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公开(公告)号：US07095297B2
公开(公告)日：2006-08-22
申请号：US10291633
申请日：2002-11-12
Applicant: Yong Ping Xu , Wai Hoong Sun , Xiaofeng Wang , Zhe Wang , Sean Ian Saxon Liw
Inventor： Yong Ping Xu , Wai Hoong Sun , Xiaofeng Wang , Zhe Wang , Sean Ian Saxon Liw
CPC classification number: H03H9/02433 , H03H9/02818
Abstract: A cancellation circuit to remove the anti-resonance signal from a resonator. Micro-mechanical and surface and bulk acoustic wave resonators include an anti-resonance in an output signal. This has an undesirable effect on certain types of systems in their function and performance. An anti-resonance cancellation circuit removes the anti-resonance from the output of the resonators by providing a signal which is subtracted from the output of the resonator. The cancellation circuit includes a capacitor which is matched to the static capacitance of the resonator. The loads of the resonator and cancellation network are also matched.
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公开(公告)号：US20050187169A1
公开(公告)日：2005-08-25
申请号：US11029640
申请日：2005-01-05
IPC: A61K31/70 , A61K31/7048 , C07H17/08
CPC classification number: C07H17/08
Abstract: The present invention discloses compounds of formulaes I, II, III, or IV, or a racemate, enantiomer, regioisomer, salt, ester or prodrug thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
Abstract translation: 本发明公开了式I，II，III或IV的化合物或其外消旋体，对映异构体，区域异构体，盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。
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公开(公告)号：US20050118822A1
公开(公告)日：2005-06-02
申请号：US11032800
申请日：2005-01-11
Applicant: Zhe Wang , Qingxin Zhang , Pang Foo , Han Feng
Inventor： Zhe Wang , Qingxin Zhang , Pang Foo , Han Feng
IPC: H01L21/00 , H01L21/306 , H01L21/302 , H01L21/461
CPC classification number: H01L21/67086 , H01L21/30608 , H01L21/6708
Abstract: When using hot alkaline etchants such as KOH, the wafer front side, where various devices and/or circuits are located, must be isolated from any contact with the etchant. This has been achieved by using two chambers that are separated from each other by the wafer that is to be etched. Etching solution in one chamber is in contact with the wafer's back surface while deionized water in the other chamber contacts the front surface. The relative liquid pressures in the chambers is arranged to be slightly higher in the chamber of the front surface so that leakage of etchant through a pin hole from back surface to front surface does not occur. As a further precaution, a monitor to detect the etchant is located in the DI water so that, if need be, etching can be terminated before irreparable damage is done.
Abstract translation: 当使用诸如KOH的热碱性蚀刻剂时，其中各种装置和/或电路所在的晶片正面必须与与蚀刻剂的任何接触隔离。 这是通过使用被待蚀刻的晶片彼此分离的两个室来实现的。 一个室中的蚀刻溶液与晶片的背面接触，而另一个室中的去离子水接触前表面。 腔室中的相对液体压力被布置为在前表面的腔室中略高，使得蚀刻剂不会通过针孔从背表面泄漏到前表面。 作为进一步的预防措施，用于检测蚀刻剂的监测器位于去离子水中，使得如果需要，可以在不可修复的损伤完成之前终止蚀刻。
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公开(公告)号：US06359164B1
公开(公告)日：2002-03-19
申请号：US09408132
申请日：1999-09-30
Applicant: Zhe Wang , Joseph M. Fortunak
Inventor： Zhe Wang , Joseph M. Fortunak
IPC: C07C500
CPC classification number: C07C17/00 , C07C13/04 , C07C17/263 , C07C2601/02 , C07C22/00
Abstract: The present invention relates generally to novel methods for the preparation of cyclopropylacetylene which is an essential reagent in the asymmetric synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one; a useful human immunodeficiency virus (HIV) reverse transcriptase inhibitor with superior anti-retroviral activity. In the process, for example, cyclopropane carboxaldehyde is alkylated to form 1,1,1-trichloro-2-cyclopropyl-ethanol; which in turn undergoes elimination to form 1,1-dichloro-2-cyclopropyl-ethene; which in turn undergoes elimination to form cyclopropyl acetylene.
