公开(公告)号：US10916348B2

公开(公告)日：2021-02-09

申请号：US16217152

申请日：2018-12-12

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： Julius Fridriksson ,  Christopher Rorden

IPC: G16H50/30 ,  G06N20/00 ,  G16H20/40 ,  G16H50/70 ,  G16H50/50 ,  A61N1/36 ,  A61B5/0476 ,  A61B5/00

Abstract: The present disclosure provides systems and methods that include or otherwise leverage a machine-learned brain injury location model to predict locations of brain injury in a patient based on test data associated with the patient, such as, for example, behavioral test data. For example, the machine-learned brain injury location model can be trained on training data associated with a corpus of patients, where the training data includes sets of example test data (e.g., behavioral test data) respectively labeled with ground truth brain injury locations.

公开(公告)号：US10913983B2

公开(公告)日：2021-02-09

申请号：US16038283

申请日：2018-07-18

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： Eugenia Broude ,  Martina McDermott

IPC: A61K31/51 ,  G01N33/68 ,  C12Q1/6886 ,  A61K31/517 ,  A61K31/506 ,  G01N33/574 ,  A61K31/519

Abstract: Disclosed are targeted anti-proliferative approaches for breast cancer utilizing CDK7 inhibitors having efficacy in multiple subtypes of breast cancer, including but without limitation to ER-positive, HER2-positive and Triple Negative Breast Cancer. Methods utilize CDK7 inhibitors alone as well in conjunction with EGFR inhibitors, which provides synergistic anti-proliferative effects on breast cancer cells across a broad spectrum of breast cancer subtypes. Methods for determining sensitivity of breast cancer subtypes to CDK7 inhibitors based upon CITED2 expression levels are also described.

公开(公告)号：US20210024591A1

公开(公告)日：2021-01-28

申请号：US16881096

申请日：2020-05-22

Applicant: University of South Carolina

Inventor： Amar N. Kar ,  Pabitra Sahoo ,  Jeffery Twiss ,  Sean McGill

IPC: C07K14/435 ,  A61P25/28 ,  C07K7/08

Abstract: Testing peptides in in vitro models of neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease, Frontotemporal dementia, Amyotrophic lateral sclerosis, to evaluate systems and methods of treatment therefore.

公开(公告)号：US10900934B2

公开(公告)日：2021-01-26

申请号：US15951566

申请日：2018-04-12

Applicant: University of South Carolina

Inventor： Victor Giurgiutiu ,  Erik Frankforter

IPC: G01N29/12 ,  G10K11/172 ,  G01N29/07 ,  G01N29/24 ,  G01N29/11 ,  G01N29/22 ,  G10K11/16 ,  G10K11/02 ,  G01N29/32

Abstract: Structural health monitoring systems and methods are described that incorporate one or more acoustic black holes in a sensing capacity. The acoustic black hole provides low- or no-reflection capabilities combined with high displacement of an edge upon excitation. The sensor can be utilized to differentiate in-plane acousto-ultrasonic wave excitations from out-of-plane excitations as well as to separate the in-plane and out-of-plane components of an excitation acousto-ultrasonic wave. Sensors can incorporate features such as mode selectivity, omnidirectional sensing, frequency tunability, quasi-static strain insensitivity, and mechanical amplification.

公开(公告)号：US10900927B2

公开(公告)日：2021-01-26

申请号：US16356019

申请日：2019-03-18

Applicant: UNIVERSITY OF SOUTH CAROLINA ,  CLEMSON UNIVERSITY

Inventor： Kenneth Walsh ,  Goutam Koley ,  Md. Sayful Islam ,  Hongmei Li

IPC: G01N27/414 ,  G01N27/333 ,  G01N27/30 ,  H01L29/16

Abstract: A graphene-based ion sensitive field effect transistor (GISFET) with high sensitivity and selectivity for ions is provided. For example, the GISFET of the present invention can exhibit high sensitivity and selectivity for K+ ions has been demonstrated utilizing a valinomycin-based ion selective membrane. The sensitivity of the GISFET can be at least about 50 millivolts/decade and can be stable for a time period of about two months, indicating the GISFET's reliability and effectiveness for physiological monitoring.

