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公开(公告)号：US20190284612A1
公开(公告)日：2019-09-19
申请号：US16363671
申请日：2019-03-25
Applicant: Gen-Probe Incorporated
Inventor： David A. BUSE , David Opalsky , Jason F. Rhubottom , Norbert D. Hagen , Jennifer L. Tidd
IPC: C12Q1/6806 , C12Q1/686 , B01L7/00 , B01L3/00 , G01N35/04
Abstract: An automated method for analyzing a plurality of samples within a housing of a self-contained system. The system is loaded with a plurality of samples, after which a first assay is performed on a first sample subset and a second assay performed on a second sample subset. The two assays include exposing the samples to a target capture reagent having a solid support for directly or indirectly immobilizing a target nucleic acid that may be present in one or more of the samples. The two assays may be performed with the same or different target capture reagents and target nucleic acids, but the receptacles for performing the exposing step have substantially identical geometries. Following the exposing step, an amplification reaction for amplifying a region of the target nucleic acid is performed with each sample. The amplification reactions of the two assays are performed in receptacles having different geometries.
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公开(公告)号：US10132821B2
公开(公告)日：2018-11-20
申请号：US15054943
申请日：2016-02-26
Applicant: GEN-PROBE INCORPORATED
Inventor： Rolf Silbert , David Opalsky , David Aaron Buse , Robert J. Rosati , Olev Tammer , Richard Capella , Matthias Merten
Abstract: The present invention provides a processing station for automatically processing a biological sample, a system for automated real-time inventory control of consumables within a biological sample handling or assay instrument, a high throughput random access automated instrument for processing biological samples, an automated instrument for processing or analysis of a sample, and processes for automated mucoid detection and elimination. Methods of using the disclosed instruments, mucoid detection processes, and systems to process and/or analyze samples are also disclosed.
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公开(公告)号：US10120136B2
公开(公告)日：2018-11-06
申请号：US15287358
申请日：2016-10-06
Applicant: GEN-PROBE INCORPORATED
Inventor： Norbert D. Hagen , David Opalsky
Abstract: An indexing signal detection module is configured to index one or more signal detectors past each of a plurality of sources of detectable signal emissions to detect or measure a signal emitted by each source. A plurality of signal transmission conduits transmit signal emitted by the sources from a first end of each conduit to a second end of each conduit where the signal may be detected by a signal detector. A conduit reformatter is configured to secure the first ends of the respective signal transmission conduits in a first spatial arrangement corresponding to a spatial arrangement of the signal emission sources and to secure the second ends of the respective signal transmission conduits in a second spatial arrangement different from the first spatial arrangement.
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公开(公告)号：US20180298427A1
公开(公告)日：2018-10-18
申请号：US16016152
申请日：2018-06-22
Applicant: Gen-Probe Incorporated
Inventor： David A. BUSE , David Opalsky , Jason F. Rhubottom , Norbert D. Hagen , Jennifer L. Tidd
IPC: C12Q1/6806 , C12Q1/686 , B01L7/00 , G01N35/04 , B01L3/00
Abstract: One or more temperature cycles are applied to the contents of a processing vial closed by an interlocked cap within a thermal cycler. The processing vial and the interlocked cap are transferred from the thermal cycler to a storage compartment within the instrument with a transfer mechanism with a probe engaged with the cap. In the storage compartment, the processing vial and interlocked cap are moved to an access opening in the instrument and are removed from the instrument through the access opening.
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Patent Agency Ranking
85.发明申请公开(公告)号：US20180230517A1
公开(公告)日：2018-08-16
申请号：US15951818
申请日：2018-04-12
Applicant: Gen-Probe Incorporated
Inventor： David Buse , David Howard Combs , Norbert D. Hagen , David Opalsky , Bruce Richardson , Anita Prasad , Keith Moravick , Tyler Moore
Abstract: First and second sets of receptacles containing reagents for first and second amplification reactions, respectively, are placed in first and second receptacle holders, each associated with a thermal element. The receptacles are subjected to different first and second incubation processes resulting in the first and second amplification reactions in each of the first and second sets of receptacles that contain a first or a second target nucleic acid, respectively. The presence or absence of the first or second target nucleic acid, if any, is determined for each receptacle of the first and second sets of receptacles.
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86.发明授权公开(公告)号：US09945780B2
公开(公告)日：2018-04-17
申请号：US13912525
申请日：2013-06-07
Applicant: GEN-PROBE INCORPORATED
Inventor： Haitao Li , David Opalsky , R. Eric Heinz , Norbert D. Hagen
CPC classification number: G01N21/645 , G01N21/276
Abstract: A System and method for self-checking a fluorometer for failure or deteriorated performance includes fluorescent reference standards mounted on a support to move with respect to one or more fixed fluorometers. The intensity of the fluorescent emission of the fluorescent reference standard is initially measured with the fluorometer, and, after a prescribed interval of usage of the fluorometer, a test measurement of the intensity of the fluorescent emission of the fluorescent standard is taken with the fluorometer. The test measurement is compared to the initial measurement, and failure or deteriorated performance of the fluorometer is determined based on a deviation of the test measurement from the initial measurement.
