公开(公告)号：US20150141775A1

公开(公告)日：2015-05-21

申请号：US14400135

申请日：2013-05-29

Applicant: Stellenbosch University

Inventor： Filippo Macaluso ,  Kathy Helen Myburgh

IPC: A61B5/00 ,  A61B10/00

CPC classification number: A61B5/4266 ,  A61B5/4875 ,  A61B5/6824 ,  A61B5/6833 ,  A61B10/0064

Abstract: A sweat measuring device (1) comprising a sweat impermeable panel (40) and an adhesive skirt on one side thereof extending about its periphery to enable the panel to be secured to a user's skin is provided. The device covers a known area of a user's skin and traps sweat (42) produced by the skin under the panel. The panel (40) defines a reservoir in which sweat can accumulate and calibrations which may be associated with the reservoir to express the total sweat produced by the user as a function of the volume of sweat in the reservoir. The panel may be relatively stiff; formed by a plastics member and the skirt may extend integrally from the panel or be provided by an adhesive patch which covers the panel.

Abstract translation: 一种汗液测量装置（1），其包括不透水的面板（40）和在其一侧围绕其周边延伸的粘合剂裙部，以使面板固定在使用者的皮肤上。 该装置覆盖用户皮肤的已知区域并捕获由面板下的皮肤产生的汗液（42）。 面板（40）限定了可以累积汗液的储存器和可与储存器相关联的校准，以表示由使用者产生的总汗液作为储存器中汗水的体积的函数。 面板可能比较僵硬 由塑料构件形成并且裙部可以从面板一体地延伸或由覆盖面板的粘合贴片提供。

公开(公告)号：US20140045946A1

公开(公告)日：2014-02-13

申请号：US14044004

申请日：2013-10-02

Applicant: Stellenbosch University

Inventor： David Meyer

IPC: A61K31/167

CPC classification number: A61K31/167

Abstract: A new use for paracetamol in a method of treating glaucoma, which method comprises administering to a patient in need of such treatment 500 mg to 1000 mg of paracetamol in oral format 4 to 6 hourly. An ophthalmic solution is also provided containing between 0.1 to 5% of paracetamol which is administered as one to two drops in each eye 4 to 6 hourly. The ophthalmic solution further includes one or more of the following excipients: hydroxypropylmethylcellulose, benzalconium chloride, polyacrylic acid such as Teargel®.

Abstract translation: 用于治疗青光眼的方法中的扑热息痛的新用途，该方法包括向需要这种治疗的患者施用4mg至6小时的口服剂型500mg至1000mg的扑热息痛。 还提供了一种眼用溶液，其含有0.1至5％的扑热息痛，每小时1至2滴滴注每只眼睛。 眼用溶液还包括一种或多种以下赋形剂：羟丙基甲基纤维素，氯化亚苄基铝，聚丙烯酸如Teargel。

公开(公告)号：US20250093369A1

公开(公告)日：2025-03-20

申请号：US18960747

申请日：2024-11-26

Applicant: STELLENBOSCH UNIVERSITY

Inventor： Novel Njweipi Chegou ,  Regan Shane Solomons ,  Gerhard Walzl ,  Masilo Charles Manyelo

IPC: G01N33/68 ,  A61B5/15 ,  A61B10/00 ,  G01N21/64

Abstract: Methods, devices, kits and computer-implemented methods for diagnosing (and optionally treating) tuberculous meningitis (TBM) are provided. In one embodiment, the method comprises testing a cerebrospinal fluid (CSF) sample from a subject suspected of having TBM for the presence of MPO and at least two other biomarkers, at least one of the other biomarkers being selected from the group consisting of IFN-γ, sICAM-1, VEGF-A and CXCL8. For example, the method can comprise testing the sample for MPO, IFN-γ and VEGF-A or for MPO, IFN-γ, sICAM-1 and CXCL8. In another embodiment, the method comprises testing a blood sample from a subject suspected of having TBM for the presence of at least one biomarker selected from the group consisting of adipsin (complement factor D), Ab42 and IL-10, and at least two other biomarkers. In one example, the method comprises testing the sample for the presence of adipsin (complement factor D), Ab42 and IL-10.

公开(公告)号：US20250009257A1

公开(公告)日：2025-01-09

申请号：US18710990

申请日：2022-11-17

Applicant: STELLENBOSCH UNIVERSITY

Inventor： Klara McCLUNAN ,  Evette VAN NIEKERK

IPC: A61B5/107

Abstract: An anthropometric growth apparatus (101, 201, 501) for measuring the anthropometry of an infant is provided. The apparatus comprises a base (103, 203, 503) with a digital scale assembly (105, 205, 505) mounted to the base and configured to measure a weight of the infant. A digital length measurement assembly (107, 207, 507) is mounted to the base and configured to measure a length of the infant. A head circumference measurement assembly (109, 209, 509) is mounted to the base and includes an array of distance sensors (111, 211, 511) provided on a support (113, 213, 513) configured to position the array of distance sensors at a selected distance from the head of the infant for non-invasive measurement of the head circumference in use. The apparatus may further be used for body composition and gestational age determination.

公开(公告)号：US20240425621A1

公开(公告)日：2024-12-26

申请号：US18719742

申请日：2022-12-14

Applicant: Stellenbosch University

Inventor： Lubertus Klumperman ,  Gestél Christine Kuyler

IPC: C08F8/36 ,  C07K1/14 ,  C08F8/32 ,  C08F8/44

Abstract: Terpolymers comprising optionally at least partially substituted styrene repeat units, N-alkylmaleimide repeat units and repeat units selected from the group consisting of maleic anhydride repeat units, maleic acid repeat units or maleic anhydride derivative repeat units and having a narrow molecular weight distribution are provided. The terpolymers may be used to solubilize lipid bilayers to form lipid nanodiscs and isolate membrane proteins.

