Steroid nitrite ester and process therefor
    85.
    发明授权
    Steroid nitrite ester and process therefor 失效
    类固醇亚硝酸酯及其制备方法

    公开(公告)号:US3218340A

    公开(公告)日:1965-11-16

    申请号:US20554262

    申请日:1962-06-27

    Applicant: ABBOTT LAB

    Inventor: TADANIER JOHN S

    CPC classification number: C07J53/00 C07J41/00 C07J75/00

    Abstract: The invention comprises the nitrite ester of 6b - hydroxy - 3a ,5a - cycloandrostan - 17 - one and the preparation thereof by treating a 6-R-3a ,5a -cycloandsrostan-17-one (wherein R is a - or b -NH2 or b -OH) or 3b -amino-androst-5-en-17-one with a nitrite salt, e.g. sodium nitrite, and aqueous acetic acid at 0 DEG to 20 DEG C., or by esterifying the 6b -hydroxy compound with nitrous chloride in pyridine. Examples are given.

    Abstract translation: 本发明包括6b-羟基-3a,5a-环戊二酮-17-酮的亚硝酸酯,其制备方法是通过处理6-R-3a,5a-环烷基甾烷酮-17-酮(其中R是α-或b-NH 2 或b-OH)或具有亚硝酸盐的3b-氨基 - 雄甾-5-烯-17-酮,例如 亚硝酸钠和乙酸水溶液,或通过吡啶中的一氯化碳将6b-羟基化合物酯化。 给出了例子。

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