公开(公告)号：US08522787B2

公开(公告)日：2013-09-03

申请号：US12511504

申请日：2009-07-29

Applicant: Andy S. Lin ,  Youzhi Li

Inventor： Andy S. Lin ,  Youzhi Li

IPC: A61M16/00

CPC classification number: A61M16/0434 ,  A61B8/0833 ,  A61B8/0841 ,  A61B8/4472 ,  A61B8/4483 ,  A61B8/461 ,  A61M16/0057 ,  A61M16/04 ,  A61M16/0443 ,  A61M16/0459 ,  A61M16/0488 ,  A61M2205/502

Abstract: An inflatable balloon cuff may be adapted to seal a patient's trachea when associated with an endotracheal tube. These cuffs may include features that facilitate detection or visualization of the cuff, for example with ultrasound devices, to ensure proper placement of the cuff and the tube. Such surface features may include particular types of materials or shaped or protruding features that may be detected in the environment of the trachea.

Abstract translation: 当与气管内导管相关联时，可充气气囊可适于密封患者的气管。 这些袖口可以包括便于检测或显示袖带的特征，例如用超声波装置，以确保袖带和管的正确放置。 这种表面特征可以包括可在气管环境中检测到的特定类型的材料或成形或突出的特征。

公开(公告)号：US20110083509A1

公开(公告)日：2011-04-14

申请号：US12576377

申请日：2009-10-09

Applicant: Youzhi Li ,  Edward McKenna ,  Andy S. Lin

Inventor： Youzhi Li ,  Edward McKenna ,  Andy S. Lin

IPC: G01N29/00 ,  G01N21/00

CPC classification number: A61B5/0059 ,  A61B5/0095 ,  A61B8/00

Abstract: Photoacoustic measurements utilize emitted light to generate an acoustic response in tissue, with the acoustic response being proportional to the presence of an absorber of the light in the tissue. The present disclosure relates the use of focused light to acquire photoacoustic measurements. In one embodiment, the light is modulated, such as spatially modulated, such that the light may be focused within an otherwise scattering medium, such as tissue.

Abstract translation: 光声测量利用发射光在组织中产生声响应，声响应与组织中光吸收体的存在成比例。 本公开涉及聚焦光的使用以获得光声测量。 在一个实施例中，光被调制，例如空间调制，使得光可以聚焦在否则散射介质（例如组织）内。

公开(公告)号：US20230277116A1

公开(公告)日：2023-09-07

申请号：US18019037

申请日：2021-07-29

Applicant: Gregory John HAUBRICH ,  Paul SHRINER ,  Justin R. BURWINKEL ,  Scott Thomas KLEIN ,  David Alan FABRY ,  Archelle GEORGIOU ,  Andy S. LIN ,  Starkey Laboratories, Inc.

Inventor： Gregory John Haubrich ,  Paul Shriner ,  Justin R. Burwinkel ,  Scott Thomas Klein ,  David Alan Fabry ,  Archelle Georgiou ,  Andy S. Lin

IPC: A61B5/00 ,  A61B5/024 ,  A61B5/11 ,  A61B5/361

CPC classification number: A61B5/4064 ,  A61B5/02405 ,  A61B5/1101 ,  A61B5/1123 ,  A61B5/4803 ,  A61B5/4839 ,  A61B5/6815 ,  A61B5/361

Abstract: Embodiments herein relate to ear-wearable devices configured to detect patterns indicative of an occurrence, prodrome or sequelae of an anoxic or hypoxic neurological injury. In an embodiment, an ear-wearable device is included. The ear-wearable device can be configured to monitor signals from a microphone and/or a motion sensor to detect a pattern or patterns indicative of an occurrence of an anoxic or hypoxic neurological injury. In some embodiments, a method of monitoring an ear-wearable device wearer for an occurrence of an anoxic or hypoxic neurological injury is included. The method can include gathering signals from one or more of a microphone, a motion sensor, or another sensor of an ear-wearable device and monitoring the signals to detect a pattern or patterns indicative of an occurrence of an anoxic or hypoxic neurological injury. Other embodiments are also included herein.

