公开(公告)号：US5726151A

公开(公告)日：1998-03-10

申请号：US472767

申请日：1995-06-07

Applicant: Pascal Anger ,  Bertrand Bonnavaud ,  Alain Callet ,  Patrick Lefevre

Inventor： Pascal Anger ,  Bertrand Bonnavaud ,  Alain Callet ,  Patrick Lefevre

IPC: A61K38/00 ,  A61K38/05 ,  A61K38/12 ,  A61P31/04 ,  C07K1/14 ,  C07K5/06 ,  C07K5/078 ,  C07K7/06 ,  C07K7/54 ,  C07K14/195 ,  C07K14/41 ,  C12P17/18

CPC classification number: C07K5/06182 ,  C07K5/06139 ,  C07K7/06 ,  A61K38/00

Abstract: This invention relates to a purified form of streptogramins, having of a combination of one or more group B components of streptogramins, of general formula: ##STR1## in which A.sub.1 is a radical of general formula: ##STR2## for which R' is H or OH and Y is H, a methylamino radical or a dimethylamino radical, R is an ethyl radical or, when R' is H, R can also represent--CH.sub.3, andR.sub.1 and R.sub.2 are H, or alternatively A.sub.1 is a radical of formula: ##STR3## R is an isobutyl radical, and R.sub.1 is OH and R.sub.2 is --CH.sub.3, and one or more group A minority components of streptogramins, of general formula: ##STR4## in which R" is H or a methyl or ethyl radical, in the state of cocrystallizate, of a coprecipitate or of a physical mixture of the powders.

Abstract translation: 本发明涉及一种纯化形式的链霉素，其具有一种或多种链霉素的一种或多种B组分组合，其通式如下：其中A1是通式如下的基团：或，其中 R'是H或OH，Y是H，甲基氨基或二甲基氨基，R是乙基，或当R'是H时，R也可以表示-CH 3，R 1和R 2是H，或者A1是 式的基团：R 1是异丁基，R 1是OH，R 2是-CH 3，以及一个或多个通式为：其中R“是H的链霉素的少数成分，其中R”是H或 以共沉淀物或粉末的物理混合物的共结晶状态的甲基或乙基。

公开(公告)号：US06384014B1

公开(公告)日：2002-05-07

申请号：US09522949

申请日：2000-03-10

Applicant: Pascal Anger ,  Jean-Claude Barriere ,  Bertrand Bonnavaud ,  Patrick Lefevre ,  Jean-Marc Paris ,  Denis Thibaut

Inventor： Pascal Anger ,  Jean-Claude Barriere ,  Bertrand Bonnavaud ,  Patrick Lefevre ,  Jean-Marc Paris ,  Denis Thibaut

IPC: A61K3812

CPC classification number: C07K5/06182 ,  A61K38/00 ,  C07K7/06

Abstract: Purified form of streptogramines, characterised in that it contains at least one component from group B streptogramines of general formula (I), wherein R1 is Me or Et, R2 is H or OH, and R3 is substituted benzyl of general formula (III), such that 1) if R2 is H, R is NR4R5, wherein one of R4 and R5 is H or an Me radical and the other is Me, and R′ is Cl or Br, or R is (C3-5)alkenyl if R4 and R5 are Me, or 2) R is H and R′ is halogen, alkylamino or dialkylamino, an ether-oxide residue, alkylthio, (C1-3)alkyl or trihalogenomethyl, or R is halogen, (C2-4)alkylamino, (C2-4)dialkylamino or methyl ethyl amino, pyrrolidino alkenyl alkyl amino, dialkylamino, an alkyl cycloalkylmethyl amino radical or in ether-oxide residue, alkylthio, alkylthiomethyl, (C1-6)alkyl, aryl or trihalogenomethyl, and R′ is H, or R is halogen, amino, alkylamino or dialkylamino, an ether-oxide residue, an alkylthio radical, (C1-6)alkyl or trihalogenomethyl and R′ is halogen, alkylamino or dialkylamino, an ether-oxide residue or alkylthio, (C1-3)alkyl, cocrystallised with one or more minor components of group A of general formula (II) wherein R″ is H, Me or Et.

Abstract translation: 其特征在于，其含有至少一种通式（I）的B组链霉素的组分，其中R 1是Me或Et，R 2是H或OH，R 3是通式（III）的取代的苄基， 使得1）如果R 2是H，R 4是NR 4 R 5，其中R 4和R 5之一是H或Me基团，而另一个是Me，R'是Cl或Br，或R 4是（C 3-5）烯基，如果R 4 和R 5是Me，或2）R是H，R'是卤素，烷基氨基或二烷基氨基，醚氧化物残基，烷硫基，（C 1-3）烷基或三卤代甲基，或R是卤素，（C 2-4）烷基氨基， （C 2-4）二烷基氨基或甲基乙基氨基，吡咯烷基链烯基烷基氨基，二烷基氨基，烷基环烷基甲基氨基或醚氧化物残基，烷硫基，烷硫基甲基，（C 1-6）烷基，芳基或三卤代甲基，R' ，或R是卤素，氨基，烷基氨基或二烷基氨基，醚氧化物残基，烷硫基，（C 1-6）烷基或三卤代甲基，R'是卤素，烷基氨基或二烷基氨基，醚氧化物 残基或烷硫基，（C 1-3）烷基，与通式（II）的基团A的一种或多种次要组分共结晶，其中R“为H，Me或Et。

公开(公告)号：US5637565A

公开(公告)日：1997-06-10

申请号：US472768

申请日：1995-06-07

Applicant: Pascal Anger ,  Bertrand Bonnavaud ,  Alain Callet ,  Patrick Lefevre

Inventor： Pascal Anger ,  Bertrand Bonnavaud ,  Alain Callet ,  Patrick Lefevre

IPC: A61K38/00 ,  A61K38/05 ,  A61K38/12 ,  A61P31/04 ,  C07K1/14 ,  C07K5/06 ,  C07K5/078 ,  C07K7/06 ,  C07K7/54 ,  C07K14/195 ,  C07K14/41 ,  C12P17/18 ,  A61K38/04 ,  A61K38/08 ,  C07K1/30 ,  C07K1/32

CPC classification number: C07K5/06182 ,  C07K5/06139 ,  C07K7/06 ,  A61K38/00

Abstract: This invention relates to a purified form of streptogramins, consisting of a combination of one or more group B components of streptogramins, of general formula: ##STR1## in which A.sub.1 is a radical of general formula: ##STR2## for which R' is H or OH and Y is H, a methylamino radical or a dimethylamino radical, R is an ethyl radical or, when R' is H, R can also represent --CH.sub.3, and R.sub.1 and R.sub.2 are H, or alternatively A.sub.1 is a radical of formula: ##STR3## R is an isobutyl radical, and R.sub.1 is OH and R.sub.2 is --CH.sub.3, and one or more group A minority components of streptogramins, of general formula: ##STR4## in which R" is H or a methyl or ethyl radical, in the state of cocrystallizate, of a coprecipitate or of a physical mixture of the powders.

Abstract translation: 本发明涉及一种纯化形式的链霉素，其由一种或多种链霉素的B组分组合组成，通式如下：其中A1是通式的基团：其中R '是H或OH，Y是H，甲基氨基或二甲基氨基，R是乙基，或当R'是H时，R也可以表示-CH 3，R 1和R 2是H，或者A 1是 式的基团：其中R是异丁基，R 1是OH，R 2是-CH 3，一个或多个通式如下：其中R“是H的链霉素的A组少数成分，或 甲基或乙基，在共结晶状态下，共沉淀物或粉末的物理混合物。