公开(公告)号：US20100119424A1

公开(公告)日：2010-05-13

申请号：US12451432

申请日：2008-05-14

Applicant: Fredrik Almqvist ,  Basudeb Basu

Inventor： Fredrik Almqvist ,  Basudeb Basu

IPC: B01J19/00 ,  B01J37/30

CPC classification number: C07C67/343 ,  B01J23/44 ,  B01J31/08 ,  B01J31/165 ,  B01J37/06 ,  B01J2231/4211 ,  B01J2231/4261 ,  B01J2531/824 ,  C07C1/321 ,  C07C17/263 ,  C07C37/18 ,  C07C41/30 ,  C07C2523/44 ,  C07C2531/08 ,  C07C2603/24 ,  C07D213/61 ,  C07D401/04 ,  C07D413/04 ,  C07D491/147 ,  C07C15/14 ,  C07C25/18 ,  C07C69/618 ,  C07C69/65 ,  C07C43/205 ,  C07C39/15

Abstract: The present invention relates to a method of producing a heterogeneous catalyst suitable for catalyzing Heck, Suzuki-Miyaura Sonogashira coupling and Buchwald-Hartwig reactions, comprising the steps of: a) providing a macroporous carrier, said macroporous carrier consisting of a core and a plurality of ion exchange groups covalently bonded to the surface of said core, where at least 90% of the ions bound to said carrier are formate ions; b) swelling said carrier in a polar solvent; c) providing a palladium (II) salt; d) suspending said carrier in an organic solvent thereby obtaining a suspension; e) adding said palladium salt to said suspension and allowing the resulting mixture to react at a temperature within the range of 0 70° C. until said carrier has turned black; f) washing said carrier in water; g) drying said carrier under vacuum.

Abstract translation: 本发明涉及适用于催化Heck，Suzuki-Miyaura Sonogashira偶联剂和Buchwald-Hartwig反应的多相催化剂的制备方法，包括以下步骤：a）提供大孔载体，所述大孔载体由核和多个 共价结合到所述芯的表面上的离子交换基团，其中与所述载体结合的至少90％的离子是甲酸根离子; b）在极性溶剂中溶胀载体; c）提供钯（II）盐; d）将所述载体悬浮在有机溶剂中，从而获得悬浮液; e）将所述钯盐加入到所述悬浮液中，并使所得混合物在0℃至70℃的温度下反应，直到所述载体变黑; f）在水中清洗载体; g）在真空下干燥所述载体。

公开(公告)号：US20120321533A1

公开(公告)日：2012-12-20

申请号：US13439232

申请日：2012-04-04

Applicant: Fredrik Almqvist ,  Basudeb Basu

Inventor： Fredrik Almqvist ,  Basudeb Basu

IPC: B01J31/04 ,  B01J19/00 ,  B01J31/08

CPC classification number: C07C67/343 ,  B01J23/44 ,  B01J31/08 ,  B01J31/165 ,  B01J37/06 ,  B01J2231/4211 ,  B01J2231/4261 ,  B01J2531/824 ,  C07C1/321 ,  C07C17/263 ,  C07C37/18 ,  C07C41/30 ,  C07C2523/44 ,  C07C2531/08 ,  C07C2603/24 ,  C07D213/61 ,  C07D401/04 ,  C07D413/04 ,  C07D491/147 ,  C07C15/14 ,  C07C25/18 ,  C07C69/618 ,  C07C69/65 ,  C07C43/205 ,  C07C39/15

Abstract: The present invention relates to a method of producing a heterogeneous catalyst suitable for catalyzing Heck, Suzuki-Miyaura Sonogashira coupling and Buchwald-Hartwig reactions, comprising the steps of: a) providing a macroporous carrier, said macroporous carrier consisting of a core and a plurality of ion exchange groups covalently bonded to the surface of said core, where at least 90% of the ions bound to said carrier are formate ions; b) swelling said carrier in a polar solvent; c) providing a palladium (II) salt; d) suspending said carrier in an organic solvent thereby obtaining a suspension; e) adding said palladium salt to said suspension and allowing the resulting mixture to react at a temperature within the range of 0-70° C. until said carrier has turned black; f) washing said carrier in water; g) drying said carrier under vacuum.

Abstract translation: 本发明涉及适用于催化Heck，Suzuki-Miyaura Sonogashira偶联剂和Buchwald-Hartwig反应的多相催化剂的制备方法，包括以下步骤：a）提供大孔载体，所述大孔载体由核和多个 共价结合到所述芯的表面上的离子交换基团，其中与所述载体结合的至少90％的离子是甲酸根离子; b）在极性溶剂中溶胀载体; c）提供钯（II）盐; d）将所述载体悬浮在有机溶剂中，从而获得悬浮液; e）将所述钯盐加入到所述悬浮液中，并使得到的混合物在0-70℃的温度下反应，直到所述载体变黑; f）在水中清洗载体; g）在真空下干燥所述载体。