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    DEVICE TO DETECT ANALYTES IN A BIOLOGICAL SAMPLE
    81.
    发明申请
    DEVICE TO DETECT ANALYTES IN A BIOLOGICAL SAMPLE 审中-公开
    在生物样本中检测分析的设备

    公开(公告)号：US20140128293A1

    公开(公告)日：2014-05-08

    申请号：US14153666

    申请日：2014-01-13

    Applicant: Patrizia MELPIGNANO

    Inventor： Patrizia MELPIGNANO

    IPC: G01N33/543 ,  G01N21/64

    CPC classification number: G01N33/54373 ,  B01L3/502715 ,  B01L2300/027 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0825 ,  B01L2300/0851 ,  G01N21/05 ,  G01N21/6454 ,  G01N21/6486 ,  G01N2021/0346 ,  G01N2021/056 ,  G01N2021/6439 ,  G01N2201/0628

    Abstract: Device to detect at least an analyte, comprising a transparent substrate (2), having a first surface (3) with which a light source (7) is associated, and a second surface (4) on which a plurality of biological protein probes (12) are disposed, a layer (6) of polymer being interposed between said second surface (4) and said biological protein probes (12). A marker (fluorophore) is associated with said analyte, having determinate characteristics of fluorescence and/or phosphorescence correlated to the emission wavelength of the light source (7). Said light source (7) is suitable to emit a light radiation in a range of wavelengths equal to 400-550 nm, inside which range the absorption peak of said marker (fluorophore) used is comprised. The value of the distance (“s”) between the wavelength corresponding to the absorption peak of the marker (fluorophore) and the wavelength corresponding to the emission peak of fluorescence (phosphorescence) is comprised between 25 and 150 nm.

    Abstract translation: 用于检测至少一种分析物的装置，包括具有与光源（7）相关联的第一表面（3）的透明基底（2），以及第二表面（4），多个生物蛋白探针（ 12），聚合物层（6）插入在所述第二表面（4）和所述生物蛋白质探针（12）之间。 标记（荧光团）与所述分析物相关联，具有与光源（7）的发射波长相关的荧光和/或磷光的确定特性。 所述光源（7）适于发射在等于400-550nm的波长范围内的光辐射，其中包括所使用的所述标记（荧光团）的吸收峰。 对应于标记（荧光团）的吸收峰的波长与对应于荧光（磷光）的发射峰的波长之间的距离（“s”）的值为25-150nm。

    Integrated test element
    83.
    发明申请
    Integrated test element 失效
    集成测试元件

    公开(公告)号：US20090061076A1

    公开(公告)日：2009-03-05

    申请号：US12231119

    申请日：2008-08-29

    Applicant: Bernd Rosicke ,  Kai Hebestreit ,  Claudia Gassler-Dietsche ,  Frederic Wehowski

    Inventor： Bernd Rosicke ,  Kai Hebestreit ,  Claudia Gassler-Dietsche ,  Frederic Wehowski

    IPC: B05D5/06 ,  G01N21/64 ,  A61B5/00

    CPC classification number: G01N21/8483 ,  G01N21/255 ,  G01N2201/0628

    Abstract: An integrated test element (110) is proposed for detecting for detecting at least one analyte in a sample (142), in particular in a liquid sample (142). The integrated test element (110) has a carrier element (112), with an application face (114) on which at least one organic electroluminescent component (126) is applied. Furthermore, at least one indicator substance (136) is applied on the application face (114), which indicator substance (136) alters at least one optical characteristic, in particular an emission characteristic (e.g. a fluorescence characteristic), when it comes into contact with the at least one analyte. Furthermore, the integrated test element (110) has at least one photodetector element (116).

