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公开(公告)号：US20200095530A1
公开(公告)日：2020-03-26
申请号：US16468653
申请日：2017-10-10
Applicant: CYFUSE BIOMEDICAL K.K.
Inventor： Yasuto KISHII , Norihiko TOKUNAGA
Abstract: The cell structure producing apparatus capable of properly piercing a cell aggregate and a cell tray are demanded. The object of the present invention is achieved by a cell structure producing apparatus that includes a movable needle-shaped body and sticks and penetrates a cell aggregate held on a cell tray, wherein the cell tray includes a frame having an opening, and a porous member that is supported at the opening by the frame and on which the cell aggregate is placeable, and a tip of the needle-shaped body is capable of penetrating through the porous member when the needle-shaped body sticks and penetrates the cell aggregate.
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公开(公告)号：US20160022870A1
公开(公告)日：2016-01-28
申请号：US14776101
申请日：2013-10-24
Applicant: SAGA UNIVERSITY , CYFUSE BIOMEDICAL K.K.
Inventor： Ryo NOGUCHI , Tadashi TAMURA , Koichi NAKAYAMA , Shigeki MORITA , Koichi NODE
CPC classification number: A61L27/3625 , A61K35/33 , A61K35/34 , A61K35/44 , A61L27/3804 , A61L27/3886 , A61L27/507 , A61L2300/64 , A61L2430/20 , C12N5/0691 , C12N5/0697 , C12N2502/1323 , C12N2502/1329 , C12N2502/28
Abstract: Provided is a method for producing a cardiac tissue spheroid or vascular tissue spheroid formed from a mixture of a myocardial cell or smooth muscle cell and at least one type of cell selected from a vascular endothelial cell and fibroblast, and a three dimensional cardiac tissue structure or three dimensional vascular tissue structure which are characterized by combining or laminating said spheroid.
Abstract translation: 本发明提供一种由心肌细胞或平滑肌细胞和至少一种选自血管内皮细胞和成纤维细胞的细胞的混合物形成的心脏组织球状体或血管组织球形体的制造方法，以及三维心脏组织结构或 三维血管组织结构，其特征在于组合或层压所述球体。
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公开(公告)号：US12247223B2
公开(公告)日：2025-03-11
申请号：US17432029
申请日：2020-02-21
Applicant: CYFUSE BIOMEDICAL K.K.
Inventor： Toshihiko Maekawa , Eri Nagao , Izumi Ide , Sakura Kajiyama
IPC: C12N5/071 , C12Q1/6883 , G01N33/50
Abstract: Long awaited is a human liver-like three-dimensional construct that makes it possible to carry out evaluation of human-specific toxicity and the like accurately and in a simple manner. The present invention provides a human liver-like three-dimensional construct comprising a heterospheroid, in which human hepatic cells and other human-derived cells which are not human hepatic cells are aggregated. This human liver-like three-dimensional construct is characterized in that the other human-derived cells are at least one selected from human hepatic stellate cells and the like, and the other human-derived cell to the human hepatic cell count ratio is at least 0.01 but less than 1.
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公开(公告)号：US20240303813A1
公开(公告)日：2024-09-12
申请号：US18599728
申请日：2024-03-08
Applicant: SCREEN Holdings Co., Ltd. , Cyfuse Biomedical K.K.
Inventor： Ryo HASEBE , Toshihiko Maekawa , Ayu Inoue
CPC classification number: G06T7/0012 , G06T7/11 , G06T2207/30024
Abstract: In an evaluation method, first, spheroids obtained by three-dimensional culture of multiple kinds of liver-derived cells are imaged by optical coherence photography, a localization region is extracted from the photographic image, the localization region is analyzed (analysis step), and the condition of the spheroid is evaluated. The analysis step includes a first calculation step of calculating the area of the entire spheroid in the photographic image, a second calculation step of calculating the area of the localization region, a third calculation step of calculating the ratio of the localization region on the basis of the two areas, and a fourth calculation step of calculating an evaluation parameter on the basis of the ratio.
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公开(公告)号：US20250129338A1
公开(公告)日：2025-04-24
申请号：US19003018
申请日：2024-12-27
Applicant: CYFUSE BIOMEDICAL K.K.
Inventor： Toshihiko MAEKAWA , Eri NAGAO , Izumi IDE , Sakura KAJIYAMA
IPC: C12N5/071 , C12Q1/6883 , G01N33/50
Abstract: Long awaited is a human liver-like three-dimensional construct that makes it possible to carry out evaluation of human-specific toxicity and the like accurately and in a simple manner. The present invention provides a human liver-like three-dimensional construct comprising a heterospheroid, in which human hepatic cells and other human-derived cells which are not human hepatic cells are aggregated. This human liver-like three-dimensional construct is characterized in that the other human-derived cells are at least one selected from human hepatic stellate cells and the like, and the other human-derived cell to the human hepatic cell count ratio is at least 0.01 but less than 1.
