公开(公告)号：US20060194871A1

公开(公告)日：2006-08-31

申请号：US10552232

申请日：2004-04-06

Applicant: Kevin Barvian ,  Andrew Carpenter ,  Joel Cooper ,  Paul Feldman ,  Dulce Garrido ,  Yu Guo ,  Anthony Handlon ,  Donald Hertzog ,  Clifton Hyman ,  Andrew Peat ,  Gregory Peckham ,  Jason Speake ,  William Swain ,  Francis Tavares ,  Huiqiang Zhou

Inventor： Kevin Barvian ,  Andrew Carpenter ,  Joel Cooper ,  Paul Feldman ,  Dulce Garrido ,  Yu Guo ,  Anthony Handlon ,  Donald Hertzog ,  Clifton Hyman ,  Andrew Peat ,  Gregory Peckham ,  Jason Speake ,  William Swain ,  Francis Tavares ,  Huiqiang Zhou

IPC: C07D311/80 ,  A61K31/353

CPC classification number: C07D495/04 ,  C07D311/80

Abstract: This invention relates to novel heterocycles which are antagonists at the melanin-concentrating hormone receptor 1 (MCHR1), also referred to as 11 CBy, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in medicines. Compounds of the invention have the formula:

Abstract translation: 本发明涉及在黑色素浓缩激素受体1（MCHR1），也称为11Cyy的拮抗剂，含有它们的药物组合物，其制备方法及其在药物中的应用的新型杂环。 本发明的化合物具有下式：

公开(公告)号：US20070078125A1

公开(公告)日：2007-04-05

申请号：US10576765

申请日：2004-10-21

Applicant: Kevin Barvian ,  Anthony Handlon ,  Donald Hertzog ,  Clifton Hyman

Inventor： Kevin Barvian ,  Anthony Handlon ,  Donald Hertzog ,  Clifton Hyman

IPC: A61K31/519 ,  A61K31/55 ,  C07D498/02

CPC classification number: C07D495/04

Abstract: This invention relates to novel arylamines which are antagonists of the melanin-concentrating hormone receptor 1 (MCH R1), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in medicines for the treatment of obesity, diabetes, depression, and/or anxiety. Compounds of the invention have the formula:

Abstract translation: 本发明涉及作为黑色素浓缩激素受体1（MCH R1）的拮抗剂的新型芳基胺，含有它们的药物组合物，其制备方法及其在药物中的用途，用于治疗肥胖症，糖尿病，抑郁症， 和/或焦虑。 本发明的化合物具有下式：

公开(公告)号：US20050107419A1

公开(公告)日：2005-05-19

申请号：US10507006

申请日：2003-02-24

Applicant: Ashok Bhandari ,  Eric Boros ,  David Cowan ,  Anthony Handlon ,  Clifton Hyman ,  Jeffrey Oplinger ,  Michael Rabinowitz ,  Philip Turnbull

Inventor： Ashok Bhandari ,  Eric Boros ,  David Cowan ,  Anthony Handlon ,  Clifton Hyman ,  Jeffrey Oplinger ,  Michael Rabinowitz ,  Philip Turnbull

IPC: A61K31/4188 ,  A61K31/4196 ,  A61K31/4745 ,  C07D471/14 ,  C07D471/22 ,  C07D487/04 ,  C07D487/14 ,  C07D491/04 ,  C07D498/04

CPC classification number: C07D471/14 ,  C07D487/04

Abstract: The present invention relates to novel fused heterocyclic ring system compounds and methods for their use in the treatment and prevention of diseases or conditions.

Abstract translation: 本发明涉及新颖的稠合杂环体系化合物及其用于治疗和预防疾病或病症的方法。