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    Methods, systems, and computer readable media for evaluating variant likelihood
    81.
    发明授权
    Methods, systems, and computer readable media for evaluating variant likelihood 有权

    公开(公告)号：US11636919B2

    公开(公告)日：2023-04-25

    申请号：US15974976

    申请日：2018-05-09

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Earl Hubbell ,  Sowmi Utiramerur

    IPC: G16B20/20 ,  G16B30/00 ,  G16B40/00 ,  C12Q1/6874 ,  C12Q1/6869

    Abstract: A method for evaluating variant likelihood includes: providing a plurality of template polynucleotide strands, sequencing primers, and polymerase in a plurality of defined spaces disposed on a sensor array; exposing the plurality of template polynucleotide strands, sequencing primers, and polymerase to a series of flows of nucleotide species according to a predetermined order; obtaining measured values corresponding to an ensemble of sequencing reads for at least some of the template polynucleotide strands in at least one of the defined spaces; and evaluating a likelihood that a variant sequence is present given the measured values corresponding to the ensemble of sequencing reads, the evaluating comprising: determining a measurement confidence value for each read in the ensemble of sequencing reads and modifying at least some model-predicted values using a first bias for forward strands and a second bias for reverse strands.

    Line Volume Calibration Systems And Methods
    84.
    发明申请
    Line Volume Calibration Systems And Methods 有权

    公开(公告)号：US20230119629A1

    公开(公告)日：2023-04-20

    申请号：US18069264

    申请日：2022-12-21

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Glen Davis

    IPC: G01F25/17 ,  G01F15/00 ,  G01N29/22

    Abstract: Provided are systems and methods for line volume calibration, and measurement of fluid samples delivered to an interrogation point. In various embodiments, a known fluid volume comprising a sample line fluid and a secondary fluid is delivered to a fluid boundary sensor. The fluid boundary sensor assists in determining the position of the boundaries between the various fluids, and the positions of these boundaries are used to determine the sample line fluid volume.

    APPARATUS AND METHODS FOR PERFORMING ELECTROCHEMICAL REACTIONS
    86.
    发明申请
    APPARATUS AND METHODS FOR PERFORMING ELECTROCHEMICAL REACTIONS 有权

    公开(公告)号：US20230101252A1

    公开(公告)日：2023-03-30

    申请号：US18077404

    申请日：2022-12-08

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： John NOBILE ,  George Thomas ROTH ,  Todd REARICK ,  Jonathan SCHULTZ ,  Jonathan M. ROTHBERG ,  David MARRAN

    IPC: G01N27/30 ,  B01L3/00 ,  G01N27/414

    Abstract: An apparatus includes a reaction vessels coupled to an electronic sensor for monitoring a reaction product in the reaction vessel; a fluidics system for sequentially delivering a plurality of reagents to the reaction vessel, the fluidics system including a plurality of reagent reservoirs in fluidic communication via a plurality of flow paths with a fluidics circuit and to a common passage in fluidic communication between the fluidics circuit and the reaction vessel, a solution reservoir in fluidic communication with the common passage via a branch passage connected with the common passage at a junction between the fluidics circuit and the reaction vessel; and an electrode in contact with a solution within the branch passage, the electrode being in electrical communication with the reaction vessel through fluid extending from the branch passage and through the common passage, the electronic sensor generating an output signal depending on a voltage of the electrode.

    Umbrella check valve assembly having retention plate
    90.
    发明授权
    Umbrella check valve assembly having retention plate 有权

    公开(公告)号：US11598434B2

    公开(公告)日：2023-03-07

    申请号：US17147586

    申请日：2021-01-13

    Applicant: Life Technologies Corporation

    Inventor： Charles R. Rhodes ,  Jonathan O. Schultz

    IPC: F16K15/14

    Abstract: A check valve assembly includes a first port fitting and a second port fitting with a base secured therebetween. The base has an annular sleeve encircling a seat, the seat having a central mounting hole and one or more flow channels passing therethrough. An umbrella valve includes a flexible sealing disk having an outer surface and an opposing inner surface, a mounting stem extending from the inner surface and projecting into the mounting hole of the base, the sealing disk being movable between a first position wherein at least a portion of the sealing disk sits on the seat so as to cover the one or more flow channels and a second position wherein the sealing disk is resiliently flexed so as to at least partially uncover the one or more flow channels. A retention plate is disposed between first port fitting and the seat of the base so that the retention plate sits against the outer surface of the sealing disk.

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