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公开(公告)号：US11833179B2
公开(公告)日：2023-12-05
申请号：US16755801
申请日：2018-10-15
Applicant: Stellenbosch University
Inventor： Deon Pieter Neveling , Leon Milner Theodore Dicks
IPC: A61K35/747 , A23K50/75 , A23K10/18 , A61P31/04 , A61K9/00 , A61K35/742 , A61K35/744
CPC classification number: A61K35/747 , A23K10/18 , A23K50/75 , A61K9/0056 , A61K35/742 , A61K35/744 , A61P31/04 , A23Y2220/43 , A23Y2220/79
Abstract: A probiotic composition comprising Bacillus amyloliquefaciens, Enterococcus faecalis, Lactobacillus salivarius, Lactobacillus johnsonii, Lactobacillus gallinarum and Lactobacillus crispatus is provided. The probiotic composition stimulates the immune response of chickens without negatively affecting growth performance. The probiotic composition can be added to poultry feed to improve the health and performance of chickens, and can be used as a replacement for antibiotic supplementation.
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公开(公告)号：US10663463B2
公开(公告)日：2020-05-26
申请号：US15124743
申请日：2014-11-03
Applicant: Stellenbosch University
Inventor： Leon Milner Theodore Dicks , Willem Jacobus Perold , Deon Nevwling , Thomas Stanley Van Den Heever
IPC: G01N33/543 , G01N33/551 , A61B5/1473 , A61B5/00 , G01N15/10 , G01N33/553
Abstract: A system and method for the detection and quantification of biomolecules by measuring a piezoelectric signal is described. The system comprises a plurality of elongate zinc oxide nanowires mounted generally parallel to each another on a semi conductive silicon substrate. The free ends of the nanowires are provided with biomolecules that are capable of associating with complementary biomolecules within a biological or water sample. Following incubation of the system in a sample, the association of molecules of interest with the immobilised biomolecules on the system results in the displacement of the zinc oxide nanowires. The displacement of the nanowires produces a piezoelectric voltage signal that is useful in diagnosing a pathogenic infection or the contamination of a sample.
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公开(公告)号：US12173344B2
公开(公告)日：2024-12-24
申请号：US18037065
申请日：2021-11-16
Applicant: Stellenbosch University
Inventor： Anton Du Preez van Staden , Carine Smith , Dominic Nicholas , Leon Milner Theodore Dicks , Ross Rayne Vermeulen
Abstract: The present invention relates to a method of producing a heterologous polypeptide of interest in a host cell, wherein the method comprises expressing a fusion protein comprising the heterologous polypeptide of interest and a fluorescent fusion partner in a host cell modified to include a nucleic acid encoding a lytic protein operably linked to a promoter, wherein translation of the lytic protein is under control of an RNA thermometer. Also provided are E. coli cells which express the fusion protein and include a nucleic acid encoding a lytic protein operably linked to a promoter, wherein translation of the lytic protein regulated by an RNA thermometer.
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公开(公告)号：US20240050496A1
公开(公告)日：2024-02-15
申请号：US18490629
申请日：2023-10-19
Applicant: Stellenbosch University
Inventor： Deon Pieter Neveling , Leon Milner Theodore Dicks
IPC: A61K35/747 , A23K50/75 , A23K10/18 , A61P31/04 , A61K9/00 , A61K35/742 , A61K35/744
CPC classification number: A61K35/747 , A23K50/75 , A23K10/18 , A61P31/04 , A61K9/0056 , A61K35/742 , A61K35/744 , A23V2400/151 , A23V2400/181
Abstract: A probiotic composition comprising Bacillus amyloliquefaciens, Enterococcus faecalis, Lactobacillus salivarius, Lactobacillus johnsonii, Lactobacillus gallinarum and Lactobacillus crispatus is provided. The probiotic composition stimulates the immune response of chickens without negatively affecting growth performance. The probiotic composition can be added to poultry feed to improve the health and performance of chickens, and can be used as a replacement for antibiotic supplementation.
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Patent Agency Ranking
公开(公告)号：US10302637B2
公开(公告)日：2019-05-28
申请号：US15352690
申请日：2016-11-16
Applicant: Stellenbosch University
Inventor： Christiaan Gunter Alwyn Viviers , Willem Jacobus Perold , Leon Milner Theodore Dicks , Giles Hubert Coyle Maybery
IPC: G01N33/553 , G01N33/543 , G01N27/12 , G01N33/573
Abstract: A device for detecting target biomolecules is provided. The device consists of an electrically conductive membrane having a biological recognition component configured to bind a target biomolecule immobilized thereon. The membrane is connected to an electric circuit by means of electrodes. A voltage source applies a voltage to the membrane and a resistance monitoring device monitors the resistance of the membrane as a selected volume of fluid sample suspected of containing the target biomolecule is delivered onto the membrane.