Abstract translation: 本发明一般涉及制备环丙基乙炔的新方法，它是不对称合成（S）-6-氯-4-环丙基乙炔基-4-三氟甲基-1,4-二氢-2H-3,1 苯并恶嗪-2-酮; 有效的人类免疫缺陷病毒（HIV）逆转录酶抑制剂具有优异的抗逆转录病毒活性。 在此过程中，例如将环丙烷甲醛烷基化形成1,1,1-三氯-2-环丙基 - 乙醇; 其又进行消除以形成1,1-二氯-2-环丙基 - 乙烯; 其又进行消除以形成环丙基乙炔。
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公开(公告)号：US06297410B1
公开(公告)日：2001-10-02
申请号：US09481812
申请日：2000-01-12
Applicant: Joseph M. Fortunak , Zhe Wang , Jianguo Yin
Inventor： Joseph M. Fortunak , Zhe Wang , Jianguo Yin
IPC: C07C202
CPC classification number: C07C51/353 , C07C1/30 , C07C13/04 , C07C17/093 , C07C51/38 , C07C2601/02 , C07C2601/04 , C07C22/00 , C07C57/26
Abstract: The present invention relates generally to novel methods for the synthesis of cyclopropylacetylene which is an essential reagent in the asymmetric synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one; a useful human immunodeficiency virus (HIV) reverse transcriptase inhibitor. In the process, cyclopropane carboxaldehyde is condensed with malonic acid to form 3-cyclopropylacrylic acid; 3-cyclopropylacrylic acid is halogenated to form (E,Z)-1-halo-2-cyclopropylethylene; and (E,Z)-1-halo-2-cyclopropylethylene is dehydrohalogenated to form cyclopropyl acetylene. This improvement provides for high conversion of inexpensive, readily available starting materials into cyclopropylacetylene, high overall yields and can be conducted on an industrial scale.
Abstract translation: 本发明一般涉及用于合成环己基乙炔的新方法，其是不对称合成（S）-6-氯-4-环丙基乙炔基-4-三氟甲基-1,4-二氢-2H-3,1 苯并恶嗪-2-酮; 一种有用的人类免疫缺陷病毒（HIV）逆转录酶抑制剂。 在此过程中，环丙烷甲醛与丙二酸缩合形成3-环丙基丙烯酸; 将3-环丙基丙烯酸卤化形成（E，Z）-1-卤代-2-环丙基乙烯; 和（E，Z）-1-卤代-2-环丙基乙烯脱卤化氢形成环丙基乙炔。 这种改进提供了廉价的，容易获得的起始原料转化成环丙基乙炔的高转化率，高的总收率并且可以在工业规模上进行。
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Patent Agency Ranking
公开(公告)号：US09150971B2
公开(公告)日：2015-10-06
申请号：US13597071
申请日：2012-08-28
Applicant: Xiangqun Zeng , Zhe Wang
Inventor： Xiangqun Zeng , Zhe Wang
IPC: C07C27/10 , C07C29/10 , C07C35/00 , C07C29/00 , C07C31/00 , C07C31/02 , C07C33/00 , C07C27/00 , C25B3/02 , C25B3/00 , C25B9/08
Abstract: An aerobic method for oxidizing an alkane is disclosed herein. At least a portion of a surface of a platinum working electrode is activated at an interface between the platinum working electrode and an ionic liquid electrolyte (i.e., 1-ethyl-1-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide, 1-propyl-1-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide, 1-butyl-1-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide, 1-pentyl-1-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide, 1-hexyl-1-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide, 1-heptyl-1-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide, 1-octyl-1-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide, 1-nonyl-1-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide, and 1-decyl-1-methylpyrrolidinium bis(trifluoromethylsulfonyl)imidem, and combinations thereof). An interface complex is formed at the interface. An alkane gas is supplied to the interface. The alkane adsorbs at or near the interface complex. The alkane gas in the presence of oxygen is supplied to the interface. While the alkane gas in the presence of oxygen is supplied to the interface, a positive electrode potential is applied to the platinum working electrode, which causes a reactive oxygen species formed at the interface to catalyze oxidation of the adsorbed alkane to form a reaction product.
