公开(公告)号：US20040263842A1

公开(公告)日：2004-12-30

申请号：US10480479

申请日：2004-08-17

Inventor： Gerwin Jan Puppels

IPC: G01J003/44

CPC classification number: G02B6/262 ,  G01N21/65 ,  G01N2021/656 ,  G01N2201/0846 ,  G02B2006/0325

Abstract: The spectrum of light, inelastically scattered by a sample (16) is measured. The light is guided through a capillary (12) from and to the sample, at least in one of these directions, through the channel no inelastic scattering of light occurs which can form an interfering background when measuring on the sample. By guiding the light through the channel, inelastic scattering of this light is prevented and it becomes possible to guide scattered light back through the channel to spectral analysis equipment (14) without problems with inelastic scattering during the guidance of the light. Preferably, the light is guided through the channel of the capillary in both directions.

Abstract translation: 测量由样品（16）非弹性散射的光谱。 通过通道，至少在这些方向中至少一个方向上，光从毛细管（12）引导到样品，不会发生光的非弹性散射，这可以在对样品进行测量时形成干扰背景。 通过引导光通过通道，防止该光的非弹性散射，并且可以在散射光的引导期间将散射光引导通过通道返回到光谱分析设备（14）而不存在非弹性散射的问题。 优选地，光在两个方向上被引导通过毛细管的通道。

公开(公告)号：US20040218176A1

公开(公告)日：2004-11-04

申请号：US10837475

申请日：2004-04-30

Applicant: Baker Hughes Incorporated

Inventor： Michael Shammal ,  Robert Gordon ,  Rocco DiFoggio

IPC: G01J003/44

CPC classification number: G01V8/02 ,  E21B49/081 ,  G01N1/14 ,  G01N21/31 ,  G01N21/65 ,  G01N33/2823 ,  G01N2021/651

Abstract: The present invention provides a sample tank having a window for introduction of electromagnetic energy into the sample tank for analyzing a formation fluid sample down hole or at the surface without disturbing the sample. Near infrared, mid infrared and visible light analysis is performed on the sample to provide a downhole in situ or surface on site analysis of sample properties and contamination level. The onsite analysis comprises determination of gas oil ratio, API gravity and various other parameters which can be estimated by a trained neural network or chemometric equation. A flexural mechanical resonator is also provided to measure fluid density and viscosity from which additional parameters can be estimated by a trained neural network or chemometric equation. The sample tank is pressurized to obviate adverse pressure drop or other effects of diverting a small sample.

Abstract translation: 本发明提供了一种具有用于将电磁能引入到样品罐中用于分析地层流体样品井下或在表面而不干扰样品的窗口的样品槽。 对样品进行近红外，中红外和可见光分析，以便对样品性质和污染水平的现场分析或现场分析提供井下。 现场分析包括确定瓦斯油比率，API重力和可以通过训练有素的神经网络或化学计量学方程估算的各种其他参数。 还提供弯曲机械谐振器以测量流体密度和粘度，通过训练的神经网络或化学计量方程可以从其中估算附加参数。 样品罐被加压以消除不利的压降或转移小样品的其他影响。

公开(公告)号：US20040004194A1

公开(公告)日：2004-01-08

申请号：US10441027

申请日：2003-05-20

Inventor： Francois Amblard ,  Xavier Sastre-Garau ,  Sylvie Robine

IPC: G01J003/44 ,  G01N021/64

CPC classification number: G01N21/6486 ,  G01N21/6458 ,  G02B21/0024 ,  G02B21/0076 ,  G02B21/0084

Abstract: An installation is provided for multi-dimensional non-linear imaging of a material comprising intrinsic chromophores, using laser scanning. This installation comprises i) at least one source (115) of time stamp pulses of synchronized photons, ii) means (12-14) for locally focusing the pulses on a material to cause its intrinsic chromophores to absorb groups of at least two synchronized photons to produce response photons, iii) means (22, 40, 53) for directing the response photons to at leat one collecting zone, iv) means (30-34) for collecting the response photons in the collecting zone(s) whatever their energy, v) processing means for converting the collected photons into data at least representative of their number and storing them in correspondence with at least the time stamp pulses that cause the material to produce the response photons, vi) means for scanning (11, 20) the pulses through a chosen area of the material, and vii) means for delivering from said data stored an image representative of said material chosen area, with a sub-millimeter resolution, and in function of the respective time stamp pulses of data.

