公开(公告)号：US12151004B2

公开(公告)日：2024-11-26

申请号：US17163145

申请日：2021-01-29

Applicant: University of Saskatchewan

Inventor： Humphrey Fonge ,  Clarence Ronald Geyer ,  Siddesh Vrushabendra swamy Hartimath

IPC: A61K51/10 ,  A61K39/00 ,  A61K47/60 ,  A61K47/64 ,  A61K47/68 ,  A61P35/00 ,  C07K16/28 ,  C07K16/32

Abstract: The disclosure provides radiolabeled and/or cytotoxin labelled antibodies and methods and uses of these antibodies. In one embodiment, provided is a cytotoxic agent comprising an antibody that specifically binds a target disease cell surface receptor, a cytotoxin, and a radiolabel, wherein the cytotoxin is linked directly or indirectly to the antibody, and wherein the radiolabel comprises a radionuclide and optionally a scaffold, wherein the scaffold is directly or indirectly coupled to the antibody. Also provided are methods of preparing the cytotoxic agent and methods of treating disease using the cytotoxic agent.

公开(公告)号：US20240199663A1

公开(公告)日：2024-06-20

申请号：US18556667

申请日：2022-04-22

Applicant: University of Saskatchewan ,  Battelle Energy Alliance, LLC

Inventor： Samuel Attah-Poku ,  George Mutwiri ,  Sylvia Van Den Hurk ,  Jan Van Den Hurk ,  John Klaehn ,  Volker Gerdts

IPC: C07F9/6593 ,  A61K39/00 ,  A61K39/39

CPC classification number: C07F9/65815 ,  A61K39/39 ,  A61K2039/55511

Abstract: Disclosed herein are cyclopolyphosphazenes of formula I:




methods for the preparation thereof and uses thereof in adjuvant compositions.

公开(公告)号：US20240124595A1

公开(公告)日：2024-04-18

申请号：US18277831

申请日：2022-02-25

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： Maruti Uppalapati ,  Ekaterina Dadachova

IPC: C07K16/28 ,  A61K51/10 ,  A61P35/00 ,  G01N33/574

CPC classification number: C07K16/2863 ,  A61K51/103 ,  A61P35/00 ,  G01N33/57407 ,  G01N33/57492 ,  A61K2039/505 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/92

Abstract: The disclosure relates to antibodies that bind human, murine, and canine IGF2R, and methods of using said antibodies. Provided herein are antibodies having specific CDRs identified herein, including functional variants of specific variable domains and IgGs having the specified CDR sequences, and immunoconjugates of said antibodies and uses thereof. Also provided herein are compositions and kits comprising said antibodies, and methods and uses of said antibodies, immunoconjugates, compositions, and kits. Also provided herein are the use of said antibodies for radioimmunotherapy (RIT) for cancer including osteosarcoma.

公开(公告)号：US20240066111A1

公开(公告)日：2024-02-29

申请号：US18153483

申请日：2023-01-12

Applicant: University of Saskatchewan

Inventor： Heather Lynne Wilson ,  Milan Obradovic

IPC: A61K39/02 ,  A61K9/107 ,  A61P31/04 ,  C07K14/195 ,  C12N15/70

CPC classification number: A61K39/105 ,  A61K9/107 ,  A61P31/04 ,  C07K14/195 ,  C12N15/70 ,  A61K2039/552

Abstract: L intracellularis antigens for use in subunit vaccine compositions to elicit immune responses against L intracellularis infections such as proliferative enteropathy (PE) are described, as well as polynucleotides encoding therefor. Also described are methods for treating and preventing L intracellularis infections.

公开(公告)号：US11826435B2

公开(公告)日：2023-11-28

申请号：US16756872

申请日：2018-10-19

Applicant: University of Saskatchewan ,  Daniel Tesolin

Inventor： Christopher Phenix ,  Daniel Tesolin ,  Morshed Chowdhury ,  Shusheng Wang

IPC: A61K51/04 ,  C07D401/12

CPC classification number: A61K51/0455 ,  C07D401/12

Abstract: The present application relates to conduritol aziridines of Formula (I), and uses thereof, for example, of 18F-labelled derivatives thereof in positron-emission tomography (PET) imaging of β-glucocerebrosidase activity.