Abstract translation: 本文公开了一种用于氧化烷烃的好氧方法。 铂工作电极的至少一部分表面在铂工作电极和离子液体电解质（即，1-乙基-1-甲基吡咯烷鎓双（三氟甲基磺酰基）酰亚胺，1-丙基-1-甲基吡咯烷鎓 （三氟甲基磺酰基）酰亚胺，双（三氟甲基磺酰基）酰亚胺，1-戊基-1-甲基吡咯烷鎓双（三氟甲基磺酰基）酰亚胺，1-己基-1-甲基吡咯烷鎓双（三氟甲基磺酰基）酰亚胺，1-庚基-1 （三氟甲基磺酰基）酰亚胺，1-辛基-1-甲基吡咯烷鎓双（三氟甲基磺酰基）酰亚胺，1-壬基-1-甲基吡咯烷鎓双（三氟甲基磺酰基）酰亚胺和1-癸基-1-甲基吡咯烷鎓双（三氟甲磺酰基）亚胺，以及组合 ）。 在接口上形成接口复合体。 烷烃气体被供应到界面。 烷烃在界面络合物处或附近吸附。 在存在氧气的情况下将烷烃气体供应给界面。 当在存在氧气的情况下将烷烃气体供应到界面时，将正极电位施加到铂工作电极，这导致在界面处形成的活性氧物质催化吸附的烷烃的氧化以形成反应产物。
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公开(公告)号：US09108840B2
公开(公告)日：2015-08-18
申请号：US13581823
申请日：2010-12-30
Applicant: Zhe Wang , Qinglin Song , Shengli Pang , Fanghui Gu
Inventor： Zhe Wang , Qinglin Song , Shengli Pang , Fanghui Gu
CPC classification number: B81B3/0018 , B81B2201/0257 , B81B2207/015 , B81C1/00158 , B81C1/00246 , H04R1/021 , H04R19/005 , H04R31/00 , H04R2201/003
Abstract: The present invention relates to a MEMS microphone and a method of manufacturing the same, the MEMS microphone comprising: a monolithic silicon chip incorporating an acoustic sensing element and one or more conditioning CMOS integrated circuits; a silicon-based carrier chip having an acoustic cavity; a substrate for surface mounting the assembly of the monolithic chip and the silicon-based carrier chip thereon; a conductive cover attached and electrically connected to the substrate to accommodates the assembly of the monolithic chip and the silicon-based carrier chip; and an acoustic port formed on either the conductive cover or the substrate for an external acoustic wave to reach the acoustic sensing element, wherein the monolithic silicon chip, the silicon-based carrier chip and the acoustic port are configured in such a way that the diaphragm of the acoustic sensing element can be vibrated by the external sound wave from one side thereof.
Abstract translation: MEMS麦克风及其制造方法技术领域本发明涉及一种MEMS麦克风及其制造方法，该MEMS麦克风包括：包含声学感测元件和一个或多个调节CMOS集成电路的单片硅芯片; 具有声腔的硅基载体芯片; 用于将单片芯片和硅基载体芯片的组件表面安装在其上的基板; 导电盖，其附接并电连接到所述基板以容纳所述单片芯片和所述硅基载体芯片的组装; 以及形成在导电盖或用于外部声波的基板上的声波端口到达声学感测元件，其中单片硅芯片，硅基载体芯片和声学端口被构造成使得隔膜 的声学传感元件可以通过外部声波从其一侧振动。
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公开(公告)号：US08962551B2
公开(公告)日：2015-02-24
申请号：US12327538
申请日：2008-12-03
Applicant: Deqiang Niu , Dong Liu , Joel D. Moore , Guoyou Xu , Ying Sun , Yonghua Gai , Datong Tang , Yat Sun Or , Zhe Wang
Inventor： Deqiang Niu , Dong Liu , Joel D. Moore , Guoyou Xu , Ying Sun , Yonghua Gai , Datong Tang , Yat Sun Or , Zhe Wang
CPC classification number: C07D487/04 , A61K38/212 , A61K38/215 , C07K5/06165 , C07K5/0812 , A61K2300/00
Abstract: The present invention relates to compounds of Formula I or II, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising a compound of the present invention.
