公开(公告)号：US20170191942A1

公开(公告)日：2017-07-06

申请号：US15313369

申请日：2015-05-22

Applicant: Case Western Reserve University

Inventor： Punkaj Ahuja ,  Maria A. Peshkova ,  Brian D. Hemphill ,  Miklós Gratzl

IPC: G01N21/78 ,  G01N33/49 ,  G01N21/80 ,  G01N33/84

CPC classification number: G01N21/78 ,  A61B5/1486 ,  C12Q1/54 ,  G01N21/80 ,  G01N33/492 ,  G01N33/4925 ,  G01N33/84 ,  G01N2021/775 ,  G01N2201/064

Abstract: One aspect of the present disclosure relates to an analyte sensor device. The analyte sensor device can include an optode layer that undergoes an optical change in the presence of an analyte. The analyte sensor device can also include a selectively-permeable membrane encapsulating the optode layer to form a stable membrane that that minimizes fouling of the analyte sensor device. The analyte sensor device can also include a plurality of microparticles that suppress a background physical interference on a detection of the optical change of the optode layer.

公开(公告)号：US09618455B2

公开(公告)日：2017-04-11

申请号：US14422886

申请日：2013-08-06

Applicant: Beri Cohen

Inventor： Beri Cohen

IPC: G01N21/76 ,  G01N33/53 ,  G01N21/25

CPC classification number: G01N21/76 ,  G01N21/253 ,  G01N33/5302 ,  G01N2201/0221 ,  G01N2201/064 ,  G01N2201/08 ,  G01N2201/0833 ,  G01N2201/084

Abstract: A clam-shell luminometer that, when closed, completely encloses an assay reaction mixture-containing reaction vessel and some portion of a reaction carousel or ring. The luminometer includes first and second portions that are coupled to each other, a photomultiplier tube, and plural fiber optic bundles that are optically coupled to the photomultiplier tube. First ends of the fiber optic bundles are disposed adjacent to the reaction vessel in the second portion so that the fiber optic bundles completely surround the perimeter or periphery of the reaction vessel.

公开(公告)号：US09372157B1

公开(公告)日：2016-06-21

申请号：US13174124

申请日：2011-06-30

Applicant: Paul W. Todd ,  Alan Jones ,  Nathan A. Thomas

Inventor： Paul W. Todd ,  Alan Jones ,  Nathan A. Thomas

IPC: G01N33/00 ,  G01N21/80 ,  G01N21/25 ,  G01N21/31

CPC classification number: G01N21/80 ,  G01N21/255 ,  G01N21/314 ,  G01N21/3151 ,  G01N2201/064 ,  G01N2201/0642

Abstract: A method for non-invasively determining a chemical property of an aqueous solution is provided. The method provides the steps of providing a colored solute having a light absorbance spectrum and transmitting light through the colored solute at two different wavelengths. The method further provides the steps of measuring light absorbance of the colored solute at the two different transmitted light wavelengths, and comparing the light absorbance of the colored solute at the two different wavelengths to determine a chemical property of an aqueous solution.

Abstract translation: 提供了非侵入性地确定水溶液的化学性质的方法。 该方法提供了提供具有吸光光谱并且以两种不同波长透过着色溶质透射光的着色溶质的步骤。 该方法还提供了测量两种不同透射光波长下的着色溶质的光吸收率的步骤，并比较了两种不同波长下的着色溶质的吸光度，以确定水溶液的化学性质。

公开(公告)号：US09234791B2

公开(公告)日：2016-01-12

申请号：US13983754

申请日：2012-01-25

Applicant: Makoto Ogusu

Inventor： Makoto Ogusu

IPC: H01J5/02 ,  G01J1/42 ,  B01L3/00 ,  G01N21/03 ,  G01N21/05 ,  G01N21/64 ,  B29D11/00

CPC classification number: G01J1/42 ,  B01L3/502707 ,  B01L2200/0689 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0877 ,  B01L2300/1827 ,  B29D11/00 ,  G01N21/0332 ,  G01N21/05 ,  G01N21/645 ,  G01N2021/0346 ,  G01N2201/064