公开(公告)号：US11604127B2

公开(公告)日：2023-03-14

申请号：US16647917

申请日：2018-09-21

Applicant: University of Saskatchewan

Inventor： Travis Kent Wiens ,  Jeremy William ven der Buhs

IPC: G01N3/30 ,  F17D5/06 ,  G01M3/24 ,  G01M5/00 ,  G01N29/07 ,  G01N29/12 ,  G01M3/36 ,  G01N3/20

Abstract: Methods of detecting pipeline weakening are described herein. The methods include creating a pressure wave in a fluid flowing in a pipeline using an input transducer located at a first position along the pipeline; measuring the pressure wave using an output transducer positioned at a second position along the pipeline that is spaced from the first position, and generating an output signal based on the pressure wave; analyzing the output signal to determine a stiffness of a sidewall of the pipeline positioned between the input transducer and output transducer; and determining if the sidewall includes a defect based on the stiffness of the sidewall, including analyzing a frequency response of the output signal to detect the defect.

公开(公告)号：US11517696B2

公开(公告)日：2022-12-06

申请号：US16098530

申请日：2017-04-18

Applicant: University of Saskatchewan

Inventor： William McKay

IPC: A61M16/04 ,  A61M16/00 ,  A61B1/01 ,  A61B1/24 ,  A61B1/267 ,  A61B1/273

Abstract: Novel airway devices and methods address complications of ventilating a patient with a mask; placing an endotracheal tube in an awake patient; and need for a bite block during flexible bronchoscopy and gastroscopy. The airway device features notches for engaging maxillary and mandibular teeth in a manner protracting the patient's mandible relative to the maxilla to open up the airway. This way, an open airway is easily maintained simply by holding the jaw closed against the device with the same hand used to operate a bag ventilator. A longitudinal channel in the device features a downwardly curved end wall for improved guidance of the endoscope into position. The channel is open sided at the top or bottom to allow rolling of the airway device off the endoscope into an offset position serving as a protective bite block and allowing feeding of the endotracheal tube along the endoscope.

公开(公告)号：US11438997B2

公开(公告)日：2022-09-06

申请号：US17250302

申请日：2019-07-04

Applicant: INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITY OF SASKATCHEWAN

Inventor： Sylvain Fourmaux ,  Jean-Claude Kieffer ,  Emil Hallin

IPC: H05G2/00 ,  G01N33/00 ,  G01N23/041

Abstract: A X-ray source, comprising a laser, of a pulse duration of at most 40 fs, instantaneous power of at least about 80 TW, a pulse repetition rate of at least 1 Hz; an optical compressor spectrally shaping the laser beam; focusing optics in the range between f#10 and f#15; and a gas target of electron density after ionization by the laser beam in a range between 1018 cm3 and 1019 cm−3; wherein the focusing optics focuses the laser beam in the gas target, and interaction of the focused laser beam with the gas target generates an X-ray beam, with a focused laser amplitude a0, given by a0=0.855 [IL (1018W/cm2)λL,2 (μm)]1/2, where IL is the on-target laser intensity and λL is the laser wavelength, of at least 2 and a P/Pc ratio value of at least 20, with P being the beam power and Pc a critical power given by Pc=17 (nc/n) GW where n is the electron density and nc is a critical electron density at which the plasma acts as a mirror reflecting the laser beam.

公开(公告)号：US11300566B2

公开(公告)日：2022-04-12

申请号：US15737846

申请日：2016-06-30

Applicant: University of Saskatchewan

Inventor： Changiz Taghibiglou ,  Nathan Pham ,  Landon Pastushok ,  Clarence Ronald Geyer

IPC: G01N33/573 ,  C07K16/40 ,  G01N33/68 ,  C07K16/28

Abstract: The present disclosure relates to a method for detecting a brain injury in a subject by comparing the amount of ADAM10 protein in a blood sample from the subject to a reference standard or to the amount of ADAM10 in a blood sample from a control. An increase in the amount of ADAM10 in the subject blood sample relative to the reference standard or control is indicative of the subject having sustained a brain injury, in particular a traumatic brain injury (TBI). The present disclosure also provides novel antibody and antibody fragments that bind to ADAM10 at different positions.

公开(公告)号：US11076573B2

公开(公告)日：2021-08-03

申请号：US16141859

申请日：2018-09-25

Applicant: University Of Saskatchewan

Inventor： Vladimir Vujanovic ,  James J. Germida

IPC: A01H17/00 ,  A01N63/00 ,  B09C1/10 ,  C12R1/465 ,  C12R1/645 ,  C12R1/80 ,  A01N63/30 ,  A01N25/00

Abstract: The present disclosure provides compositions comprising novel endophytes capable of promoting germination endophytes that have a symbiotic relationship with plants. The present disclosure further provides methods of improving seed vitality, biotic and abiotic stress resistance, plant health and yield under both stressed and unstressed environmental conditions, comprising inoculating a seed with the novel endophyte strains and cultivating a plant therefrom.