    Abstract translation: 提出了一种集成测试元件（110），用于检测样品（142）中的至少一种分析物，特别是在液体样品（142）中。 集成测试元件（110）具有载体元件（112），其上施加有至少一个有机电致发光元件（126）的施加面（114）。 此外，在应用面（114）上施加至少一个指示物质（136），该指示物质（136）在接触时改变至少一种光学特性，特别是发射特性（例如荧光特性） 与至少一种分析物。 此外，集成测试元件（110）具有至少一个光电检测元件（116）。

    Electrophoretic system with multi-notch filter and laser excitation source
    84.
    发明授权
    Electrophoretic system with multi-notch filter and laser excitation source 有权
    具有多陷波滤波器和激光源的电泳系统

    公开(公告)号：US07486396B2

    公开(公告)日：2009-02-03

    申请号：US11894829

    申请日：2007-08-22

    Applicant: Mark F. Oldham ,  Eric S. Nordman ,  Richard T. Reel ,  Janice G. Shigeura, legal representative

    Inventor： John S. Shigeura

    IPC: G01N21/00

    CPC classification number: G01N21/6456 ,  B82Y10/00 ,  B82Y20/00 ,  G01N27/44721 ,  G01N2021/6417 ,  G01N2021/6419 ,  G01N2021/6471 ,  G01N2201/0628

    Abstract: Apparatus and methods for detecting analytes in a sample are provided. The apparatus can include: one or more channels having a detection zone; one or more irradiation sources disposed for irradiating the detection zone with radiation; a detector capable of collecting at least one charge corresponding to an emission beam emitted from the detection zone, the detector having an output; and a time delay integration system coupled to the detector for effecting time delay integration of the at least one charge by accumulating the at least one charge before reading the at least one charge at the output of the detector. Various embodiments provide an apparatus with a multi-notch filter. Various embodiments provide a solid state laser, a micro-wire laser, or an organic light-emitting diode as a irradiation source.

    Abstract translation: 提供了用于检测样品中分析物的装置和方法。 该装置可以包括：具有检测区域的一个或多个通道; 设置用于辐射照射检测区域的一个或多个照射源; 检测器，其能够收集对应于从所述检测区域发射的发射光束的至少一个电荷，所述检测器具有输出; 以及耦合到所述检测器的时间延迟积分系统，用于通过在所述检测器的输出读取所述至少一个电荷之前积累所述至少一个电荷来实现所述至少一个电荷的时间延迟积分。 各种实施例提供具有多陷波滤波器的装置。 各种实施例提供固态激光器，微线激光器或有机发光二极管作为照射源。

    Electrophoretic system with multi-notch filter and laser excitation source
    85.
    发明申请
    Electrophoretic system with multi-notch filter and laser excitation source 有权
    具有多陷波滤波器和激光源的电泳系统

    公开(公告)号：US20080043235A1

    公开(公告)日：2008-02-21

    申请号：US11894829

    申请日：2007-08-22

    Applicant: Mark Oldham ,  Eric Nordman ,  Richard Reel ,  John Shigeura ,  Janice Shigeura

    Inventor： Mark Oldham ,  Eric Nordman ,  Richard Reel ,  John Shigeura ,  Janice Shigeura

    IPC: G01N21/00

    CPC classification number: G01N21/6456 ,  B82Y10/00 ,  B82Y20/00 ,  G01N27/44721 ,  G01N2021/6417 ,  G01N2021/6419 ,  G01N2021/6471 ,  G01N2201/0628

    Abstract: Apparatus and methods for detecting analytes in a sample are provided. The apparatus can include: one or more channels having a detection zone; one or more irradiation sources disposed for irradiating the detection zone with radiation; a detector capable of collecting at least one charge corresponding to an emission beam emitted from the detection zone, the detector having an output; and a time delay integration system coupled to the detector for effecting time delay integration of the at least one charge by accumulating the at least one charge before reading the at least one charge at the output of the detector. Various embodiments provide an apparatus with a multi-notch filter. Various embodiments provide a solid state laser, a micro-wire laser, or an organic light-emitting diode as a irradiation source.

