公开(公告)号：US10444979B2

公开(公告)日：2019-10-15

申请号：US13609729

申请日：2012-09-11

Applicant: Xuedong David Huang ,  Samuel Y. Shen ,  Hongjiang Zhang ,  Yong Rui

Inventor： Xuedong David Huang ,  Samuel Y. Shen ,  Hongjiang Zhang ,  Yong Rui

IPC: G06F17/30 ,  G06F3/0488 ,  G06F3/01 ,  G06F16/951

Abstract: Computer-readable media, computer systems, and computing devices for initiating a search function, such as presentation of a search box or initiation of a search, is provided. In one embodiment, the method includes detecting movement of a selector from within a display area to an edge of the display area. Such a selector can be controlled by an input device coupled to a user device. In response to detecting movement of the selector from within the display area to the edge of the display area, a search-query input area associated with a search engine is presented within a display screen view.

公开(公告)号：US20190150729A1

公开(公告)日：2019-05-23

申请号：US16308901

申请日：2017-06-15

Applicant: David Huang ,  Gangjun Liu ,  Yali Jia

Inventor： David Huang ,  Gangjun Liu ,  Yali Jia

IPC: A61B3/10 ,  A61B3/00 ,  A61B3/12 ,  A61B5/00 ,  A61B5/11 ,  A61B5/02

Abstract: Disclosed are systems and methods for generating wide-field optical coherence tomography angiography (OCTA) images. In embodiments, multiple OCTA scans of a sample are automatically acquired at overlapping locations. The systems and methods include functionality to adaptively control the scanning procedure such that eye blink and eye motion events are detected in real time and accounted for during 3D scan acquisition. Also disclosed are methods for detecting and correcting motion-related artifacts in OCTA datasets which allow for the longer scan times over larger fields of view required for wide-field imaging. These methods may include division of en face angiogram images into a set of motion-free parallel strips, and application of gross and fine registration methods to align overlapping strips into a motion-corrected composite image. A series of overlapping motion-corrected composite images may be combined into a larger montage to enable wide-field OCTA imaging using multiple OCTA scans.

公开(公告)号：US20160284085A1

公开(公告)日：2016-09-29

申请号：US15080498

申请日：2016-03-24

Applicant: David Huang ,  Yali Jia ,  Li Liu

Inventor： David Huang ,  Yali Jia ,  Li Liu

IPC: G06T7/00 ,  G06T5/50 ,  G06T5/00 ,  G06T5/20 ,  A61B3/10 ,  G01B9/02

CPC classification number: G06T7/0016 ,  A61B3/102 ,  G01B9/02091 ,  G06T7/136 ,  G06T2207/10101 ,  G06T2207/20036 ,  G06T2207/20192 ,  G06T2207/30041

Abstract: Disclosed are systems and methods to automatically detect choroidal neovasculatization (CNV) in the outer retina using OCT angiography. Further disclosed are methods of removing projection artifacts from the outer retina and for combining brightness, orientation, and position information in a context-aware saliency model to quantify CNV area in OCT angiograms.

Abstract translation: 公开了使用OCT血管造影自动检测外视网膜中的脉络膜新血管化（CNV）的系统和方法。 进一步公开的是从外部视网膜去除投影伪影并且用于在上下文感知显着性模型中组合亮度，取向和位置信息以量化OCT血管造影图中的CNV面积的方法。

公开(公告)号：US20160278627A1

公开(公告)日：2016-09-29

申请号：US15080471

申请日：2016-03-24

Applicant: David Huang ,  Yali Jia

Inventor： David Huang ,  Yali Jia

IPC: A61B3/00 ,  A61B3/12 ,  A61B3/14 ,  A61B3/10

CPC classification number: A61B3/0025 ,  A61B3/0041 ,  A61B3/102 ,  A61B3/1233 ,  A61B3/1241 ,  A61B3/14 ,  G06T2207/30041

Abstract: Methods of applying OCT angiography are disclosed. In particular, methods of detecting, visualizing and measuring the extent of retinal neovascularization are disclosed. Further disclosed are methods measuring retinal nonperfusion area and choriocapillaris defect area.