Abstract: A light emission detection device having a flow path from which light to be detected is emitted is provided. The device includes a detection-side substrate having a joining surface and a detection surface provided opposite the joining surface, the joining surface having a depression and a light-shielding film provided over an area excluding the depression, the depression forming the flow path, the detection surface transmitting the light emitted from the flow path; and a wiring-side substrate having a joining surface and a conductive pattern provided with a varying thickness on the joining surface, the joining surface of the wiring-side substrate joining the joining surface of the detection-side substrate. In the area over which the light-shielding film is provided, adhesive is provided with a thickness corresponding to the varying thickness of the conductive pattern and the detection-side substrate and the wiring-side substrate are closely joined to each other with the adhesive.

Abstract translation: 提供一种发光检测装置，其具有从其被发射的光的流路。 该装置包括检测侧基板，其具有接合面和与接合面相对设置的检测面，所述接合面具有设置在不包括凹部的区域上的凹部和遮光膜，形成流路的凹部， 检测表面透射从所述流路发射的光; 以及布线侧基板，其具有接合面和在接合面上具有变化厚度的导电图案，所述布线侧基板的接合面与检测侧基板的接合面接合。 在设置有遮光膜的区域中，粘合剂具有与导电图案的变化厚度对应的厚度，并且检测侧基板和布线侧基板用粘合剂彼此紧密接合。

公开(公告)号：US09179848B2

公开(公告)日：2015-11-10

申请号：US14304106

申请日：2014-06-13

Applicant: SEIKO EPSON CORPORATION

Inventor： Hideto Yamashita ,  Yoshitaka Iijima

IPC: G01N21/55 ,  A61B5/024 ,  A61B5/1455 ,  A61B5/00 ,  G01N21/47 ,  G01N21/49

CPC classification number: A61B5/0059 ,  A61B5/02055 ,  A61B5/02427 ,  A61B5/02438 ,  A61B5/02444 ,  A61B5/14552 ,  A61B5/681 ,  A61B5/7278 ,  A61B2562/0219 ,  A61B2562/0238 ,  G01N21/474 ,  G01N21/49 ,  G01N2201/064

Abstract: A biological information detector includes a light-emitting part, a reflecting part, a light-receiving part, a protecting part, and a processing part. The reflecting part has a curve shaped reflecting surface that is configured to reflect light emitted by the light-emitting part. The light-receiving part is configured to receive incident light that is emitted by the light-emitting part and reflected at a detection site of a user. The protecting part is configured to protect the light-emitting part, and the protecting part haw a contact surface adapted to contact with the detection site. The processing part is configured to process a light-receiving signal outputted from the light-receiving part. The light-emitting part has a light-emitting surface substantially in parallel to the contact surface, and a distance between the light-emitting surface and the contact surface is within a range of 0.4 mm to 0.9 mm.

Abstract translation: 生物信息检测器包括发光部，反射部，受光部，保护部和处理部。 反射部具有弯曲形状的反射面，被配置为反射由发光部发射的光。 光接收部被配置为接收由发光部发射并在用户的检测部位反射的入射光。 保护部被配置为保护发光部，保护部具有与检测部位接触的接触面。 处理部被配置为处理从光接收部输出的光接收信号。 发光部具有与接触面大致平行的发光面，发光面与接触面的距离在0.4mm〜0.9mm的范围内。

公开(公告)号：US20150293015A1

公开(公告)日：2015-10-15

申请号：US14670958

申请日：2015-03-27

Applicant: Fondarex S.A.

Inventor： Konrad Baumgartner ,  Yves Gerard Laurent Huguenin-Vuillemin

IPC: G01N21/3554 ,  G01N21/3504 ,  G01N21/359

CPC classification number: G01N21/3554 ,  B22C9/067 ,  B22D17/145 ,  B22D17/2007 ,  B22D17/32 ,  B29C45/34 ,  B29C45/76 ,  B29C2945/7614 ,  B29C2945/76254 ,  G01N21/15 ,  G01N21/3504 ,  G01N21/359 ,  G01N21/85 ,  G01N2021/151 ,  G01N2021/354 ,  G01N2021/8416 ,  G01N2021/8578 ,  G01N2201/024 ,  G01N2201/062 ,  G01N2201/0622 ,  G01N2201/0626 ,  G01N2201/064

