公开(公告)号：US20040170547A1

公开(公告)日：2004-09-02

申请号：US10726076

申请日：2003-12-02

Inventor： Wansheng Liu

IPC: C07F015/00 ,  C01G053/00

CPC classification number: C07F15/0066 ,  B01D15/00 ,  B01J20/321 ,  B01J20/3219 ,  B01J20/3246 ,  B01J45/00

Abstract: A process is provided for removing one or more metals from liquids. Also provided is a process for the synthesis of aP2 inhibiting compounds having the formula (I) 1 wherein R1, R2, R3, R4, HET, and X-Z are as described herein, which process comprising the step of removing one or more metals from a solution of the compound of formula I or an intermediate or precursor thereof. The processes for removing metal comprise the step of contacting the liquid with a solid extractant comprising a metal-binding functionality.

Abstract translation: 提供了从液体中去除一种或多种金属的方法。 还提供了合成具有式（I）的P 2抑制化合物的方法，其中R 1，R 2，R 3，R 4，HET和XZ如本文所述，该方法 包括从式I化合物或其中间体或前体的溶液中除去一种或多种金属的步骤。 除去金属的方法包括使液体与包含金属结合官能团的固体萃取剂接触的步骤。

公开(公告)号：US06780323B2

公开(公告)日：2004-08-24

申请号：US10272733

申请日：2002-10-16

Applicant: George M. Murray

Inventor： George M. Murray

IPC: C02E142

CPC classification number: B01D67/0006 ,  B01D61/00 ,  B01D61/002 ,  B01D61/005 ,  B01D67/003 ,  B01D69/02 ,  B01D71/28 ,  B01D2323/18 ,  B01D2323/30 ,  B01D2325/04 ,  B01D2325/14 ,  B01D2325/16 ,  B01D2325/20 ,  B01J20/26 ,  B01J20/261 ,  B01J20/267 ,  B01J20/268 ,  B01J20/28033 ,  B01J20/3057 ,  B01J45/00 ,  B01J47/12 ,  C02F1/285 ,  C02F1/44 ,  C02F2101/105 ,  C02F2101/163 ,  C02F2101/203 ,  Y10T436/25

Abstract: Molecularly imprinted polymer membranes for selectively collecting phosphate, nitrate and ferric ions are disclosed, prepared by copolymerizing a matrix monomer, cross-linking agent, ion imprinting complex, permeability agent and polymerization initiator, after which the ions of the ion imprinting complex are permeability agent are removed. The permeability agent creates channels in the membrane permitting the ion binding sites in the membrane to communicate with the exterior surface of the membrane.

Abstract translation: 公开了用于选择性收集磷酸盐，硝酸盐和铁离子的分子印迹聚合物膜，其通过共聚基质单体，交联剂，离子印迹络合物，渗透剂和聚合引发剂制备，其后离子印迹络合物的离子是渗透剂 被删除。 渗透剂在膜中产生通道，允许膜中的离子结合位点与膜的外表面连通。

公开(公告)号：US20040141904A1

公开(公告)日：2004-07-22

申请号：US10480163

申请日：2004-02-26

Inventor： Robert Lewis Clarke ,  Dean Butler

IPC: C01B021/082

CPC classification number: B01D15/00 ,  B01J20/0211 ,  B01J20/06 ,  B01J41/10 ,  B01J45/00 ,  C01C3/08 ,  C01G27/006 ,  C01P2004/61 ,  C01P2006/16 ,  C02F1/281 ,  Y10S210/904 ,  Y10S423/14

Abstract: A metal hydroxide complex has a formula Me(OH)4*Anull*nH2O or MeO2*Anull*nH2O. Preferred complexes are formed in an alkaline medium, and particularly especially preferred anions include cyanide and cyanide gold complexes. Contemplated complexes are formed on a metal hydroxide (e.g., hydrated zirconium, hafnium, and titanium hydroxide), which may be disposed in a porous container. Consequently, contemplated compounds may be used in methods of reducing the concentration of an anion in an alkaline medium.

