Abstract:
A seal mechanism, apparatus and method are suggested for confining a chemical reaction in a reaction vessel that is accessible through a self-sealing diaphragm. A movable plunger is reversibly operable between a retracted position where the diaphragm is accessible for injection and/or extraction of reagents, and an operational position wherein the plunger is controlled to apply an external pressure in direct contact with the self-sealing diaphragm.
Abstract:
The present invention provides a method for the acoustic ejection of fluid droplets from each of a plurality of fluid-containing reservoirs to prepare combinatorial libraries in the form of microarrays. An acoustic ejection device is used comprised of a plurality of fluid reservoirs, an ejector for generating acoustic radiation and focusing the acoustic radiation generated at a focal point sufficiently near the fluid surface in each of the reservoirs such that a fluid droplet is ejected therefrom toward a site on a substrate surface, and a means for positioning the ejector in acoustically coupled relationship to each of the reservoirs. The combinatorial libraries may comprise biological or nonbiological moieties.
Abstract:
Remediation of gases is accomplished by intimately mixing the products of combustion with a minute quantity of ozone to convert pollutants to highly soluble compounds. The resulting gas mixture is then reduced in temperature and the problematic gas constituents are placed into solution. This is accomplished through the use of one or more water spray towers, placed in series with the gas flow. The clean gas is released. The contaminated water is remediated by water treatment methods and apparatuses, such as those employing the CBR Patents.
Abstract:
Fluidic methods and devices for conducting parallel chemical reactions are disclosed. The methods are based on the use of in situ photogenerated reagents such as photogenerated acids, photogenerated bases, or any other suitable chemical compounds that produce active reagents upon light radiation. The present invention describes devices and methods for performing a large number of parallel chemical reactions without the use of a large number of valves, pumps, and other complicated fluidic components. The present invention provides microfluidic devices that contain a plurality of microscopic vessels for carrying out discrete chemical reactions. Other applications may include the preparation of microarrays of DNA and RNA oligonucleotides, peptides, oligosacchrides, phospholipids and other biopolymers on a substrate surface for assessing gene sequence information, screening for biological and chemical activities, identifying intermolecular complex formations, and determining structural features of molecular complexes.
Abstract:
The present invention is directed to an article of footwear and method for making the same, where the article of footwear has a minimal number of upper pieces. The method of the present invention is directed to a process for manufacturing an article of footwear having a single or multiple layer upper. Each layer of the upper according to the present invention is constructed of a one-piece upper material. At least the outer layer of the upper is molded utilizing an embossing tool according to the present invention, such that the desired appearance of the upper is embossed on the outer layer. Additionally, the improved shoe manufacturing process of the present invention may further comprise the step of decorating at least the outer layer of the upper, by screen printing, sublimation, large format ink jet printing, cold and hot peel transfers, fabric dyeing and/or multi-layered digital printing, allowing for multiple or different colorways to be created using a single base color upper material. The tool and process according to the present invention exhibit great flexibility with respect to aesthetics, construction and cost values, allowing for the creation of an unlimited variety of upper appearances with minimal retooling time and costs.
Abstract:
Chemical reaction apparatus, materials and methods are provided for the automatable, efficient synthesis of chemical species and libraries. In accordance with preferred embodiments, chemical droplet generation and direction techniques are employed to prepare oligomers and libraries of chemical species. Reaction assemblies adapted for efficient synthetic employment and for improved collection are also disclosed.
Abstract:
Described herein are methods for separating one or more analytes present in a fluid sample. The methods involve passing the fluid through or into a microporous material, wherein the analytes are localized near the surface of the microporous material. Additional processing steps such as hybridization and amplification can be performed once the analyte is localized. In one method, once the analyte is localized, the analyte can be detected, counted, and correlated in order to determine the concentration of the analyte in the sample. In another method, the localized analyte is destabilized to make the localized analyte more accessible for chemical manipulation. Modified microporous materials and composite materials are also disclosed that can be used in any of the methods and articles described herein. The composite is composed of a microporous material and a pigment, wherein the pigment is incorporated in the microporous material. The pigments alter the optical properties of the microporous material, which enhances the detection of analyte once it is localized. Methods for making pigmented composites are also disclosed. In a further aspect, various kits and articles such as filtration devices containing any of the microporous materials described herein are provided.
Abstract:
The invention relates to device for carrying out a reaction, which device comprises a substrate (2) provided with a well (4) for carrying out the reaction, and a cover means (3). According to the invention the cover means (3) is provided with an aperture (5), which in a first position does not overlap the well (4), while in a second position overlapping the well at least partly. Such a device can be filled in a simple manner and evaporation of liquid from the well (4) is to a large extent prevented. The invention also relates to a method for carrying out a reaction in a device according to the invention.
Abstract:
A chemical reactor includes a pair of substrates joined to each other, a micro flow path is provided between the pair of substrates. An injection section is provided to inject and supply a material to cause a chemical reaction into the flow path.