Abstract translation: 本发明涉及式I或II的化合物或其药学上可接受的盐，酯或前药：其抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。 因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。 本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。
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89.发明授权公开(公告)号：US08847289B2
公开(公告)日：2014-09-30
申请号：US13581499
申请日：2010-07-28
Applicant: Zhe Wang
Inventor： Zhe Wang
CPC classification number: H04R31/00 , B81B2201/0221 , B81B2201/0257 , B81B2207/015 , B81C1/00246 , B81C2203/0714 , B81C2203/0735 , H04R19/005 , H04R19/04
Abstract: A CMOS compatible MEMS microphone is disclosed. In one embodiment, the microphone comprises an SOI substrate, wherein a CMOS circuitry is accommodated on its silicon device layer; a microphone diaphragm formed with a part of the silicon device layer, wherein the microphone diaphragm is doped to become conductive; a microphone backplate including CMOS passivation layers with a metal layer sandwiched and a plurality of through holes, provided above the silicon device layer, wherein the plurality of through holes are formed in the portion thereof opposite to the microphone diaphragm, and the metal layer forms an electrode plate of the backplate; a plurality of dimples protruding from the lower surface of the microphone backplate opposite to the diaphragm; and an air gap provided between the diaphragm and the microphone backplate.
Abstract translation: 公开了一种CMOS兼容的MEMS麦克风。 在一个实施例中，麦克风包括SOI衬底，其中CMOS电路容纳在其硅器件层上; 形成有硅器件层的一部分的麦克风隔膜，其中所述麦克风隔膜被掺杂以变成导电; 麦克风背板，包括设置在硅器件层上方的金属层的CMOS钝化层和多个通孔，其中多个通孔形成在与麦克风隔膜相对的部分中，金属层形成 背板电极板; 从所述麦克风背板的与所述隔膜相对的下表面突出的多个凹坑; 以及设置在隔膜和麦克风背板之间的气隙。
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公开(公告)号：US08835376B2
公开(公告)日：2014-09-16
申请号：US13120146
申请日：2009-09-24
Applicant: Zhigang Shen , Jimmy Sung Lai Yun , Jun Hu , Nital Arvind Jugade , Jiyao Zhang , Wenhao Chen , Zhe Wang , Lingyan Gao , William Glover , Jian Feng Chen
Inventor： Zhigang Shen , Jimmy Sung Lai Yun , Jun Hu , Nital Arvind Jugade , Jiyao Zhang , Wenhao Chen , Zhe Wang , Lingyan Gao , William Glover , Jian Feng Chen
IPC: A61K38/02 , A61K31/216 , A61K31/513 , A61K31/546 , A61K38/13 , A61K31/357 , A61K31/57 , A61K31/7052 , A61K31/277 , A61K31/197 , A61K47/38 , A61K47/24 , B01J2/06 , A61K9/16 , A61K9/20 , A61K9/14 , B01J19/00
CPC classification number: A61K9/14 , A61K9/1623 , A61K9/1652 , A61K9/1694 , A61K9/2077 , B01J2/06 , B01J19/0093 , B01J2219/00788 , B01J2219/00889
Abstract: A process for making particles for delivery of drug nanoparticles is disclosed herein. The process comprises the steps of (a) forming a suspension of drug nanoparticles by mixing a precipitant solution with an anti-solvent solution under micro-mixing environment, where the formed nanoparticles have a narrow particle size distribution; (b) providing an excipient to at least one of the precipitant solution, the anti-solvent solution and the suspension of drug nanoparticles, the excipient being selected to maintain said drug nanoparticles in a dispersed state when in liquid form; and (c) drying the suspension of drug nanoparticles containing the excipient therein to remove solvent therefrom, wherein removal of the solvent causes the excipient to solidify and thereby form micro-sized matrix particles, each micro-sized particle being comprised of drug nanoparticles dispersed in a solid matrix of the excipient.
Abstract translation: 本文公开了用于制备用于递送药物纳米颗粒的颗粒的方法。 该方法包括以下步骤：（a）通过在微混合环境下将沉淀剂溶液与抗溶剂溶液混合形成药物纳米颗粒的悬浮液，其中所形成的纳米颗粒具有窄的粒度分布; （b）向沉淀剂溶液，抗溶剂溶液和药物纳米颗粒的悬浮液中的至少一种提供赋形剂，所述赋形剂被选择为当液体形式时将所述药物纳米颗粒维持在分散状态; 和（c）干燥其中含有赋形剂的药物纳米颗粒的悬浮液以从其中除去溶剂，其中去除溶剂导致赋形剂固化，从而形成微尺寸的基质颗粒，每个微尺寸颗粒由分散在 赋形剂的固体基质。
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