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公开(公告)号：US09724693B2
公开(公告)日：2017-08-08
申请号：US14669531
申请日：2015-03-26
Applicant: GEN-PROBE INCORPORATED
Inventor： Norbert D. Hagen , Byron J. Knight , David Opalsky
IPC: B03C1/06 , B01L3/00 , G01N35/00 , B03C1/033 , B03C1/28 , B65B3/04 , B03C1/12 , B03C1/14 , B01L9/00 , B25J11/00 , C12N15/10
CPC classification number: B01L3/52 , B01L3/561 , B01L9/52 , B01L2300/0609 , B01L2300/12 , B03C1/0332 , B03C1/12 , B03C1/14 , B03C1/28 , B03C1/286 , B03C1/288 , B03C2201/18 , B03C2201/26 , B25J11/00 , B65B3/04 , C12N15/1013 , G01N35/0098 , Y10T29/49815
Abstract: Methods, systems, and apparatus are provided for automated isolation of selected analytes, to which magnetically-responsive solid supports are bound, from other components of a sample. An apparatus for performing an automated magnetic separation procedure includes a mechanism for effecting linear movement of a magnet between operative and non-operative positions with respect to a receptacle device. A receptacle holding station within which a receptacle device may be temporarily stored prior to moving the receptacle to the apparatus for performing magnetic separation includes magnets for applying a magnetic field to the receptacle device held therein, thereby drawing at least a portion of the magnetically-responsive solid supports out of suspension before the receptacle device is moved to the magnetic separation station. An automated receptacle transport mechanism moves the receptacle devices between the apparatus for performing magnetic separation and the receptacle holding station.
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公开(公告)号：US09465161B2
公开(公告)日：2016-10-11
申请号：US14200460
申请日：2014-03-07
Applicant: GEN-PROBE INCORPORATED
Inventor： Norbert D. Hagen , David Opalsky
CPC classification number: G02B6/3668 , G01N21/253 , G01N21/6452 , G01N2021/6484 , G02B6/06 , G02B6/08 , G02B6/3672 , G02B6/4214 , G02B6/4246 , G02B6/4269
Abstract: An indexing signal detection module is configured to index one or more signal detectors past each of a plurality of sources of detectable signal emissions to detect or measure a signal emitted by each source. A plurality of signal transmission conduits transmit signal emitted by the sources from a first end of each conduit to a second end of each conduit where the signal may be detected by a signal detector. A conduit reformatter is configured to secure the first ends of the respective signal transmission conduits in a first spatial arrangement corresponding to a spatial arrangement of the signal emission sources and to secure the second ends of the respective signal transmission conduits in a second spatial arrangement different from the first spatial arrangement.
Abstract translation: 索引信号检测模块被配置为将一个或多个信号检测器转移到多个可检测信号发射源中的每一个上，以检测或测量由每个源发射的信号。 多个信号传输管道将源发射的信号从每个管道的第一端传送到每个管道的第二端，其中信号可由信号检测器检测。 导管重新配置器被配置为以对应于信号发射源的空间布置的第一空间布置来固定各个信号传输导管的第一端，并且将相应的信号传输导管的第二端固定在不同于 第一个空间安排。
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公开(公告)号：US09393565B2
公开(公告)日：2016-07-19
申请号：US14487580
申请日：2014-09-16
Applicant: GEN-PROBE INCORPORATED
Inventor： Norbert D. Hagen , Byron J. Knight , David Opalsky
IPC: B03C1/06 , B01L3/00 , G01N35/00 , B03C1/033 , B03C1/28 , B65B3/04 , B03C1/12 , B03C1/14 , B01L9/00 , B25J11/00
CPC classification number: B01L3/52 , B01L3/561 , B01L9/52 , B01L2300/0609 , B01L2300/12 , B03C1/0332 , B03C1/12 , B03C1/14 , B03C1/28 , B03C1/286 , B03C1/288 , B03C2201/18 , B03C2201/26 , B25J11/00 , B65B3/04 , C12N15/1013 , G01N35/0098 , Y10T29/49815
Abstract: Methods, systems, and apparatus are provided for automated isolation of selected analytes, to which magnetically-responsive solid supports are bound, from other components of a sample. An apparatus for performing an automated magnetic separation procedure includes a mechanism for effecting linear movement of a magnet between operative and non-operative positions with respect to a receptacle device. A receptacle holding station within which a receptacle device may be temporarily stored prior to moving the receptacle to the apparatus for performing magnetic separation includes magnets for applying a magnetic field to the receptacle device held therein, thereby drawing at least a proton of the magnetically-responsive solid supports out of suspension before the receptacle device is moved to the magnetic separation station. An automated receptacle transport mechanism moves the receptacle devices between the apparatus for performing magnetic separation and the receptacle holding station.
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