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    Cosmetic or pharmaceutical composition comprising, in combination, a peroxidase and an anti-singlet oxygen agent
    1.
    发明授权
    Cosmetic or pharmaceutical composition comprising, in combination, a peroxidase and an anti-singlet oxygen agent 失效
    组合物包含过氧化物酶和抗单质氧剂的组合物或药物组合物

    公开(公告)号：US06316012B1

    公开(公告)日：2001-11-13

    申请号：US09413496

    申请日：1999-10-06

    Applicant: Quang lan N'Guyen ,  Christian Colin

    Inventor： Quang lan N'Guyen ,  Christian Colin

    IPC: A61K3843

    CPC classification number: A61Q11/00 ,  A61K8/66 ,  A61K38/44 ,  A61K45/06 ,  A61K2800/522 ,  A61Q5/00 ,  A61Q17/00 ,  Y10S514/844 ,  Y10S514/937 ,  A61K2300/00

    Abstract: A method of preventing damage caused to healthy skin, hair or mucous membranes by free radicals, includes applying to the healthy skin, hair or mucous membrane a composition containing at least one product having a peroxidase activity capable of reducing organic peroxides and at least one antioxidant capable of neutralizing singlet oxygen, the composition being free of peroxide. The product having a peroxidase activity is present in an amount of from 0.005 to 5.0% by weight, and the antioxidant is present in an amount of from 0.005 to 3.0% by weight, with a weight ratio of the product having a peroxidase activity to the antioxidant of from 0.001 to 0.3. The product having a peroxidase activity capable of reducing organic peroxides is lactoperoxidase, and the antioxidant is selected from quinolines, polyphenols, and carotenoids.

    Abstract translation: 防止由自由基对健康的皮肤，毛发或粘膜造成的损害的方法包括向健康的皮肤，毛发或粘膜施用含有至少一种具有能够还原有机过氧化物的过氧化物酶活性的产物和至少一种抗氧化剂的组合物 能够中和单线态氧，该组合物不含过氧化物。 具有过氧化物酶活性的产物的存在量为0.005-5.0重量％，抗氧化剂的存在量为0.005-3.0重量％，具有过氧化物酶活性的产物与 抗氧化剂为0.001〜0.3。 具有能够还原有机过氧化物的过氧化物酶活性的产物是乳过氧化物酶，抗氧化剂选自喹啉，多酚和类胡萝卜素。

    Melatonin derivatives and anti-free-radical dermocosmetics comprised thereof
    2.
    发明授权
    Melatonin derivatives and anti-free-radical dermocosmetics comprised thereof 失效
    褪黑激素衍生物及其抗自由基皮肤用药物

    公开(公告)号：US6093409A

    公开(公告)日：2000-07-25

    申请号：US900832

    申请日：1997-07-25

    Applicant: Jean-Fran.cedilla.ois Nadaud ,  Christian Colin

    Inventor： Jean-Fran.cedilla.ois Nadaud ,  Christian Colin

    IPC: A61K8/00 ,  A61K8/49 ,  A61Q1/02 ,  A61Q1/14 ,  A61Q5/00 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/08 ,  C07D209/16 ,  A61K6/00

    CPC classification number: A61K8/492 ,  A61Q19/08 ,  A61Q5/00 ,  A61K2800/522

    Abstract: Topically applicable dermocosmetic compositions for combating the clinical signs of skin aging and/or for improving the appearance of the skin, the scalp or the hair, comprise an anti-free-radical effective amount of at least one novel melatonin derivative having the structural formula (I): ##STR1## in which R.sub.1 is a lower alkyl radical, R.sub.2 is a hydrogen atom or a lower alkyl radical, and R.sub.3 is a hydrogen atom or a lower acyl radical, with the proviso that the hydroxyl radical is in the 4-, 6- or 7-position on the indole ring system, or a physiologically acceptable salt, solvate or bioprecursor/prodrug thereof, formulated into a topically applicable, cosmetically/dermatologically acceptable vehicle, carrier or diluent therefor.