Abstract: The invention relates to a device (1) and a method for measuring the moisture in die cast molds (24), the cavity (25) of which is connected via an evacuation conduit (31) to an evacuation device (28). The modular assembly of the device (1) is connectable to the evacuation conduit (31) and comprises a sensor assembly (S) by means of which the moisture of gases evacuated from the mold cavity (25) is measurable. The sensor assembly (S) comprises an emitter (7) emitting electromagnetic radiation and a detector (14) detecting electromagnetic radiation. On the basis of the measured values obtained during the evacuation action it can be determined whether the amount of a water/release agent mixture jetted into the mold cavity (25) needs to be altered before the actual casting action.

Abstract translation: 本发明涉及一种用于测量压铸模具（24）中的水分的装置（1），其空腔（25）经由抽空导管（31）连接到排气装置（28）。 装置（1）的模块化组件可连接到排气管道（31）并且包括传感器组件（S），通过该传感器组件，从模腔（25）排出的气体的湿气是可测量的。 传感器组件（S）包括发射电磁辐射的发射器（7）和检测电磁辐射的检测器（14）。 基于抽空动作期间获得的测量值，可以确定喷射到模腔（25）内的水/脱模剂混合物的量是否在实际铸造作用之前被改变。

公开(公告)号：US20140049836A1

公开(公告)日：2014-02-20

申请号：US13964802

申请日：2013-08-12

Applicant: Hach Company

Inventor： Perry A. Palumbo

IPC: G02B13/18

CPC classification number: G02B19/0076 ,  G01N15/06 ,  G01N21/01 ,  G01N21/53 ,  G01N33/18 ,  G01N2015/0693 ,  G01N2201/064 ,  G02B3/04 ,  G02B5/001 ,  G02B13/18 ,  G02B19/0028 ,  G02B19/008 ,  G02B26/0808 ,  G02B2003/0093 ,  Y10T29/49826

Abstract: One embodiment provides an annular optical device (100), comprising: an annular meso-optic (1) including an annulus (11) centered about an axis of revolution (A); and a secondary optical structure (2) substantially coaxial within the annulus (11) of the annular meso-optic (1), wherein the secondary optical structure (2) and the annular meso-optic (1) are separated by a media (12) comprising a media refractive index that is lower than a secondary optical structure refractive index, with the secondary optical structure (2) being configured to hold a specimen to be radiated by impinging electromagnetic radiation directed into the secondary optical structure (2) substantially along the axis of revolution (A), wherein re-directed radiation from the specimen is allowed into the annular meso-optic (1) by the secondary optical structure (2) if an angle of incidence of the re-directed radiation exceeds the angle of Total Internal Reflectance. Other embodiments are described and claimed.

Abstract translation: 一个实施例提供了一种环形光学装置（100），包括：环形介质光学元件（1），其包括以旋转轴线（A）为中心的环形部分（11）; 以及在所述环形中视光学器件（1）的所述环形空间（11）内基本上同轴的次级光学结构（2），其中所述次级光学结构（2）和所述环形中视镜（1）由介质（12） ）包括低于二次光学结构折射率的介质折射率，其中所述次级光学结构（2）构造成通过基本上沿着所述第二光学结构（2）的入射入射到所述次级光学结构（2）中的电磁辐射来保持要辐射的样本 旋转轴（A），其中如果重新引导的辐射的入射角超过总和的角度，则来自试样的重新定向的辐射被第二光学结构（2）允许进入环形介质光学器件（1） 内部反射。 描述和要求保护其他实施例。

公开(公告)号：US20130286399A1

公开(公告)日：2013-10-31

申请号：US13456467

申请日：2012-04-26

Applicant: Robert Freese ,  Christopher Michael Jones ,  David Perkins ,  Michael Simcock ,  William Soltmann

Inventor： Robert Freese ,  Christopher Michael Jones ,  David Perkins ,  Michael Simcock ,  William Soltmann