公开(公告)号：US09138181B2

公开(公告)日：2015-09-22

申请号：US13328619

申请日：2011-12-16

Applicant: Charles K. Haisley ,  Andy S. Lin ,  Friso Schlottau ,  Sarah Hayman

Inventor： Charles K. Haisley ,  Andy S. Lin ,  Friso Schlottau ,  Sarah Hayman

IPC: A61B5/1455 ,  A61B5/00

CPC classification number: A61B5/1455 ,  A61B5/14552 ,  A61B5/14553 ,  A61B5/6803

Abstract: Medical sensors configured to provide enhanced patient comfort when worn over a period of time are provided. The medical sensors may include a first padding layer and a second padding layer disposed on either side of an emitter and a detector for measuring a physiological parameter of a patient. The medical sensors may also include an island padding layer secured to a patient-facing side of the second padding layer for reducing localized pressure points that may be caused by protrusions of the sensor. Additionally or alternatively, certain edges of the sensors may be rounded and/or stepped to reduce marking on the patient's tissue and to reduce strain and shear forces produced on the patient's tissue. Still further, certain embodiments provide enhanced light transmission between the emitter and detector of the sensors.

Abstract translation: 提供了构造成在一段时间内佩戴时提供增强的患者舒适度的医疗传感器。 医疗传感器可以包括第一填充层和设置在发射器两侧的第二填充层和用于测量患者的生理参数的检测器。 医疗传感器还可以包括固定到第二衬垫层的面向患者侧的岛状填充层，用于减少可能由传感器的突起引起的局部压力点。 附加地或替代地，传感器的某些边缘可以是圆形和/或台阶以减少患者组织上的标记并且减少在患者组织上产生的应变和剪切力。 此外，某些实施例在传感器的发射器和检测器之间提供增强的光透射。

公开(公告)号：US08930145B2

公开(公告)日：2015-01-06

申请号：US12845198

申请日：2010-07-28

Applicant: Youzhi Li ,  Edward M. McKenna ,  Andy S. Lin

Inventor： Youzhi Li ,  Edward M. McKenna ,  Andy S. Lin

IPC: G01N33/48 ,  A61B5/05 ,  A61B5/00 ,  G01N21/17 ,  A61B5/1455

CPC classification number: A61B5/0059 ,  A61B5/0095 ,  A61B5/1455 ,  G01N21/1702

Abstract: The present disclosure describes systems and methods that use spatial modulation to focus continuous wave light into a localized region of interest such as an individual blood vessel. In certain embodiments, intensity modulation techniques, such as linear frequency modulation, are used in conjunction with spatial modulation to achieve more precise measurements through otherwise scattering medium. The focused beam of continuous wave light is capable of penetrating several centimeters of tissue to deliver measurements and images associated with individual blood vessels and other discrete vascular components.

Abstract translation: 本公开描述了使用空间调制以将连续波光聚焦到诸如个体血管的局部感兴趣区域中的系统和方法。 在某些实施例中，诸如线性频率调制的强度调制技术与空间调制结合使用，以通过另外的散射介质实现更精确的测量。 聚焦的连续波光束能够穿透几厘米的组织以提供与各个血管和其它离散的血管成分相关联的测量和图像。

公开(公告)号：US08433382B2

公开(公告)日：2013-04-30

申请号：US12512127

申请日：2009-07-30

Applicant: Youzhi Li ,  Andy S. Lin ,  Edward M. McKenna

Inventor： Youzhi Li ,  Andy S. Lin ,  Edward M. McKenna

IPC: A61B5/1455

CPC classification number: A61B5/0261 ,  A61B5/14551 ,  A61B5/14552 ,  A61B5/6826 ,  A61B5/6838 ,  A61B5/7228

