公开(公告)号：US20230263443A1

公开(公告)日：2023-08-24

申请号：US18308382

申请日：2023-04-27

Applicant: Medtronic Ireland Manufacturing Unlimited Company

Inventor： Abhijeet Dubhashi

IPC: A61B5/20 ,  A61B5/021 ,  A61B5/00 ,  G06N3/08

CPC classification number: A61B5/201 ,  A61B5/02108 ,  A61B5/6824 ,  A61B5/7267 ,  G06N3/08 ,  G16H10/60

Abstract: Example devices, systems, and techniques predict renal denervation efficacy for reducing hypertension in a patient based on pulse information. For example, a system may include processing circuitry configured to obtain pulse information representative of pulses from both wrists of a patient, obtain a plurality of values representative of respective patient metrics for the patient, and apply the pulse information and the plurality of values to a deep learning model trained to represent a relationship of the pulse information and the patient metrics to an efficacy of renal denervation in reducing hypertension. In some examples, responsive to applying the pulse information and the plurality of values to the deep learning model, the processing circuitry obtains, from the deep learning model, a score indicative of renal denervation efficacy in reducing hypertension for the patient, and generates a graphical user interface comprising a graphical representation of the score for the patient.

公开(公告)号：US20230173111A1

公开(公告)日：2023-06-08

申请号：US18162163

申请日：2023-01-31

Applicant: MediBeacon Inc.

Inventor： Martin P. Debreczeny ,  Raghavan Rajagopalan ,  Richard B. Dorshow ,  William L. Neumann ,  Thomas E. Rogers

IPC: A61K49/00 ,  C07D241/26 ,  A61B5/20 ,  A61B5/00 ,  C09B57/00

CPC classification number: A61K49/0021 ,  C07D241/26 ,  A61B5/201 ,  A61B5/7203 ,  A61B5/6815 ,  A61B5/0071 ,  A61K49/0054 ,  C09B57/00 ,  A61K49/0004 ,  A61B5/1495

Abstract: The present disclosure relates to systems and methods for determining the renal glomerular filtration rate or assessing the renal function in a patient in need thereof. The system includes a computing device, a power supply, one or more sensors, and at least one tracer agent that fluoresces when exposed to electromagnetic radiation. The electromagnetic radiation is detected using the sensors, and the rate in which the fluorescence decreases in the patient is used to calculate the renal glomerular filtration rate in the patient.

公开(公告)号：US11642061B2

公开(公告)日：2023-05-09

申请号：US16517180

申请日：2019-07-19

Applicant: RECOR MEDICAL, INC.

Inventor： Jin Shimada ,  Harry A. Puryear

IPC: A61B5/24 ,  A61B5/00 ,  A61B18/14 ,  A61B5/20 ,  A61N1/18 ,  A61B18/18 ,  A61B18/00 ,  A61B18/12 ,  A61B18/16

CPC classification number: A61B5/24 ,  A61B5/201 ,  A61B5/4836 ,  A61B5/725 ,  A61B18/1492 ,  A61B18/1815 ,  A61N1/18 ,  A61B2018/00023 ,  A61B2018/00267 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00839 ,  A61B2018/126 ,  A61B2018/1253 ,  A61B2018/1407 ,  A61B2018/1467 ,  A61B2018/162 ,  A61B2018/1861 ,  A61B2562/028

Abstract: An intraluminal microneurography probe has a probe body configured to be introduced into an artery near an organ of a body without preventing the flow of blood through the artery. An expandable sense electrode and an expandable stimulation electrode are fixed to the probe body at one end of each electrode such that movement of the other end toward the fixed end causes the sense electrode to expand from the probe body toward a wall of the artery. A ground electrode is configured to couple to the body, and a plurality of electrical connections are operable to electrically couple the electrodes to electrical circuitry. The sense electrode is operable to measure sympathetic nerve activity in response to excitation of the stimulation electrode. A radio frequency ablation element is located between the expandable sense electrode and expandable stimulation electrode, and is operable to ablate nerves proximate to the artery.

公开(公告)号：US20190183400A1

公开(公告)日：2019-06-20

申请号：US15843199

申请日：2017-12-15

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION

Inventor： Hariklia Deligianni ,  Stephen W. Bedell ,  Bruce B. Doris

IPC: A61B5/20 ,  H04N5/225 ,  H04N5/374 ,  H04N5/232 ,  G06T7/00 ,  A61B1/00 ,  A61B1/04 ,  A61B1/307 ,  A61B5/07 ,  A61B5/00 ,  A61B17/22

CPC classification number: A61B5/201 ,  A61B1/00009 ,  A61B1/00016 ,  A61B1/0002 ,  A61B1/00045 ,  A61B1/00156 ,  A61B1/041 ,  A61B1/307 ,  A61B5/07 ,  A61B5/4836 ,  A61B5/7264 ,  A61B5/7282 ,  A61B17/22012 ,  A61B2017/00057 ,  A61B2017/0011 ,  A61B2017/00734 ,  F03G3/00 ,  G06T7/0014 ,  G06T2207/30084 ,  G16H40/63 ,  H04N5/2256 ,  H04N5/23293 ,  H04N5/374 ,  H04N2005/2255

Abstract: A cognitive urinary tract microcomputer is provided. The cognitive urinary tract microcomputer includes a propulsion device for moving the cognitive urinary tract microcomputer through a urinary tract. The cognitive urinary tract microcomputer further includes an image sensor for capturing images of the urinary tract. The cognitive urinary tract microcomputer also includes a computer having an image processor and a memory. The memory stores a cognitive algorithm executed by the image processor for comparing images of normal urinary tract segments to the captured images to detect abnormalities in the urinary tract and provide an indication of the abnormalities to a user.

