公开(公告)号：US20180180814A1

公开(公告)日：2018-06-28

申请号：US15886431

申请日：2018-02-01

Applicant: NORTHWESTERN UNIVERSITY ,  AMERICAN BIOOPTICS LLC

Inventor： Vadim Backman ,  Jeremy D. Rogers ,  Nikhil N. Mutyal ,  Bradley Gould ,  Andrew J. Radosevich

IPC: G02B6/26 ,  G02B6/38 ,  A61B5/00 ,  G01N21/47

Abstract: Low-coherence enhanced backscattering (LEBS) spectroscopy is an angular resolved backscattering technique that is sensitive to sub-diffusion light transport length scales in which information about the scattering phase function is preserved. Lens-based and lens-free fiber optic LEBS probes are described that are capable of measuring optical properties of a target tissue through depth-limited measurements of backscattering angles within the enhanced backscattered cone.

公开(公告)号：US20210063644A1

公开(公告)日：2021-03-04

申请号：US16883930

申请日：2020-05-26

Applicant: Northwestern University ,  American BioOptics, LLC

Inventor： Vadim Backman ,  Jeremy D. Rogers ,  Nikhil N. Mutyal ,  Bradley Gould ,  Andrew J. Radosevich ,  The Quyen Nguyen

IPC: G02B6/26 ,  G01N21/47 ,  G02B6/38 ,  A61B5/00

Abstract: Low-coherence enhanced backscattering (LEBS) spectroscopy is an angular resolved backscattering technique that is sensitive to sub-diffusion light transport length scales in which information about the scattering phase function is preserved. Lens-based and lens-free fiber optic LEBS probes are described that are capable of measuring optical properties of a target tissue through depth-limited measurements of backscattering angles within the enhanced backscattered cone.

公开(公告)号：US10921212B2

公开(公告)日：2021-02-16

申请号：US16011034

申请日：2018-06-18

Applicant: NORTHWESTERN UNIVERSITY ,  AMERICAN BIOOPTICS, LLC

Inventor： Vadim Backman ,  Bradley Gould ,  Nikhil Mutyal ,  Frank Garrett, Jr. ,  The Quyen Nguyen ,  Michael Garrett

IPC: A61B5/00 ,  G01N21/47 ,  G01M11/08

Abstract: An automated calibration system that includes a probe guide and a target assembly. The probe guide receives an optical probe, and the target assembly includes one or more calibration targets. The target assembly is slideable relative to the probe guide so that a first calibration target is aligned under the optical probe in a first position of the target assembly and a second calibration target is aligned under the optical probe in a second position of the target assembly.

公开(公告)号：US09885834B2

公开(公告)日：2018-02-06

申请号：US13963560

申请日：2013-08-09

Applicant: NORTHWESTERN UNIVERSITY ,  AMERICAN BIOOPTICS LLC

Inventor： Vadim Backman ,  Jeremy D. Rogers ,  Nikhil N. Mutyal ,  Bradley Gould ,  Andrew J. Radosevich

IPC: G02B6/26 ,  G02B6/36 ,  G02B6/00 ,  G01B11/02 ,  A61B6/00 ,  G01N21/47 ,  G02B6/38 ,  A61B5/00

CPC classification number: G02B6/262 ,  A61B5/0066 ,  A61B5/0084 ,  G01N21/474 ,  G02B6/3807

Abstract: Low-coherence enhanced backscattering (LEBS) spectroscopy is an angular resolved backscattering technique that is sensitive to sub-diffusion light transport length scales in which information about the scattering phase function is preserved. Lens-based and lens-free fiber optic LEBS probes are described that are capable of measuring optical properties of a target tissue through depth-limited measurements of backscattering angles within the enhanced backscattered cone.

公开(公告)号：US20210007673A1

公开(公告)日：2021-01-14

申请号：US16319669

申请日：2017-06-21

Applicant: Northwestern University ,  American BioOptics, LLC ,  NorthShore University HealthSystem

Inventor： Vadim Backman ,  David S. Mueller ,  Andrew J. Cittadine ,  Sarah Ruderman ,  Hemant Roy ,  Bradley Gould

IPC: A61B5/00 ,  A61B5/1459

Abstract: Methods and apparatus initiate a procedure performed by a probe on tissue. A signal is obtained from the probe, the signal varying with changes in a proximity of the probe to the tissue. The obtained signal is analyzed by a controller to determine whether the probe is within a predetermined distance of the tissue. The controller initiates the procedure when it is determined that the probe is within the predetermined distance of the tissue. The obtaining and analyzing may be repeated until the probe is determined to be within the predetermined distance of the tissue. The analyzing may include comparing the obtained signal to a predetermined threshold.