Abstract: Present embodiments are directed to a monitor system, such as a pulse oximetry system. The system may include a detection feature, an emission feature capable of emitting light into tissue and arranged relative to the detection feature such that the detection feature is capable of detecting the light from the tissue after passing generally through a portion of the tissue, a modulator capable of modulating the light to generate photon density waves at a modulation frequency generally in a range of 50 MHz to 3 GHz, a detector communicatively coupled with the detection feature, wherein the detector is capable of detecting characteristics of the photon density waves comprising amplitude changes and phase shifts, and a processor capable of making determinations relating to a value of a physiologic parameter of the tissue based at least in part on the detected characteristics.

Abstract translation: 本实施例涉及一种监测系统，例如脉搏血氧饱和度测定系统。 该系统可以包括检测特征，能够将光发射到组织中并相对于检测特征布置的发射特征，使得检测特征能够在通常通过组织的一部分之后检测来自组织的光，调制器 能够调制光以通常在50MHz至3GHz范围内的调制频率产生光子密度波，检测器与检测特征通信耦合，其中检测器能够检测包括振幅变化的光子密度波的特性 和相移，以及能够至少部分地基于检测到的特性来进行关于组织的生理参数的值的确定的处理器。

公开(公告)号：US20110071373A1

公开(公告)日：2011-03-24

申请号：US12563852

申请日：2009-09-21

Applicant: Youzhi Li ,  Andy S. Lin ,  Edward M. McKenna

Inventor： Youzhi Li ,  Andy S. Lin ,  Edward M. McKenna

IPC: A61B5/1455

CPC classification number: A61B5/14551 ,  A61B5/0059 ,  A61B2562/223

Abstract: Multi-wavelength photon density wave medical systems, methods, and devices are provided. In one embodiment, a multi-wavelength system may include a sensor, a sensor cable, and a patient monitor. The sensor may have an emitter output and a detector input configured to pass a multi-wavelength photon density wave input signal into a patient and receive a resulting multi-wavelength photon density wave output signal. The sensor cable may couple to the sensor using two optical cables for transmitting and receiving the multi-wavelength photon density wave signals. The patient monitor may couple to the sensor cable and generate several time-division multiplexed single-wavelength input signals by modulating one or more light sources at a frequency sufficient to produce resolvable photon density waves. By combining the several time-division multiplexed single-wavelength input signals into one of the optical cables of the sensor cable, the patient monitor may generate the multi-wavelength photon density wave input signal.

Abstract translation: 提供了多波长光子密度波医疗系统，方法和装置。 在一个实施例中，多波长系统可以包括传感器，传感器电缆和患者监护仪。 传感器可以具有发射器输出和检测器输入，其被配置为将多波长光子密度波输入信号传递到患者体内并且接收所得到的多波长光子密度波输出信号。 传感器电缆可以使用两根光缆耦合到传感器，用于发射和接收多波长光子密度波信号。 患者监护仪可以耦合到传感器电缆，并通过以足以产生可分辨的光子密度波的频率调制一个或多个光源来产生几个时分复用的单波长输入信号。 通过将几个时分复用的单波长输入信号组合成传感器电缆的光缆之一，患者监视器可以产生多波长光子密度波输入信号。

公开(公告)号：US20100081897A1

公开(公告)日：2010-04-01

申请号：US12512127

申请日：2009-07-30

Applicant: Youzhi Li ,  Andy S. Lin ,  Edward M. McKenna

Inventor： Youzhi Li ,  Andy S. Lin ,  Edward M. McKenna

IPC: A61B5/1455

CPC classification number: A61B5/0261 ,  A61B5/14551 ,  A61B5/14552 ,  A61B5/6826 ,  A61B5/6838 ,  A61B5/7228

Abstract: Present embodiments are directed to a monitor system, such as a pulse oximetry system. The system may include a detection feature, an emission feature capable of emitting light into tissue and arranged relative to the detection feature such that the detection feature is capable of detecting the light from the tissue after passing generally through a portion of the tissue, a modulator capable of modulating the light to generate photon density waves at a modulation frequency generally in a range of 50 MHz to 3 GHz, a detector communicatively coupled with the detection feature, wherein the detector is capable of detecting characteristics of the photon density waves comprising amplitude changes and phase shifts, and a processor capable of making determinations relating to a value of a physiologic parameter of the tissue based at least in part on the detected characteristics.

