MICROCAPSULES CONTAINING NATURAL OIL AND PREPARATION METHOD THEREFOR

    公开(公告)号:US20210388314A1

    公开(公告)日:2021-12-16

    申请号:US17283518

    申请日:2019-11-12

    Abstract: The present invention relates to microcapsules comprising natural oil and, more specifically, to microcapsules which contain gelatin, natural polymers, oil, and an oil thickener and have enhanced mechanical properties, and a preparation method therefor. The microcapsules comprising natural oil according to the present invention have remarkably enhanced mechanical properties and retention properties, and when co-cultured with cells, the microcapsules provide the effect of inducing maturation of the cells, and thus may be used in various fields of microcarriers, cell cultures, and co-culture systems.

    DEVICE FOR PRODUCING A DISPERSION, ASSOCIATED ASSEMBLY AND ASSOCIATED METHOD

    公开(公告)号:US20210039059A1

    公开(公告)日:2021-02-11

    申请号:US16964025

    申请日:2019-01-24

    Applicant: CAPSUM

    Abstract: The application relates to a device for producing a dispersion including elements including a first phase, which are dispersed in a continuous phase immiscible with the first phase. The device including at least one production nozzle including a first duct intended to convey a first fluid that forms the first phase, a second duct, coaxially surrounding part of the first duct, able to convey a second fluid that forms the continuous phase, and an outlet. The nozzle is able to form, at the outlet, a fluid jet including the first fluid and the second fluid surrounding the first fluid. The production device additionally includes a fragmentation device for mechanically breaking up the fluid jet, positioned in the vicinity of the outlet of the nozzle, the fragmentation device including a mobile part intended to break up the fluid jet mechanically into a plurality of elements.

    EMULSIONS, METHODS AND USES THEREOF

    公开(公告)号:US20210024883A1

    公开(公告)日:2021-01-28

    申请号:US16647137

    申请日:2018-09-14

    Abstract: The present disclosure relates to emulsions, methods of preparation thereof, and uses of said emulsions to fabricate porous polymeric microspheres as microcarriers for cell culture. In particular, the present disclosure relates to an emulsion with enhanced stability, characterized in that the emulsion comprises a) a water phase, the water phase is an aqueous solution comprising a salt; and b) an oil phase, the oil phase comprising a polymer; wherein the oil phase is immiscible with the water phase, and wherein the density differential of the water phase and oil phase is less than about 0.02 g/cm3. In a preferred embodiment, the polymer is polycaprolactone (PCL).

    Methods and Systems for Forming Microcapsules

    公开(公告)号:US20200078758A1

    公开(公告)日:2020-03-12

    申请号:US16548865

    申请日:2019-08-23

    Abstract: A method for producing microcapsules is disclosed. The method includes providing a core liquid having one or more oils and one or more surfactants and providing a shell liquid including water, one or more surfactants and at least one wall forming material having a glass transition temperature, Tg, greater than 50° C.

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