Abstract translation: 公开了应用OCT血管造影术的方法。 特别地，公开了检测，可视化和测量视网膜新生血管形成程度的方法。 还公开了测量视网膜非灌注面积和绒毛膜毛细血管缺损区域的方法。

公开(公告)号：US20150324978A1

公开(公告)日：2015-11-12

申请号：US14704175

申请日：2015-05-05

Applicant: David Huang ,  Yan Li ,  James T. Rosenbaum ,  Jennifer Rose-Nussbaumer

Inventor： David Huang ,  Yan Li ,  James T. Rosenbaum ,  Jennifer Rose-Nussbaumer

IPC: G06T7/00

CPC classification number: A61B3/102 ,  A61B3/117 ,  G06T7/0012 ,  G06T2207/10101 ,  G06T2207/30041

Abstract: Methods and systems for determining a percentage composition of aqueous cells in an anterior chamber of an eye of a subject based on cell reflectance distributions calculated from OCT image data are disclosed. In one example approach, determining a percentage composition of detected aqueous cells may comprise calculating a percentage of the detected aqueous cells which are polymorphonuclear and calculating a percentage of detected aqueous cells which are mononuclear.

Abstract translation: 公开了基于由OCT图像数据计算的细胞反射率分布来确定受试者眼睛前房中的水细胞百分比组成的方法和系统。 在一个示例性方法中，确定检测到的水溶性细胞的百分比组成可以包括计算检测到的水合细胞的百分比，其是多形核，并计算检测到的单核水溶液细胞的百分比。

公开(公告)号：US20150265344A1

公开(公告)日：2015-09-24

申请号：US14731355

申请日：2015-06-04

Applicant: Mehmet Kemal AKTAS ,  Spencer Z. ROSERO ,  David HUANG

Inventor： Mehmet Kemal AKTAS ,  Spencer Z. ROSERO ,  David HUANG

IPC: A61B18/14

CPC classification number: A61B18/1492 ,  A61B2018/00196 ,  A61B2018/00351 ,  A61B2018/0038 ,  A61B2018/0212 ,  A61M2025/0089

Abstract: A cardiac treatment system of the subject technology provides access across an interatrial septum of a patient. Such a treatment system can include a catheter having an ablation treatment device on an outer surface of a distal region thereof. A needle is provided at least partially within a lumen of the catheter. A control unit is operatively connected to the ablation treatment device for ablation of a portion of a septum by RF ablation. A distal end of a catheter is provided to the septum (e.g., at the fossa ovalis) of the patient while a distal tip of the needle is within the lumen and proximal to the distal end of the catheter. The distal tip of the needle punctures and crosses the septum, and a portion of the septum is ablated with an ablation treatment device aligned with the septum by guidance from the needle.

Abstract translation: 本科技术的心脏治疗系统提供穿过患者的房间隔的通路。 这种治疗系统可以包括在其远侧区域的外表面上具有消融治疗装置的导管。 针至少部分地设置在导管的内腔内。 控制单元可操作地连接到消融治疗装置，用于通过RF消融消融隔膜的一部分。 导管的远端提供给患者的隔膜（例如，在卵窝窝处），而针的远侧末端位于内腔内并且靠近导管的远端。 针的远端穿刺并穿过隔膜，并且通过来自针的引导与隔膜对准的消融治疗装置消融隔膜的一部分。

公开(公告)号：US08758707B2

公开(公告)日：2014-06-24

申请号：US12999259

申请日：2009-06-16

Applicant: Andrew Watkins ,  Nathan Ray ,  David Huang

Inventor： Andrew Watkins ,  Nathan Ray ,  David Huang

IPC: B01L3/02 ,  G01N1/30

CPC classification number: G01N1/312

Abstract: An apparatus and method for applying reagents to tissue mounted on slides, in the field of histology is disclosed. The apparatus holds a number of slides, in slide trays, which are loaded onto the apparatus. Each slide tray forms a batch of slides, with all the batched forming a group. The apparatus holds a number of reagents, grouped into a first group comprising bulk type reagents, and a second group comprising antibodies or probes, and detection systems, for identifying elements of the tissue. A group fluid dispenser, in the form of a robot arm, dispense reagents to the group of slides. Each batch of slides has its own batch fluid dispenser to dispense reagents onto the batch of slides. In on embodiment, the group fluid dispenser dispense antibodies, probes, detection reagents to all slides depending on the protocol defined for each slide, and the batch dispensers dispense bulk reagent to each batch, thus freeing the group fluid dispense from dispensing bulk reagents to all slides.