Abstract translation: 提供了一种用于使用激光扫描对包括内在发色团的材料进行多维非线性成像的装置。 该装置包括i）同步光子的时间戳脉冲的至少一个源（115），ii）用于将材料上的脉冲局部聚焦以使其内在发色团吸收至少两个同步光子的组的装置（12-14） 以产生响应光子，iii）用于将响应光子引导到一个收集区的装置（22,40,53），iv）用于收集收集区中的响应光子的装置（30-34），无论其能量如何 v）处理装置，用于将所收集的光子转换成至少代表其数量的数据，并且至少存储它们与至少引起材料产生响应光子的时间戳脉冲相对应; vi）扫描装置（11,20） 脉冲通过材料的选定区域，以及vii）用于从所述数据传送的装置，用于存储表示所述材料选择区域的图像，具有亚毫米分辨率，并且具有数据的相应时间戳脉冲的功能。

公开(公告)号：US20030231304A1

公开(公告)日：2003-12-18

申请号：US10171357

申请日：2002-06-12

Inventor： Selena Chan ,  Andrew A. Berlin ,  Mineo Yamakawa

IPC: G01J003/44

CPC classification number: C12Q1/6825 ,  G01J3/44 ,  G01N21/658 ,  G01N2021/653 ,  C12Q2565/632 ,  C12Q2563/155

Abstract: The methods and apparatus 300 disclosed herein concern Raman spectroscopy using metal coated nanocrystalline porous silicon substrates 240, 340. In certain embodiments of the invention, porous silicon substrates 110, 210 may be formed by anodic etching in dilute hydrofluoric acid 150. A thin coating of a Raman active metal, such as gold or silver, may be coated onto the porous silicon 110, 210 by cathodic electromigration or any known technique. The metal-coated substrate 240, 340 provides an extensive, metal rich environment for SERS, SERRS, hyper-Raman and/or CARS Raman spectroscopy. In certain embodiments of the invention, metal nanoparticles may be added to the metal-coated substrate 240, 340 to further enhance the Raman signals. Raman spectroscopy may be used to detect, identify and/or quantify a wide variety of analytes, using the disclosed methods and apparatus 300.

Abstract translation: 本文公开的方法和装置300涉及使用金属涂覆的纳米晶多孔硅衬底240,340的拉曼光谱。在本发明的某些实施例中，多孔硅衬底110,210可以通过在稀氢氟酸150中的阳极蚀刻形成。薄涂层 诸如金或银的拉曼活性金属可以通过阴极电迁移或任何已知技术涂覆到多孔硅110,210上。 金属涂覆的基底240,340为SERS，SERRS，超拉曼和/或CARS拉曼光谱提供了广泛的金属富集环境。 在本发明的某些实施方案中，可以将金属纳米颗粒加入到金属涂覆的基底240,340中以进一步增强拉曼信号。 使用所公开的方法和装置300，可以使用拉曼光谱来检测，鉴定和/或定量各种各样的分析物。

公开(公告)号：US20030142304A1

公开(公告)日：2003-07-31

申请号：US10350525

申请日：2003-01-24

Inventor： Joseph B. Slater

IPC: G01J003/44 ,  G01N021/65

CPC classification number: G01N21/8507 ,  G01N2021/656

Abstract: In an optical measurement probe of the type which incorporates a window configuration suited to on-line process control and other applications this invention provides an improved technique for bonding such a window to probe body or process vessel. In general terms, the improvement arises through the use of a compression ring around the bonding area to maintain a consistent seal. In terms of apparatus, a hollow probe body terminates in a distal end having a flanged portion with an inner and outer wall that extends back into the body. The outer wall of the window is sealed against the inner wall of the flanged portion, with compression material urged against the outer wall of the flanged portion to pressurize the seal between the window and the inner wall of the flanged portion. In the preferred embodiment, the compression material is ring-shaped and exhibits substantially the same thermal expansion coefficient as the window. In the case where a sapphire window is used, titanium or Invar may be used for the compression material. The window may be generally cylindrical though, in the preferred embodiments, cork-shaped or spherical window are used.