    Abstract translation: 提供了用于检测样品中分析物的装置和方法。 该装置可以包括：具有检测区域的一个或多个通道; 设置用于辐射照射检测区域的一个或多个照射源; 检测器，其能够收集对应于从所述检测区域发射的发射光束的至少一个电荷，所述检测器具有输出; 以及耦合到所述检测器的时间延迟积分系统，用于通过在所述检测器的输出读取所述至少一个电荷之前积累所述至少一个电荷来实现所述至少一个电荷的时间延迟积分。 各种实施例提供具有多陷波滤波器的装置。 各种实施例提供固态激光器，微线激光器或有机发光二极管作为照射源。

    Electrophoretic system with multi-notch filter and laser excitation source
    87.
    发明授权
    Electrophoretic system with multi-notch filter and laser excitation source 有权
    具有多陷波滤波器和激光源的电泳系统

    公开(公告)号：US07265833B2

    公开(公告)日：2007-09-04

    申请号：US10887528

    申请日：2004-07-08

    Applicant: Mark F. Oldham ,  Eric S. Nordman ,  Richard T. Reel ,  Janice G. Shigeura, legal representative

    Inventor： John S. Shigeura, deceased

    IPC: G01J3/18

    CPC classification number: G01N21/6456 ,  B82Y10/00 ,  B82Y20/00 ,  G01N27/44721 ,  G01N2021/6417 ,  G01N2021/6419 ,  G01N2021/6471 ,  G01N2201/0628

    Abstract: Apparatus and methods for detecting analytes in a sample are provided. The apparatus can include: one or more channels having a detection zone; one or more irradiation sources disposed for irradiating the detection zone with radiation; a detector capable of collecting at least one charge corresponding to an emission beam emitted from the detection zone, the detector having an output; and a time delay integration system coupled to the detector for effecting time delay integration of the at least one charge by accumulating the at least one charge before reading the at least one charge at the output of the detector. Various embodiments provide an apparatus with a multi-notch filter. Various embodiments provide a solid state laser, a micro-wire laser, or an organic light-emitting diode as a irradiation source.

    Abstract translation: 提供了用于检测样品中分析物的装置和方法。 该装置可以包括：具有检测区域的一个或多个通道; 设置用于辐射照射检测区域的一个或多个照射源; 检测器，其能够收集对应于从所述检测区域发射的发射光束的至少一个电荷，所述检测器具有输出; 以及耦合到所述检测器的时间延迟积分系统，用于通过在所述检测器的输出读取所述至少一个电荷之前积累所述至少一个电荷来实现所述至少一个电荷的时间延迟积分。 各种实施例提供具有多陷波滤波器的装置。 各种实施例提供固态激光器，微线激光器或有机发光二极管作为照射源。

    Sensor having integrated light detector and/or light source
    89.
    发明申请
    Sensor having integrated light detector and/or light source 有权
    具有集成光检测器和/或光源的传感器

    公开(公告)号：US20060132786A1

    公开(公告)日：2006-06-22

    申请号：US11013373

    申请日：2004-12-17

    Applicant: Rene Helbing

    Inventor： Rene Helbing

    IPC: G01N21/47

    CPC classification number: G01N21/77 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B2562/0295 ,  G01N2201/0628

    Abstract: A sensor, such as a lateral flow sensor, which includes a chemical layer and a detector on a flexible substrate. An optical signal is produced in response to an analyte placed on the chemical layer. The detector detects the signal, to thereby detect the presence, absence or concentration of the analyte. The detector is on the substrate. The chemical layer and the substrate are laminated together, to thereby form an integrated sensor. The sensor can include a light source. The light source can be on the substrate, or on an opposite side of the chemical layer than the detector.

    Abstract translation: 传感器，例如横向流量传感器，其包括柔性基板上的化学层和检测器。 响应于放置在化学层上的分析物产生光信号。 检测器检测信号，从而检测分析物的存在，不存在或浓度。 检测器位于基板上。 将化学层和基板层叠在一起，从而形成集成的传感器。 传感器可以包括光源。 光源可以在基板上，或者在化学层的与检测器相反的一侧。

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