公开(公告)号：US11946066B2

公开(公告)日：2024-04-02

申请号：US17935024

申请日：2022-09-23

Applicant: California Institute of Technology

Inventor： Xiaojing Gao ,  Lucy S. Chong ,  Michael B. Elowitz ,  Matthew S-M Kim

IPC: C12N15/86 ,  C07K14/005 ,  C07K14/81 ,  C07K16/18 ,  C12N7/00 ,  C12N9/50 ,  C12N15/62

CPC classification number: C12N15/86 ,  C07K14/005 ,  C07K16/18 ,  C12N7/00 ,  C12N9/506 ,  C12N15/62 ,  C12Y304/21098 ,  C07K2317/569 ,  C07K2317/622 ,  C07K2319/30 ,  C07K2319/50 ,  C12N2740/11045 ,  C12N2760/20143 ,  C12N2810/6054 ,  C12N2820/002 ,  C12N2820/007

Abstract: Disclosed herein include methods, compositions, and systems suitable for use in delivering a polynucleotide to a target cell of a subject in need thereof. In some embodiments, a viral vector comprises a polynucleotide encoding nucleoprotein (N), phosphoprotein (P), matrix protein (M), RNA-dependent RNA polymerase (L), and one or more transgenes. The viral vector can comprise one or more of a conditionally stable fusion protein, a protease fusion protein, a degron fusion protein, and/or a glycoprotein derived of another species than the viral vector polynucleotide to enable control of viral vector transduction and/or replication.

公开(公告)号：US20240103510A1

公开(公告)日：2024-03-28

申请号：US18271986

申请日：2022-01-13

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  CHEVRON U.S.A. Inc.

Inventor： Virisha Timmaraju ,  Eric Junkins ,  Valentinos Constantinou ,  Asitang Mishra ,  Sakthivel Kandasamy

IPC: G05B23/02

CPC classification number: G05B23/027 ,  G05B23/0275

Abstract: Relationships between alarms are modeled using a graph to identify root cause of a sequence of alarms (an alarm flood). The nodes of the graph represent different alarms, and the edges between the nodes are scored using pairwise analysis of when the alarms occurred. The graph is divided into multiple subgraphs representing alarm clusters. Root cause analysis of the sequence of alarms is performed by generating and simplifying directed graphs for events within the alarm clusters.

公开(公告)号：US20240092509A1

公开(公告)日：2024-03-21

申请号：US18468611

申请日：2023-09-15

Applicant: California Institute of Technology

Inventor： Jonathan Sauder ,  Nacer E. Chahat ,  Juan M. Mejia-Ariza

IPC: B64G4/00 ,  B64G3/00

CPC classification number: B64G4/00 ,  B64G3/00

Abstract: A device can be configured as an under-constrained deployable system. Such a system can use under-constrained deployable couplers. A device may include a second segment coupled to the first segment by a high strain structure, wherein the high strain structure is bent to store deployment energy in a stowed configuration. Releasing the stored deployment energy can allow an under-constrained deployable system to transition to an expanded configuration. A tensioning system can transition an under-constrained deployable system to a deployed configuration.

公开(公告)号：US20240091762A1

公开(公告)日：2024-03-21

申请号：US18466726

申请日：2023-09-13

Applicant: California Institute of Technology

Inventor： Samuel J. Schulte ,  Jining Huang ,  Nikhil T. Linaval ,  Niles A. Pierce

IPC: B01L3/00

CPC classification number: B01L3/5023 ,  B01L2300/069 ,  B01L2300/0825

Abstract: The present disclosure relates to an HCR lateral flow device for amplified detection of a target in a sample and methods of using the same. In some embodiments, the device and methods of use combine the sensitivity of HCR signal amplification with the simplicity of the lateral flow assay format to facilitate user-friendly amplified detection of a target in a sample.

公开(公告)号：US11926589B2

公开(公告)日：2024-03-12

申请号：US17625414

申请日：2020-07-06

Applicant: BASF CORPORATION ,  California Institute of Technology

Inventor： Sarah Reisman ,  Michael Rombola ,  Carolyn L. Ladd ,  Martin John McLaughlin ,  Stephan Zuend ,  Roland Goetz

IPC: C07C67/293 ,  C07B53/00

CPC classification number: C07C67/293 ,  C07B53/00 ,  C07B2200/07

Abstract: This invention relates to a process for the synthesis of a non-racemic cyclohexene compound of formula (I) by a Diels-Alder reaction of a compound of formula (II) with a compound of formula (III) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and Y have the meanings as defined in the description in the presence of a catalyst comprising at least one m-valent metal cation Mm+ wherein the metal M is selected from Scandium (Sc), Yttrium (Y), Lanthanum (La), Cerium (Ce), Praseodymium (Pr), Neodymium (Nd), Promethium (Pm), Samarium (Sm), Europium (Eu), Gadolinium 15 (Gd), Terbium (Tb), Dysprosium (Dy), Holmium (Ho), Erbium (Er), Thulium (Tm), Ytterbium (Yb), Lutetium (Lu), Gallium (Ga) and Indium (In), and m is an integer of 1, 2 or 3, and a chiral ligand of the formula (IV) wherein R10a, R10b, R10c, R10d, R10a′, R10b′, R10c′, R10d′, Z and Z′ have the meanings as defined in the description.

