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1.发明申请公开(公告)号：US20200333305A1
公开(公告)日：2020-10-22
申请号：US16756669
申请日：2018-10-19
Inventor： Viola FOLLI , Andrea SANTINELLI , Marco BROGLIA
Abstract: Apparatus (1000) and method for automatically detecting odorant substances based on use of nematodes that includes a mechanical selection unit (100) configured to select nematodes in adult stage from an initial nematode population obtaining an intermediate nematode population, a nematode optical selection unit (200) configured to select from the intermediate population a final population of nematodes in adult stage and to select nematodes in young adult stage from nematodes in egg producing adult stage to be sent to a measurement unit (300) configured to detect the response of nematodes of the final population to a stimulus of an odorant substance, the mechanical selection unit (100) being connected to the optical selection unit (200) by a connection channel with an at least three way branch and the optical selection unit (200) being connected to the measurement unit (300) by a loading microchannel.
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Patent Agency Ranking
公开(公告)号：US10905324B2
公开(公告)日：2021-02-02
申请号：US16461359
申请日：2017-11-21
Applicant: CRESTOPTICS S.p.A.
Inventor： Vincenzo Ricco , Raino Ceccarelli , Andrea Latini
Abstract: Fluorescence microscopy apparatus for the analysis of a fundus of a sample eye, based on the use of an optical equipment configured to generate a Bessel beam inside a sample eye and an objective configured to increase the numerical aperture of an “objective-cornea-lens” assembly by reducing the overall focal length of the fluorescence microscopy apparatus, also allowing a significant increase in spatial resolution compared to conventional microscopy systems.
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公开(公告)号：US11867893B2
公开(公告)日：2024-01-09
申请号：US17040301
申请日：2019-03-26
Inventor： Marco Leonetti , Giuseppe Antonacci , Raino Ceccarelli
CPC classification number: G02B21/365 , G01N21/6458 , G02B21/16
Abstract: Fluorescence microscopy method comprising: illuminating a scattering sample with a coherent excitation light beam having a wavefront with an initial configuration for exciting fluorescent emitters in the scattering sample; acquiring an initial image; selecting target pixels in an area of the initial image; optimising the initial configuration of the wavefront for each target pixel for decreasing the speckle grain size and obtaining a final image; subtracting the initial image from the final image for each target pixel, obtaining an image; fitting the image with a Gaussian function with free center coordinates for each target pixel; generating an image containing a Gaussian distribution centered at the coordinates and intensity, and with a waist equal to an average size S of speckle grain of the scattering sample, for each target pixel; and generating a final image of the sample by summing the images of the target pixels.
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公开(公告)号：US20210063721A1
公开(公告)日：2021-03-04
申请号：US17040301
申请日：2019-03-26
Inventor： Marco LEONETTI , Giuseppe ANTONACCI , Raino CECCARELLI
Abstract: Fluorescence microscopy method comprising: illuminating a scattering sample with a coherent excitation light beam having a wavefront with an initial configuration for exciting fluorescent emitters in the scattering sample; acquiring an initial image; selecting target pixels in an area of the initial image; optimising the initial configuration of the wavefront for each target pixel for decreasing the speckle grain size and obtaining a final image; subtracting the initial image from the final image for each target pixel, obtaining an image; fitting the image with a Gaussian function with free center coordinates for each target pixel; generating an image containing a Gaussian distribution centered at the coordinates and intensity, and with a waist equal to an average size S of speckle grain of the scattering sample, for each target pixel; and generating a final image of the sample by summing the images of the target pixels.
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公开(公告)号：US20190320894A1
公开(公告)日：2019-10-24
申请号：US16461359
申请日：2017-11-21
Applicant: CRESTOPTICS S.p.A.
Inventor： Vincenzo Ricco , Raino Ceccarelli , Andrea Latini
Abstract: Fluorescence microscopy apparatus for the analysis of a fundus of a sample eye, based on the use of an optical equipment configured to generate a Bessel beam inside a sample eye and an objective configured to increase the numerical aperture of an “objective-cornea-lens” assembly by reducing the overall focal length of the fluorescence microscopy apparatus, also allowing a significant increase in spatial resolution compared to conventional microscopy systems.
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公开(公告)号：US20180292634A1
公开(公告)日：2018-10-11
申请号：US15764332
申请日：2016-10-12
Applicant: CRESTOPTICS S.p.A.
Inventor： Vincenzo RICCO , Andrea SANTINELLI
Abstract: Confocal microscopy apparatus, and related process, comprising: a structured light generating component configured to be illuminated with a basic light beam and to generate a structured light beam focused on a first plane; a spinning disk configured to receive said structured light beam and to transmit a resulting excitation beam to an optics of a microscope focused on a plane of a sample, wherein the spinning disk lies on a second plane and comprises a disk-shaped substrate composed of an optically transparent material, the substrate of the spinning disk comprising a planar first surface and an opposing planar second surface and a patterned mask disposed on one of the first surface and the second surface and comprising at least one sector provided with one or more continuous spiral slit apertures, wherein the patterned mask or an outer surface thereof is composed of a highly black material opaque to light; a housing configured to house on a third plane an acquisition sensor configured to detect a fluorescent beam emitted from said plane of the sample; a set of relay lenses configured to optically conjugate the first plane, the second plane and said plane of the sample to the third plane; optical means configured to transmit said structured light beam from the structured light generating component to said plane of the sample and said emitted fluorescent beam from said plane of the sample to said housing configured to house the acquisition sensor; and moving means configured to move the structured light generating component, so as to shift the structured light beam in the first plane, and the spinning disk in the second plane.
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