公开(公告)号：US20180125407A1

公开(公告)日：2018-05-10

申请号：US15861299

申请日：2018-01-03

Applicant: MediBeacon Inc.

Inventor： Norbert Gretz ,  Johannes Pill ,  Daniel Schock-Kusch ,  Thomas Walter ,  Jürgen Hesser ,  Maliha Sadick ,  Felix Eickemeyer ,  Jae Hyung Hwang ,  Christian Schildknecht ,  Soichi Watanabe ,  Wolfgang Wach ,  Thomas Rose

IPC: A61B5/20 ,  A61K49/00 ,  A61B5/00 ,  A61B5/1455 ,  A61B5/145

CPC classification number: A61B5/201 ,  A61B5/0002 ,  A61B5/0071 ,  A61B5/0082 ,  A61B5/145 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/6833 ,  A61B5/68335 ,  A61B90/39 ,  A61B2090/3941 ,  A61B2560/0219 ,  A61B2560/0412 ,  A61K49/0043 ,  G01N33/582 ,  G01N2800/065 ,  G01N2800/28 ,  G01N2800/347

Abstract: A sensor plaster (116) for the transcutaneous measurement of an organ function, more particularly of a kidney function, is proposed. The sensor plaster (116) comprises at least one flexible carrier element (134) having at least one adhesive surface (138) which can be stuck onto a body surface. Furthermore, the sensor plaster (116) comprises at least one radiation source, more particularly a light source (142), wherein the radiation source is designed to irradiate the body surface with at least one interrogation light (162). Furthermore, the sensor plaster (116) comprises at least one detector (146) designed to detect at least one response light (176) incident from the direction of the body surface.

公开(公告)号：US09949652B2

公开(公告)日：2018-04-24

申请号：US14963179

申请日：2015-12-08

Applicant: Ablative Solutions, Inc.

Inventor： David R. Fischell ,  Tim A. Fischell ,  Vartan Ghazarossian ,  Steven Almany ,  Michael Sasha John

IPC: A61B3/02 ,  A61B5/04 ,  A61M31/00 ,  A61B5/00 ,  A61B18/14 ,  A61B17/32 ,  A61B5/20 ,  A61B18/18 ,  A61B18/00 ,  A61B18/02 ,  A61B18/04 ,  A61M25/00 ,  A61B90/00 ,  A61B18/12 ,  A61B17/00

CPC classification number: A61B5/04001 ,  A61B5/201 ,  A61B5/4035 ,  A61B5/6848 ,  A61B5/6852 ,  A61B17/320068 ,  A61B18/0218 ,  A61B18/1233 ,  A61B18/1477 ,  A61B18/1492 ,  A61B18/1815 ,  A61B2017/00039 ,  A61B2018/00214 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00541 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00666 ,  A61B2018/00738 ,  A61B2018/00779 ,  A61B2018/00815 ,  A61B2018/00821 ,  A61B2018/00827 ,  A61B2018/00839 ,  A61B2018/00875 ,  A61B2018/00892 ,  A61B2018/00898 ,  A61B2018/00916 ,  A61B2018/0212 ,  A61B2018/046 ,  A61B2018/048 ,  A61B2018/1425 ,  A61B2018/143 ,  A61B2018/1432 ,  A61B2018/1467 ,  A61B2018/1475 ,  A61B2090/376 ,  A61B2090/3966 ,  A61M2025/0095

Abstract: An intravascular catheter for nerve activity ablation and/or sensing includes one or more needles advanced through supported guide tubes (needle guiding elements) which expand to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the extra-luminal tissue including the media, adventitia and periadvential space. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. Electrodes near the distal ends of the needles allow sensing of nerve activity before and after attempted renal denervation. In a combination embodiment ablative energy or fluid is delivered from the needles in or near the adventitia to ablate nerves outside of the media while sparing nerves within the media.

公开(公告)号：US20180098704A1

公开(公告)日：2018-04-12

申请号：US15837388

申请日：2017-12-11

Applicant: Medtronic, Inc.