公开(公告)号：US20240066074A1

公开(公告)日：2024-02-29

申请号：US18024477

申请日：2021-09-07

Applicant: California Institute of Technology

Inventor： Anastasiya O. MOISEYENKO ,  Timothy R. SAMPSON ,  Sarkis K. MAZMANIAN

IPC: A61K35/741 ,  A61K45/06 ,  A61P25/16

CPC classification number: A61K35/741 ,  A61K45/06 ,  A61P25/16

Abstract: Some embodiments herein relate generally to compositions comprising microbial organisms and/or components thereof for improving a neurological disorder, or symptoms associated with a neurological disorder, such as Parkinson's disease, and methods of using the same.

公开(公告)号：US11912807B2

公开(公告)日：2024-02-27

申请号：US17211134

申请日：2021-03-24

Applicant: Samsung Electronics Co., Ltd. ,  California Institute of Technology

Inventor： Yeong Suk Choi ,  Tae Hyun Kim ,  Linghui Wang ,  Vincenzo Costanza ,  Zhun Zhou ,  Chiara Daraio

IPC: C08F293/00 ,  C08K3/04 ,  G01J5/20 ,  H10K85/10 ,  H10K30/30 ,  H10K30/65 ,  H10K39/32

CPC classification number: C08F293/005 ,  C08K3/04 ,  G01J5/20 ,  H10K85/141 ,  H10K85/151 ,  C08F2438/03 ,  C08F2810/50 ,  H10K30/30 ,  H10K30/65 ,  H10K39/32

Abstract: A composite for sensing heat or infrared light includes a block copolymer including a first structural group represented by Chemical Formula 1, a second structural group represented by Chemical Formula 2, and a third structural group represented by Chemical Formula 3; and a polyvalent metal ion that is coordinated with a side chain group of the block copolymer.

公开(公告)号：US20240061316A1

公开(公告)日：2024-02-22

申请号：US18448700

申请日：2023-08-11

Applicant: California Institute of Technology

Inventor： Gordon H.Y. Li ,  Midya Parto ,  Ryoto Sekine ,  James Williams ,  Christian Leefmans ,  Alireza Marandi

IPC: G02F1/39 ,  G06E3/00

CPC classification number: G02F1/39 ,  G06E3/001

Abstract: A device including a programmable photonic processor configured to operate on optical pulses to perform computational sequences of linear operations and nonlinear operations each based on a parametric nonlinear optical process; a memory coupled to the processor and programmable to store or accumulate the analog optical pulse amplitudes of the optical pulses; a control circuit controlling the transfer of the analog optical pulse amplitudes between the processor and the memory according to a computation schedule; and wherein information is multiplexed in time by encoding the information onto the analog optical pulse amplitudes of the optical pulses occupying time bins at a fixed repetition rate such that the optical pulses, occupying different ones of the time bins, can be made to interact using appropriate temporal delays.

公开(公告)号：US11896629B2

公开(公告)日：2024-02-13

申请号：US16935837

申请日：2020-07-22

Applicant: California Institute of Technology

Inventor： Sarkis K Mazmanian ,  Paul H Patterson ,  Janet Chow ,  Elaine Hsiao ,  Sara W McBride

IPC: A61K35/741 ,  A61K35/00

CPC classification number: A61K35/741 ,  A61K2035/11

Abstract: Provided is a method and a composition for improving behavioral performance in an individual comprising identifying an individual in need of treatment, and providing such an individual a composition comprising bacteria within the genus Bacteroides.

公开(公告)号：US11891170B2

公开(公告)日：2024-02-06

申请号：US17451895

申请日：2021-10-22

Applicant: California Institute of Technology

Inventor： Ellande Tang ,  Patrick Spieler ,  Matthew J Anderson ,  Soon-Jo Chung

IPC: B64C29/00 ,  B64C3/56 ,  B64C5/06 ,  B64U10/20 ,  B64U30/12 ,  B64U101/58

CPC classification number: B64C29/0025 ,  B64C3/56 ,  B64C5/06 ,  B64U10/20 ,  B64U30/12 ,  B64U2101/58

Abstract: An air transport vehicle that capitalizes on the strengths and complexities of a fixed and rotary winged aircraft. The air transport vehicle comprises a body aerodynamically designed to avoid substantial drag. The vehicle has a plurality of rotors configured to generate vertical thrust with a rear rotor configured to generate forward thrust. Additionally, each of the rotors are connected to the fixed wing elements and the fixed wing is positioned about the center of mass of the fuselage. Furthermore, each of the rotors are positioned at a fixed tilt angle such that the stability of the vehicle is maintained in a number of different flight configurations.