公开(公告)号：US20240264147A1

公开(公告)日：2024-08-08

申请号：US18571901

申请日：2022-06-23

Applicant: STELLENBOSCH UNIVERSITY

Inventor： Gideon WOLFAARDT ,  Kyle Brent KLOPPER

IPC: G01N33/497 ,  G01N21/59 ,  G01N21/85 ,  G01N21/94

CPC classification number: G01N33/4977 ,  G01N21/59 ,  G01N21/85 ,  G01N21/94 ,  G01N2021/8557 ,  G01N2201/062

Abstract: An apparatus and system for measuring and monitoring fouling parameters in a fluid are provided. The apparatus includes a conduit within a housing, wherein at least a portion of the conduit provides a carbon dioxide permeable membrane through which carbon dioxide in the fluid can permeate in use. A carbon dioxide sensor within the housing is configured to measure carbon dioxide levels at the sensor. The housing further includes a light source that irradiates a portion of the conduit and a light sensor that is configured to measure light transmitted through or reflected by the irradiated portion of the conduit to measure the amount of fouling material within the fluid and attached to the irradiated portion of the conduit in use.

公开(公告)号：US20230392177A1

公开(公告)日：2023-12-07

申请号：US18037065

申请日：2021-11-16

Applicant: Stellenbosch University

Inventor： Anton Du Preez van Staden ,  Carine Smith ,  Dominic Nicholas ,  Leon Milner Theodore Dicks ,  Ross Rayne Vermeulen

IPC: C12P21/02 ,  C12N15/70 ,  C07K14/00

CPC classification number: C12P21/02 ,  C12N15/70 ,  C07K14/00 ,  C07K2319/02 ,  C07K2319/20 ,  C07K2319/60 ,  C07K2319/50

Abstract: The present invention relates to a method of producing a heterologous polypeptide of interest in a host cell, wherein the method comprises expressing a fusion protein comprising the heterologous polypeptide of interest and a fluorescent fusion partner in a host cell modified to include a nucleic acid encoding a lytic protein operably linked to a promoter, wherein translation of the lytic protein is under control of an RNA thermometer. Also provided are E. coli cells which express the fusion protein and include a nucleic acid encoding a lytic protein operably linked to a promoter, wherein translation of the lytic protein regulated by an RNA thermometer.

公开(公告)号：US20230183721A1

公开(公告)日：2023-06-15

申请号：US17923659

申请日：2021-05-05

Applicant: STELLENBOSCH UNIVERSITY

Inventor： BIANCA ANINA BRANDT ,  JOHANN FERDINAND GÖRGENS ,  WILLEM HEBER VAN ZYL

IPC: C12N15/81 ,  C12N9/04 ,  C12N9/02 ,  C12N9/10

CPC classification number: C12N15/81 ,  C12N9/0006 ,  C12N9/0093 ,  C12N9/1029 ,  C12N9/1085 ,  C12N9/1022 ,  C12Y101/01001 ,  C12Y203/01051

Abstract: A method of producing a modified Saccharomyces cerevisiae yeast strain with enhanced resistance (or tolerance) to pretreatment-derived microbial inhibitors such as furans, phenolics and weak acids is provided, which comprises integrating at least one copy of the TAL1 gene and at least one copy of two or more of the FDH1, AR11 and ADH6 genes into the S. cerevisiae genome. A modified yeast strain so obtained is also provided, the modified yeast strain being capable of simultaneously overexpressing these genes relative to a yeast strain which hasn't been modified in the same manner. S. cerevisiae strains which have been modified as described herein can be used to ferment lignocellulosic hydrolysates containing pretreatment inhibitors such as furans, phenolics and weak acids. Suitable lignocellulosic hydrolysates include sugarcane bagasse (SCB) and waste streams from the pulp and paper industry, such as spent sulphite liquor (SSL).

公开(公告)号：US20220192532A1

公开(公告)日：2022-06-23

申请号：US17600414

申请日：2020-04-01

Applicant: KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY ,  STELLENBOSCH UNIVERSITY

Inventor： Jürgen KOSEL ,  Liam SWANEPOEL ,  Pieter FOURIE

IPC: A61B5/06

Abstract: A subcutaneous medical device system includes a subcutaneous medical device, a magnetic element arranged on a portion of the subcutaneous medical device, the magnetic element including at least two poles, and a magnetic detector arranged spaced apart from the magnetic element and outside of a patient. The magnetic detector includes a single magnetic sensor and a processor coupled to the single magnetic sensor. The processor is programmed to determine a position of the portion of the subcutaneous medical device within the patient based on a static magnetic flux measurement of the magnetic element by the single magnetic sensor without externally applying an external magnetic field to the magnetic element.

公开(公告)号：US11357822B2

公开(公告)日：2022-06-14

申请号：US16640039

申请日：2017-10-04

Applicant: Stellenbosch University

Inventor： Etheresia Pretorius ,  Douglas Bruce Kell

IPC: A61K38/17 ,  A61P25/28

Abstract: A method for treating a subject suffering from Alzheimer's disease is provided. The method includes administering to the subject a therapeutically effective amount of lipopolysaccharide-binding protein (LBP). A composition including a therapeutically effective amount of LBP is also provided.