Abstract translation: 金属氢氧化物配合物具有式Me（OH）4 * A- * nH 2 O或MeO 2 * A- * n H 2 O。 优选的络合物在碱性介质中形成，特别优选的阴离子包括氰化物和氰化物金络合物。 在金属氢氧化物（例如，水合锆，铪和氢氧化钛）上形成沉淀的复合物，其可以设置在多孔容器中。 因此，预期的化合物可用于降低碱性介质中阴离子浓度的方法。

公开(公告)号：US20040138488A1

公开(公告)日：2004-07-15

申请号：US10469669

申请日：2004-02-20

Inventor： David H. Solomon ,  Marcus J. Caulfield ,  Tiziana Russo ,  Rav Shaw ,  Duncan J. McAllister

IPC: C07F009/70 ,  C07F007/22

CPC classification number: C07D295/096 ,  B01J39/18 ,  B01J45/00 ,  C02F1/42 ,  C02F1/683 ,  C02F2101/006 ,  C02F2101/20 ,  C07C215/50 ,  C07C217/58 ,  C08G73/0627 ,  C08G73/0633 ,  C08G73/0638

Abstract: A complexing ligand for forming a complex with a cation, the ligand comprising an aromatic component including two or more attachment sites for the cation, an optionally substituted amine, such as an aminoalkylene group, and a hydrocarbon chain of from 1 to 12 carbon atoms in length. The amine component of the ligand is capable of taking on an internal counterion (Hnull) so that the complex of the target cation and ligand has an overall neutral charge. Such ligands can be used to extract a target cation or cations from an aqueous solution. This has particular application for the separation of aluminium and silicon in aqueous liqors in a Bayer process. The ligand can be a simple compound formed by the Mannich condensation of catechol with formaldehyde and an amine. The ligand may alternatively be a bis-ligand, a polymer or an ion exchange resin. A range of new compounds and intermediates are also described.

Abstract translation: 用于与阳离子形成络合物的络合配体，所述配体包含芳族组分，其包含阳离子的两个或更多个连接位点，任选取代的胺，例如氨基亚烷基和具有1至12个碳原子的烃链， 长度。 配体的胺组分能够承受内抗衡离子（H +），使得目标阳离子和配体的络合物具有总体中性电荷。 这种配体可用于从水溶液中提取目标阳离子或阳离子。 这特别适用于在拜耳法中分离铝和硅的水溶液。 配体可以是由邻苯二酚与甲醛和胺的曼尼希缩合形成的简单化合物。 配体可以是双配体，聚合物或离子交换树脂。 还描述了一系列新的化合物和中间体。

公开(公告)号：US06670159B1

公开(公告)日：2003-12-30

申请号：US09915214

申请日：2001-07-25

Applicant: M. Dean Savage ,  Laura L. Sykaluk

Inventor： M. Dean Savage ,  Laura L. Sykaluk

IPC: C12N908

CPC classification number: C12N9/0065 ,  B01J45/00 ,  C07K1/1075 ,  C07K14/765 ,  C08H1/00 ,  C12N9/16 ,  Y10S530/812 ,  Y10S530/815 ,  Y10S530/816

Abstract: A precursor for the construction of chelated metal conjugates which demonstrate improved assay performance and utility in minimizing non-specific binding while maintaining specificity for target molecules is disclosed. The precursor has tridentate functionality towards multivalent ions such as iron and nickel and contains a diacetyl glycine group covalently linked via an amide to a molecule such as a proteinaceous molecule providing a primary amide group for amide bond formation. The precursor is preferably prepared in monomeric form by reacting nitrilotriacetic acid or a salt thereof in an aqueous medium at an alkaline pH of at least 8 with a proteinaceous molecule containing a primary amine group in the presence of a carbodiimide. The proteinaceous molecule may be bovine serum albumin or an enzyme such as alkaline phosphatase or horseradish peroxidase.

Abstract translation: 公开了构建螯合金属共轭物的前体，其表现出改进的测定性能和用于最小化非特异性结合同时保持靶分子的特异性。 前体具有三价离子如铁和镍的三齿功能，并且含有通过酰胺共价连接的分子（例如提供用于酰胺键形成的伯酰胺基团的蛋白质分子）的二乙酰基甘氨酸基团。 优选通过使次氮基三乙酸或其盐在水性介质中在至少8的碱性pH下与含有伯胺基的蛋白质分子在碳二亚胺的存在下反应制备前体。 蛋白质分子可以是牛血清白蛋白或酶如碱性磷酸酶或辣根过氧化物酶。

公开(公告)号：US20030075508A1

公开(公告)日：2003-04-24

申请号：US09949010

申请日：2001-09-07

Inventor： L. Andy Woodruff ,  Andrei V. Bordunov ,  Christopher A. Pohl

IPC: C02F001/42

CPC classification number: B01J45/00 ,  B01J41/14

Abstract: One embodiment of the invention comprises an ion exchange composition formed by reacting unsaturated carbon to carbon moieties pendant from derivatized ion binding cryptands with a support substrate under free radical activation conditions to form a covalent bond therebetween. In another embodiment, a cryptand ion exchange composition is made by covalently bonding unsaturated carbon to carbon moieties pendant from a derivatized ion binding cryptands with unsaturated carbon to carbon moieties pendant from a support substrate under free radical activation conditions to form covalent bond.