    Abstract translation: 用于抵抗皮肤老化的临床症状和/或改善皮肤，头皮或毛发的外观的局部适用的皮肤粘合剂组合物包含抗自由基有效量的至少一种具有结构式的新型褪黑素衍生物（ I）：其中R1是低级烷基，R2是氢原子或低级烷基，R3是氢原子或低级酰基，条件是羟基在4-，6- 或其吲哚环体系上的7-位，或其生理学上可接受的盐，溶剂合物或生物前体/前药，配制成局部适用的，美容/皮肤病学可接受的载体，载体或稀释剂。

    METHOD FOR THE PRODUCTION OF RECOMBINANT HUMAN FACTOR VIII
    5.
    发明申请
    METHOD FOR THE PRODUCTION OF RECOMBINANT HUMAN FACTOR VIII 审中-公开
    生产重组人因子VIII的方法

    公开(公告)号：US20140051832A1

    公开(公告)日：2014-02-20

    申请号：US14004235

    申请日：2011-03-11

    Applicant: Marcos A. A. Demasi ,  Mari Cleide Sogayar ,  Christian Colin

    Inventor： Marcos A. A. Demasi ,  Mari Cleide Sogayar ,  Christian Colin

    IPC: C07K14/755

    CPC classification number: C07K14/755 ,  C12N9/6454 ,  C12P21/06 ,  C12Y304/21826

    Abstract: The object of the present invention is to provide methods for the production of recombinant human Factor VIII, employing specific endoproteases, thus assuring full proteolytic processing of said factor even during its biosynthesis, consequently avoiding additional purification steps. Other objects of the present invention are the recombinant human Factor VIII as obtained by said methods, pharmaceutical compositions, related uses and therapeutic methods.

    Abstract translation: 本发明的目的是提供使用特异性内切蛋白酶生产重组人因子VIII的方法，从而即使在其生物合成过程中也能保证所述因子的完全蛋白水解加工，从而避免了额外的纯化步骤。 本发明的其它目的是通过所述方法获得的重组人因子VIII，药物组合物，相关用途和治疗方法。

    Container for transporting, storing and dispensing chemical products
    6.
    发明授权
    Container for transporting, storing and dispensing chemical products 失效
    运输，储存和分配化学产品的集装箱

    公开(公告)号：US5692631A

    公开(公告)日：1997-12-02

    申请号：US697636

    申请日：1996-08-29

    Applicant: Marie-Anne Tillard ,  Christian Colin ,  Werner Buttner ,  Winfried Trinkaus ,  Martin Benzinger

    Inventor： Marie-Anne Tillard ,  Christian Colin ,  Werner Buttner ,  Winfried Trinkaus ,  Martin Benzinger

    IPC: B65D8/06 ,  B65D77/04 ,  B65D77/06 ,  B65D85/84 ,  B65D7/00

    CPC classification number: B65D11/06 ,  B65D77/0486 ,  B65D85/84

    Abstract: Container for transporting, storing and dispensing chemical products, including an inner shell made of fluoroplastic, particularly PFA, fitted at its upper part with a stopper device traversed by filling and dispensing connections, and an outer shell exhibiting a substantially cylindrical outer shape and an inner shape substantially matching that of the inner shell. The outer shell (1) is made up of a cylindrical part (6) which, at its lower part, is integral with a base (7) of quadrilateral cross-section and of greater cross-sectional area than that of the cylindrical part of the outer shell.

    Abstract translation: 用于运输，储存和分配化学产品的容器，包括由氟塑料制成的内壳，特别是PFA，其上部安装有通过填充和分配连接件穿过的止动装置，以及外壳，其具有基本上圆柱形的外部形状和内部 形状基本上与内壳的形状相匹配。 外壳（1）由圆柱形部分（6）组成，圆柱形部分（6）在其下部与四边形横截面的基部（7）成一体，并且具有比圆柱形部分 外壳。

    SHOE SOLE DEVICE AND SHOE COMPRISING SUCH A SOLE DEVICE
    8.
    发明申请
    SHOE SOLE DEVICE AND SHOE COMPRISING SUCH A SOLE DEVICE 审中-公开
    SHOE SOLE设备和SHOE包含这样一个独立的设备

    公开(公告)号：US20140223781A1

    公开(公告)日：2014-08-14

    申请号：US14241462

    申请日：2012-08-31

    Applicant: Christian Colin

    Inventor： Christian Colin

    IPC: A43B13/18 ,  A43B9/00 ,  A43B7/32

    CPC classification number: A43B7/32 ,  A43B3/244 ,  A43B9/00 ,  A43B13/127 ,  A43B13/141 ,  A43B13/181 ,  A43B13/189

    Abstract: The invention relates to a shoe sole device comprising two superposed chassis articulated relative to one another. For preference, movement-absorbing means, which notably absorb pivoting movements of the chassis relative to one another are provided. The invention also covers a shoe having such a shoe sole device and an assembly rig for manufacturing such a shoe.

    Abstract translation: 本发明涉及一种鞋底装置，其包括相对于彼此铰接的两个叠置的底盘。 优选地，提供了特别吸收底盘相对于彼此的枢转运动的运动吸收装置。 本发明还包括具有这种鞋底装置的鞋和用于制造这种鞋的装配钻机。

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