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Patent Agency Ranking
公开(公告)号：US20220331483A1
公开(公告)日：2022-10-20
申请号：US17611472
申请日：2020-05-14
Inventor： Tetsuya IMAMURA , Mitsuru SHIMAMURA
IPC: A61L27/36
Abstract: A material for inducing nerve regeneration in a transplantation site, or a material for recovering the function of nerve tissues in a transplantation site, the material comprising a cell structure having a thickness of at least 300 μm that is constructed by stacking the spheroids of bone marrow-derived cells, adipose tissue-derived cells, dental pulp-derived cells, amnion-derived cells, placenta-derived cells, umbilical cord-derived cells, or umbilical cord blood-derived cells, on a needle-shaped body arranged on a substrate.
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公开(公告)号：US20210293704A1
公开(公告)日：2021-09-23
申请号：US17338841
申请日：2021-06-04
Applicant: Sumitomo Electric Industries, Ltd. , Cyfuse Biomedical K.K. , National University Corporation Tokai National Higher Education and Research System
Inventor： Asako MOTOMURA , Yoko SUGIYAMA , Hiroshi SUGANUMA , Akinori KIMURA , Shizuka AKIEDA , Yudai MIYAZAKI , Ryuji KATO , Mayu SHIBUTA , Ryohei YAMAMOTO
IPC: G01N21/59
Abstract: A method for quality evaluation includes emitting measurement light having a wavelength of 300 nm or more and 2,000 nm or less to a cell mass and acquiring a plurality of light intensity information corresponding to each of a plurality of measuring positions in the cell mass, generating a feature amount from a variation of the acquired plurality of light intensity information, and evaluating quality of the cell mass using the generated feature amount as an index.
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公开(公告)号：US10087415B2
公开(公告)日：2018-10-02
申请号：US15114970
申请日：2015-09-25
Applicant: CYFUSE BIOMEDICAL K.K.
Inventor： Koji Kuchiishi , Tadashi Tamura
Abstract: Provided are: a cell tray provided with a concave part for supporting a cell aggregate and a hole formed on the bottom of the concave part; and a device for producing a cell structure, said device being provided with the cell tray and a puncture part passing through the cell tray and the cell aggregate, characterized in that the puncture part passes through the cell aggregate supported by the concave part until the tip thereof intrudes into the hole. Also provided is a system for producing a cell structure, said system comprising: a determination part that examines the characteristics of cell aggregates; a fractionation part that classifies the cell aggregates depending on the results of the examination by the determination part; a discharge part that disposes the cell aggregates in a cell tray depending on the results of the classification by the fractionation part; a puncture part that pass through a plurality of cell aggregates disposed in the cell tray; and a holding part that aligns and holds a plurality of puncture parts passing through a plurality of cell aggregates.
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公开(公告)号：US20210332318A1
公开(公告)日：2021-10-28
申请号：US16616347
申请日：2019-02-01
Applicant: Cyfuse Biomedical K.K.
Inventor： Yasuto KISHII
Abstract: The cell structure fixing and removing system includes: an alignment base made of a silicone resin, the alignment base including a flat sticking surface to which needles with skewed cell aggregates are to be stuck; and a cell structure removing tool placed on the sticking surface between the alignment base and the cell aggregate, the cell structure removing tool including: a frame extending to correspond to an outline of the sticking surface, the frame including a puncture opening in middle, a bottom surface of the frame forming an alignment surface parallel to the sticking surface; and a porous sheet stretched and arranged on the alignment surface to close the puncture opening of the frame, the porous sheet allowing penetration by the needle, wherein an outline edge of the puncture opening in the alignment surface of the frame of the cell structure removing tool is located in the outline of the sticking surface.
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公开(公告)号：US10961495B2
公开(公告)日：2021-03-30
申请号：US16308343
申请日：2017-10-30
Applicant: Cyfuse Biomedical K.K.
Inventor： Yasuto Kishii , Norihiko Tokunaga
Abstract: The cell structure producing apparatus including needles, a sticking unit configured to detachably hold an end portion of each of the needles, descend the each of the needles with respect to a cell tray in which cell aggregates are held, stick and penetrate each of the cell aggregates with the tip end, and ascend the needle after sticking, at least one time or more, a base unit, and a control unit configured to move the sticking unit so that for the each of the needles, each of the needles sticking the cell aggregates is positioned at a predetermined position over the base unit, descend each of the needles by a predetermined amount to stick the tip end into the base unit at the predetermined position on the base unit, and control the sticking unit.
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