Abstract translation: 本发明的一个实施方案包括通过使自由基活化条件下的不饱和碳与衍生化的离子结合穴状物侧链的碳部分与支持底物反应形成的离子交换组合物，以在它们之间形成共价键。 在另一个实施方案中，通过共价键合不饱和碳与从自由基活化条件下从支持底物悬挂的不饱和碳与碳部分的衍生化离子结合穴状结构的碳部分共价键合而形成穴状离子交换组合物以形成共价键。

公开(公告)号：US06551515B1

公开(公告)日：2003-04-22

申请号：US09838663

申请日：2001-04-19

Applicant: Ronald L. Bruening ,  Krzysztof E. Krakowiak

Inventor： Ronald L. Bruening ,  Krzysztof E. Krakowiak

IPC: B01D1500

CPC classification number: B01J20/3204 ,  B01J20/321 ,  B01J20/3219 ,  B01J20/3251 ,  B01J45/00

Abstract: Compositions and methods for selectively binding specific metal ions, such as Ca2+and Cd2+, contained in a source solution are disclosed and described. This is accomplished by the use of a composition comprised of an EGTA ligand covalently bonded to a particulate solid supports through a hydrophilic spacer. The composition formula of the present invention is SS—A—X—L where SS is a particulate solid support such as silica or a polymeric bead, A is a covalent linkage mechanism, X is a hydrophilic spacer grouping, L is an EGTA ligand with the proviso that when SS is a particulate organic polymer, A—X may be combined as a single covalent linkage. The separation is accomplished by passing a source solution containing the ions to be separated through a column containing the particulate composition, causing the selected ions to be complexed to the EGTA ligand and subsequently removing the selected ions from the column or other separation device by passing an aqueous receiving solution through the separation device and quantitatively stripping the selected ions from the EGTA ligand.

Abstract translation: 公开和描述了包含在源溶液中的用于选择性结合特定金属离子（例如Ca 2+和Cd 2+）的组合物和方法。 这是通过使用由通过亲水间隔物与颗粒状固体支持物共价结合的EGTA配体组成的组合来实现的。 本发明的组成式是SS-AXL，其中SS是颗粒状固体载体如二氧化硅或聚合物珠，A是共价连接机理，X是亲水间隔基，L是EGTA配体，条件是当 SS是颗粒状有机聚合物，AX可以作为单一共价键组合。 通过使含有待分离的离子的源溶液通过含有颗粒组合物的柱来进行分离，使所选择的离子与EGTA配体络合，随后通过使经过一个或多个分离装置从柱或其它分离装置中除去所选离子 水接收溶液通过分离装置并定量地从EGTA配体中剥离选定的离子。

公开(公告)号：US06544422B2

公开(公告)日：2003-04-08

申请号：US09859937

申请日：2001-05-17

Applicant: Bryon J. Tarbet ,  Ronald L. Bruening ,  Anthony J. Di Leo ,  Philip M. Goddard ,  Louis M. Scarmoutzos

Inventor： Bryon J. Tarbet ,  Ronald L. Bruening ,  Anthony J. Di Leo ,  Philip M. Goddard ,  Louis M. Scarmoutzos

IPC: B01D600

CPC classification number: B01D67/0093 ,  B01D2323/30 ,  B01J20/24 ,  B01J20/261 ,  B01J20/262 ,  B01J20/264 ,  B01J20/267 ,  B01J20/28033 ,  B01J20/28078 ,  B01J20/28097 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3217 ,  B01J20/3219 ,  B01J20/3251 ,  B01J20/3282 ,  B01J45/00 ,  B01J2220/4825 ,  G21F9/04 ,  Y10T428/3154 ,  Y10T428/31544 ,  Y10T428/31739 ,  Y10T428/31913 ,  Y10T428/31935 ,  Y10T428/31938 ,  Y10T428/31971