公开(公告)号：US10881273B2

公开(公告)日：2021-01-05

申请号：US14638714

申请日：2015-03-04

Applicant: NORTHWESTERN UNIVERSITY ,  AMERICAN BIOOPTICS LLC

Inventor： Vadim Backman ,  Bradley Gould ,  Andrew J. Cittadine ,  Nikhil Mutyal

IPC: A61B1/00 ,  A61B5/00 ,  G02B6/36 ,  G02B6/24 ,  G02B6/38 ,  A61B90/30

Abstract: A pre-fabricated, on-demand interface provides optical coupling between disposable and reusable portions of a fiber-optic probe. The interface uses a pre-cured, compressible optically-transmissive gel in a cavity of the disposable portion, which can be a disposable insertion tip of the fiber optic probe. The disposable portion includes an elongated housing, or sheath, and the cavity is located within and proximal of a distal end of the elongated housing. A proximal end of an optical assembly of the disposable portion is located within the cavity and contacts the gel. A first coupling, provided at a proximal end of the elongated housing, detachably couples to a mating, second coupling of the probe reusable portion. When the disposable and reusable portions are coupled together, the gel is compressed between the proximal end of the optical assembly of the disposable portion and a distal optical member of an optical assembly of the reusable portion.

公开(公告)号：US10684417B2

公开(公告)日：2020-06-16

申请号：US15886431

申请日：2018-02-01

Applicant: NORTHWESTERN UNIVERSITY ,  AMERICAN BIOOPTICS, LLC

Inventor： Vadim Backman ,  Jeremy D. Rogers ,  Nikhil N. Mutyal ,  Bradley Gould ,  Andrew J. Radosevich ,  The Quyen Nguyen

IPC: G02B6/26 ,  G01N21/47 ,  G02B6/38 ,  A61B5/00

Abstract: Low-coherence enhanced backscattering (LEBS) spectroscopy is an angular resolved backscattering technique that is sensitive to sub-diffusion light transport length scales in which information about the scattering phase function is preserved. Lens-based and lens-free fiber optic LEBS probes are described that are capable of measuring optical properties of a target tissue through depth-limited measurements of backscattering angles within the enhanced backscattered cone.

公开(公告)号：US20160256037A1

公开(公告)日：2016-09-08

申请号：US14638714

申请日：2015-03-04

Applicant: NORTHWESTERN UNIVERSITY ,  AMERICAN BIOOPTICS LLC

Inventor： Vadim BACKMAN ,  Bradley GOULD ,  Andrew J. CITTADINE ,  Nikhil MUTYAL

IPC: A61B1/00 ,  A61B5/00

Abstract: A pre-fabricated, on-demand interface provides optical coupling between disposable and reusable portions of a fiber-optic probe. The interface uses a pre-cured, compressible optically-transmissive gel in a cavity of the disposable portion, which can be a disposable insertion tip of the fiber optic probe. The disposable portion includes an elongated housing, or sheath, and the cavity is located within and proximal of a distal end of the elongated housing. A proximal end of an optical assembly of the disposable portion is located within the cavity and contacts the gel. A first coupling, provided at a proximal end of the elongated housing, detachably couples to a mating, second coupling of the probe reusable portion. When the disposable and reusable portions are coupled together, the gel is compressed between the proximal end of the optical assembly of the disposable portion and a distal optical member of an optical assembly of the reusable portion.

Abstract translation: 预制的按需接口提供光纤探针的一次性和可重复使用部分之间的光耦合。 该界面在一次性部分的空腔中使用预固化的可压缩光学透射凝胶，其可以是光纤探针的一次性插入尖端。 一次性部分包括细长的壳体或护套，并且腔体位于细长壳体的远端内部和近侧。 一次性部分的光学组件的近端位于空腔内并与凝胶接触。 设置在细长壳体的近端处的第一联接件可拆卸地联接到探针可重复使用部分的配合的第二联接件。 当一次性和可重复使用的部分联接在一起时，凝胶在一次性部分的光学组件的近端与可重复使用部分的光学组件的远端光学构件之间被压缩。

公开(公告)号：US20140036271A1

公开(公告)日：2014-02-06

申请号：US13963560

申请日：2013-08-09

Applicant: AMERICAN BIOOPTICS LLC ,  NORTHWESTERN UNIVERSITY

Inventor： Vadim BACKMAN ,  Jeremy D. ROGERS ,  Nikhil N. MUTYAL ,  Bradley GOULD ,  Andrew J. RADOSEVICH

IPC: G01N21/47

CPC classification number: G02B6/262 ,  A61B5/0066 ,  A61B5/0084 ,  G01N21/474 ,  G02B6/3807

Abstract: Low-coherence enhanced backscattering (LEBS) spectroscopy is an angular resolved backscattering technique that is sensitive to sub-diffusion light transport length scales in which infoniiation about the scattering phase function is preserved. Lens-based and lens-free fiber optic LEBS probes are described that are capable of measuring optical properties of a target tissue through depth-limited measurements of backscattering angles within the enhanced backscattered cone.

Abstract translation: 低相干增强后向散射（LEBS）光谱是一种角度分辨后向散射技术，对于其中保留了关于散射相位函数的信号的子扩散光传输长度尺度敏感。 描述了基于透镜和无镜头的光纤LEBS探针，其能够通过在增强后向散射锥体内的后向散射角度的深度限制测量来测量目标组织的光学性质。