公开(公告)号：US20230284940A1

公开(公告)日：2023-09-14

申请号：US18319840

申请日：2023-05-18

Applicant: Kang LEE ,  Andrew Barszczyk ,  Sijia Wu ,  Yousef Yasin ,  Winston De Armas ,  Alan Ding

Inventor： Kang LEE ,  Andrew Barszczyk ,  Sijia Wu ,  Yousef Yasin ,  Winston De Armas ,  Alan Ding

IPC: A61B5/1455 ,  G06N20/20 ,  G06N20/10 ,  A61B5/145

CPC classification number: A61B5/1455 ,  G06N20/20 ,  G06N20/10 ,  A61B5/14532 ,  A61B5/14551

Abstract: Provided are systems and methods for determination of a concentration of one or more blood biomarkers of a human subject. The method including: determining, using a first machine learning model trained with a hemoglobin concentration (HC) changes training set, bit values from a set of bitplanes in a captured image sequence that represent the HC changes of the subject, the set of bitplanes being those that are determined to approximately maximize a signal-to-noise ratio (SNR), the HC changes training set including bit values from each bitplane of images captured from a set of subjects for which HC changes are known; determining, using a second machine learning model trained using a blood biomarkers training set, concentration of one or more blood biomarkers, the blood biomarkers training set including previously determined HC change signals from other subjects and one or more blood panels from those subjects as ground truth data.