IPC: G01N21/59 ,  G06E3/00

CPC classification number: G01N21/59 ,  G01N21/31 ,  G01N21/85 ,  G01N2201/064 ,  G06E3/00 ,  G06E3/001

Abstract: Optical computing devices are disclosed. One optical computing device includes an electromagnetic radiation source that emits electromagnetic radiation into an optical train to optically interact with a sample and at least one integrated computational element, the sample being configured to generate optically interacted radiation. A sampling window is arranged adjacent the sample and configured to allow transmission of the electromagnetic radiation therethrough and has one or more surfaces that generate one or more stray signals. A first focal lens is arranged to receive the optically interacted radiation and the one or more stray signals and generate a primary focal point from the optically interacted radiation. A structural element defines a spatial aperture aligned with the primary focal point such that the optically interacted radiation is able to pass therethrough while transmission of the one or more stray signals is substantially blocked by the structural element.

公开(公告)号：US20130004967A1

公开(公告)日：2013-01-03

申请号：US13510191

申请日：2010-11-22

Applicant: Kurt J. Halverson ,  Raymond J. Kenney ,  Olester Benson, JR. ,  Raymond P. Johnston ,  Guoping Mao ,  Patrick R. Fleming ,  George Van Dyke Tiers ,  Naiyong Jing

Inventor： Kurt J. Halverson ,  Raymond J. Kenney ,  Olester Benson, JR. ,  Raymond P. Johnston ,  Guoping Mao ,  Patrick R. Fleming ,  George Van Dyke Tiers ,  Naiyong Jing

IPC: G01N21/75 ,  C08L33/08 ,  C08L33/02 ,  C08L63/00 ,  C08L33/14 ,  G02B1/12 ,  C08L75/04 ,  B01L3/00 ,  G01N21/64 ,  C12M1/40 ,  C07C50/18 ,  C08K5/18 ,  C08L57/00

CPC classification number: G01N21/75 ,  B01L3/50853 ,  B01L2200/0689 ,  B01L2200/12 ,  B01L2300/044 ,  B01L2300/0654 ,  B01L2300/0819 ,  B01L2300/0822 ,  B01L2300/0851 ,  B01L2300/0887 ,  B29C35/0888 ,  B29C59/046 ,  B29C59/08 ,  B29C59/10 ,  B29C59/14 ,  B29C59/16 ,  B29C2035/0827 ,  B29C2059/023 ,  G01N21/03 ,  G01N21/253 ,  G01N21/31 ,  G01N21/55 ,  G01N21/6428 ,  G01N21/6452 ,  G01N2021/0346 ,  G01N2201/0446 ,  G01N2201/064 ,  G01N2201/08

Abstract: The disclosure provides microstructured articles and methods useful for detecting an analyte in a sample. The articles include microwell arrays. The articles can be used with an optical system component in methods to detect or characterize an analyte

Abstract translation: 本公开提供了用于检测样品中的分析物的微结构化制品和方法。 文章包括微孔阵列。 在用于检测或表征分析物的方法中，物品可以与光学系统组件一起使用

公开(公告)号：US08289511B2

公开(公告)日：2012-10-16

申请号：US13336013

申请日：2011-12-23

Applicant: Anthony C. Gilby

Inventor： Anthony C. Gilby

IPC: G01N1/10 ,  G01N21/01

CPC classification number: G01N21/552 ,  G01N21/0303 ,  G01N21/05 ,  G01N30/74 ,  G01N2021/0346 ,  G01N2021/052 ,  G01N2201/064

Abstract: The present invention is directed to the use of a light absorbing wall material to eliminate stray light paths in light-guiding structures, such as those used for HPLC absorbance detection. More specifically, the present invention relates to the use of carbon-doped Teflon® AF, or “black Teflon® AF,” for all or part of the walls of a light-guiding flowcell adapted for use in HPLC absorbance detection.

Abstract translation: 本发明涉及使用光吸收壁材料来消除导光结构中的杂散光路径，例如用于HPLC吸光度检测的那些。 更具体地，本发明涉及适用于HPLC吸光度检测的导光流动池的全部或部分壁的碳掺杂Teflon AF或黑色Teflon AF的用途。