公开(公告)号：US20030002039A1

公开(公告)日：2003-01-02

申请号：US09958688

申请日：2001-10-12

Inventor： Michael Homer

IPC: G01J003/44

CPC classification number: G01D5/38 ,  G01D5/34715

Abstract: A scale (10) is illuminated by a light source (18). After interaction with an index grating (12), fringes (F) are formed in a Talbot plane and analyzed by an analyzer grating (14). Th decrease the sensitivity to changes in the ride height of the index grating above the scale, the light source is restricted to a small but finite size, and positioned so that it subtends a small angle null at the analyzer grating (or, if a collimating lens (24) is used, positioned so that it subtends a small angle null at the lens). The size of the light source should preferably be smaller than a predetermined value such that the extent of a geometric fringe visibility envelope exceeds the extent of a Talbot fringe visibility envelope.

Abstract translation: 标尺（10）由光源（18）照亮。 在与索引光栅（12）相互作用之后，边缘（F）形成在Talbot平面中并由分析器光栅（14）分析。 降低对标尺上方的索引光栅的行驶高度的变化的敏感度，光源被限制在小但有限的尺寸，并且被定位成使得它在分析器光栅处对准一个小角度Ø（或者如果准直 使用透镜（24），定位成使其在透镜处对角一个小角度Ø）。 光源的尺寸应优选地小于预定值，使得几何条纹可见度包络的范围超过Talbot边缘可见度包络的程度。

公开(公告)号：US20020159055A1

公开(公告)日：2002-10-31

申请号：US09936305

申请日：2001-09-12

Inventor： Robert Bennett ,  Brian J E Smith

IPC: G01J003/44 ,  G01N021/65 ,  G01N021/91

CPC classification number: G02B6/29364 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/0291

Abstract: A spectroscopic probe includes a monolithic block (10) of transparent material and GRIN lenses (20,22,24). Light for illuminating a sample is delivered by an optical fiber (31), and light scattered by the sample is output by an optical fiber (33). The block (10) has opposing angled faces (12A, 12B), coated with a dichroic filter coating and a reflective coating respectively. A method for making blocks (10) is also disclosed in which the coatings are first provided on a large sheet, and blocks (10) are then cut from the sheet using angled cuts. Since the coated block reduces the number of components required, the probe can be miniaturized, e.g. for use in an endoscope.

Abstract translation: 光谱探针包括透明材料的整体块（10）和GRIN透镜（20,22,24）。 用于照射样品的光由光纤（31）传送，由样品散射的光由光纤（33）输出。 块（10）具有分别涂覆有二向色过滤器涂层和反射涂层的相对的倾斜面（12A，12B）。 还公开了制造块（10）的方法，其中首先将涂层设置在大片材上，然后使用角度切割从片材上切割块（10）。 由于涂覆的块减少了所需的组分数量，所以可以使探针小型化，例如， 用于内窥镜。

公开(公告)号：US20020093651A1

公开(公告)日：2002-07-18

申请号：US09985649

申请日：2001-11-05

Inventor： Jeffrey N. Roe

IPC: G01J003/44

CPC classification number: G01N21/658 ,  G01N21/35 ,  G01N33/49 ,  G01N33/54366

Abstract: Surface-enhanced spectroscopy for quantitative analysis of analytes in biological liquid samples. A device for testing a biological liquid sample for the presence or concentration of an analyte includes: (a) a substrate defining a surface which has electrically conductive particles disposed thereon, wherein the surface is adapted to accommodate the liquid sample; (b) means for generating radiation and directing the radiation to be incident on said surface of the substrate so that radiation is emitted from the electrically conductive particles; and (c) means for detecting the emitted radiation. In another embodiment a matrix having electrically conductive particles that are incorporated in the matrix or that are disposed on a surface thereof, wherein the matrix is permeable to the liquid biological sample is used in place of the substrate. The device is particularly suited for determining glucose in human whole blood.

Abstract translation: 用于定量分析生物液体样品中分析物的表面增强光谱。 用于测试生物液体样品以用于分析物的存在或浓度的装置包括：（a）限定其上设置有导电颗粒的表面的基底，其中所述表面适于容纳液体样品; （b）用于产生辐射并引导入射在所述衬底的所述表面上以使辐射从所述导电颗粒发射的装置; 和（c）用于检测所发射的辐射的装置。 在另一个实施方案中，使用具有引入到基质中或设置在其表面上的导电颗粒的基质，其中基质对液体生物样品是可渗透的，代替基底。 该装置特别适用于测定人全血中的葡萄糖。

公开(公告)号：US20020067479A1

公开(公告)日：2002-06-06

申请号：US09974837

申请日：2001-10-12

Inventor： Pentti Niemela ,  Janne Suhonen ,  Juha Sumen

IPC: G01J003/44

CPC classification number: G01N21/65 ,  G01J3/0256 ,  G01J3/44

Abstract: The invention relates to an optical measuring head for measuring a Raman spectrum and to a method of manufacturing an optical measuring head. The measuring head comprises a first optical fiber means for guiding radiation causing a Raman excitation to an object being measured, a second optical fiber means for guiding the optical radiation from the object being measured for measuring, and a high-pass filter that is made of a semi-conducting material for filtering the optical radiation causing a Raman excitation from the radiation received from the object being measured before the radiation propagates to the second optical fiber means. A desired cut-on wavelength is adjusted for the high-pass filter by changing the thickness or impurity content of the high-pass filter.

Abstract translation: 本发明涉及一种用于测量拉曼光谱的光学测量头和一种制造光学测量头的方法。 测量头包括用于引导对被测物体进行拉曼激发的辐射的第一光纤装置，用于引导被测量物体的光辐射用于测量的第二光纤装置，以及用于测量的高通滤波器， 半导体材料，用于过滤在辐射传播到第二光纤装置之前从被测量物体接收的辐射引起拉曼激发的光辐射。 通过改变高通滤波器的厚度或杂质含量来调节高通滤波器的期望的截止波长。