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公开(公告)号：US11649433B2
公开(公告)日：2023-05-16
申请号：US16482160
申请日：2018-01-31
Applicant: Osaka University
Inventor： Kohji Nishida , Kiyotoshi Sekiguchi , Ryuhei Hayashi , Shun Shibata
IPC: A61K35/545 , C12N5/079 , A61K38/18
CPC classification number: C12N5/0621 , A61K35/545 , A61K38/1825 , A61K38/18 , C12N2501/998 , C12N2506/45 , C12N2533/52
Abstract: The present invention relates to a method for controlling differentiation of pluripotent stem cells, which method comprises selecting a laminin or a fragment thereof based on binding affinity for the pluripotent stem cells and inducing differentiation of the pluripotent stem cells in the presence of the laminin or a fragment thereof. Here, the binding affinity for cells can be assessed by time-course observation of the survival rate and motility of the cells. According to the present invention, a cell population containing any desired proportion of differentiated cells can be produced from pluripotent stem cells in a simple manner. The cell population obtained by this production method is very useful for cell therapy-based treatment strategies for diseases.
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公开(公告)号：US20230146964A1
公开(公告)日：2023-05-11
申请号：US18091384
申请日：2022-12-30
Applicant: Japan Display Inc. , OSAKA UNIVERSITY
Inventor： Shinichiro OKA , Yasushi TOMIOKA , Junji KOBASHI , Hiroyuki YOSHIDA
IPC: H01L31/054 , G02F1/133 , G02F1/137
CPC classification number: H01L31/0547 , G02F1/13324 , G02F1/13718
Abstract: According to one embodiment, a photovoltaic cell device includes an optical waveguide, an optical element, and a photovoltaic cell. The optical element includes a first liquid crystal layer which contains a cholesteric liquid crystal, reflects, of visible light, circularly polarized light of one of first circularly polarized light and second circularly polarized light rotating in an opposite direction of the first circularly polarized light toward the optical waveguide and the photovoltaic cell, and transmits the other circularly polarized light. The first liquid crystal layer reflects one of the first circularly polarized light and the second circularly polarized light of part of wavelength ranges.
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公开(公告)号：US20230136958A1
公开(公告)日：2023-05-04
申请号：US18091387
申请日：2022-12-30
Applicant: Japan Display Inc. , OSAKA UNIVERSITY
Inventor： Shinichiro OKA , Yasushi TOMIOKA , Junji KOBASHI , Hiroyuki YOSHIDA
IPC: H01L31/054 , G02B6/42
Abstract: According to one embodiment, a photovoltaic cell device includes a first optical waveguide including a first main surface, a second main surface facing the first main surface, and a first side surface, an optical element facing the second main surface, containing a cholesteric liquid crystal, and reflecting at least part of light incident on the first main surface toward the first optical waveguide, and a first photovoltaic cell facing the first side surface. The first photovoltaic cell is attached to the first side surface by a transparent first adhesive layer.
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公开(公告)号：US11633469B2
公开(公告)日：2023-04-25
申请号：US16316186
申请日：2017-07-11
Inventor： Takao Fujimoto , Junji Fujita
IPC: C12N7/00 , A61K39/145
Abstract: Provided is a method of producing reassortant influenza virus containing an antigenic protein of the first influenza virus strain, the method including the following steps: 1) a step of irradiating the first influenza virus strain with ultraviolet light in such an irradiation dose that the first influenza virus strain has initial infection ability and loses or is reduced in virus growth potential; 2) a step of infecting a host with the first influenza virus strain and the second influenza virus strain; 3) a step of culturing the host infected with the first influenza virus strain and the second influenza virus strain, to obtain culture product; 4) a step of inactivating influenza virus strain having an antigenic protein of the second influenza virus strain in the culture product obtained in the step 3); and 5) a step of collecting reassortant influenza virus after the step 4).
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公开(公告)号：US20230119663A1
公开(公告)日：2023-04-20
申请号：US17907187
申请日：2021-03-25
Applicant: OSAKA UNIVERSITY
Inventor： Michiya MATSUSAKI , Donghee KANG
Abstract: [Problem] To provide a method for producing an artificial three-dimensional muscle tissue, said method enabling stable, efficient and easy production of a muscle tissue, and an artificial three-dimensional muscle tissue produced by this method. [Solution] A method for producing an artificial three-dimensional muscle tissue, said method comprising steps of (i) forming a three-dimensional muscle tissue precursor, which is configured from a first muscle tissue support, a second muscle tissue support and muscle cells, by linearly arranging the muscle cells on the first muscle tissue support in such a manner that the muscle cells are located close to the first muscle tissue support at one end of the line and close to the second muscle tissue support at the other end of the line, and (ii) culturing the three-dimensional muscle tissue precursor to give an artificial three-dimensional muscle tissue, and an artificial three-dimensional muscle tissue obtained by this method.