Abstract translation: 公开了一种在组织学领域中对安装在载玻片上的组织施加试剂的装置和方法。 该装置在装载到装置中的多个幻灯片托盘中保持多个幻灯片。 每个滑动托架形成一批幻灯片，所有的批量形成一组。 该装置保持多个试剂，分组为包含本体试剂的第一组，以及包含抗体或探针的第二组和用于鉴定组织元件的检测系统。 以机器人手臂的形式的组液体分配器将试剂分配到一组载玻片。 每批幻灯片都有自己的批量流体分配器，以将试剂分配到批次的载玻片上。 在一个实施方案中，组流体分配器根据为每个载片定义的方案向所有载玻片分配抗体，探针，检测试剂，并且批量分配器将批量试剂分配给每个批次，从而释放基团流体分配以将散装试剂分配给所有 幻灯片。

公开(公告)号：US08486320B2

公开(公告)日：2013-07-16

申请号：US13170457

申请日：2011-06-28

Applicant: David Huang

Inventor： David Huang

IPC: B32B37/00

CPC classification number: B29C31/048

Abstract: A spindle motor tray adhesive dispensing method and supplementary apparatus is disclosed. The apparatus includes a base block and a pressure block. The base block supports the tray to be processed, having a blind hole for receiving one end of the center axle of the tray and three adhesive troughs around the blind hole. The pressure block pressed on the tray above the base block and axially movable relative to the base block, having a guide hole for receiving the other end of the center axle of the tray. An open space is defined above the base block around the pressure block within which an adhesive dispenser is movable to dispense a polymer adhesive to the through holes on the tray and the adhesive troughs of the base block to form rubber pads at the tray when cured.

Abstract translation: 公开了一种主轴电机托盘粘合剂分配方法和补充装置。 该装置包括基座块和压力块。 基座支撑待处理的托盘，具有用于接收托盘的中心轴的一端的盲孔和围绕盲孔的三个粘合槽。 压块被压在基座上方的托盘上并相对于基座可轴向移动，具有用于容纳托盘的中心轴的另一端的引导孔。 在压块周围的基座上方限定了开放空间，粘合剂分配器可移动到其中，以将聚合物粘合剂分配到托盘上的通孔和基块的粘合剂槽，以在固化时在托盘处形成橡胶垫。

公开(公告)号：US08399484B2

公开(公告)日：2013-03-19

申请号：US12560752

申请日：2009-09-16

Applicant: David Huang ,  Gerhard Gustav Steinmann ,  Jerry Oscar Stern

Inventor： David Huang ,  Gerhard Gustav Steinmann ,  Jerry Oscar Stern

IPC: A01N43/42 ,  A01N43/78 ,  A01N43/36 ,  A61K31/47 ,  A61K31/425 ,  A61K31/40

CPC classification number: A61K31/7056 ,  A61K38/06 ,  A61K38/212 ,  A61K2300/00

Abstract: The present invention relates to therapeutic combinations comprising (a) Compound (1), or a pharmaceutically acceptable salt thereof, as herein described, (b) an interferon alfa and (c) ribavirin. Compound (1) is a selective and potent inhibitor of the HCV NS3 serine protease. The present invention also relates to methods of using such therapeutic combinations for treating HCV infection or alleviating one or more symptoms thereof in a patient.

Abstract translation: 本发明涉及治疗性组合，其包含（a）如本文所述的化合物（1）或其药学上可接受的盐，（b）干扰素α和（c）利巴韦林。 化合物（1）是HCV NS3丝氨酸蛋白酶的选择性和有效的抑制剂。 本发明还涉及使用这种治疗组合来治疗患者的HCV感染或缓解其一种或多种症状的方法。

公开(公告)号：US08244334B2

公开(公告)日：2012-08-14

申请号：US12101006

申请日：2008-04-10

Applicant: David Huang ,  Yimin Wang

Inventor： David Huang ,  Yimin Wang

IPC: A61B6/00

CPC classification number: A61B3/102

Abstract: This invention provides methods for non-invasive, real-time measuring and/or monitoring of local blood flow in a subject. Methods of the invention generally include the steps of obtaining Doppler shift images of at least two planes intersecting blood vessels at the scanned location; determining Doppler angles using the Doppler shift images; and then using the Doppler angles thus determined together with the Doppler shift signals to arrive at a measure of the volumetric blood flow. Also provided are systems and software for performing the methods.

Abstract translation: 本发明提供了用于非侵入性，实时测量和/或监测受试者中局部血流的方法。 本发明的方法通常包括以下步骤：在扫描位置处获得与血管相交的至少两个平面的多普勒频移图像; 使用多普勒频移图像确定多普勒角度; 然后使用与多普勒频移信号一起确定的多普勒角度来达到体积血流量的量度。 还提供了用于执行方法的系统和软件。