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公开(公告)号：US20170138934A1
公开(公告)日：2017-05-18
申请号：US15352690
申请日：2016-11-16
Applicant: Stellenbosch University
Inventor： Christiaan Gunter Alwyn Viviers , Willem Jacobus Perold , Leon Milner Theodore Dicks , Giles Hubert Coyle Maybery
IPC: G01N33/543 , G01N33/573 , G01N27/12
CPC classification number: G01N33/5438 , G01N27/125 , G01N33/573 , G01N2333/936 , G01N2469/20
Abstract: A device for detecting target biomolecules is provided. The device consists of an electrically conductive membrane having a biological recognition component configured to bind a target biomolecule immobilized thereon. The membrane is connected to an electric circuit by means of electrodes. A voltage source applies a voltage to the membrane and a resistance monitoring device monitors the resistance of the membrane as a selected volume of fluid sample suspected of containing the target biomolecule is delivered onto the membrane.
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公开(公告)号：US20170023557A1
公开(公告)日：2017-01-26
申请号：US15124743
申请日：2014-11-03
Applicant: Stellenbosch University
Inventor： Leon Milner Theodore Dicks , Willem Jacobus Perold , Deon Nevwling , Thomas Stanley Van Den Heever
IPC: G01N33/543 , G01N15/10 , A61B5/1473 , A61B5/00 , G01N33/551 , G01N33/553
CPC classification number: G01N33/5438 , A61B5/14735 , A61B5/6861 , A61B2562/0285 , G01N15/1056 , G01N33/54373 , G01N33/551 , G01N33/553 , G01N2015/1062
Abstract: A system and method for the detection and quantification of biomolecules by measuring a piezoelectric signal is described. The system comprises a plurality of elongate zinc oxide nanowires mounted generally parallel to each another on a semi conductive silicon substrate. The free ends of the nanowires are provided with biomolecules that are capable of associating with complementary biomolecules within a biological or water sample. Following incubation of the system in a sample, the association of molecules of interest with the immobilised biomolecules on the system results in the displacement of the zinc oxide nanowires. The displacement of the nanowires produces a piezoelectric voltage signal that is useful in diagnosing a pathogenic infection or the contamination of a sample.
Abstract translation: 描述了通过测量压电信号来检测和定量生物分子的系统和方法。 该系统包括在半导电硅衬底上大体平行地安装的多个细长的氧化锌纳米线。 纳米线的自由端设置有能够与生物或水样品中的互补生物分子缔合的生物分子。 在体系在样品中孵育后，感兴趣的分子与系统上固定的生物分子的结合导致氧化锌纳米线的位移。 纳米线的位移产生压电电压信号，其可用于诊断病原体感染或样品的污染。
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公开(公告)号：US20230392177A1
公开(公告)日：2023-12-07
申请号：US18037065
申请日：2021-11-16
Applicant: Stellenbosch University
Inventor： Anton Du Preez van Staden , Carine Smith , Dominic Nicholas , Leon Milner Theodore Dicks , Ross Rayne Vermeulen
CPC classification number: C12P21/02 , C12N15/70 , C07K14/00 , C07K2319/02 , C07K2319/20 , C07K2319/60 , C07K2319/50
Abstract: The present invention relates to a method of producing a heterologous polypeptide of interest in a host cell, wherein the method comprises expressing a fusion protein comprising the heterologous polypeptide of interest and a fluorescent fusion partner in a host cell modified to include a nucleic acid encoding a lytic protein operably linked to a promoter, wherein translation of the lytic protein is under control of an RNA thermometer. Also provided are E. coli cells which express the fusion protein and include a nucleic acid encoding a lytic protein operably linked to a promoter, wherein translation of the lytic protein regulated by an RNA thermometer.
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公开(公告)号：US20210393709A1
公开(公告)日：2021-12-23
申请号：US16755801
申请日：2018-10-15
Applicant: Stellenbosch University
Inventor： Deon Pieter NEVELING , Leon Milner Theodore Dicks
IPC: A61K35/747 , A61K35/742 , A61K35/744 , A61K9/00 , A61P31/04 , A23K10/18 , A23K50/75
Abstract: A probiotic composition comprising Bacillus amyloliquefaciens, Enterococcus faecalis, Lactobacillus salivarius, Lactobacillus johnsonii, Lactobacillus gallinarum and Lactobacillus crispatus is provided. The probiotic composition stimulates the immune response of chickens without negatively affecting growth performance. The probiotic composition can be added to poultry feed to improve the health and performance of chickens, and can be used as a replacement for antibiotic supplementation.
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