METHOD OF TREATING A DISEASE USING A GLYCOLYTIC DEPENDENT COMPOUND
    75.
    发明申请
    METHOD OF TREATING A DISEASE USING A GLYCOLYTIC DEPENDENT COMPOUND 审中-公开
    使用糖苷依赖性化合物治疗疾病的方法

    公开(公告)号:US20170042930A1

    公开(公告)日:2017-02-16

    申请号:US15234177

    申请日:2016-08-11

    Applicant: Ethicon, Inc.

    Inventor: James Galloway

    Abstract: Provided is a method of enhancing toxicity of a glycolytic dependent compound towards a cell, tissue and/or organ e.g. a diseased cell, tissue and/or organ, the method comprises contacting Oxidized Regenerated Cellulose (ORC) and/or Oxidized Cellulose (OC); and a glycolytic dependent compound with the cell, tissue and/or organ. The ORC and/or OC; and the glycolytic dependent compound are contacted with the cell, tissue and/or organ in a non-blended form.

    Abstract translation: 提供了一种增强糖酵解依赖性化合物对细胞,组织和/或器官的毒性的方法。 病变细胞,组织和/或器官,所述方法包括使氧化再生纤维素(ORC)和/或氧化纤维素(OC)接触; 和与细胞,组织和/或器官的糖酵解依赖性化合物。 ORC和/或OC; 并且糖酵解依赖性化合物以非混合形式与细胞,组织和/或器官接触。

    NANOFIBRIL-POLYMER COMPOSITES
    80.
    发明申请
    NANOFIBRIL-POLYMER COMPOSITES 审中-公开
    纳米比尔聚合物复合材料

    公开(公告)号:US20160152811A1

    公开(公告)日:2016-06-02

    申请号:US14905349

    申请日:2014-07-17

    Abstract: The present invention provides, among other things, compositions comprising nanofibrils, at least one maleic-anhydride (MA) copolymer and at least one matrix polymer, and methods of making such compositions. The provided methods and compositions allow for the production of composites with unexpectedly superior properties including improved impact resistance, tensile modulus of elasticity, tensile strength, and flexural modulus of elasticity as compared to previously known composites. In some embodiments, the present invention provides methods including the steps of providing cellulose nanofibrils, associating the cellulose nanofibrils with a maleic-anhydride (MA) copolymer to form a nanofibril-MA copolymer blend, preparing the nanofibril-MA copolymer blend for addition to a matrix polymer, and forming a composite by associating the nanofibril-MA copolymer blend with the matrix polymer, wherein the amount of cellulose nanofibrils in the composite is between 3% and 50% by weight of the composite.

    Abstract translation: 本发明尤其提供包含纳米原纤维,至少一种马来酸酐(MA)共聚物和至少一种基质聚合物的组合物以及制备这种组合物的方法。 所提供的方法和组合物允许与先前已知的复合材料相比,具有意想不到的优异性能的复合材料的生产,包括改进的抗冲击性,拉伸弹性模量,拉伸强度和挠曲弹性模量。 在一些实施方案中,本发明提供了包括以下步骤的方法:提供纤维素纳米原纤维,将纤维素纳米原纤维与马来酸酐(MA)共聚物缔合以形成纳米纤维MA共聚物共混物,制备纳米纤维MA共聚物共混物, 基质聚合物,并通过将纳米纤维-MA共聚物共混物与基质聚合物缔合而形成复合材料,其中复合材料中纤维素纳米原纤维的量为复合材料重量的3%至50%。

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