Abstract translation: 在包括适合于在线过程控制和其它应用的窗口配置的类型的光学测量探针中，本发明提供了一种用于将这样的窗口结合到探针体或处理容器的改进技术。 一般来说，通过在粘合区域周围使用压缩环来保持一致的密封，产生了改进。 在设备方面，空心探针体终止于远端，其具有凸缘部分，其内壁和外壁延伸回身体。 窗口的外壁被密封在法兰部分的内壁上，压缩材料被压靠在凸缘部分的外壁上，以加压窗口与法兰部分的内壁之间的密封。 在优选实施例中，压缩材料是环形的并且表现出与窗口基本上相同的热膨胀系数。 在使用蓝宝石窗的情况下，可以使用钛或殷钢作为压缩材料。 在优选实施例中，窗口可以是大致圆柱形的，但是使用软木形或球形窗。

公开(公告)号：US20030073139A1

公开(公告)日：2003-04-17

申请号：US10245922

申请日：2002-09-18

Inventor： David I. Kreimer ,  Oleg A. Yevin

IPC: G01N033/53 ,  G01N033/542 ,  C12M001/34 ,  G01J003/44

CPC classification number: G01N21/553 ,  G01N21/554 ,  G01N21/658

Abstract: Embodiments of devices and methods are provided that permit validation of analyte detection using both surface enhanced Raman spectroscopy (SERS) and surface plasmon resonance (SPR). In specific embodiments, a substrate having a surface suitable for SPR is provided, along with a source of electromagnetic radiation to interact with the surface and thereby elicit surface plasmon resonance characteristic of the analyte under study. In some embodiments, surface enhancing structures are also provided on the substrate, and analytes under study are associated with enhancing structures. Another source of electromagnetic radiation is directed at the analyte on the enhancing structures to produce surface enhanced Raman scattering. In certain embodiments, data obtained by these two methods are compared, thereby providing an internally consistent and self-validating method for analyte detection.

Abstract translation: 提供了使用表面增强拉曼光谱（SERS）和表面等离子体共振（SPR）两者来验证分析物检测的装置和方法的实施例。 在具体实施方案中，提供具有适于SPR的表面的基底，以及电磁辐射源与表面相互作用，从而引起研究中的分析物的表面等离子体共振特征。 在一些实施方案中，还在基底上提供表面增强结构，并且研究中的分析物与增强结构相关联。 电磁辐射的另一个来源是针对增强结构上的分析物，以产生表面增强的拉曼散射。 在某些实施方案中，比较通过这两种方法获得的数据，从而提供用于分析物检测的内部一致和自验证方法。

公开(公告)号：US20030016350A1

公开(公告)日：2003-01-23

申请号：US10173139

申请日：2002-06-17

Applicant: CITY UNIVERSITY OF HONG KONG

Inventor： Yuk Sun Andrew Cheng ,  Yongkang Guo ,  Jianhua Zhu

IPC: G01J003/44

CPC classification number: G01S17/95 ,  Y02A90/19

Abstract: A micropulse lidar system is described that comprises, a laser light source for emitting a pulsed laser beam, beam shaping means for shaping the intensity distribution of said beam such that said beam has a substantially annular intensity distribution in cross-section, a Schmidt-Cassegrain telescope for transmitting the annular beam to an atmospheric target and for collecting backscattered light returned from said target, and means for detecting and analyzing said backscattered light. The system has higher efficiency and better signal-to-noise ration than a corresponding system without the beam shaping means. There is also a disclosed a method for optimising the design of the beam shaping means.

