公开(公告)号：US5652362A

公开(公告)日：1997-07-29

申请号：US643819

申请日：1996-05-06

Applicant: Pine-Sci Kuo ,  Shiao-Jung Chu ,  Chu-Ching Dai ,  Ching-Tang Lin ,  Hsi-Yen Hsu

Inventor： Pine-Sci Kuo ,  Shiao-Jung Chu ,  Chu-Ching Dai ,  Ching-Tang Lin ,  Hsi-Yen Hsu

IPC: C07D201/08

CPC classification number: C07D201/08

Abstract: A method of making caprolactam from aminohexanoic acid or aminohexanoate ester comprising the steps of: (a) obtaining a reactor containing at least one catalyst, the catalyst being a metal oxide having acid-base-paired active sites; (b) charging a reaction feed into the reactor, the reaction feed containing a reactant, which is either amniohexanoic acid or C.sub.1 to C.sub.12 alkyl aminohexanoate ester, and a solvent; (c) reacting the reaction feed at a reaction temperature between 140.degree. and 300.degree. C. and a reaction pressure between 10 and 100 atm, to form a product stream; and (d) separating caprolactam from the product stream. The metal oxide catalyst is prepared from a process comprising the steps of: (a) dissolving at least a metal salt, which is not a metal oxide, in a solvent to form a metal salt solution, wherein: (i) the metal salt contains a metal element selected from the group consisting of silicon, titanium, tin, barium, calcium, magnesium, aluminum, and zinc; (ii) the solvent is selected from the group consisting of water, alcohol, ether, and mixtures thereof, and (iii) the metal salt is a salt which is soluble in the solvent; (b) adjusting the pH of the metal salt solution to be between 8 and 11, to thereby cause a precipitation of metal hydroxide; and (c) calcining the metal hydroxide at 300.degree. to 1,000.degree. C. to form a metal oxide.

Abstract translation: 一种由氨基己酸或氨基己酸酯制备己内酰胺的方法，包括以下步骤：（a）获得含有至少一种催化剂的反应器，该催化剂是具有酸碱配位活性位点的金属氧化物; （b）将反应进料装入反应器中，反应进料含有反应物，其为氨基己酸或C 1至C 12烷基氨基己酸酯，和溶剂; （c）使反应进料在140℃至300℃的反应温度和10至100atm的反应压力下反应，形成产物流; 和（d）从产物流中分离己内酰胺。 金属氧化物催化剂由包括以下步骤的方法制备：（a）将至少一种不是金属氧化物的金属盐溶解在溶剂中以形成金属盐溶液，其中：（i）金属盐包含 选自硅，钛，锡，钡，钙，镁，铝和锌的金属元素; （ii）溶剂选自水，醇，醚及其混合物，和（iii）金属盐是可溶于溶剂的盐; （b）将金属盐溶液的pH调节至8〜11，使金属氢氧化物析出; 和（c）在300-1,000℃下煅烧金属氢氧化物以形成金属氧化物。