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Patent Agency Ranking
公开(公告)号：US20230110754A1
公开(公告)日：2023-04-13
申请号：US17911572
申请日：2021-03-25
Applicant: OSAKA UNIVERSITY
Inventor： Yasuhiro SUGAWARA
Abstract: In order to increase the order of a frequency of an AC signal to be applied between a vibration section and a sample to an order at substantially the same level as the order of a vibration frequency of the vibration section in measuring a vibration component of the vibration control section, a vibration component measuring device (2) includes: a vibration section (4); a first AC signal generator (20) configured to generate a first AC signal; a second AC signal generator (44) configured to generate a second AC signal having a frequency which is (a) more than one time and less than two times or (b) more than two times and less than three times as high as a frequency of the first AC signal; a signal applying section (14, 56) configured to apply the second AC signal between the vibration section and a sample (X); a vibration control section (10) configured to cause the vibration section to vibrate; and a measuring section (16, 18, 20, 22, 42, 44, 50) configured to measure a varying component of vibration of the vibration section, the varying component being varied by an interaction between the vibration section and the sample.
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公开(公告)号：US20230086672A1
公开(公告)日：2023-03-23
申请号：US17794650
申请日：2021-01-13
Applicant: KABUSHIKI KAISHA TOYOTA JIDOSHOKKI , OSAKA UNIVERSITY
Inventor： Hiroyasu KAWAUCHI , Hideaki SUZUKI , Yoshitaka TAKEUCHI , Ryuichi MURAI , Fumiteru AKAMATSU , Yu IMAHASHI
Abstract: A combustor includes: a housing having an annular shape of which one end side is open and of which the other end side is closed; at least one introduction portion that introduces a fuel and an oxidizing gas into the housing to generate a tubular flow; and an ignition unit that ignites the fuel introduced into the housing. The ignition unit includes a discharge electrode and a ground electrode. A space that the fuel and the oxidizing gas reach is provided between the discharge electrode and the ground electrode.
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公开(公告)号：US20230078523A1
公开(公告)日：2023-03-16
申请号：US17801115
申请日：2021-01-21
Applicant: MENICON CO., LTD. , OSAKA UNIVERSITY
Inventor： Koji UESUGI , Hidetoshi EGUCHI , Kunihito GOTOH
Abstract: A material or method that can serve as an alternative to a related-art digestive fluid leak preventative material and method of preventing a leak of a digestive fluid, the digestive fluid leak preventative material includes a self-assembling peptide gel, has an adhesion persistence ratio with respect to a collagen sheet of at least 40%, and has a decomposition ratio of 35% or less in pancreatic juice treatment at 37° C. for 7 days.
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公开(公告)号：US11604235B2
公开(公告)日：2023-03-14
申请号：US17274604
申请日：2019-10-15
Applicant: TOKYO INSTITUTE OF TECHNOLOGY , OSAKA UNIVERSITY
Inventor： Mutsuko Hatano , Takayuki Iwasaki , Yoshie Harada , Yuji Hatano
Abstract: A magnetic measuring device includes: a determination part configured to identify four maximum inclination points in an average value in a visual field of a light detection magnetic resonance spectrum and configured to determined a degree of decrease in relative fluorescence intensity and a microwave frequency at each of the maximum inclination points; a setting part configured to set a reference decrease degree of the relative fluorescence intensity in a predetermined area and configured to set operating point frequency initial values at four points at which the reference decrease degree is achieved, near the microwave frequencies at the respective maximum inclination points; a frequency update part configured to update operating point frequencies at the four points; and a frequency correction part configured to input the updated operating point frequencies to a microwave oscillator as corrected operating point frequencies.
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公开(公告)号：US11601091B1
公开(公告)日：2023-03-07
申请号：US17793180
申请日：2020-12-28
Applicant: OSAKA UNIVERSITY
Inventor： Teruo Kanki , Yasushi Hotta
Abstract: A fluctuating oscillator includes: an adder that has an input terminal to which an input signal including a main signal and an uncorrelated signal that is uncorrelated with the main signal and is higher in frequency than the main signal is input, and adds a feedback signal to the input signal; a threshold discrimination unit that generates a pulse signal by comparing an addition signal added by the adder with a threshold; a transient response unit that generates an output signal by transiently responding the generated pulse signal; and a feedback loop that feeds back the output signal to the adder as the feedback signal.
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