Abstract translation: 描述了一种微脉冲激光雷达系统，其包括用于发射脉冲激光束的激光源，用于对所述光束的强度分布进行成形的光束整形装置，使得所述光束在横截面中具有基本环形的强度分布，施密特 - 卡塞格林 用于将环形光束传送到大气目标并用于收集从所述目标物返回的反向散射光的望远镜，以及用于检测和分析所述反向散射光的装置。 该系统比没有光束整形装置的相应系统具有更高的效率和更好的信噪比。 还公开了一种用于优化光束整形装置的设计的方法。

公开(公告)号：US20020196436A1

公开(公告)日：2002-12-26

申请号：US09887826

申请日：2001-06-22

Applicant: LUCENT TECHNOLOGIES INC.

Inventor： Joseph A. Abys ,  Michael L. Ammerman ,  Alan Blair ,  E. J. Kudrak ,  Chen Xu

IPC: G01J003/44

CPC classification number: G01N21/65 ,  G01J3/44

Abstract: In accordance with the invention, the quality of hard gold is determined by Raman vibrational spectroscopy. A sample of the hard gold is provided, a monochromatic light beam is directed onto the sample, and the frequency and intensity of the light scattered by the sample is analyzed for the vibrational frequencies of polymer molecules. Scattering frequencies offset from the initial beam frequency by about 2132 cmnull1 and about 2182 cmnull1, for example, are indicative of high quality nickel-hardened gold.

Abstract translation: 根据本发明，硬金的质量由拉曼振动光谱法确定。 提供硬金的样品，将单色光束引导到样品上，并分析由样品散射的光的频率和强度以获得聚合物分子的振动频率。 例如，偏离初始光束频率约2132cm -1和约2182cm -1的散射频率表示高质量的镍硬化金。

公开(公告)号：US20020142480A1

公开(公告)日：2002-10-03

申请号：US10056808

申请日：2002-01-25

Applicant: SURROMED, INC.

Inventor： Michael J. Natan

IPC: G01N021/62 ,  G01J003/44

CPC classification number: G01N21/658 ,  G01J3/44 ,  Y10T436/10 ,  Y10T436/13

Abstract: Surface-enhanced Raman spectroscopy (SERS) uses nanoscale metal particles (SERS-active particles) or surface roughness to enhance the Raman signal of Raman-active analytes contacting the surface. SERS sandwich particles contain SERS-active particles sandwiching a Raman-active substance and serve as optical tags. Preferably, the particles are rod-shaped, with each layer (SERS-active and Raman-active) formed as a distinct stripe of the particle. These freestanding particles can be derivatized with surface ligands capable of associating with analytes of interest in, for example, a biological sample. The acquired Raman spectrum of the particle encodes the identity of the ligand. Because of the simplicity and intensity of Raman spectra, highly multiplexed assays are capable using SERS particles with different Raman-active species.

Abstract translation: 表面增强拉曼光谱（SERS）使用纳米级金属颗粒（SERS-活性颗粒）或表面粗糙度来增强与表面接触的拉曼活性分析物的拉曼信号。 SERS夹心颗粒含有夹带拉曼活性物质的SERS活性颗粒并用作光学标签。 优选地，颗粒是棒状的，每个层（SERS-活性和拉曼活性）形成为颗粒的不同条纹。 这些独立颗粒可以用能够与例如生物样品中的感兴趣的分析物结合的表面配体进行衍生化。 所获得的该粒子的拉曼光谱编码配体的同一性。 由于拉曼光谱的简单性和强度，高度多重测定能够使用具有不同拉曼活性物质的SERS颗粒。

公开(公告)号：US20020123050A1

公开(公告)日：2002-09-05

申请号：US09876298

申请日：2001-06-07

Inventor： Vladimir Poponin

IPC: C12Q001/68 ,  C12M001/34 ,  G01J003/44

CPC classification number: C12Q1/6825 ,  C12Q2565/632

Abstract: The invention generally relates to a new gene probe biosensor employing near field surface enhanced Raman scattering (NFSERS) for direct spectroscopic detection of hybridized molecules (such as hybridized DNA) without the need for labels, and the invention also relates to methods for using the biosensor.

Abstract translation: 本发明一般涉及使用近场表面增强拉曼散射（NFSERS）的新型基因探针生物传感器，用于直接光谱检测杂交分子（如杂交DNA）而不需要标记，本发明还涉及使用生物传感器的方法 。