, the method includes applying a composition onto the device and drying the composition at elevated temperature in an environment having increased relative humidity.

    Abstract translation: 公开了一种涂覆可植入医疗装置的方法，该方法包括将组合物施加到装置上并在具有相对湿度增加的环境中在升高的温度下干燥组合物。

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