公开(公告)号：US10816513B2

公开(公告)日：2020-10-27

申请号：US15670372

申请日：2017-08-07

Applicant: University of South Carolina

Inventor： Paul Henry Ziehl

IPC: G01N29/44 ,  G01M99/00 ,  G01N29/04 ,  G01N29/14 ,  G01N29/24 ,  H04W84/18

Abstract: A non-intrusive monitoring method and system for the detection and potential assessment of damage that may occur during a manufacturing process is described. Potential damage events such as impact events can be detected by one or more sensors located on a workpiece or on a machine utilized in the manufacturing process. Through wireless monitoring of the sensors, potential damage events are detected and products of the manufacturing process can be examined to determine if the event has led to damage.

公开(公告)号：US10814270B2

公开(公告)日：2020-10-27

申请号：US15975807

申请日：2018-05-10

Applicant: University of South Carolina

Inventor： Kevin Huang ,  Peng Zhang

IPC: B01D53/22 ,  B01D69/14 ,  B01D67/00 ,  B01D69/10 ,  B01D71/02 ,  B01D69/02

Abstract: A low-cost and easy-to-fabricate mixed e− and CO32− conducting membrane for advanced high-flux and selective electrochemical CO2 separation from flue gas is provided. The membrane includes a CO32−-conducting molten carbonate phase and an e−-conducting lithiated Ni-oxide interphase that can be formed in situ during operation. The membrane exhibits a CO2 flux density greater than 0.8 mL/(minute·cm2) at 850° C. with a selectivity ranging from about 100 to about 500 and excellent stability for up to about 450 hours. Further, the self-formed interphase Li0.4Ni1.6O2 is highly electron conducting and can provide electrons to the co-reduction of CO2 and O2 into CO32−. Such a membrane is an alternative to the conventional “size-sieving” inorganic and “dissolution-diffusion” organic counterparts for CO2 capture from flue gas.

公开(公告)号：US10800704B2

公开(公告)日：2020-10-13

申请号：US16127496

申请日：2018-09-11

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： Paul Henry Ziehl ,  Lateef Assi

IPC: C04B28/04 ,  C04B40/00 ,  C04B18/14 ,  C04B22/06 ,  C04B28/00

Abstract: Fly ash-based geopolymer binders and activating solutions for use in forming a concrete as well as methods for forming concrete including the binders are described. The fly ash-based geopolymer binders include a combination of fly ash, silica fume, and sodium hydroxide as well as an amount of Portland cement. Concretes formed of the binders can exhibit excellent compressive strength and fuel energy characteristics as well as being more cost efficient as compared to other concretes. The inclusion of an amount of Portland cement in the binders can allow for a decrease in sodium hydroxide and silica fume content while maintaining desirable compressive strength characteristics.

公开(公告)号：US20200278282A1

公开(公告)日：2020-09-03

申请号：US16805926

申请日：2020-03-02

Applicant: University of South Carolina

Inventor： Alaa Alsharaballi

IPC: G01N3/08 ,  G01N3/06

Abstract: Novel markers that can be attached physically to a tensile specimen with a center guide to allow for measuring correct strain, as well as a binder that fixes and holds a pin guide to its location on the specimen during the test.

公开(公告)号：US10737948B2

公开(公告)日：2020-08-11

申请号：US16561190

申请日：2019-09-05

Applicant: University of South Carolina ,  National Institute For Materials Science

Inventor： Hans-Conrad Zur Loye ,  Yoshihiro Tsujimoto

IPC: C01G9/00 ,  B01J2/22 ,  G02F1/355 ,  G02F1/37

Abstract: Single crystals of a new noncentrosymmetric polar oxysulfide SrZn2S2O (s.g. Pmn21) grown in a eutectic KF—KCl flux with unusual wurtzite-like slabs consisting of close-packed corrugated double layers of ZnS3O tetrahedra vertically separated from each other by Sr atoms and methods of making same.