Abstract translation: 本实施例涉及一种监测系统，例如脉搏血氧饱和度测定系统。 该系统可以包括检测特征，能够将光发射到组织中并相对于检测特征布置的发射特征，使得检测特征能够在通常通过组织的一部分之后检测来自组织的光，调制器 能够调制光以通常在50MHz至3GHz范围内的调制频率产生光子密度波，检测器与检测特征通信耦合，其中检测器能够检测包括振幅变化的光子密度波的特性 和相移，以及能够至少部分地基于检测到的特性来进行关于组织的生理参数的值的确定的处理器。

公开(公告)号：US08886290B2

公开(公告)日：2014-11-11

申请号：US13608585

申请日：2012-09-10

Applicant: Youzhi Li ,  Edward M. McKenna ,  Andy S. Lin ,  Sarah Hayman

Inventor： Youzhi Li ,  Edward M. McKenna ,  Andy S. Lin ,  Sarah Hayman

IPC: A61B5/00 ,  G01B11/02 ,  A61B5/107 ,  A61M25/01 ,  A61M16/04 ,  A61M25/00

CPC classification number: A61M16/0488 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/1076 ,  A61B2562/223 ,  A61M16/04 ,  A61M16/0434 ,  A61M16/0443 ,  A61M25/0043 ,  A61M25/01 ,  A61M2025/0166 ,  A61M2205/3306 ,  G01B11/026

Abstract: According to various embodiments, a tracheal tube may employ optical sensing techniques for determining a distance between the inserted tube and an anatomical structure, such as a carina. The distance information may provide an indication as to whether or not the tracheal tube is properly placed within the trachea. The optical techniques may include backscattered intensity measurements.

Abstract translation: 根据各种实施例，气管插管可以采用光学感测技术来确定插入的管和解剖结构之间的距离，例如小孔。 距离信息可以提供关于气管管是否适当地放置在气管内的指示。 光学技术可以包括后向散射强度测量。

公开(公告)号：US08712492B2

公开(公告)日：2014-04-29

申请号：US13149606

申请日：2011-05-31

Applicant: Daniel Lisogurski ,  Doug P. Miller ,  Friso Schlottau ,  Youzhi Li ,  Andy S. Lin ,  Edward M. McKenna

Inventor： Daniel Lisogurski ,  Doug P. Miller ,  Friso Schlottau ,  Youzhi Li ,  Andy S. Lin ,  Edward M. McKenna

IPC: A61B5/1455

CPC classification number: A61B5/1455 ,  A61B5/02028 ,  A61B5/024

Abstract: A system for measuring a physiological parameter of blood in a patient is presented. The system includes a transmission module configured to emit a plurality of photon density waves into tissue of the patient from a plurality of modulated light sources. The system also includes a receiver module configured to detect characteristics of the plurality of photon density waves. The system also includes a processing module configured to identify characteristics of a pulsatile perturbation of the tissue based on the characteristics of the plurality of photon density waves, and identify a value of the physiological parameter based on at least the characteristics of the pulsatile perturbation of the tissue and the characteristics of the plurality of photon density waves.

Abstract translation: 提出了一种用于测量患者血液生理参数的系统。 该系统包括被配置为从多个调制光源向患者的组织发射多个光子密度波的传输模块。 该系统还包括被配置为检测多个光子密度波的特性的接收器模块。 该系统还包括处理模块，该处理模块被配置为基于多个光子密度波的特性来识别组织的脉动扰动的特性，并且至少基于脉冲扰动的特征来识别生理参数的值 组织和多个光子密度波的特性。