Abstract: A method for removing, separating, and concentrating certain selected ions from a source solution that may contain larger concentrations of other ions comprises bringing the source solution in contact with a composition comprising an ion-binding ligand covalently bonded to a membrane having hydrophilic surface properties. The ligand portion of the composition has affinity for and forms a complex with the selected ions, thereby removing them from the source solution. The selected ions are then removed from the composition through contact with a much smaller volume of a receiving solution in which the selected ions are either soluble or which has greater affinity for the selected ions than does the ligand portion of the composition, thereby quantitatively stripping the complexed ions from the ligand and recovering them in concentrated form in the receiving solution. The concentrated ions thus removed may be further separated and recovered by known methods. The process if useful in the removal of selected ions, including noble metals and other transition metals from a variety of source solutions such as are encountered in semiconductor, nuclear waste cleanup, metals refining, environmental cleanup, providing ultra high purity fluids, electric power, and other industrial enterprises. The invention is also drawn to the ligand-membrane compositions.

Abstract translation: 用于从可能含有较大浓度的其它离子的源溶液中去除，分离和浓缩某些选定离子的方法包括使源溶液与包含共价键合到具有亲水表面性质的膜的离子结合配体的组合物接触。 组合物的配体部分与所选择的离子具有亲和力并与选择的离子形成复合物，从而将其从源溶液中除去。 然后通过与少量体积的接收溶液（其中所选择的离子是可溶的或对组合物的配体部分具有比选择的离子更大的亲和力）与组合物的配体部分接触来从组合物中除去选定的离子，从而定量地剥离 从配体中复合离子并将其以浓缩形式在接收溶液中回收。 这样除去的浓缩离子可以通过已知的方法进一步分离和回收。 该方法如果可用于从各种源解决方案中去除选定的离子，包括贵金属和其它过渡金属，例如半导体遇到的核废料清除，金属精炼，环境清洁，提供超高纯度流体，电力， 等工业企业。 本发明还涉及配体 - 膜组合物。

公开(公告)号：US20030057154A1

公开(公告)日：2003-03-27

申请号：US10282855

申请日：2002-10-28

Applicant: Transgenomic, Inc.

Inventor： Douglas T. Gjerde ,  Robert M. Haefele ,  David Togami

IPC: B01D015/08

CPC classification number: C12N15/101 ,  B01D15/12 ,  B01D15/366 ,  B01D15/38 ,  B01J45/00 ,  G01N30/14 ,  G01N2030/528

Abstract: The invention recognizes the deleterious effects of trace, and even undetectable amounts of multivalent cations on the separation of mixtures of polynucleotides, especially double stranded polynucleotides, and provides an improved method for separating such mixtures on wide pore, non-polar separation media by eliminating multivalent cations from the all aspects of the separation process. This is accomplished by using components in the separation process which are materials which do not release metal cations. In addition, the use of cation capture resins and other methods to remove residual traces of multivalent cations from eluting solvents, sample solutions, separation media, and system components is described. It is also important to remove any traces or organic contaminants from solvents solutions and system parts. Taking similar steps to remove residual traces of multivalent cations and organic impurities from the separation process, the invention may also be used in a batch process to separate mixtures of polynucleotide fragments.

公开(公告)号：US06524482B2

公开(公告)日：2003-02-25

申请号：US09838664

申请日：2001-04-19

Applicant: Ronald L. Bruening ,  Krzysztof E. Krakowiak ,  Anthony J. DiLeo ,  Tongbo Jiang

Inventor： Ronald L. Bruening ,  Krzysztof E. Krakowiak ,  Anthony J. DiLeo ,  Tongbo Jiang

IPC: B01D6100

CPC classification number: B01D67/0088 ,  B01D15/00 ,  B01D61/00 ,  B01D67/0093 ,  B01D69/141 ,  B01D2323/30 ,  B01J20/3219 ,  B01J20/3242 ,  B01J45/00

Abstract: The present invention provides methods for removing species of ions from biological solutions, thereby allowing controlled study of the biological effect of one or more ion on a biological system or environment. In general, a solution from which one or more ion species are to be removed is contacted with an ion binding ligand having an affinity for the desired ion wherein the ligand is bound to a substrate such as a solid support or membrane. After the ions have been bound by the ligand-substrate composition, the composition having the ions bound thereto is removed, leaving a solution with a reduced concentration of the one or more ions which were targeted. The biological solution may then be compared to a control biological solution in its original state, or ions may added back into the depleted biological solution at known concentrations. Under either scenario, the biological effects of one or more ions may be studied.