Inventor： Orhan Soykan ,  VenKatesh R. Manda ,  Martin T. Gerber ,  Christopher M. Hobot ,  Linda L. Ruetz ,  Carl Schu

IPC: A61B5/0205 ,  A61B5/0452 ,  A61B5/00 ,  A61B5/0488 ,  A61B5/145 ,  A61B5/20 ,  B01D61/24 ,  B01D61/32 ,  B01D65/02

CPC classification number: A61B5/0205 ,  A61B5/0031 ,  A61B5/0452 ,  A61B5/0488 ,  A61B5/0537 ,  A61B5/14503 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/201 ,  A61B5/4836 ,  A61B5/6866 ,  A61B5/7275 ,  A61B2560/0223 ,  A61M1/14 ,  A61M1/1601 ,  A61M1/3609 ,  A61M2205/18 ,  A61M2205/3523 ,  A61M2205/52 ,  A61M2205/70 ,  A61M2230/20 ,  A61M2230/207 ,  A61M2230/208 ,  A61M2230/30 ,  B01D61/243 ,  B01D61/32 ,  B01D65/02 ,  B01D2321/12 ,  B01D2321/40 ,  G16H50/30

Abstract: A medical monitoring device for monitoring electrical signals from the body of a subject is described. The medical monitoring device monitors electrical signals originating from a cardiac cycle of the subject and associates each cardiac cycle with a time index. The medical monitoring device applies a forward computational procedure to generate a risk score indicative of hyperkalemia, hypokalemia or arrhythmia of the subject. The medical monitoring device can adjust the forward computational procedure based upon clinical data obtained from the subject.

公开(公告)号：US20180071407A9

公开(公告)日：2018-03-15

申请号：US14488655

申请日：2014-09-17

Applicant: Tal Burt

Inventor： Tal Burt

IPC: A61K49/00 ,  A61B5/00 ,  A61M5/172 ,  A61B5/02 ,  A61B5/20 ,  A61B5/145 ,  A61B5/04 ,  G01N33/50 ,  A61K51/04

CPC classification number: A61K49/0004 ,  A61B5/02007 ,  A61B5/02028 ,  A61B5/04001 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/201 ,  A61B5/4064 ,  A61B5/4244 ,  A61B5/425 ,  A61B5/4848 ,  A61B6/037 ,  A61K51/0491 ,  A61M5/1723 ,  G01N33/5088

Abstract: Systems and methods for intra-target microdosing are disclosed. According to an aspect, a method for intra-target microdosing includes administering a microdose of drug into target tissue within a subject. The method also includes measuring efficacy of the administered drug to the target tissue.

公开(公告)号：US20180042670A1

公开(公告)日：2018-02-15

申请号：US15691768

申请日：2017-08-31

Applicant: SYMAP MEDICAL (SUZHOU), LTD

Inventor： Jie WANG ,  Chuwu LI ,  Bo Zou ,  Jiancong WANG

IPC: A61B18/14 ,  A61B5/20

CPC classification number: A61B18/1492 ,  A61B5/0205 ,  A61B5/0215 ,  A61B5/024 ,  A61B5/04001 ,  A61B5/0538 ,  A61B5/201 ,  A61B5/4833 ,  A61B5/4836 ,  A61B5/4893 ,  A61B5/6852 ,  A61B5/6853 ,  A61B18/18 ,  A61B18/24 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00505 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00708 ,  A61B2018/00791 ,  A61B2018/00839 ,  A61B2018/00875 ,  A61N1/36117 ,  A61N7/02 ,  A61N2007/003 ,  G06F19/00 ,  G16Z99/00

Abstract: This invention provides a device for mapping and ablating the renal nerves distributed on renal artery, having a guide catheter, a mapping-ablation catheter, a handle and a connector. The guide catheter has at least one lumen and a distal end with adjustable curvature. The mapping-ablation catheter is housed in one of the lumens of the guide catheter and its distal end has one or more electrodes and one or more detecting devices. The distal end of the mapping-ablation catheter is curved, rotatable, and can be extended out of or retracted into the guide catheter. The handle connects the guide catheter and mapping-ablation catheter, and has one or more controlling components for controlling the movement of the guide catheter and mapping-ablation catheter. The connector is designed to supply energy to the electrodes.

公开(公告)号：US20170367756A1

公开(公告)日：2017-12-28

申请号：US15630134

申请日：2017-06-22

Applicant: St. Jude Medical, Cardiology Division, Inc.

Inventor： John Sliwa ,  Stephen A. Morse ,  Cary Hata

IPC: A61B18/14 ,  A61N7/02 ,  A61N7/00 ,  A61B5/0215 ,  A61B18/00

CPC classification number: A61B18/1492 ,  A61B5/0215 ,  A61B5/201 ,  A61B5/4836 ,  A61B5/6858 ,  A61B5/6859 ,  A61B2017/00039 ,  A61B2018/00267 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00821 ,  A61B2018/00839 ,  A61B2018/00863 ,  A61B2018/00988 ,  A61B2018/1465 ,  A61B2018/1467 ,  A61N7/02 ,  A61N2007/003

Abstract: The present disclosure provides catheter systems, electrode assemblies, and methods for electrically stimulating one or more points about the circumference of the renal artery to provide real time intraprocedural operational feedback to the operator of a renal denervation procedure to allow for more precise and thorough ablation of the renal artery and better patient outcomes. In many embodiments, an electrode assembly is provided that includes multiple splines that extend from an insulated proximal hub to an insulated distal hub and are interconnected to an electrical wire to allow the splines to independently function as electrical stimulation electrodes. The electrically active splines can then be energized at one or more desired points during a renal denervation procedure to provide operational feedback.